Παρασκευή, 10 Νοεμβρίου 2017

Comparison of fasting and non-fasting lipid profiles in a large cohort of patients presenting at a community hospital

Publication date: Available online 9 November 2017
Source:Clinical Biochemistry
Author(s): Louis-Jacques Cartier, Charlene Collins, Mathieu Lagace, Pierre Douville
ObjectiveTo compare the fasting and non-fasting lipid profile including ApoB in a cohort of patients from a community setting. Our purpose was to determine the proportion of results that could be explained by the known biological variation in the fasting state and to examine the additional impact of non-fasting on these same lipid parameters.Methods1093 adult outpatients with fasting lipid requests were recruited from February to September 2016 at the blood collection sites of the Moncton Hospital. Participants were asked to come back in the next 3–4days after having eaten a regular breakfast to have their blood drawn for a non-fasting lipid profile.Results91.6% of patients in this study had a change in total cholesterol that fell within the biological variation expected for this parameter. Similar results were seen for HDL-C (94.3%) non-HDL-C (88.8%) and ApoB (93.0%). A smaller number of patients fell within the biological variation expected for TG (78.8%) and LDL-C (74.6%). An average TG increase of 0.3mmol/L was observed in fed patients no matter the level of fasting TG. A gradual widening in the range of change in TG concentration was observed as fasting TG increased. Similar results were seen in diabetic patients.ConclusionOutside of LDL-C and TG, little changes were seen in lipid parameters in the postprandial state. A large part of these changes could be explained by the biological variation. We observed a gradual widening in the range of increase in TG for patients with higher fasting TG. Non HDL-C and ApoB should be the treatment target of choice for patients in the non-fasting state.



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