Onkologische Nachsorge von Kopf-Hals-Tumor-Patienten

paythelady.61 shared this article with you from Inoreader Onkologische Nachsorge von Kopf-Hals-Tumor-Patienten Via Latest Results for HNO Zusammenfassung Trotz leitliniengerechter Versorgung erleiden stadien- und entitätsabhängig etwa 25–30 % der Patienten mit Kopf-Hals-Karzinomen ein Rezidiv. Primäre Ziele der systematischen Nachsorge bestehen u. a. darin, Rezidive und ggf. metachrone Zweitkarzinome frühzeitig zu erkennen und der adäquaten Therapie zuzuleiten, aber auch, eine Fernmetastasierung auszuschließen. Sekundärziele sind Erkennung und Behandlung von therapieassoziierten Nebenwirkungen zur Optimierung der Lebensqualität. Da das Rezidivrisiko v. a. in den ersten beiden Nachsorgejahren hoch ist, werden i. d. R. vierteljährliche Kontrollintervalle empfohlen, die später auf 6 Monate verlängert werden können. Eine Schnittbildgebung erfolgt bei klinischem Verdacht auf ein Rezidiv und ansonsten sowohl bei der jährlichen Nachsorge in der Primärtumorregion als auch bei der Suche nach Fernmetastasen. Die onkologische Nachsorge ist im Regelfall nach 5‑jähriger Rezidivfreih eit abgeschlossen. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Chemotherapie und zielgerichtete Therapie von Kopf-Hals-Plattenepithelkarzinomen beim ASCO-Kongress 2021

paythelady.61 shared this article with you from Inoreader Chemotherapie und zielgerichtete Therapie von Kopf-Hals-Plattenepithelkarzinomen beim ASCO-Kongress 2021 Via Latest Results for HNO Zusammenfassung Hintergrund Bei der Konferenz der American Society of Clinical Oncology (ASCO) 2021 wurde Neues rund um Chemotherapien und zielgerichtete Therapien vorgestellt. im vorliegenden Beitrag werden einige dieser Publikationen zusammengefasst. Ziel der Arbeit Relevante Publikationen werden zusammenfasst dargestellt und bewertet. Methoden Über eine Datenbankabfrage wurden Abstracts des diesjährigen ASCO-Kongresses gesucht, die sich mit Chemotherapie oder zielgerichteten Therapien bei Kopf-Hals-Plattenepithelkarzinomen beschäftigten. Forschungsankündigungen ohne Daten sowie Publikationen mit Überschneidung zu den weiteren Artikeln dieser Ausgabe wurden aussortiert. Ergebnisse Die Autor*innen stellen 6 Artikel weiterführend vor. Hierbei geht es um neue Applikationsformen sowie die Dosisfindung bei Cisplatin. Zudem geht es um Neoadjuvanzien sowie Cetuximab nach Immuntherapie. Neu untersucht werden liposomales Irinotecan und der mHRAS-Inhibitor Tipifarnib. Schlussfolgerung Patientenspezifischere Dosierungen von Cisplatin sowie die lokale Applikation könnten in Zukunft von Bedeutung sein. Die Blockade von mHRAS wird im Einzelfall nach Sequenzierung Nutzen finden. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A comparative assessment of the amount and rate of orthodontic space closure toward a healed vs recent lower premolar extraction site

paythelady.61 shared this article with you from Inoreader A comparative assessment of the amount and rate of orthodontic space closure toward a healed vs recent lower premolar extraction site Via pubmed: "angle orthod"[jour] Angle Orthod. 2022 Mar 28. doi: 10.2319/102921-797.1. Online ahead of print. ABSTRACT OBJECTIVES: To investigate and compare the amount and rate of space closure and tooth tipping during orthodontic space closure toward a recent vs healed first premolar extraction site. MATERIALS AND METHODS: The mandibular arches of 23 patients were included. Treatment plans included lower first premolar extractions. After reaching 0.019 × 0.025-inch stainless-steel archwires (SSAW), patients were subdivided into two groups (Group 1: space closure was carried out toward a healed first premolar extraction space and Group 2: space closure was carried out immediately after first premolar extraction). Elastomeric power chain from second molar to second molar was used to close lower extraction spaces. The following time points were defined: T1: just before space closure; T2-T4: 1-3 months after initial space closure. Records consisted of dental study models. The amount and rate of extraction space closure were evaluated at each time point. RESULTS: In Group 1 (healed socket), a total amount of 1.98 mm (coronally) and 1.75 mm (gingivally) of space closure was achieved. The rate of space closure was 0.66 mm/month coronally and 0.58 mm/month gingivally. In Group 2 (recent socket), the total amount of space closure was 3.02 mm coronally and 2.68 mm gingivally. The rate of space closure was 1.01 mm/month coronally and 0.89 mm/month gingivally. Differences between t he two groups were significant (P < .01). Tipping of adjacent teeth during space closure was similar in both groups (P > .05). CONCLUSIONS: In the lower arch, the amount and rate of space closure toward a recent extraction site were higher than that toward a healed extraction socket with similar tipping of teeth in both groups. PMID:35344007 | DOI:10.2319/102921-797.1 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Functional Impact and Regulation of Alternative Splicing in Mouse Heart Development and Disease

paythelady.61 shared this article with you from Inoreader Functional Impact and Regulation of Alternative Splicing in Mouse Heart Development and Disease Via Latest Results for Journal of Cardiovascular Translational Research Abstract Alternative splicing (AS) plays a major role in the generation of transcript diversity. In the heart, roles have been described for some AS variants, but the global impact and regulation of AS patterns are poorly understood. Here, we studied the AS profiles in heart disease, their relationship with heart development, and the regulatory mechanisms controlling AS dynamics in the mouse heart. We found that AS profiles characterized the different groups and that AS and gene expression changes affected independent genes and biological functions. Moreover, AS changes, specifically in heart disease, were associated with potential protein–protein interaction changes. While developmental transitions were mainly driven by the upregulation of MBNL1, AS changes in disease were driven by a complex regulatory network, where PTBP1 played a central role. Indeed, PTBP1 over-expression was sufficient to induce cardiac hypertrophy and diastolic dysfunction, potentially by perturb ing AS patterns. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Readmission Rates Following Major Head and Neck Surgery With Concurrent Tracheostomy

paythelady.61 shared this article with you from Inoreader Readmission Rates Following Major Head and Neck Surgery With Concurrent Tracheostomy Via SAGE-Journals: Annals of Otology, Rhinology & Laryngology: Table of Contents Annals of Otology, Rhinology &Laryngology, Ahead of Print. Objectives:To determine the influence of major head and neck procedures on readmission and complication rates following tracheostomy.Methods:A retrospective cohort study using the 2005 to 2017 National Surgical Quality Improvement Program (NSQIP) database. Current Procedural Terminology codes were used to identify tracheostomy patients and to define the underlying head and neck procedure. Patients under the age of 18 and with unknown pre-operative variables were excluded. Univariate and multivariable analyses were performed.Results:A total of 3240 tracheostomy patients undergoing major head and neck surgery were identified in NSQIP. The 30-day mortality rate was 104 (3.2%) and 258 (9.0%) patients were readmitted. 637 (19.7%) patients had an unplanned return to the operating room. There were 1606 (49.6%) non-tracheostomy specific complications, which included 850 (26.2%) medical and 1142 (35.2%) surgical complica tions. On multivariable analysis, we found that the underlying procedures did not impact the risk of readmission (P > .05 for all). The underlying procedure was also not associated with unplanned return to the operating room except for thyroidectomies, which had a lower risk than free tissue graft reconstruction (OR = 0.53 (95%CI 0.31, 0.88), P = .018).Conclusion:While almost 1 in every 2 patients had a complication following major head and neck surgery that included creation of a tracheostomy, the rate of readmission is comparatively low and is not associated with the underlying procedure. These findings should reassure head and neck surgeons that properly managed tracheostomies do not constitute a disproportionate risk of readmission. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Benign paroxysmal positional vertigo

paythelady.61 shared this article with you from Inoreader Benign paroxysmal positional vertigo Via Auris Nasus Larynx Benign paroxysmal positional vertigo (BPPV) is characterized by positional vertigo (brief attacks of rotatory vertigo triggered by head position changes in the direction of gravity) and is the most common peripheral cause of vertigo. There are two types of BPPV pathophysiology: canalolithiasis and cupulolithiasis. In canalolithiasis, otoconial debris is detached from the otolithic membrane and floats freely within the endolymph of the canal. In cupulolithiasis, the otoconial debris released from the otolithic membrane settles on the cupula of the semicircular canal and the specific gravity of the cupula is increased. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.