Δευτέρα, 3 Ιουνίου 2019

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome...
The Toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liverAbstractThe Toll-like receptor 7 agonist imiquimod (IMQ) is an approved drug for the topical treatment of various skin diseases that, in addition, is currently tested in multiple clinical trials for the immunotherapy of various types of cancers. As all of these trials include application of IMQ to the skin and evidence exists that exposure to...
Αλέξανδρος Γ. Σφακιανάκης
5m
Okadaic acid activates Wnt/β-catenin-signaling in human HepaRG cells Abstract The lipophilic phycotoxin...
Okadaic acid activates Wnt/β-catenin-signaling in human HepaRG cellsAbstractThe lipophilic phycotoxin okadaic acid (OA) occurs in the fatty tissue and hepatopancreas of filter-feeding shellfish. The compound provokes the diarrhetic shellfish poisoning (DSP) syndrome after intake of seafood contaminated with high levels of the DSP toxin. In animal experiments, long-term exposure to OA is associated with an elevated risk for tumor formation in different organs including the liver. Although OA is a...
Αλέξανδρος Γ. Σφακιανάκης
5m
Novel insight in estrogen homeostasis and bioactivity in the ACI rat model of estrogen-induced mammary...
Novel insight in estrogen homeostasis and bioactivity in the ACI rat model of estrogen-induced mammary gland carcinogenesisAbstractDespite being widely used to investigate 17β-estradiol (E2)-induced mammary gland (MG) carcinogenesis and prevention thereof, estrogen homeostasis and its significance in the female August Copenhagen Irish (ACI) rat model is unknown. Thus, levels of 12 estrogens including metabolites and conjugates were determined mass spectrometrically in 38 plasmas and 52 tissues exhibiting...
Αλέξανδρος Γ. Σφακιανάκης
5m
The in vivo developmental toxicity of diethylstilbestrol (DES) in rat evaluated by an alternative testing...
The in vivo developmental toxicity of diethylstilbestrol (DES) in rat evaluated by an alternative testing strategyAbstractIn the present study, we evaluated an alternative testing strategy to quantitatively predict the in vivo developmental toxicity of the synthetic hormone diethylstilbestrol (DES). To this end, a physiologically based kinetic (PBK) model was defined that was subsequently used to translate concentration–response data for the in vitro developmental toxicity of DES, obtained in the...
Αλέξανδρος Γ. Σφακιανάκης
6m
Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation...
Ecdysteroids as non-conventional anabolic agent: performance enhancement by ecdysterone supplementation in humansAbstractRecent studies suggest that the anabolic effect of ecdysterone, a naturally occurring steroid hormone claimed to enhance physical performance, is mediated by estrogen receptor (ER) binding. In comparison with the prohibited anabolic agents (e.g., metandienone and others), ecdysterone revealed to be even more effective in a recent study performed in rats. However, scientific studies...
Αλέξανδρος Γ. Σφακιανάκης
6m
Toxicology
Verification of soman-related nerve agents via detection of phosphonylated adducts from rabbit albumin in vitro and in vivoAbstractA major challenge in organophosphate compound (OP) and OP nerve agent (OPNA) research has been in the identification and utilization of reliable biomarkers for rapid, sensitive, and efficient detection of OP exposure. Albumin has been widely studied as a biomarker for retrospective verification of exposure to OPNAs, including soman (GD), by detecting the phosphonylation...
Αλέξανδρος Γ. Σφακιανάκης
6m
Proteomic analysis of hippocampal proteins in acrylamide-exposed Wistar rats Abstract Acrylamide has...
Proteomic analysis of hippocampal proteins in acrylamide-exposed Wistar ratsAbstractAcrylamide has been used industrially and also found in certain foods cooked at high temperatures. Previous reports described acrylamide-related human intoxication who presented with ataxia, memory impairment, and/or illusion. The aim of this study was to characterize the molecular mechanisms of neurotoxicity of acrylamide by analyzing the expression levels of various proteins in the hippocampus of rats exposed to...
Αλέξανδρος Γ. Σφακιανάκης
6m
Comparison of volumetric-modulated arc therapy and intensity-modulated radiation therapy prostate cancer...
Comparison of volumetric-modulated arc therapy and intensity-modulated radiation therapy prostate cancer plans accounting for cold spotsAbstractThis study compared dosimetric indices of volumetric-modulated arc therapy (VMAT) with intensity-modulated radiation therapy (IMRT) accounting for cold spots in prostate cancer plans. IMRT plans were retrospectively generated from 30 prostate cancer patients with ten cases for each risk group, who received VMAT plans. The mean, maximum, and minimum doses,...
Αλέξανδρος Γ. Σφακιανάκης
7m
A new approach for detecting abnormalities in mammograms using a computer-aided windowing system based...
A new approach for detecting abnormalities in mammograms using a computer-aided windowing system based on Otsu's methodAbstractBreast cancer is the most common cancer and the leading cause of cancer deaths in women worldwide. This study aimed to provide an automatic windowing method in mammograms, based on the principles of Otsu's thresholding function, to help radiologists more easily detect abnormalities on mammograms. A total of 322 mammographic images from the Mammographic Image Analysis Society...
Αλέξανδρος Γ. Σφακιανάκης
8m
Clinical application of biological fingerprints extracted from averaged chest radiographs and template-matching...
Clinical application of biological fingerprints extracted from averaged chest radiographs and template-matching technique for preventing left–right flipping mistakes in chest radiographyAbstractWe aimed to evaluate the identification performance achieved using biological fingerprints extracted from averaged chest radiographs and template-matching techniques for the prevention of left–right flipping mistakes. We produced averaged chest radiographs for each sex by averaging 100 posteroanterior chest...
Αλέξανδρος Γ. Σφακιανάκης
8m
Radiological Physics and Technology
Early-age Ndufs4 knockout mice are an inappropriate animal model of Leigh syndromeEarly detection of elevated lactate levels in a mitochondrial disease model using chemical exchange saturation transfer (CEST) and magnetic resonance spectroscopy (MRS) with 7T MR imagingProposal of a new method to prove that unnecessary information is not drawn on the image using statistical analysisAbstractThe purpose of this study is to propose a new method of image evaluation using statistical analysis. We used...
Αλέξανδρος Γ. Σφακιανάκης
9m
Cinematic rendering: a new imaging approach for ulcerative colitis AbstractPurpose Cinematic rendering...
Cinematic rendering: a new imaging approach for ulcerative colitisAbstractPurposeCinematic rendering (CR) is a new technique for visualizing volumetric three-dimensional data. The purpose of this study was to investigate the added value of CR to conventional computed tomography (CT) in the diagnosis and evaluation of ulcerative colitis (UC).Materials and methodsWe retrospectively evaluated the CT data of 48 patients (33 men, 15 women; mean age, 44.35 years) with a definitive diagnosis of UC. All...
Αλέξανδρος Γ. Σφακιανάκης
16m
Cryoablation of renal cell carcinoma for patients with stage 4 or 5 non-dialysis chronic kidney disease...
Cryoablation of renal cell carcinoma for patients with stage 4 or 5 non-dialysis chronic kidney diseaseAbstractPurposeTo evaluate the safety and efficacy of cryoablation for renal cell carcinoma (RCC) in patients with stage 4 or 5 non-dialysis chronic kidney disease (CKD).Materials and methodsThis retrospective multicenter study included patients with maximum tumor diameter ≤ 4 cm, estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73 m2, in whom cryoablation was performed percutaneously...
Αλέξανδρος Γ. Σφακιανάκης
16m
Ethanol fixation method for heart and lung imaging in micro-CT AbstractPurpose The soft tissue imaging...
Ethanol fixation method for heart and lung imaging in micro-CTAbstractPurposeThe soft tissue imaging in micro-CT remains challenging due to its low intrinsic contrast. The aim of this study was to create a simple staining method omitting the usage of contrast agents for ex vivo soft tissue imaging in micro-CT.Materials and methodsHearts and lungs from 30 mice were used. Twenty-seven organs were either fixed in 97% or 50% ethanol solution or in a series of ascending ethanol concentrations. Images...
Αλέξανδρος Γ. Σφακιανάκης
17m
Detectability of the choroid plexus of the third ventricle with magnetic resonance ventriculography...
Detectability of the choroid plexus of the third ventricle with magnetic resonance ventriculographyAbstractPurposeTo clarify the detectability of the choroid plexus of the third ventricle (ChPl3V) with magnetic resonance ventriculography (MRVn) employing a steady-state free precession (SSFP) sequence in comparison to surgical endoscopic movies as a golden standard, as we encountered some clinical cases of total agenesis of corpus callosum (ACC) where we could not recognize the choroid plexus of the...
Αλέξανδρος Γ. Σφακιανάκης
17m
Radiation with concomitant superselective intra-arterial cisplatin infusion for maxillary sinus squamous...
Radiation with concomitant superselective intra-arterial cisplatin infusion for maxillary sinus squamous cell carcinomaAbstractPurposeTo assess the efficacy and prognostic factors after superselective intra-arterial chemoradiation (RADPLAT) for maxillary sinus squamous cell carcinoma (MS-SCC).Materials and methodsPrognostic significance of age, gender, T and N factors, gross tumor volume of the primary-site (GTV), total cisplatin dosage, and total cisplatin dosage per GTV (CDDP/GTV) for primary-site...
Αλέξανδρος Γ. Σφακιανάκης
17m
Distinction between benign and malignant breast masses at breast ultrasound using deep learning method...
Distinction between benign and malignant breast masses at breast ultrasound using deep learning method with convolutional neural networkAbstractPurposeWe aimed to use deep learning with convolutional neural network (CNN) to discriminate between benign and malignant breast mass images from ultrasound.Materials and MethodsWe retrospectively gathered 480 images of 96 benign masses and 467 images of 144 malignant masses for training data. Deep learning model was constructed using CNN architecture GoogLeNet...
Αλέξανδρος Γ. Σφακιανάκης
18m
Radiology
Change in hepatic hemodynamics assessed by hepatic arterial blood pressure and computed tomography during hepatic angiography with the double balloon techniqueAbstractPurposeTo assess the change in hepatic arterial blood pressure (HABP) and computed tomography during hepatic arteriography (CTHA) using the double balloon technique.Materials and methodsNine patients with hepatocellular carcinoma (HCC) were enrolled. We inserted a 5.2-Fr balloon catheter into the common or proper hepatic artery and...
Αλέξανδρος Γ. Σφακιανάκης
18m
T2*-weighted MR imaging findings of giant cell tumors of bone: radiological–pathological correlation...
T2*-weighted MR imaging findings of giant cell tumors of bone: radiological–pathological correlationAbstractPurposeTo assess the correlation between T2*-weighted MR imaging and pathological findings of giant cell tumors (GCT) of bone.MethodsOf the 33 patients with histopathologically proven GCT of bone, 12 were examined using 1.5-T MR imaging, including T2*-weighted imaging, and were included in this study. The imaging and pathological findings of GCTs were compared between GCTs with and without...
Αλέξανδρος Γ. Σφακιανάκης
18m
Head and neck involvement with histoplasmosis; the great masquerader Author links open overlay panelA.SinghaM.GauriaP.GautamaD.GautambM.HaqaA.C.HandaaK.K.Handaa...
Head and neck involvement with histoplasmosis; the great masqueraderAuthor links open overlay panelA.SinghaM.GauriaP.GautamaD.GautambM.HaqaA.C.HandaaK.K.HandaaaDepartment of Otorhinolaryngology and Head and Neck Surgery, Medanta- The Medicity, Gurugram, Haryana, IndiabDepartment of Pathology, Medanta- The Medicity, Gurugram, Haryana, IndiaReceived 7 March 2019, Available online 3 June 2019.   https://doi.org/10.1016/j.amjoto.2019.06.002Get rights and contentAbstractIntroductionHead and neck involvement...
Αλέξανδρος Γ. Σφακιανάκης
19m
Cough. Sore throat. Burning sensation behind the breastbone. Headache. Shortness of breath.
FormaldehydeFormaldehyde is commonly used as a preservative.What is formaldehyde?Formaldehyde is a colorless, strong-smelling, flammable chemical that is produced industrially and used in building materials such as particleboard, plywood, and other pressed-wood products. In addition, it is commonly used as a fungicide, germicide, and disinfectant, and as a preservative in mortuaries and medical laboratories. Formaldehyde also occurs naturally in the environment. It is produced during the decay of...
Αλέξανδρος Γ. Σφακιανάκης
23m
Radiation Protection and Environment
Radon in dwellings and workplaces: An update on current regulationsPushparaja Radiation Protection and Environment 2019 42(1):1-4A comparative study for 235U radioactivity concentration calculation methods in phosphate samplesA Salman, Z Ahmed, Kh A Allam, S El-SharkawyRadiation Protection and Environment 2019 42(1):5-9In this study, a comparison is made between the selection of the most proper and accurate methods for 235U activity determination according to the available conditions with the smallest...
Αλέξανδρος Γ. Σφακιανάκης
31m
Natural Medicines
Rapid discovery and identification of the anti-inflammatory constituents in Zhi-Shi-Zhi-Zi-Chi-TangPublication date: April 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 4Author(s): Hai-Qiang WANG, Yun-Xiang ZHU, Yi-Ning LIU, Ruo-Liu WANG, Shu-Fang WANGAbstractThe anti-inflammatory active ingredients of Zhi-Shi-Zhi-Zi-Chi-Tang (ZSZZCT), a traditional Chinese medicine formula, were predicted and identified using an approach based on activity index, LC-MS, semi-preparative LC and...
Αλέξανδρος Γ. Σφακιανάκης
32m
Acta Histochemica
Prognostic significance of resident CD103+CD8+T cells in human colorectal cancer tissuesPublication date: Available online 30 May 2019Source: Acta HistochemicaAuthor(s): Wenwei Hu, Runzi Sun, Lujun Chen, Xiao Zheng, Jingting JiangAbstractThe prognostic significance and clinical implications of resident CD103+CD8+T cells in human colorectal cancer tissues still remains largely unexplored. In our present study, we aimed to characterize the resident CD8+T cells in human colorectal cancer tissues by...
Αλέξανδρος Γ. Σφακιανάκης
35m
Age related changes in the dermal mast cells and the associated changes in the dermal collagen and...
Age related changes in the dermal mast cells and the associated changes in the dermal collagen and cells: A histological and electron microscopy studyPublication date: Available online 22 May 2019Source: Acta HistochemicaAuthor(s): Sara Mohamed Naguib Abdel HafezAbstractMast cells are widely distributed bone marrow cells. They have a crucial role in the dermal aging process. The aim of the present study was to describe the biochemical and the histological changes that occur in the aged dermal mast...
Αλέξανδρος Γ. Σφακιανάκης
35m
Improved accuracy of hemimandibular reconstructions involving the condyle by utilizing hydroformed reconstruction...
Improved accuracy of hemimandibular reconstructions involving the condyle by utilizing hydroformed reconstruction plates rather than hand‐bent stock platesHui Shan Ong BDS, MD, PhD  Jian Nan Liu DDS, MD, PhD  Abdelrehem Ahmed DDS, MD, PhD  Xing Zhou Qu DDS, MD, PhD  Kenneth Wan DDS, MD, MClinOMFS  Dong Ping Xie MS … See all authorsFirst published: 28 May 2019 https://doi.org/10.1002/hed.25809All authors have read and approved the manuscript. All authors abide by the ethical protocol and certified...
Αλέξανδρος Γ. Σφακιανάκης
37m
Risk stratification of fine‐needle aspiration cytology of parotid neoplasms based on the Milan system—Experience...
Risk stratification of fine‐needle aspiration cytology of parotid neoplasms based on the Milan system—Experience from a tertiary center in AsiaKevin C. C. Choy MBChB  Manish M. Bundele MBBS  Hao Li MMED  Ernest W. Fu MMED  Nandini C. L. Rao MD  Ming Yann Lim MMEDFirst published: 27 May 2019 https://doi.org/10.1002/hed.25804Read the full textePDFPDFTOOLS SHAREAbstractBackgroundThe recently described Milan system provides a unified way of categorizing salivary gland fine‐needle aspiration (FNA) cytology....
Αλέξανδρος Γ. Σφακιανάκης
37m
Catching condyle – Endoscopic-assisted transoral open reduction and rigid fixation of condylar process...
Catching condyle – Endoscopic-assisted transoral open reduction and rigid fixation of condylar process fractures using an auto reposition and fixation osteosynthesis platePublication date: May 2019Source: Journal of Cranio-Maxillofacial Surgery, Volume 47, Issue 5Author(s): Philipp Poxleitner, Pit Jacob Voss, David Steybe, Stefan Schlager, Steffen Schwarz, Marc Anton Fuessinger, Rainer Schmelzeisen, Marc MetzgerAbstractIntroductionFractures of the mandibular condyle are reported to account for 9...
Αλέξανδρος Γ. Σφακιανάκης
39m
Single-step surgical treatment of odontogenic maxillary sinusitis: A retrospective study of 98 cases...
Single-step surgical treatment of odontogenic maxillary sinusitis: A retrospective study of 98 casesPublication date: Available online 4 May 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Fabio Costa, Enzo Emanuelli, Leonardo Franz, Alessandro Tel, Massimo RobionyAbstractPurposeThe aim of this study was to review clinical and radiological presentation, surgery, and results of treatment in patients with chronic odontogenic maxillary sinusitis (OMS) treated with a single surgical procedure,...
Αλέξανδρος Γ. Σφακιανάκης
39m
In vitro proinflammatory gene expression changes in human whole blood after contact with plasma-treated...
In vitro proinflammatory gene expression changes in human whole blood after contact with plasma-treated implant surfacesPublication date: Available online 9 May 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Merlind Becker, Susanne Quabius, Thorben Kewitz, Luka Hansen, Gesa Becker, Matthias Kern, Holger Kersten, Sönke HarderSummaryBackgroundThe aim of this in vitro study was to identify changes in gene expression of proinflammatory cytokines in human whole blood after contact with...
Αλέξανδρος Γ. Σφακιανάκης
39m
Cranio-Maxillofacial Surgery
Scaffold implantation in the omentum majus of rabbits for new bone formationPublication date: Available online 3 June 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Falk Birkenfeld, Andre Sengebusch, Chiara Völschow, Björn Möller, Hendrik Naujokat, Jörg WiltfangAbstractRestoration of the mandible after defects caused by ablative surgery remains challenging. Microvascular free flaps from the scapula, fibula or iliac crest remain the 'gold standard'. A drawback of these methods is donor-side...
Αλέξανδρος Γ. Σφακιανάκης
40m
Computed tomography visualizing alterations in the upper airway after orthognathic surgery Publication...
Computed tomography visualizing alterations in the upper airway after orthognathic surgeryPublication date: Available online 10 May 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Luis Fernando Azambuja Alcalde, Paulo Esteves Pinto Faria, Renato Luiz Maia Nogueira, Letícia Chihara, Eduardo Sant'AnaAbstractThree-dimensional (3D) software has revolutionized planning in orthognathic surgery. This technology allows the simulation of surgical movements and evaluation of the volume and area...
Αλέξανδρος Γ. Σφακιανάκης
40m
Microdialysis in postoperative monitoring of microvascular free flaps: experiences with a decision...
Microdialysis in postoperative monitoring of microvascular free flaps: experiences with a decision algorithmPublication date: Available online 28 May 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Falk Birkenfeld, Hendrik Naujokat, Ann-Kristin Helmers Nicolai Purcz, Björn Möller, Jörg WiltfangAbstractBackgroundReconstruction with free flaps has become a usual practice in maxillofacial surgery. Clinical monitoring is still the standard approach for postoperative follow-up, but can be...
Αλέξανδρος Γ. Σφακιανάκης
40m
Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma Yuan Zhang, M.D., Ph.D.,...
Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal CarcinomaYuan Zhang, M.D., Ph.D., Lei Chen, M.D., Ph.D., Guo-Qing Hu, M.D., Ning Zhang, M.D., Xiao-Dong Zhu, M.D., Ph.D., Kun-Yu Yang, M.D., Feng Jin, M.D., Mei Shi, M.D., Ph.D., Yu-Pei Chen, M.D., Wei-Han Hu, M.D., Zhi-Bin Cheng, M.D., Si-Yang Wang, M.D., et al.https://www.nejm.org/doi/full/10.1056/NEJMoa1905287?query=oncology-hematologyAbstractBACKGROUNDPlatinum-based concurrent chemoradiotherapy is the standard of care for patients...
Αλέξανδρος Γ. Σφακιανάκης
55m
Daratumumab plus Lenalidomide and Dexamethasone for Untreated Myeloma Thierry Facon, M.D., Shaji Kumar,...
Daratumumab plus Lenalidomide and Dexamethasone for Untreated MyelomaThierry Facon, M.D., Shaji Kumar, M.D., Torben Plesner, M.D., Robert Z. Orlowski, M.D., Philippe Moreau, M.D., Nizar Bahlis, M.D., Supratik Basu, M.D., Hareth Nahi, M.D., Cyrille Hulin, M.D., Hang Quach, M.D., Hartmut Goldschmidt, M.D., Michael O'Dwyer, M.D., et al., for the MAIA Trial Investigators*https://www.nejm.org/doi/full/10.1056/NEJMoa1817249?query=oncology-hematologyAbstractBACKGROUNDLenalidomide plus dexamethasone is a...
Αλέξανδρος Γ. Σφακιανάκης
59m
Ibrutinib and Venetoclax for First-Line Treatment of CLL Nitin Jain, M.D., Michael Keating, M.D., Philip...
Ibrutinib and Venetoclax for First-Line Treatment of CLLNitin Jain, M.D., Michael Keating, M.D., Philip Thompson, M.D., Alessandra Ferrajoli, M.D., Jan Burger, M.D., Ph.D., Gautam Borthakur, M.D., Koichi Takahashi, M.D., Zeev Estrov, M.D., Nathan Fowler, M.D., Tapan Kadia, M.D., Marina Konopleva, M.D., Ph.D., Yesid Alvarado, M.D., et al.https://www.nejm.org/doi/full/10.1056/NEJMoa1900574?query=oncology-hematologyAbstractBACKGROUNDIbrutinib, an inhibitor of Bruton's tyrosine kinase, and venetoclax,...
Αλέξανδρος Γ. Σφακιανάκης
1h
Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast Cancer Fabrice André, M.D.,...
Alpelisib for PIK3CA-Mutated, Hormone Receptor–Positive Advanced Breast CancerFabrice André, M.D., Eva Ciruelos, M.D., Gabor Rubovszky, M.D., Mario Campone, M.D., Sibylle Loibl, M.D., Hope S. Rugo, M.D., Hiroji Iwata, M.D., Pierfranco Conte, M.D., Ingrid A. Mayer, M.D., Bella Kaufman, M.D., Toshinari Yamashita, M.D., Yen-Shen Lu, M.D., et al., for the SOLAR-1 Study Group*https://www.nejm.org/doi/full/10.1056/NEJMoa1813904?query=oncology-hematologyAbstractBACKGROUNDPIK3CA mutations occur in approximately...
Αλέξανδρος Γ. Σφακιανάκης
1h
A STEMI Mimic Dongbo Yu, M.D., Ph.D., and John E.A. Blair, M.D. https://www.nejm.org/doi/full/10.1056/NEJMicm1810236?query=oncology-hematology...
A STEMI MimicDongbo Yu, M.D., Ph.D., and John E.A. Blair, M.D.https://www.nejm.org/doi/full/10.1056/NEJMicm1810236?query=oncology-hematologyAn 84-year-old man presented to the emergency department with generalized weakness and shortness of breath. Electrocardiographic results aroused concern that he had an ST-segment elevation myocardial infarction (STEMI), and the patient was transferred to a hospital that had a cardiac catheterization laboratory. On arrival at the second hospital, the patient had...
Αλέξανδρος Γ. Σφακιανάκης
1h
Metastatic Uveal Melanoma Lesley Everett, M.D., Ph.D., and Thomas Copperman, M.D. https://www.nejm.org/doi/full/10.1056/NEJMicm1810596?query=oncology-hematology...
Metastatic Uveal MelanomaLesley Everett, M.D., Ph.D., and Thomas Copperman, M.D.https://www.nejm.org/doi/full/10.1056/NEJMicm1810596?query=oncology-hematologyA 59-year-old woman presented to the emergency department with a 4-day history of inflammation and pain in the right eye. She had been blind in the eye for several years before presentation. The physical examination showed proptosis of the right eye, with periorbital inflammation, ophthalmoplegia, and a right relative afferent pupillary defect....
Αλέξανδρος Γ. Σφακιανάκης
1h
Ibrutinib and Venetoclax — Doubling Down on CLL Adrian Wiestner, M.D., Ph.D. This article has no abstract;...
Ibrutinib and Venetoclax — Doubling Down on CLLAdrian Wiestner, M.D., Ph.D.This article has no abstract; the first 100 words appear below.https://www.nejm.org/doi/full/10.1056/NEJMe1904362?query=oncology-hematologyChronic lymphocytic leukemia (CLL) is a clonal expansion of mature B cells in blood, bone marrow, and lymphoid tissues that usually manifests as a high lymphocyte count in the circulating blood. Cell expansion is driven by constitutive B-cell receptor signaling and sustained by overexpression...
Αλέξανδρος Γ. Σφακιανάκης
1h
Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs...
Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese PatientsA Randomized Clinical TrialWriting Committee for the PROBESE Collaborative Group of the PROtective VEntilation Network (PROVEnet) for the Clinical Trial Network of the European Society of AnaesthesiologyArticle InformationJAMA. Published online June 3, 2019. doi:10.1001/jama.2019.7505visual abstract icon VisualAbstracteditorial comment...
Αλέξανδρος Γ. Σφακιανάκης
1h
Artificial Intelligence in Medicine
Combining clustering and classification ensembles: A novel pipeline to identify breast cancer profilesPublication date: June 2019Source: Artificial Intelligence in Medicine, Volume 97Author(s): Utkarsh Agrawal, Daniele Soria, Christian Wagner, Jonathan Garibaldi, Ian O. Ellis, John M.S. Bartlett, David Cameron, Emad A. Rakha, Andrew R. GreenAbstractBreast Cancer is one of the most common causes of cancer death in women, representing a very complex disease with varied molecular alterations. To assist...
Αλέξανδρος Γ. Σφακιανάκης
17h
Recurrent cutaneous abscesses due to Panton‐Valentine leukocidin (PVL)‐positive Staphylococcus aureus...
Recurrent cutaneous abscesses due to Panton‐Valentine leukocidin (PVL)‐positive Staphylococcus aureus in immunocompetent patients with travel history: an increasing problemMeike Förster  Mosaad Megahed  Thomas Bieber  Julia Altengarten  Dominik Schultes  Jean‐Pierre Allam  Galina BalakirskiFirst published: 27 May 2019 https://doi.org/10.1111/ddg.13866
Αλέξανδρος Γ. Σφακιανάκης
17h
Facial folliculocystic and collagen hamartoma: a variant of fibrous cephalic plaque with prominent cyst...
Facial folliculocystic and collagen hamartoma: a variant of fibrous cephalic plaque with prominent cyst formation?Alejandra Reolid  Raquel Navarro  Esteban Daudén  María Concepción Alonso‐Cerezo  Javier Fraga  Mar Llamas‐VelascoFirst published: 30 May 2019 https://doi.org/10.1111/ddg.13867
Αλέξανδρος Γ. Σφακιανάκης
17h
Medical Research
Creating political commitment for antimicrobial resistance in developing countriesRajesh Bhatia, Vishwa Mohan Katoch, Hajime InoueIndian Journal of Medical Research 2019 149(2):83-86Antimicrobial susceptibility profile & resistance mechanisms of Global Antimicrobial Resistance Surveillance System (GLASS) priority pathogens from IndiaBalaji Veeraraghavan, Kamini WaliaIndian Journal of Medical Research 2019 149(2):87-96Antimicrobial resistance is a major concern globally. Infections due to drug-resistant...
Αλέξανδρος Γ. Σφακιανάκης
17h
Allergy, Asthma ,Immunology
Association Between Early-Childhood Antibiotic Exposure and Subsequent Asthma in the US Medicaid PopulationPublication date: Available online 31 May 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Ezra Fishman, Geoffrey Crawford, Andrea DeVries, Jesse Hackell, Kevin Haynes, Mark Helm, Eric Wall, Abiy AgiroThe significance of CD163 expressing macrophages in asthmaPublication date: Available online 30 May 2019Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Yoshihisa Tokunaga,...
Αλέξανδρος Γ. Σφακιανάκης
17h
Perceptions about e-cigarette flavors: a qualitative investigation of young adult cigarette smokers...
Perceptions about e-cigarette flavors: a qualitative investigation of young adult cigarette smokers who use e-cigarettesJulia Cen Chen, Kerry Green, Craig Fryer & Dina BorzekowskiPages 420-428 | Received 13 Mar 2018, Accepted 22 Oct 2018, Published online: 22 Jan 2019Download citation  https://doi.org/10.1080/16066359.2018.1540693  Select Language▼Translator disclaimerAbstractBackground: Although in recent years, an increased number of young adult smokers have used flavored e-cigarettes, little...
Αλέξανδρος Γ. Σφακιανάκης
17h
Reactions to tobacco warning labels: predictors and outcomes of adaptive and maladaptive responses Daniel...
Reactions to tobacco warning labels: predictors and outcomes of adaptive and maladaptive responsesDaniel Owusu, Jiyeon So & Lucy PopovaPages 383-393 | Received 20 Nov 2017, Accepted 28 Sep 2018, Published online: 22 Feb 2019Download citation  https://doi.org/10.1080/16066359.2018.1531127  Select Language▼Translator disclaimerAbstractBackground: The Extended Parallel Process Model (EPPM) responses that emerge from spontaneous reactions to cigarette warning labels remain understudied. We identified...
Αλέξανδρος Γ. Σφακιανάκης
17h
How detergent advertisements can bleach national identity: Postcolonial content analysis of Iranian...
How detergent advertisements can bleach national identity: Postcolonial content analysis of Iranian TV advertisementsAzra Ghandeharion | Lincoln Geraghty (Reviewing editor:)Article: 1626204 | Received 22 Nov 2018, Accepted 28 May 2019, Accepted author version posted online: 02 Jun 2019Download citation  In this articleAbstractINTRODUCTIONLITERATURE REVIEWPOSTCOLONIAL THEORY AS THE CLASSIFICATION SCHEMEMETHODS, MATERIALS AND OBJECTIVERESEARCH FINDINGSANALYSIS AND DISCUSSION: THE CONCEPTUALIZATION...
Αλέξανδρος Γ. Σφακιανάκης
17h
Immunopharmacology and Immunotoxicology
Anti-TNF effect of combined pravastatin and cilostazol treatment in an    in vivo mouse model    Hae-Ri Lee, Min-Kyung Jo, Kyung-Yeon Park, You-Jin Jang & Tae-Hwe Heo    Pages: 179-184    DOI: 10.1080/08923973.2019.1569045    https://www.tandfonline.com/action/doSecureKeyLogin?uuid=d8594a82-ce8d-4e6c-8a1f-0da062c12f34&dateTime=201906100357&key=wabkvy8ugTKYp86Ff7bc8e6rG6yAFmu9Z1I2iXk0Qvc%3D&uri=https%3A%2F%2Fwww.tandfonline.com%2Fdoi%2Fabs%2F10.1080%2F08923973.2019.1569045%3Fai%3D1lf97%26ui%3D843fx%26af%3DT  ...
Αλέξανδρος Γ. Σφακιανάκης
17h
Rapid alert system for dangerous non-food products
Weekly report on consumer productsProducts with serious risks 1 of 2 photosPreviousNextShare on         Alert number: A12/0795/19       Category:  Hobby/sports equipment Product:  Inflatable swim seat Brand: Summer Sea Name: Unknown Type / number of model:  Unknown Batch number / Barcode: Unknown Risk type:  Chemical The plastic valve of the swim-ring contains bis (2-ethylhexyl) phthalate (DEHP) (measured value: 16.2% by weight).This phthalate may harm the health of children, causing possible damage...
Αλέξανδρος Γ. Σφακιανάκης
17h
Rapid alert system for dangerous non-food products
Weekly report on consumer productsProducts with serious risks 1 of 1 photoShare on         Alert number: A12/0823/19       Category:  Jewellery Product:  Earring set Brand: Unknown Name: i love you to the moon and back Type / number of model:  Art. 2567506 Batch number / Barcode:  8719189209280 Risk type:  Chemical The earrings release an excessive amount of nickel (measured value: 9.7 μg/cm²/week).Nickel is a strong sensitiser and can cause allergic reactions if present in articles that come into...
Αλέξανδρος Γ. Σφακιανάκης
17h
Factors associated with Oral Health Related Quality of Life of children with severe -Early Childhood...
Factors associated with Oral Health Related Quality of Life of children with severe -Early Childhood CariesPublication date: July–September 2019Source: Journal of Oral Biology and Craniofacial Research, Volume 9, Issue 3Author(s): Shahnaz Mansoori, Abhishek Mehta, Mohd. Irfan AnsariAbstractBackgroundEarly Childhood Caries (ECC) is a chronic childhood disease affecting children worldwide. Severe cases of ECC can significantly affect child's Oral Health Related Quality of Life (OHRQoL) owing to its...
Αλέξανδρος Γ. Σφακιανάκης
17h
Comparison between N-butyl cyanoacrylate tissue adhesive and Ethilon nylon sutures in extraoral maxillofacial...
Comparison between N-butyl cyanoacrylate tissue adhesive and Ethilon nylon sutures in extraoral maxillofacial incisions: A randomized prospective studyPublication date: July–September 2019Source: Journal of Oral Biology and Craniofacial Research, Volume 9, Issue 3Author(s): Sudipto Sahu, Sobhan Mishra, Sthitaprajna Lenka, Rajarshi Banerjee, Sandeep Pachisia, Sucharu GhoshAbstractObjectivesWound closure is a part of any surgical procedure. Wound care and healing process are concepts, which are usually...
Αλέξανδρος Γ. Σφακιανάκης
17h
Extensive temporomandibular joint ankylosis involving medial pterygoid plates and the maxillary tuberosity-...
Extensive temporomandibular joint ankylosis involving medial pterygoid plates and the maxillary tuberosity- a case reportPublication date: July–September 2019Source: Journal of Oral Biology and Craniofacial Research, Volume 9, Issue 3Author(s): Sujay M. Bhave, Divya Mehrotra, Praveen Singh, Anand ShuklaAbstractBackgroundTemporomandibular joint ankylosis is a distressing condition which leads to significant functional debility and facial blemish. It can be surgically managed with gap or interposition...
Αλέξανδρος Γ. Σφακιανάκης
17h
Diamond-like carbon films over reconstructive TMJ prosthetic materials: Effects in the cytotoxicity,...
Diamond-like carbon films over reconstructive TMJ prosthetic materials: Effects in the cytotoxicity, chemical and mechanical propertiesPublication date: July–September 2019Source: Journal of Oral Biology and Craniofacial Research, Volume 9, Issue 3Author(s): Alecsandro de Moura Silva, Viviane Maria Gonçalves de Figueiredo, Renata Falchete do Prado, Gabriela de Fátima Santanta-Melo, Milagros del Valle El Abras Ankha, Luana Marotta Reis de Vasconcellos, Argemiro Soares da Silva Sobrinho, Alexandre...
Αλέξανδρος Γ. Σφακιανάκης
17h
MIDAS (Minimally Invasive Drilling And Styptic) protocol - A modified approach to treating patients...
MIDAS (Minimally Invasive Drilling And Styptic) protocol - A modified approach to treating patients under therapeutic anticoagulantsPublication date: July–September 2019Source: Journal of Oral Biology and Craniofacial Research, Volume 9, Issue 3Author(s): Yazad Gandhi, Neel BhatavdekarAbstractPatients with cardiac or allied medical conditions mandating long term oral anticoagulant therapy form a sizeable database in an implant practice today.The management of such patients during surgical and dental...
Αλέξανδρος Γ. Σφακιανάκης
17h
Loricrin expression and its implication in oral submucous fibrosis, hyperkeratosis and normal mucosa...
Loricrin expression and its implication in oral submucous fibrosis, hyperkeratosis and normal mucosa with association to habits – An immunohistochemical studyPublication date: July–September 2019Source: Journal of Oral Biology and Craniofacial Research, Volume 9, Issue 3Author(s): Nithya S, Elizabeth Joshua, Ranganathan K, Rooban Thavarajah, Umadevi K. RaoAbstractObjectiveThe coarse fibres of areca nut and the continuous friction from occluding teeth are major causes of mechanical stress to the oral...
Αλέξανδρος Γ. Σφακιανάκης
17h
Development of Moxifloxacin Hydrochloride loaded in-situ gel for the treatment of periodontitis: In-vitro drug...
Development of Moxifloxacin Hydrochloride loaded in-situ gel for the treatment of periodontitis: In-vitro drug release study and antibacterial activityPublication date: July–September 2019Source: Journal of Oral Biology and Craniofacial Research, Volume 9, Issue 3Author(s): Ganesh P. Swain, Shivani Patel, Jaimini Gandhi, Pranav ShahAbstractPeriodontitis is one of the most widespread oral diseases. Medicated in-situ gels of Moxifloxacin Hydrochloride for extended period of retention in infected cavity...
Αλέξανδρος Γ. Σφακιανάκης
17h
Oral Biology and Craniofacial Research
Development of Moxifloxacin Hydrochloride loaded in-situ gel for the treatment of periodontitis: In-vitro drug release study and antibacterial activityPublication date: July–September 2019Source: Journal of Oral Biology and Craniofacial Research, Volume 9, Issue 3Author(s): Ganesh P. Swain, Shivani Patel, Jaimini Gandhi, Pranav ShahAbstractPeriodontitis is one of the most widespread oral diseases. Medicated in-situ gels of Moxifloxacin Hydrochloride for extended period of retention in infected cavity...
Αλέξανδρος Γ. Σφακιανάκης
17h
Dexmedetomidine and fentanyl combination versus dexmedetomidine and pethidine as sedatives during colonoscopy...
Dexmedetomidine and fentanyl combination versus dexmedetomidine and pethidine as sedatives during colonoscopyAhmed M.M El-Garhy, Khaled S.S MakboulThe Scientific Journal of Al-Azhar Medical Faculty, Girls 2019 3(1):72-78Background and aim Endoscopy procedures are generally performed under sedation, which ranging from minimal sedation to deep sedation. Conscious sedation during colonoscopic procedures provides a high level of patient and physician satisfaction. An ideal sedative agent should allow...
Αλέξανδρος Γ. Σφακιανάκης
17h
Diagnostic utility of flexible bronchoscopy in mediastinal and hilar lymphadenopathies Taghreed S Farag,...
Diagnostic utility of flexible bronchoscopy in mediastinal and hilar lymphadenopathiesTaghreed S Farag, Abeer S FaragThe Scientific Journal of Al-Azhar Medical Faculty, Girls 2019 3(1):60-71Background Mediastinal and/or hilar lymphadenopathy with or without parenchymal lesions are difficult in the diagnosis via noninvasive techniques. Objective To assess the role of flexible fiberoptic bronchoscopy (FOB), in particular, blind transbronchial needle aspiration (TBNA) in the diagnosis of mediastinal...
Αλέξανδρος Γ. Σφακιανάκης
17h
Management of lower limb superficial varicosities using conventional surgery versus endovenous laser ablation (EVLA) therapy
Challenges in the management of primary lower extremity varicose veins: what is the best treatment option?Ahmed Mousa, Mohamed El Azzazi, Bosat E BosatThe Scientific Journal of Al-Azhar Medical Faculty, Girls 2019 3(1):50-59Background Varicose vein is considered as one of the commonly practiced venous problems for decades not only by vascular surgeons but also by general surgeons. Aim The purpose of the current study was to compare the results of management of lower limb superficial varicosities...
Αλέξανδρος Γ. Σφακιανάκης
17h
intrathecal hyperbaric bupivacaine with fentanyl and hyperbaric levobupivacaine with fentanyl for knee...
intrathecal hyperbaric bupivacaine with fentanyl and hyperbaric levobupivacaine with fentanyl for knee arthroscopyAyman Esmail Hussien, Mohamed Adel Gawad Abdel HalimThe Scientific Journal of Al-Azhar Medical Faculty, Girls 2019 3(1):44-49Background The use of levobupivacaine as a pure S (−) enantiomer of bupivacaine was progressively increased due to lower cardiotoxicity and neurotoxicity and shorter motor block duration. The aim of this work was to compare the effectiveness of lower-dose local...
Αλέξανδρος Γ. Σφακιανάκης
17h
Prolotherapy for knee osteoarthritis Hesham El-Dosoky, Saad M El Zokm, El Sayed Abd El-Hamid, Yousra...
Prolotherapy for knee osteoarthritisHesham El-Dosoky, Saad M El Zokm, El Sayed Abd El-Hamid, Yousra Abo StateThe Scientific Journal of Al-Azhar Medical Faculty, Girls 2019 3(1):33-43Background and aim Osteoarthritis (OA) is the most common type of chronic arthritis and represents a major cause of pain and disability. Prolotherapy is an injection of hypertonic dextrose used for painful chronic musculoskeletal pain conditions, including knee OA. Patients and methods This study was done to evaluate...
Αλέξανδρος Γ. Σφακιανάκης
17h
Association of platelet endothelial cell adhesion molecule-1 gene polymorphism (Leu125Val) with coronary...
Association of platelet endothelial cell adhesion molecule-1 gene polymorphism (Leu125Val) with coronary artery disease in type II diabetics and nondiabeticsMaha M.S El-Kishki, Amal M Abdelfattah Alramly, Mohamed O Taha, Rana A El Din MedhatThe Scientific Journal of Al-Azhar Medical Faculty, Girls 2019 3(1):23-32Background and objectives Platelet endothelial cell adhesion molecule-1 (PECAM-1) plays a key role in the transendothelial migration of circulating leukocytes (diapedesis) during vascular...
Αλέξανδρος Γ. Σφακιανάκης
17h
Al-Azhar Medical Faculty, Girls
Airway management in morbidly obese adolescents: a comparison between Bonfils fiberscope and fiberoptic bronchoscope assisted with direct laryngoscopyMostafa M SabraThe Scientific Journal of Al-Azhar Medical Faculty, Girls 2019 3(1):1-6Background and aim Pediatric patients presenting to bariatric surgery is increasing in percentage in the last years and has become a fast growing epidemic problem. The aim of this study was to evaluate the usefulness of Bonfils fiberscope (BF-L) and fiberoptic bronchoscope...
Αλέξανδρος Γ. Σφακιανάκης
17h
Pulmonary fungal infection in patients with acute exacerbation of chronic obstructive pulmonary disease...
Pulmonary fungal infection in patients with acute exacerbation of chronic obstructive pulmonary diseaseEman M Mahmoud, Magd M. Galal El-Din, Manal R Hafez, Eman Sobh, Radwa S IbrahimThe Scientific Journal of Al-Azhar Medical Faculty, Girls 2019 3(1):7-13Background Pulmonary fungal infection (PFI) is increasing among patients with chronic obstructive pulmonary disease (COPD). Survival depends on rapid diagnosis and early treatment. Aims To assess the prevalence of PFI in acute exacerbation of chronic...
Αλέξανδρος Γ. Σφακιανάκης
17h
Airway management in morbidly obese adolescents: a comparison between Bonfils fiberscope and fiberoptic...
Airway management in morbidly obese adolescents: a comparison between Bonfils fiberscope and fiberoptic bronchoscope assisted with direct laryngoscopyMostafa M SabraThe Scientific Journal of Al-Azhar Medical Faculty, Girls 2019 3(1):1-6Background and aim Pediatric patients presenting to bariatric surgery is increasing in percentage in the last years and has become a fast growing epidemic problem. The aim of this study was to evaluate the usefulness of Bonfils fiberscope (BF-L) and fiberoptic bronchoscope...
Αλέξανδρος Γ. Σφακιανάκης
17h
Στην απλότητα κρύβεται η ευτυχία – Οδυσσέας Ελύτης,..
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Αλέξανδρος Γ. Σφακιανάκης
17h
E‐cigarettes and head and neck cancers: A systematic review of the current literature Susanne Flach ...
E‐cigarettes and head and neck cancers: A systematic review of the current literatureSusanne Flach  Pavithran Maniam  Jaiganesh ManickavasagamFirst published: 30 May 2019 https://doi.org/10.1111/coa.13384This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/coa.13384ePDFPDFTOOLS...
Αλέξανδρος Γ. Σφακιανάκης
19h
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
Nutrients to Protect Your Skin From Summer Sun Mercola Natural Health Articles - 1h ago Preview  ...Nutrients to Protect Your Skin From Summer SunMercola Natural Health Articles - 1h ago Preview    AUTO POST  SAVE TO EVERNOTESummer and sunshine-filled days are upon us and, with that, increased calls for the use of sunscreen. Unfortunately, most sunscreens contain toxic ingredients that are easily absorbed through your skin and can jeopardize your health.The good news is you can support healthy skin...
Αλέξανδρος Γ. Σφακιανάκης
23h
Nutrients to Protect Your Skin From Summer Sun Mercola Natural Health Articles - 1h ago Preview  ...
Nutrients to Protect Your Skin From Summer SunMercola Natural Health Articles - 1h ago Preview    AUTO POST  SAVE TO EVERNOTESummer and sunshine-filled days are upon us and, with that, increased calls for the use of sunscreen. Unfortunately, most sunscreens contain toxic ingredients that are easily absorbed through your skin and can jeopardize your health.The good news is you can support healthy skin and protect it from ultraviolet damage from the inside. Scientists have identified several nutrients...
Αλέξανδρος Γ. Σφακιανάκης
23h
Do Hair, Skin and Nail Supplements Work? Mercola Natural Health Articles - 1h ago Preview     AUTO...
Do Hair, Skin and Nail Supplements Work?Mercola Natural Health Articles - 1h ago Preview    AUTO POST  SAVE TO EVERNOTEStrong, shiny hair and fingernails (and toenails) that are smooth and uniform in color, and soft, glowing skin are typically viewed as some of the more visible signs of health. Most children have all of the above, but often with factors like stress hormones, oxidative stress and a less-than-healthy diet, your hair and nails can become dry and brittle, and your skin rough and blemished.If...
Αλέξανδρος Γ. Σφακιανάκης
23h
Bacteria, Agriculture and Cupping Mercola Natural Health Articles - 1h ago Preview     AUTO POST ...
Bacteria, Agriculture and CuppingMercola Natural Health Articles - 1h ago Preview    AUTO POST  SAVE TO EVERNOTE1 Research suggests the following herbicide and desiccant, when combined with lectin-rich foods such as peas, beans or potatoes, can trigger the neurological damage seen in patients with Parkinson's disease:GlyphosateDiquatDicambaParaquatResearch shows the desiccant paraquat can trigger Parkinson's disease when combined with plant lectins found in peas, beans, potatoes and many other foods,...
Αλέξανδρος Γ. Σφακιανάκης
23h
Fasting Prevents and Halts Diabetes Mercola Natural Health Articles - 1h ago Preview     AUTO POST ...
Fasting Prevents and Halts DiabetesMercola Natural Health Articles - 1h ago Preview    AUTO POST  SAVE TO EVERNOTEFasting has been practiced for centuries. In fact, science shows that, like animals, we have a fasting instinct that extends through the ages: Hippocrates prescribed and championed fasting while using apple cider vinegar.1Religions around the world developed fasting independently as a practice and the Greeks not only prescribed it for illness, but required it in preparation for many rituals...
Αλέξανδρος Γ. Σφακιανάκης
23h
The Benefits of Vacations for Your Mental Health What is psychology? by Wip - 1h ago Preview    ...
The Benefits of Vacations for Your Mental HealthWhat is psychology? by Wip - 1h ago Preview    AUTO POST  SAVE TO EVERNOTEHave you gone on a trip recently? If you've been doing nothing but work work work, then chances are, a vacation is something that can help you.  While getting therapy from different outlets, including Regain.us, is beneficial, sometimes taking a break and going on vacation can really help you feel better and kickstart your mental health once again. How? Well, read on to find out!Reduces...
Αλέξανδρος Γ. Σφακιανάκης
23h

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

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