Author(s): Sabine Kienesberger, Laura M. Cox, Alexandra Livanos, Xue-Song Zhang, Jennifer Chung, Guillermo I. Perez-Perez, Gregor Gorkiewicz, Ellen L. Zechner, Martin J. Blaser
Helicobacter pylori is a late-in-life human pathogen with potential early-life benefits. Although H. pylori is disappearing from the human population, little is known about the influence of H. pylori on the host’s microbiota and immunity. Studying the interactions of H. pylori with murine hosts over 6 months, we found stable colonization accompanied by gastric histologic and antibody responses. Analysis of gastric and pulmonary tissues revealed increased expression of multiple immune response genes, conserved across mice and over time in the stomach and more transiently in the lungs. Moreover, H. pylori infection led to significantly different population structures in both the gastric and intestinal microbiota. These studies indicate that H. pylori influences the microbiota and host immune responses not only locally in the stomach, but distantly as well, affecting important target organs.
TeaserKienesberger et al. utilize a mouse model to study H. pylori infections over 6 months. They report that H. pylori significantly affects the population structure of the gastric and intestinal microbiota. The infection alters gastric immune and inflammatory responses and causes distant effects via altered hormones and immunity.
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