Παρασκευή, 30 Ιουνίου 2017

Using nonlinear finite element models to analyse stress distribution during subluxation and torque required for dislocation of newly developed total hip structure after prosthetic impingement

Abstract

Dislocation is a serious potential complication of total hip replacement. Previous studies have proposed a newly developed total hip structure that meets the required oscillation angle of 120°, for which the chamfer on the acetabular liner rim was designed to enable the neck to impinge on the chamfer over a large area after impingement occurs. This study adopted the finite element method to further analyse the torque limits leading to dislocation and the contact stresses at the impingement and egress sites of the liner during subluxation. The compressive stress–strain curve for ultra-high molecular weight polyethylene is nonlinear. The results reveal that an adequate chamfer angle of the acetabular cup liner can significantly increase dislocation torque and decrease contact stress on the liner rim. By means of the new design, when the head–neck ratio (HNR) is 2.5 or 3.0, the maximum torque value that a 36-mm head can withstand is 1.38 (8.7 Nm/6.3 Nm) or 1.47 (8.4 Nm/5.7 Nm) times that of a 22-mm head, while the maximum stress of a 36-mm head is 0.41 (14.58 MPa/35.73 MPa) or 0.70 (33.71 MPa/47.90 MPa) times that of a 22-mm head. When the head diameters are identical, the dislocation torque of the HNR = 2.5 structure is slightly greater than that of the HNR = 3.0 structure (3.3–10.5%); thus, the newly developed structure can disperse contact stress, and the structure of a large head with a low HNR exhibits a higher dislocation torque value and lower stress.



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Classification of upper limb disability levels of children with spastic unilateral cerebral palsy using K -means algorithm

Abstract

Treatment for cerebral palsy depends upon the severity of the child's condition and requires knowledge about upper limb disability. The aim of this study was to develop a systematic quantitative classification method of the upper limb disability levels for children with spastic unilateral cerebral palsy based on upper limb movements and muscle activation. Thirteen children with spastic unilateral cerebral palsy and six typically developing children participated in this study. Patients were matched on age and manual ability classification system levels I to III. Twenty-three kinematic and electromyographic variables were collected from two tasks. Discriminative analysis and K-means clustering algorithm were applied using 23 kinematic and EMG variables of each participant. Among the 23 kinematic and electromyographic variables, only two variables containing the most relevant information for the prediction of the four levels of severity of spastic unilateral cerebral palsy, which are fixed by manual ability classification system, were identified by discriminant analysis: (1) the Falconer index (CAIE ) which represents the ratio of biceps to triceps brachii activity during extension and (2) the maximal angle extension (θ Extension,max). A good correlation (Kendall Rank correlation coefficient = −0.53, p = 0.01) was found between levels fixed by manual ability classification system and the obtained classes. These findings suggest that the cost and effort needed to assess and characterize the disability level of a child can be further reduced.



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Long-term (≥20 years) application of fertilizers and straw return enhances soil carbon storage: a meta-analysis

Abstract

Increasing soil carbon (C) storage is crucial to addressing climate change and ensuring food security. The C sequestration potential of the world's cropland soil is 0.4–0.8 Pg soil C year−1, which may be achieved through the adoption of recommended management practices (RMPs), including fertilizer management. This study aimed to quantitatively evaluate the influence of long-term application of different fertilizers and straw retention on soil organic carbon (SOC) storage, to compare the calculated response ratios with Intergovernmental Panel on Climate Change (IPCC)-recommended default relative stock change factors, and to propose recommendations for enhancing SOC sequestration. The meta-analysis indicated that the long-term application of chemical fertilizers (CF), organic fertilizers (OF), combined chemical and organic fertilizers (CFOF), and straw return (SR) significantly enhanced the SOC storage. Response ratios varied significantly (p < 0.05) across different fertilization measures and climatic zones, and was sensitive to the initial SOC content. The mean response ratio was 0.94 for no fertilizer (NF), 1.08 for CF, 1.48 for OF, 1.38 for CFOF, and 1.28 for SR. When IPCC default values for response ratios were applied, SOC storage with OF and CFOF treatments in warm temperate regions with a dry climate was underestimated by 26%, and in the cool temperate region with a moist climate was overestimated by 25% (p < 0.05). Analysis showed that sustained application of organic fertilizers and straw return could be a beneficial measures to mitigate climate change and ensure food security in China. Our findings highlight the importance of deriving SOC stock change factors for a detailed classification of cropland by fertilizer management, climate, and soil types in order to more accurately reflect the effects of policy measures.



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Phase I clinical trial of olprinone in liver surgery

Abstract

Purpose

Post-hepatectomy liver failure is one of the most serious complications liver surgeons must overcome. We previously examined olprinone, a selective phosphodiesterase III inhibitor, and demonstrated its hepatoprotective effects in rats and pigs. We herein report the results of a phase I clinical trial of olprinone in liver surgery (UMIN000004975).

Methods

Twenty-three patients who underwent hepatectomy between 2011 and 2015 were prospectively registered. In the first 6 cases, olprinone (0.1 μg/kg/min) was administered for 24 h from the start of surgery. In the remaining 17 cases, olprinone (0.05 μg/kg/min) was administered from the start of surgery until just before the transection of the liver parenchyma. The primary endpoint was safety, and the secondary endpoint was efficacy. For the evaluation of efficacy, the incidence of post-hepatectomy liver failure in 20 hepatocellular carcinoma patients was externally compared with 20 propensity score-matched patients.

Results

No intraoperative side effects were observed, and the morbidity rates in the analyzed cohorts were acceptable. The rate of post-hepatectomy liver failure frequency tended to be lower in the olprinone group.

Conclusions

The safety of olprinone in liver surgery was confirmed. The efficacy of olprinone will be re-evaluated in clinical trials.



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Histopathologic risk stratification of stage IIB colorectal cancer

Abstract

Purpose

To stratify stage IIB (pT4a PN0) colorectal cancer in terms of histopathologic findings.

Methods

We reviewed the medical records of 80 patients who underwent surgery for stage IIB colorectal cancer. The disease-free survival (DFS) and overall survival (OS) rates were evaluated and correlated with the presence or absence of "Tumor Necrosis", "Crohn's-like lymphoid reaction", and "Perineural Invasion".

Results

Patients with "Tumor Necrosis" had significantly lower DFS rates (p < 0.0001), those with "Crohn's-like lymphoid reaction" had significantly higher DFS rates (p = 0.037), and those with "Perineural Invasion" had significantly lower DFS rates (p < 0.0001). Patients with "Tumor Necrosis" had significantly lower OS rates (p = 0.016), those with "Crohn's-like lymphoid reaction" had significantly higher OS rates (p = 0.022), and those with "Perineural Invasion" had significantly lower OS rates (p = 0.003).

Conclusions

Since stage IIB colorectal cancers accompanied by the pathological findings of "Tumor Necrosis" and "Perineural Invasion", but with the absence of "Crohn's-like lymphoid reaction" carried a poor prognosis, the efficacy of adjuvant chemoradiation must be considered for these patients.



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Relationship between ABO blood group and clinicopathological factors and their effect on the survival of Japanese patients with esophageal squamous cell carcinoma

Abstract

Purpose

Several studies have evaluated the association between ABO blood group and the prognosis of various types of cancer; however, little is known about the relationship between ABO blood group and esophageal squamous cell carcinoma (SCC). We investigated how ABO blood group and clinicopathological characteristics are related to the survival of Japanese patients with esophageal SCC.

Methods

We reviewed the medical records of 181 patients who underwent surgery for esophageal SCC between June, 2004 and December, 2015 and analyzed the association between ABO blood group and clinicopathological factors. Clinicopathological factors were also evaluated by univariate and multivariate analyses for possible association with survival.

Results

The prevalence of each blood group was as follows: A, 35.5%; B, 22.4%; O, 32.8%; and AB, 8.2%. The 5-year overall survival of all patients was 37.1%. Patients with non-type B blood had significantly worse 5-year overall survival than those with type B blood (30.2 vs. 58.8%, P < 0.05).

Conclusions

ABO blood groups were associated with the survival of Japanese patients with esophageal SCC. Patients with non-B blood groups had significantly worse overall survival than those with the B blood group.



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The single-center experience with the standardization of single-site laparoscopic colectomy for right-sided colon cancer

Abstract

Purpose

Complete mesocolic excision (CME) with central vascular ligation (CVL) has been widely accepted as a surgical treatment for right-sided colon cancer. Single-site laparoscopic colectomy (SLC) is associated with reduced pain and improved cosmesis, in comparison to the multi-site laparoscopic colectomy (MCL). Although the feasibility of CME + CVL under MCL has been reported, SLC for right-sided colon cancer is generally challenging. The purpose of this study is to demonstrate our efforts to standardize the SLC for right-sided colon cancer.

Methods

This retrospective study enrolled 202 consecutive patients with right-sided colon cancer who underwent laparoscopic colectomy for right-sided colon cancer, using an inferior approach and intraoperative navigation surgery, between 2008 and 2014. The patients were divided into 3 groups, based on the period of treatment, as follows: Period I (2008–2009, n = 56), Period II (2010–2011, n = 70), and Period III (2012–2014, n = 76).

Results

The patient's baseline characteristics did not differ among the three periods. The ratio of SLC significantly increased with the passage of the time. The short-term outcomes were similar among the three periods. As for oncological clearance, there was a significant increase in the number of resected lymph nodes with the passage of the time (P < 0.05).

Conclusions

We successfully standardized SLC for right-sided colon cancer.



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The influence of specific technical maneuvers utilized in the creation of diverting loop-ileostomies on stoma-related morbidity

Abstract

Purpose

The association between technical maneuvers in fashioning a diverting loop-ileostomy and stoma-related complications remains unclear. Thus, this study aimed to evaluate their relevance to stoma-related morbidity.

Methods

This retrospective multicenter study was designed to collect data from 37 institutions. We evaluated the perioperative outcomes of consecutive patients who underwent surgery to create a diverting loop-ileostomy in 2013.

Results

A total of 4137 patients with colorectal disease underwent colorectomy, 279 of whom received an ileostomy. The results of these 279 patients were analyzed. The most common complications were parastomal dermatitis (n = 132) followed by ileus (n = 36), mucocutaneous separation (n = 24), parastomal hernia (n = 16), stoma retraction (n = 15), and stoma prolapse (n = 9). The technical maneuvers used in the creation of ileostomies were heterogeneous and some had a great deal of relevance to the complications. A long distance from the ileocecal valve to the ileostomy was associated with a low risk of stoma retraction and a high risk of ileus. Additionally, the height of the distal limb of the ileostomy significantly affected the incidence of parastomal dermatitis and mucocutaneous separation.

Conclusions

Specific technical maneuvers that are utilized in the creation of diverting loop-ileostomies had a significant influence on the incidence of stoma-related morbidities. Our findings emphasize the possibility of minimizing stoma-related complications with appropriate surgical techniques.



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Omitting perioperative urinary catheterization in laparoscopic cholecystectomy: a single-institution experience

Abstract

Purpose

In 2009, the Centers for Disease Control and Prevention published Guidelines for the Prevention of Catheter-Associated Urinary Tract Infections, which limited the indications for perioperative urinary catheter use. We conducted this study to evaluate the safety of elective laparoscopic cholecystectomy (LC) without urinary catheter placement and to investigate whether it reduces the incidence of urinary complications.

Methods

Of 244 patients who underwent elective LC between March, 2010 and April 2011, 192 patients fulfilled the eligibility criteria and underwent surgery without urinary catheterization (non-catheterized group). We compared the clinical features and surgical outcomes of the non-catheterized group with those of an historical control of 90 patients who underwent LC with routine urinary catheterization.

Results

The operating times were similar in the two groups and there was no case of conversion to open surgery. The postoperative hospital stay was slightly shorter and the incidence of urinary complications was significantly lower in the non-catheterized group. Three patients in the non-catheterized group suffered urinary retention, which resolved after temporary catheterization.

Conclusion

Our study demonstrated that elective LC without urinary catheter placement is feasible for most patients and might reduce the incidence of perioperative urinary complications.



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Normal platelet function

Abstract

Platelets play an important role in the vessel. Following their formation from megakaryocytes, platelets exist in circulation for 5–7 days and primarily function as regulators of hemostasis and thrombosis. Following vascular insult or injury, platelets become activated in the blood resulting in adhesion to the exposed extracellular matrix underlying the endothelium, formation of a platelet plug, and finally formation and consolidation of a thrombus consisting of both a core and shell. In pathological conditions, platelets are essential for formation of occlusive thrombus formation and as a result are the primary target for prevention of arterial thrombus formation. In addition to regulation of hemostasis in the vessel, platelets have also been shown to play an important role in innate immunity as well as regulation of tumor growth and extravasations in the vessel. These primary functions of the platelet represent its normal function and versatility in circulation.



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Platelets, circulating tumor cells, and the circulome

Abstract

Platelets are cytoplasmic fragments generated by megakaryocytes in the bone marrow and do not possess a nucleus. They contribute to the "Circulome" consisting of all circulating cells, factors and macromolecules such as cfDNA. Their primary function is to recognize vascular lesions and initiate thrombus formation that ceases bleeding. This distinctive characteristic of platelets also contributes to cancer and its progression. The ability of platelets to recognize and interact with other cells and neighboring platelets enables them to interact with tumor cells in the circulation. Receptor recognition and factor mediated crosstalk between tumor cells and platelets stimulate platelet activation, release of factors, and aggregation that promotes tumor cell survival and cancer progression. This review describes platelet: (i) contributions to the "Circulome" (ii) their importance as diagnostic tools in predicting cancer risk and (iii) therapies targeting platelet activation in inhibiting tumor progression and metastasis.



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The evaluation of cartilage differentiations using transforming growth factor beta3 alone and with combination of bone morphogenetic protein-6 on adult stem cells

Abstract

In our quest to standardize our formula for a clinical trial, transforming growth factor-beta3 (TGF-β3) alone and in combination with bone morphogenetic protein-6 (BMP-6) were evaluated for their effectiveness in cartilage differentiation. Bone Marrow Stem Cells (BMSCs) and Adipose Derived Stem Cells (ADSCs) were induced to chondrogenic lineage using two different media. Native chondrocytes served as positive control. ADSCs and BMSCs proved multipotency by tri-lineage differentiations. ADSC has significantly higher growth kinetics compare to Chondrocyte only p ≤ 0.05. Using TGF-β3 alone, BMSC revealed higher expressions for hyaline cartilage genes compare to ADSCs. Chondrocyte has significantly higher early chondrogenic markers expression to ADSCs and BMSCs, while BMSCs was only higher to ADSC at chondroadherin, p ≤ 0.0001. On mature chondrogenic markers, chondrocytes were significantly higher to ADSCs and BMSCs for aggrecan, collagen IX, sry (sex determining region y)-box9, collagen II and fibromodullin; and only to ADSC for collagen XI. BMSC was higher to ADSC for aggrecan and collagen IX, p ≤ 0.0001. The combination of TGF-β3 + BMP-6 revealed increased gene expressions on both BMSCs and ADSCs for early and mature chondrogenic markers, but no significance difference. For dedifferentiation markers, ADSC was significantly higher to chondrocyte for collagen I. Glycosaminoglycan evaluations with both formulas revealed that chondrocytes were significantly higher to ADSCs and BMSCs, but none was significant to each other, p ≤ 0.0001. Combination of 10 ng TGF-β3 with 10 ng of BMP-6 enhanced chondrogenic potentials of BMSCs and ADSCs compare to TGF-β3 alone. This could be the ideal cocktail for either cell's chondrogenic induction.



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The Pitfalls of Left Trisectionectomy or Central Bisectionectomy for Biliary Cancer: Anatomical Classification Based on the Ventral Branches of Segment VI Portal Vein Relative to the Right Hepatic Vein

Abstract

Backgrounds

Some patients have P6a running on the ventral side (Ventral-P6a), relative to the right hepatic vein (RHV).

Study Design

Forty-one patients who underwent left trisectionectomy or central bisectionectomy for biliary cancer were enrolled. We compared the anatomical features using 3D images and surgical outcomes between patients with Ventral-P6a (n = 17) and those with P6a running on the dorsal side relative to the RHV (Dorsal-P6a; n = 25). Moreover, the liver volume by hand-tracing 2D axial images was compared to the volume calculated using the 3D images.

Results

The frequency of complete exposure of RHV on the transection plane was less in Ventral-P6a (12 vs. 76%; p < 0.001), and the frequency of supraportal type of right posterior hepatic artery (RPHA, 29 vs. 4%, p = 0.020), the presence of inferior RHV (47 vs. 12%, p = 0.011), and the angle between the transection plane of segment VI and VII (S6–S7angle, 29.0° vs. 4.9°; p < 0.001) were greater in Ventral-P6a than in Dorsal-P6a. In Dorsal-P6a, the volume of posterior section calculated using 2D images was greater than that calculated using 3D images (404 vs. 370 mL; p = 0.004). The incidence of daily diuretic administration in Dorsal-P6a was greater than in Ventral-P6a (88 vs. 54%, p = 0.035).

Conclusion and Relevance

In Ventral-P6a, the complete exposure of RHV was rare in left trisectionectomy or central bisectionectomy. Surgeons should preoperatively recognize the course of RPHA, the presence of inferior RHV, and the S6–S7angle. In Dorsal-P6a, the volume of posterior section, which tended to be overestimated using 2D images, was smaller than that in Ventral-P6a.



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Development of a pilot cartilage surgery register

Abstract

Background

Norway has no prospective surveillance system to monitor the outcome of knee cartilage surgery. In 2004 the Norwegian Registry of Knee Ligament (NKLR) was successfully established, and has yielded useful information on the treatment of patients with both knee ligament and combined knee injuries. Patients with focal cartilage defects (FCDs) in their knees have reduced function and the treatment is difficult. There are geographical variations in treatment, and the generalizability from randomized controlled studies is low. These patients would benefit from a standardized long-time follow-up through a cartilage surgery register.

The aim of the present study was to describe the development and report baseline challenges during the setting up of a pilot of a knee cartilage surgery register.

Methods

The study was designed as a prospective cohort study in the form of a register. Patients with full-thickness FCDs in the knee with International Cartilage Repair Society (ICRS) grade 3–4 on arthroscopy were included. The pilot included two hospitals; Oslo University Hospital (OUS), Ullevål and Akershus University Hospital (Ahus).

Results

We registered 58 patients with isolated FCDs, whereas 16 additional patients with full-thickness FCDs were registered through the NKLR. The patient cohort of patients with isolated FCDs consisted of 65% men and had a mean age of 29.8 years. The data are incomplete and the compliance varies from 18 to 73%. The distribution of mean KOOS scores were similar to previous patient cohorts with FCDs, with low scores for the KOOS Sport/Recreation and Quality of Life subscales.

Conclusion

The level of compliance demonstrated a large difference between the two participating hospitals. The compliance for the isolated FCDs were low in both locations, although it reached an acceptable level in one hospital when patients with combined injuries from the NKLR were included. The forms were incompletely filled out by the surgeons postoperatively and need to be revised prior the establishment of a nation-wide register.



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Prediction of the Effect of Renal Impairment on the Pharmacokinetics of New Drugs

Abstract

Introduction

Renal impairment may have a significant impact on the pharmacokinetics of drugs. Ad hoc studies in subjects with renal impairment are required by the regulatory authorities to propose dose adjustments in these subjects, to find a dosing regimen able to provide a systemic exposure similar to those in subjects with a normal renal function given the relevant clinical dose.

Methods

To evaluate the main descriptors and establish a predictive model of the effect of renal impairment on the exposure of new drugs, we considered 73 marketed drugs, for which studies in subjects with different degrees of renal impairment were available in the literature. Multivariate analysis was performed using the main pharmacokinetic parameters. Other approaches, including data mining and machine learning techniques, were tested to propose models based on a categorical definition of the exposure changes.

Results

Stepwise multivariate regression analyses revealed, as expected, that the fraction of dose excreted unchanged in urine and plasma protein binding were the factors primarily related to the change in exposure between subjects with normal and impaired renal function. Data mining techniques provided similar results.

Discussion

The pharmacokinetic predictions were however not always satisfactory, especially for drugs which, despite the negligible renal excretion, are characterized by significant increases in the systemic exposure in subjects with renal impairment. This phenomenon, interpreted considering the accumulation of endogenous metabolism inhibitors in subjects with moderate and severe renal disease (uremic toxins), cannot be fully captured and described, likely owing to an incomplete understanding of the pathophysiological phenomena and to some limitations of the available database of clinical studies.



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Extracellular Secretion of Phytase from Transgenic Wheat Roots Allows Utilization of Phytate for Enhanced Phosphorus Uptake

Abstract

A significant portion of organic phosphorus comprises of phytates which are not available to wheat for uptake. Hence for enabling wheat to utilize organic phosphorus in form of phytate, transgenic wheat expressing phytase from Aspergillus japonicus under barley root-specific promoter was developed. Transgenic events were initially screened via selection media containing BASTA, followed by PCR and BASTA leaf paint assay after hardening. Out of 138 successfully regenerated To events, only 12 had complete constructs and thus further analyzed. Positive T1 transgenic plants, grown in sand, exhibited 0.08–1.77, 0.02–0.67 and 0.44–2.14 fold increase in phytase activity in root extracts, intact roots and external root solution, respectively, after 4 weeks of phosphorus stress. Based on these results, T2 generation of four best transgenic events was further analyzed which showed up to 1.32, 56.89, and 15.40 fold increase in phytase activity in root extracts, intact roots and external root solution, respectively, while in case of real-time PCR, maximum fold increase of 19.8 in gene expression was observed. Transgenic lines showed 0.01–1.18 fold increase in phosphorus efficiency along with higher phosphorus content when supplied phytate or inorganic phosphorus than control plants. Thus, this transgenic wheat may aid in reducing fertilizer utilization and enhancing wheat yield.



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Adjuvant versus salvage radiotherapy in prostate cancer: multi-institutional retrospective analysis of the Spanish RECAP database

Abstract

Purpose

To compare adjuvant radiotherapy (ART) to salvage radiotherapy (SRT) after radical prostatectomy (RP) in a cohort of prostate cancer (PCa) patients. The primary aim was to comparatively assess 2- and 5-year biochemical relapse-free survival (BRFS). A secondary aim was to identify predictors of survival.

Patients and methods

Data were acquired from the RECAP database, a population-based prostate cancer registry in Spain. Inclusion criteria included RP (with or without lymphadenectomy) followed by ART or SRT. A total of 702 patients were analyzed. Pre-RT PSA values (>0.5 vs. ≤0.5 ng/ml), pathological stage (T1–2 vs. T3–4), post-surgical Gleason score (≤7 vs. 8–10), margin status (positive vs. negative), hormonal treatment (yes vs. no), and RT dose (≤66 Gy vs. >66 Gy) were evaluated to assess their impact on BRFS.

Results

The mean patient age in the ART and SRT groups, respectively, was 64 years (range 42–82) and 64.8 years (range 42–82). Median follow-up after RT in the whole sample was 34 months (range 3–141). A total of 702 patients were included: 223 (31.8%) received ART and 479 (68.2%) SRT. BRFS rates (95% CI) in the ART and SRT groups at months 24 and 60 were, respectively: 98.1% (95.9–100.0%) vs. 91.2% (88.2–94.2%) and 84.5% (76.4–92.6%) vs. 74.0% (67.4–80.7%) (p = 0.004). No significant differences in OS were observed (p = 0.053). The following variables were significant predictors of biochemical recurrence in the SRT group: (1) positive surgical margin status (p = 0.049); (2) no hormonotherapy (p = 0.03); (3) total prostate dose ≤66 Gy (p = 0.004); and pre-RT PSA ≥0.5 ng/ml (p = 0.013).

Conclusions

This is the first nationwide study in Spain to evaluate a large cohort of PCa patients treated with RP followed by postoperative RT. ART yielded better 2- and 5-year BRFS rates, although OS was equivalent. These findings are consistent with most other published studies and support ART in patients with adverse prognostic characteristics after radical prostatectomy. Prospective trials are needed to compare immediate ART to early SRT to better determine their relative benefits.



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Role of contrast-enhanced ultrasound to define prognosis and predict response to biotherapy in pancreatic neuroendocrine tumors

Abstract

Purpose

The incidence of neuroendocrine tumors (NETs) is progressively increasing. Most cases arise from the digestive system, where ileum, rectum and pancreas represent the commonest site of origin. Liver metastases are frequently detected at diagnosis or during the follow-up. Contrast-enhanced ultrasound (CEUS) is used in patients with pancreatic NETs (P-NETs) and liver metastases from P-NET but its role has not been standardized. The aim of this retrospective study was to investigate CEUS in patients with P-NETs and liver metastases from P-NET both as prognostic factor and predictor of response to therapy with somatostatin analogues (SSAs).

Methods

CEUS was performed at the diagnosis of NET and 3, 6 and 12 months after the beginning of SSAs. CEUS pattern was compared with contrast-enhanced computed tomography (CT) pattern.

Results

There was a significant association between CEUS and CT pattern (X 2 = 79.0; p < 0.0001). A significant association was found between CEUS pattern and Ki-67 index (X 2 = 24.6; p < 0.0001). The hypervascular homogeneous CEUS typical pattern was associated with low tumor grading (G1 or G2) (X 2 = 24.0; p < 0.0001). CEUS pattern changed from hypervascular homogeneous in baseline to hypovascular/hypervascular inhomogeneous after SSA therapy, with a significant association between tumor response at CT scan and appearance of hypervascular inhomogeneous pattern at CEUS evaluation (6 months: X 2 = 57.0; p < 0.0001; 12 months: X 2 = 49.8; p < 0.0001).

Conclusions

In patients with P-NET, CEUS pattern correlates with tumor grading, being homogeneous in G1–G2 but not in G3 tumors. After therapy with SSAs, CEUS is predictive of response to SSAs. These findings seem to support a role of CEUS as prognostic and predictive factor of response.



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Heterogeneous ribonuclear protein E2 (hnRNP E2) is associated with TDP-43-immunoreactive neurites in Semantic Dementia but not with other TDP-43 pathological subtypes of Frontotemporal Lobar Degeneration

Abstract

Frontotemporal Lobar Degeneration (FTLD) encompasses certain related neurodegenerative disorders which alter personality and cognition. Heterogeneous ribonuclear proteins (hnRNPs) maintain RNA metabolism and changes in their function may underpin the pathogenesis of FTLD. Immunostaining for hnRNP E2 was performed on sections of frontal and temporal cortex with hippocampus from 80 patients with FTLD, stratified by pathology into FTLD-tau and FTLD-TDP type A, B and C subtypes, and by genetics into patients with C9orf72 expansions, MAPT or GRN mutations, or those with no known mutation, and on 10 healthy controls. Semi-quantitative analysis assessed hnRNP staining in frontal and temporal cortex, and in dentate gyrus (DG) of hippocampus, in the different pathology and genetic groups. We find that hnRNP E2 immunostaining detects the TDP-43 positive dystrophic neurites (DN) within frontal and temporal cortex, and the neuronal cytoplasmic inclusions (NCI) seen in DG granule cells, characteristic of patients with Semantic Dementia (SD) and type C TDP-43 pathology, but did not detect TDP-43 or tau inclusions in any of the other pathological or genetic variants of FTLD. Double immunofluorescence for hnRNP E2 and TDP-43 showed most TDP-43 immunopositive DN to contain hnRNP E2. Present findings indicate an association between TDP-43 and hnRNP E2 which might underlie the pathogenetic mechanism of this form of FTLD.



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European Society of Neuroradiology (ESNR)



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Intracameral Dexamethasone Injection as Adjuvant Therapy in Endothelial Immune Reaction After Penetrating and Posterior Lamellar Keratoplasty: A Retrospective Clinical Observation

Abstract

Introduction

The aim of this observational study is to evaluate the effectiveness of an adjuvant intracameral corticosteroid injection (ICI) in cases of severe endothelial immune reaction (SEIR) (anterior chamber cells and flare, retrocorneal precipitates, Descemet's folds, and corneal edema) after penetrating keratoplasty and posterior lamellar keratoplasty.

Methods

In this retrospective study, 24 subjects treated between November 2011 and September 2014 were divided into two groups. The control group received topical and systemic steroid therapy while the study group received additionally ICI (400 µg dexamethasone). Outcome measures included changes in best corrected visual acuity (BCVA), central corneal thickness (CCT, Pentacam), endothelial cell count (ECC), and intraocular pressure (IOP). The follow-up examinations were conducted after a period of 6 weeks and 3 months. Results were compared using the Wilcoxon signed-rank test.

Results

BCVA of the patients in the study group increased from logMAR 1.5 ± 0.77 at baseline to 0.99 ± 0.44 (p = 0.009) at 6 weeks and to 0.78 ± 0.45 (p = 0.017) at 3 months following the ICI. The CCT decreased from 835 ± 211 µm at baseline to 609 ± 63 µm (p = 0.005) after 3 months. ECC showed a significant reduction 12 weeks after treatment in both groups (p = 0.012 in the control group and p = 0.005 in the study group). This reflects a mean ECC loss of 17% and 19% due to the immune reaction in the control and study group, respectively. A significant temporary increase in the IOP was documented only in the control group (p = 0.005).

Conclusion

The ICI seems to be a safe adjuvant approach, which improves therapeutic efficacy of SEIR after keratoplasty.



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Increase in Hospital Discharges for Inflammatory Bowel Diseases in Chile Between 2001 and 2012

Abstract

Aim

To determine the number of annual hospital discharges for inflammatory bowel diseases in Chile. The hypothesis is that there is a significant increase in the hospital discharges due to this disease from 2001 to 2012.

Materials and Methods

This is a descriptive study. Data were obtained from the Web site of the Department of Health Statistics. All hospital discharges from 2001 to 2012 were included. The following variables were analyzed: length of stay, hospital mortality, and eventual surgical procedure. Data are presented as descriptive statistics. The B-coefficient was calculated to establish the significance of the annual trend.

Results

There were 13,001 hospital discharges with the diagnosis of ulcerative colitis or Crohn's disease, corresponding to 0.067% of all hospital discharges in the whole period. Within these discharges, 31.2% were Crohn's disease and 68.8% were ulcerative colitis. At least one surgical procedure was performed in 12.9% of the hospitalizations. There was a significant increase in the annual rate of hospital discharges from 5.25 in 2001 to 8.64 per 100 thousand inhabitants in 2012. This increase was from 1.68 to 3.11 in Crohn's disease and from 3.58 to 5.53 in ulcerative colitis. However, a decrease was observed in length of stay, need of surgical treatment and in-hospital mortality.

Conclusion

From 2001 until 2012, there has been a significant increase in hospital discharges for inflammatory bowel diseases in Chile, associated with a decrease in length of stay, need of surgery and in-hospital mortality.



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Active instance matching with pairwise constraints and its application to Chinese knowledge base construction

Abstract

Instance matching is the problem of determining whether two instances describe the same real-world entity or not. Instance matching plays a key role in data integration and data cleansing, especially for building a knowledge base. For example, we can regard each article in encyclopedias as an instance, and a group of articles which refers to the same real-world object as an entity. Therefore, articles about Washington should be distinguished and grouped into different entities such as Washington, D.C (the capital of the USA), George Washington (first president of the USA), Washington (a state of the USA), Washington (a village in West Sussex, England), Washington F.C. (a football club based in Washington, Tyne and Wear, England), Washington, D.C. (a novel). In this paper, we proposed a novel instance matching approach Active Instance Matching with Pairwise Constraints, which can bring the human into the loop of instance matching. The proposed approach can generate candidate pairs in advance to reduce the computational complexity, and then iteratively select the most informative pairs according to the uncertainty, influence, connectivity and diversity of pairs. We evaluated our approach one two publicly available datasets AMINER and WIDE-NUS and then applied our approach to the two large-scale real-world datasets, Baidu Baike and Hudong Baike, to build a Chinese knowledge base. The experiments and practice illustrate the effectiveness of our approach.



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Medicine A


15:57
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Obstructive sleep apnea in postmenopausal women: a comparative study using drug induced sleep endoscopy
 
Abstract Introduction: The key to successful treatment of OSAS is to individually tailor such treatment. Thus, it is very important to determine the severity of OSAS, its pattern, and the extent of collapse, by gender, age, and BMI. Objective: The objective of the study was to understand the characteristics...
15:57
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Comparison of microRNA profiles between benign and malignant salivary gland tumors in tissue, blood and saliva samples: a prospective, case-control study
 
Abstract Introduction: Salivary gland tumors (SGTs) are rare head and neck malignancies consisting of a spectrum of tumors with different biological behaviors. Objective: In this study we aimed to find out differential expression of microRNA profiles between benign and malignant SGTs. Methods: We investigated...
15:57
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
The role of facial canal diameter in the pathogenesis and grade of Bell's palsy: a study by high resolution computed tomography
 
Abstract Introduction: The exact etiology of Bell's palsy still remains obscure. The only authenticated finding is inflammation and edema of the facial nerve leading to entrapment inside the facial canal. Objective: To identify if there is any relationship between the grade of Bell's palsy and diameter...
15:57
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Airway reconstruction: review of an approach to the advanced-stage laryngotracheal stenosis
 
Abstract Introduction: The management of laryngotracheal stenosis is complex and is influenced by multiple factors that can affect the ultimate outcome. Advanced lesions represent a special challenge to the treating surgeon to find the best remedying technique. Objective: To review the efficacy of our...
15:57
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Ophthalmic complications of endoscopic sinus surgery
 
Abstract Introduction: The proximity of the paranasal sinuses to the orbit and its contents allows the occurence of injuries in both primary or revision surgery. The majority of orbital complications are minor. The major complications are seen in 0.01-2.25% and some of them can be serious, leading to...
15:57
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
LS CE-Chirp® vs. Click in the neuroaudiological diagnosis by ABR
 
Abstract Introduction: The chirp stimulus was developed seeking to counterbalance the delay of the sound wave on its journey through the cochlea, allowing the hair cells to depolarize at the same time. The result is a simultaneous stimulation providing better neural synchrony and, consequently, the recording...
15:57
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Ethics is the best professional policy
 
Abstract Introduction: The relationship between gastroesophageal reflux disease (GERD) and chronic rhinosinusitis (CRS) is still a controversial issue in literature. Objective: A systematic review of the association between these two diseases in adult patients. Methods: Systematic review in PubMed and...
15:57
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Combined ocular and cervical vestibular evoked myogenic potential in individuals with vestibular hyporeflexia and in patients with Ménière's disease,
 
Abstract Introduction: The vestibular evoked myogenic potential is a potential of mean latency that measures the muscle response to auditory stimulation. This potential can be generated from the contraction of the sternocleidomastoid muscle and also from the contraction of extraocular muscles in response...
15:57
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Deep neck abscesses: study of 101 cases
 
Abstract Introduction: Although the incidence of Deep Cervical Abscess (DCA) has decreased mainly for the availability of antibiotics, this infection still occurs with considerable frequency and can be associated with high morbidity and mortality. Objective: This study aimed to present our clinical-surgical...
15:57
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Relation between chronic rhinosinusitis and gastroesophageal reflux in adults: systematic review
 
Abstract Introduction: The relationship between gastroesophageal reflux disease (GERD) and chronic rhinosinusitis (CRS) is still a controversial issue in literature. Objective: A systematic review of the association between these two diseases in adult patients. Methods: Systematic review in PubMed and...
15:57
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Postoperative otorhinolaryngologic complications in transnasal endoscopic surgery to access the skull base
 
Abstract Introduction: The large increase in the number of transnasal endoscopic skull base surgeries is a consequence of greater knowledge of the anatomic region, the development of specific materials and instruments, and especially the use of the nasoseptal flap as a barrier between the sinus tract...
15:57
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
Vertebral artery dissection: an important differential diagnosis of vertigo
 
Abstract Introduction: The relationship between gastroesophageal reflux disease (GERD) and chronic rhinosinusitis (CRS) is still a controversial issue in literature. Objective: A systematic review of the association between these two diseases in adult patients. Methods: Systematic review in PubMed and...
15:57
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026
First branchial cleft fistula: a difficult challenge
 
Abstract Introduction: The relationship between gastroesophageal reflux disease (GERD) and chronic rhinosinusitis (CRS) is still a controversial issue in literature. Objective: A systematic review of the association between these two diseases in adult patients. Methods: Systematic review in PubMed and...
15:56
OtorhinolaryngologySfakianakis
Lower limb kinematics during the swing phase in patients with knee osteoarthritis measured using an inertial sensor
 
Publication date: September 2017Source:Gait & Posture, Volume 57 Author(s): Kenji Tanimoto, Makoto Takahashi, Kazuki Tokuda, Tomonori Sawada, Masaya Anan, Koichi Shinkoda BackgroundDuring gait, the swing limb requires flexible control to adapt to ever changing environmental circumstances. However,...
15:55
OtoRhinoLaryngology by Alexandros G.Sfakianakis
Efficacy of a standardized extract of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) in infantile colic: An open randomized controlled trial
 
Abstract Background Infant colic (IC) is a prevalent physiological event of infants, which can disrupt the child's home environment. We aimed to investigate the effectiveness of a mixture of Matricariae chamomilla L., Melissa officinalis L. and tyndallized Lactobacillus acidophilus (HA122) compared...
15:54
ΩΡΛ Ιατρικά Άρθρα απ' το Μελετητή
Scholar : The American Journal of Bioethics, Volume 17, Issue 7, July 2017 is now available online on Taylor & Francis Online
 
The online platform for Taylor & Francis Online content The American Journal of Bioethics, Volume 17, Issue 7, July 2017 is now available online on Taylor & Francis Online. This new issue contains the following articles: Guest Editorial Modernizing...
15:53
Medicine by Sfakianakis Alexandros
Seeing the soil through the net: an eye-opener on the soil map of the Flemish region (Belgium)
 
A systematic soil survey of Belgium was conducted from 1948 to 1991. Field surveys were done at the detailed scale of 1:5000 with the final maps published at a 1:20,000 scale. The legend of these detailed soil maps (scale 1:20,000) has been converted to the 3rd edition of the international soil classification...
15:53
Medicine by Sfakianakis Alexandros
Identification of candidate oncogenes and chromosomal breakpoint sequencing by targeted locus amplification in T-cell acute lymphoblastic leukemia
 
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15:53
Medicine by Sfakianakis Alexandros
Comparison between FLT3-ITD measurements based on RNA and DNA of childhood myeloid leukemia samples
 
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15:53
Medicine by Sfakianakis Alexandros
The long non-coding RNA H19 is regulated by LIN28B
 
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15:53
Medicine by Sfakianakis Alexandros
Morphology and spatial patterns of Macrotermes mounds in the SE Katanga, D.R. Congo
 
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15:53
Medicine by Sfakianakis Alexandros
Delineating the roles of lysine 27 methylation-associated epigenetic modulators in T cell leukemia
 
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15:51
Ιατρικά Άρθρα Αλέξανδρος Γ. Σφακιανάκης
Sporotrichosis: Update on Diagnostic Techniques
 
Abstract Purpose of Review Sporotrichosis, the disease caused by Sporothrix spp, ranges from subcutaneous infections to the severe disseminated or invasive diseases. The taxonomy of Sporothrix has been revised. The subcutaneous disease is suspected easily, but the extra-cutaneous disease is diagnosed...
15:50
Medicine Sfakianakis G. Alexandros
Toll like Receptor 2 engagement on CD4+ T cells promotes TH9 differentiation and function
 
We have recently demonstrated that mycobacterial ligands engage Toll like receptor 2 (TLR2) on CD4+ T cells and up-regulate T-cell receptor (TCR) triggered Th1 responses in vitro and in vivo. To better understand the role of T-cell expressed TLR2 on CD4+ T-cell differentiation and function, we conducted...
15:50
Medicine Sfakianakis G. Alexandros
Extracellular vesicles mediate intercellular communication: Transfer of functionally active microRNAs by microvesicles into phagocytes
 
Cell activation and apoptosis lead to the formation of extracellular vesicles (EVs) such as exosomes or microvesicles (MVs). EVs have been shown to modulate immune responses; recently, MVs were described to carry microRNA (miRNA) and a role for MVs in the pathogenesis of autoimmune diseases has been...
15:50
OtorhinolaryngologySfakianakis
Preparation and characterization of bioadhesive system containing hypericin for local photodynamic therapy
 
Publication date: Available online 29 June 2017Source:Photodiagnosis and Photodynamic Therapy Author(s): Fernanda Belincanta Borghi-Pangoni, Mariana Volpato Junqueira, Sabrina Barbosa de Souza Ferreira, Larissa Lachi Silva, Bruno Ribeiro Rabello, Lidiane Vizioli de Castro, Mauro Luciano Baesso, Andréa...
15:49
Cancer by Sfakianakis G.Alexandros
Dickkopf-4 is frequently overexpressed in epithelial ovarian carcinoma and promotes tumor invasion
 
Abstract Background Dickkopf-4 (DKK4), a member of DKK family, appears to be a divergent protein. It remained multi-biological functions in carcinogenesis. The effect of DKK4 on the ovarian cancer cells remains unclear. This study...
15:49
Cancer by Sfakianakis G.Alexandros
Optimizing the treatment of bevacizumab as first-line therapy for human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer: an updated meta-analysis of published randomized trials
 
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15:49
Cancer by Sfakianakis G.Alexandros
Clinical importance of serum HE4 and MMP2 levels in endometrial cancer patients
 
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15:49
Cancer by Sfakianakis G.Alexandros
Phase I dose-escalation study of long-acting pasireotide in patients with neuroendocrine tumors
 
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15:49
Cancer by Sfakianakis G.Alexandros
Patients harboring ALK rearrangement adenocarcinoma after acquired resistance to crizotinib and transformation to small-cell lung cancer: a case report
 
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15:49
Cancer by Sfakianakis G.Alexandros
RE: "RISK PREDICTION FOR EPITHELIAL OVARIAN CANCER IN 11 UNITED STATES–BASED CASE-CONTROL STUDIES: INCORPORATION OF EPIDEMIOLOGIC RISK FACTORS AND 17 CONFIRMED GENETIC LOCI"
 
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15:49
Cancer by Sfakianakis G.Alexandros
Protecting Confidentiality in Cancer Registry Data With Geographic Identifiers
 
AbstractThe National Cancer Institute's Surveillance, Epidemiology, and End Results Program releases research files of cancer registry data. These files include geographic information at the county level, but no finer. Access to finer geography, such as census tract identifiers, would enable richer analyses—for...
15:49
Cancer by Sfakianakis G.Alexandros
RE: "ASSOCIATIONS OF ACCELEROMETRY-ASSESSED AND SELF-REPORTED PHYSICAL ACTIVITY AND SEDENTARY BEHAVIOR WITH ALL-CAUSE AND CARDIOVASCULAR MORTALITY AMONG US ADULTS"
 
In the article "Associations of Accelerometry-Assessed and Self-Reported Physical Activity and Sedentary Behavior With All-Cause and Cardiovascular Mortality Among US Adults" by Evenson et al. (1), the units of measure for screen time were incorrectly listed as hours/week and MET-hours/week in Tables...
15:49
Cancer by Sfakianakis G.Alexandros
Skin Pigmentation and Risk of Hearing Loss in Women
 
AbstractBlack individuals have a lower risk of hearing loss than do whites, possibly because of differences in cochlear melanocytes. Previous studies have suggested that darker-skinned individuals tend to have more inner ear melanin, and cochlear melanocytes are important in generating the endocochlear...
15:49
Cancer by Sfakianakis G.Alexandros
RE: "MULTI-SITE CLINICAL ASSESSMENT OF MYALGIC ENCEPHALOMYELITIS/CHRONIC FATIGUE SYNDROME (MCAM): DESIGN AND IMPLEMENTATION OF A PROSPECTIVE/RETROSPECTIVE ROLLING COHORT STUDY"
 
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15:49
Cancer by Sfakianakis G.Alexandros
Association Between Serum Tumor Necrosis Factor Receptor 1 and Trajectories of Functional Status The Northern Manhattan Study
 
AbstractWe hypothesized that tumor necrosis factor receptor 1 (TNFR1) levels are associated with long-term trajectories of functional status independently of vascular risk factors and the occurrence of stroke and myocardial infarction (MI) during follow-up. In the Northern Manhattan Study, stroke-free...
15:49
Cancer by Sfakianakis G.Alexandros
Cigarette Smoking and Risk of Incident Rosacea in Women
 
AbstractThe relationship between smoking and rosacea is poorly understood. We aimed to conduct the first cohort study to determine the association between smoking and risk of incident rosacea. We included 95,809 women from Nurses' Health Study II (1991–2005). Information on smoking was collected biennially...
15:49
Cancer by Sfakianakis G.Alexandros
Modeling Seasonal and Spatiotemporal Variation: The Example of Respiratory Prescribing
 
AbstractMany measures of chronic diseases, including respiratory disease, exhibit seasonal variation together with residual correlation between consecutive time periods and neighboring areas. We demonstrate a strategy for modeling data that exhibit both seasonal trend and spatiotemporal correlation,...
15:49
Cancer by Sfakianakis G.Alexandros
Time-Dependent Associations Between Body Composition, Physical Activity, and Current Asthma in Women: A Marginal Structural Modeling Analysis
 
AbstractThe role of obesity in adult asthma is well-known and has been partly attributed to a confounding role of physical inactivity. However, the interrelationships between obesity, physical activity, and asthma have been incompletely addressed, probably because their time-dependent and bidirectional...
15:49
Cancer by Sfakianakis G.Alexandros
Original Findings and Updated Meta-Analysis for the Association Between Maternal Diabetes and Risk for Congenital Heart Disease Phenotypes
 
AbstractMaternal diabetes is associated with congenital heart defects (CHDs) as a group, but few studies have assessed risk for specific CHD phenotypes. We analyzed these relationships using data from the Texas Birth Defects Registry and statewide vital records for deliveries taking place in 1999–2009...
15:49
Cancer by Sfakianakis G.Alexandros
RE: "RESPONSE AND FOLLOW-UP BIAS IN COHORT STUDIES"
 
In the article "Response and Follow-up Bias in Cohort Studies" by Greenland (1), there is a missing decimal point in the first footnote of Table 3. The risk ratio of 70 should be 0.70. from Cancer via xlomafota13 on Inoreader http://ift.tt/2trLoQR via IFTTT
15:47
OtoRhinoLaryngology - Head and Neck Surgery
Neuropsychiatry phenotype in asthma: Psychological stress-induced alterations of the neuroendocrine-immune system in allergic airway inflammation
 
Publication date: Available online 29 June 2017Source:Allergology International Author(s): Isao OhnoSince the recognition of asthma as a syndrome with complex pathophysiological signs and symptoms, recent research has sought to classify asthma phenotypes based on its clinical and molecular pathological...
15:47
OtoRhinoLaryngology - Head and Neck Surgery
CME Activities Calendar
 
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OtoRhinoLaryngology - Head and Neck Surgery
Cover 1
 
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OtoRhinoLaryngology - Head and Neck Surgery
News & Notes
 
Are you seeking additional training in the causes and mechanisms of atopic and contact dermatitis? Need to enhance your overall hands-on skills to accurately apply patch tests and interpret the results? Mark your calendar for the new, live course "Eczema and Contact Dermatitis in the Allergy/Immunology...
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OtoRhinoLaryngology - Head and Neck Surgery
Brief Overview of This Month's JACI
 
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OtoRhinoLaryngology - Head and Neck Surgery
News Beyond Our Pages
 
Infection with respiratory syncytial virus (RSV) during infancy has been linked to increased risk for later onset of asthma. Additionally, prophylactic use within the first year of life of palivizumab, an mAb directed against the RSV fusion glycoprotein, protects against chronic wheezing through the...
15:47
OtoRhinoLaryngology - Head and Neck Surgery
An exposome perspective: Early-life events and immune development in a changing world
 
Advances in metagenomics, proteomics, metabolomics, and systems biology are providing a new emphasis in research; interdisciplinary work suggests that personalized medicine is on the horizon. These advances are illuminating sophisticated interactions between human-associated microbes and the immune system....
15:47
OtoRhinoLaryngology - Head and Neck Surgery
The environment, epigenome, and asthma
 
Asthma prevalence has been on the increase, especially in North America compared with other continents. However, the prevalence of asthma differs worldwide, and in many countries the prevalence is stable or decreasing. This highlights the influence of environmental exposures, such as allergens, air pollution,...
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OtoRhinoLaryngology - Head and Neck Surgery
Environmental determinants of allergy and asthma in early life
 
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15:47
OtoRhinoLaryngology - Head and Neck Surgery
The Editors' Choice
 
Perturbations or "dysbiosis" of the bronchial microbiota have been implicated in the pathogenesis of asthma. However, it remains unclear whether reported differences are reflective of atopy, a common comorbidity of asthma. In a National Heart, Lung, and Blood Institute AsthmaNet study of well-characterized...
15:47
OtoRhinoLaryngology - Head and Neck Surgery
The Journal of Allergy and Clinical Immunology: An update on style and substance
 
Our stewardship of the Journal of Allergy and Clinical Immunology (JACI) is now in its sophomore year.1 In this short time, we have had the privilege of working with our authors and readers and have endeavored to respond to your concerns and suggestions. We have instituted several changes in our quest...
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OtoRhinoLaryngology - Head and Neck Surgery
Information for Readers
 
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15:47
OtoRhinoLaryngology - Head and Neck Surgery
Correction
 
With regard to the article in the July 2016 issue entitled "Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis" (J Allergy Clin Immunol 2016;138:187-99), it has been brought to the Editors' attention that Fig 1 was incorrect as printed....
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OtoRhinoLaryngology - Head and Neck Surgery
Table of Contents
 
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OtoRhinoLaryngology - Head and Neck Surgery
Editorial Board
 
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15:46
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Cells, Vol. 6, Pages 17: Standard Immunohistochemical Assays to Assess Autophagy in Mammalian Tissue
 
Autophagy is a highly conserved lysosomal degradation pathway with major impact on diverse human pathologies. Despite the development of different methodologies to detect autophagy both in vitro and in vivo, monitoring autophagy in tissue via immunohistochemical techniques is hampered due to the lack...
15:43
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174
Increase in Hospital Discharges for Inflammatory Bowel Diseases in Chile Between 2001 and 2012
 
Abstract Aim To determine the number of annual hospital discharges for inflammatory bowel diseases in Chile. The hypothesis is that there is a significant increase in the hospital discharges due to this disease from 2001 to 2012. Materials and Methods This is a descriptive study. Data were obtained...
15:42
Head and Neck Diseases by Alexandros G.Sfakianakis
Evolution of Spitz Nevi
 
Abstract Background/Objectives Spitz nevi are melanocytic lesions with clinical, dermoscopic, and histopathologic presentations that may resemble those of melanoma. The evolution of Spitz nevi is a well-known feature. The objectives of this study were to investigate the clinical and dermoscopic...
15:41
Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolao
Photo-Induced Bending Behavior of Post-Crosslinked Liquid Crystalline Polymer/Polyurethane Blend Films
 
Photoresponsive blend films with post-crosslinked liquid crystalline polymer (CLCP) as a...
15:40
Emergency Medicine by Alexandros G. Sfakianakis
Prehospital parameters can help to predict coagulopathy and massive transfusion in trauma patients
 
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15:40
Emergency Medicine by Alexandros G. Sfakianakis
US Senate health bill would decimate long-term care coverage
 
Reuters Health Newsfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2trExqr
15:40
Emergency Medicine by Alexandros G. Sfakianakis
Reconstruction of AAOS type III and IV acetabular defects with the Ganz reinforcement ring: High failure in pelvic discontinuity
 
Archives of Orthopaedic and Trauma Surgeryfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2tryi63
15:40
Emergency Medicine by Alexandros G. Sfakianakis
Cancer researchers may overestimate reliability of mouse studies
 
Reuters Health Newsfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s8LGrN
15:40
Emergency Medicine by Alexandros G. Sfakianakis
Concussion assessment recommendations not followed during last World Cup, research finds
 
St. Michael's Hospitalfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s8Cp3f
15:40
Emergency Medicine by Alexandros G. Sfakianakis
Smoking is a risk factor for proliferative vitreoretinopathy after traumatic retinal detachment
 
Retinafrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2trKrYS
15:40
Emergency Medicine by Alexandros G. Sfakianakis
Markedly increased incidence of critical illness in adults with Type 1 diabetes
 
Diabetic Medicinefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2trKqEi
15:40
Emergency Medicine by Alexandros G. Sfakianakis
US FDA outlines plan to speed rare disease drug reviews
 
Reuters Health Newsfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s8Za6Y
15:40
Emergency Medicine by Alexandros G. Sfakianakis
Patient-proxy agreement on the health-related quality of life one year after traumatic brain injury
 
Archives of Physical Medicine and Rehabilitationfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2trgxno
15:40
Emergency Medicine by Alexandros G. Sfakianakis
Intraoperative cholangiography during cholecystectomy among hospitalized Medicare beneficiaries with non-neoplastic biliary disease
 
The American Journal of Surgeryfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2trGGCG
15:40
Emergency Medicine by Alexandros G. Sfakianakis
Impact of a cardiac intensivist on mortality in patients with cardiogenic shock
 
International Journal of Cardiologyfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s8FaBo
15:40
Emergency Medicine by Alexandros G. Sfakianakis
Effect of bariatric surgery on emergency department visits and hospitalizations for atrial fibrillation
 
The American Journal of Cardiologyfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s8CuE5
15:40
Emergency Medicine by Alexandros G. Sfakianakis
Risk factors for early return visits to the emergency department in patients with urinary tract infection
 
The American Journal of Emergency Medicinefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s98szM
15:40
Emergency Medicine by Alexandros G. Sfakianakis
Salvage of failed ankle arthrodesis after posttraumatic septic arthritis by Ilizarov external fixator: Mid-term results
 
Current Orthopaedic Practicefrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2trFXBx
15:40
Emergency Medicine by Alexandros G. Sfakianakis
Pain intensity, interference, and medication use after spinal cord injury: relationship with risk of mortality after controlling for socioeconomic and other health factors
 
Archives of Physical Medicine and Rehabilitationfrom Emergency Medicine via xlomafota13 on Inoreader http://ift.tt/2s8OJAu

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