Πέμπτη, 18 Ιουλίου 2019

Otology & Neurotology

Speech Perception Growth Patterns in Prelingual Deaf Children With Bilateral Sequential Cochlear Implantation
Objective: To evaluate speech perception following the first (CI-1) and second (CI-2) cochlear implantation (CI) in children with sequential bilateral CI. Study Design: Retrospective. Patients: Seventy children with follow-up for 60 months post CI-1 and 36 months post CI-2. Main Outcome Measures: Word recognition score (WRS) was the main outcome. WRSs were compared by age at CI operation (group A ≤ 3.5 yr, B 3.6–8.6, for CI-1; group I ≤ 3.5 yr, II 3.6–7.0, III 7.1–13, IV > 13, for CI-2). Results: For CI-1, the WRS of group A exceeded 80% at 24 months post procedure, earlier than group B (54 mo). Group A also had a shorter period of CI-1 use up to the WRS plateau than group B. CI-2 showed an initial burst of WRS growth much earlier than CI-1. This initial burst was most robust within 3 months in group II, but modest in group IV. The periods of CI-2 use (11–17 mo) up to the WRS plateau were much shorter than CI-1 (40–64 mo). Group I did not show the best WRS at 1 month post CI but later exceeded the other groups. Conclusion: Children received an immediate benefit by a burst of WRS growth from CI-2 earlier than CI-1, even within 3 months, suggesting that CI-1 gets the auditory cortex ready to foster speech processing from CI-2. The CI-2 performance depends on age at CI-2 implantation and on CI-1 performance. Our current findings will be relevant for clinicians who are counselling parents on CI-2 surgery. Address correspondence and reprint requests to Hong Ju Park, M.D., Ph.D., Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea; E-mail: dzness@hotmail.com The authors disclose no conflicts of interest. Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Long-term outcomes of bone conduction hearing implants in patients with bilateral microtia-atresia
Objectives: To evaluate the long-term outcomes of three different types of bone conduction hearing implants (BCHI)—BAHA, Ponto, and Bonebridge—in Mandarin-speaking patients with bilateral microtia-atresia. Methods: This cohort study enrolled 59 patients affected by bilateral microtia-atresia, with an upper bone conduction threshold limit of 30 dB HL at frequencies of 0.5 to 4 kHz. All subjects underwent unilateral BCHI surgery, including 26 (18 males, 8 females, of mean age 8.7 ± 1.9 yr) implanted with BAHA devices; 10 (7 males, 3 females, of mean age 11.7 ± 2.8 yr) implanted with Ponto devices; and 23 (14 males, 9 females, of mean age 9.0 ± 1.8 yr) implanted with Bonebridge devices. The main outcome measures included long-term audiological benefits, patient satisfaction, and complications. Each subject acted as his or her own control. Results: Two years after BCHI surgery, the mean hearing thresholds in the BAHA, Ponto, and Bonebridge groups had improved to 22.6 ± 1.6 dB HL, 21.6 ± 1.2 dB HL, and 22.5 ± 1.5 dB HL, respectively. The mean percentages of subjects in these three groups recognizing speech at 65 dB SPL under quiet conditions were 97.7 ± 4.2%, 96.3 ± 1.1%, and 94.4 ± 9.4%, respectively, whereas the mean percentages recognizing speech under noise conditions (signal:noise ratio +5) were 87.0 ± 1.8%, 89.3 ± 9.3%, and 85.3 ± 4.7%, respectively. Questionnaires revealed patients' benefits and satisfaction with this surgery. Three (11.5%) of 26 patients in the BAHA group and 1 (10%) of 10 in the Ponto group experienced skin irritation, but all recovered after local treatment. Five (19.2%) patients in the BAHA group and two (20%) in the Ponto experienced abutment extrusion about 6 months postoperatively, with all achieving good results after revision surgery to replace the abutment. One (3.8%) patient in the BAHA group experienced local chronic inflammation and underwent surgery to replace the BAHA with a Bonebridge implant. One (4.3%) patient in the Bonebridge group developed a local infection 3 months postoperatively and underwent implant removal. Conclusions: All three BCHIs were well tolerated after long-term follow-up, and all improved audiometric thresholds and the intelligibility of speech in the presence of both quiet and noise. These implants should be considered valid and safe options for the functional rehabilitation of patients with bilateral microtia-atresia. Address correspondence and reprint requests to Xiaowei Chen, M.D., Department of Otolaryngology, Peking Union Medical College Hospital, #1 shuaifuyuan, Beijing 100730, China; E-mail: chenxw_pumch@163.com This work was supported by grant to X.C. from the General Programs of National Natural Science Foundation of China (81271053) and The National Key Research and Development Program of China (2016YFC0901501). The authors have received no payment in the preparation of this manuscript. The authors alone are responsible for the content and writing of this article. X.C. acted as head surgeon for the BCHIs performed in this study and collected data. X.F. analyzed data, composed the manuscript, and participated in some of the operations as an assistant. T.Y., X.N., Y.W., and Y.F. participated in some of the operations as assistants, and collected and analyzed data. All authors read and approved the final manuscript. The authors disclose no conflicts of interest. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://journals.lww.com/otology-neurotology). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Anatomical Correlates and Surgical Considerations for Localized Therapeutic Hypothermia Application in Cochlear Implantation Surgery
Hypothesis: Application of localized, mild therapeutic hypothermia during cochlear implantation (CI) surgery is feasible for residual hearing preservation. Background: CI surgery often results in a loss of residual hearing. In preclinical studies, local application of controlled, mild therapeutic hypothermia has shown promising results as a hearing preservation strategy. This study investigated a suitable surgical approach to deliver local hypothermia in patients utilizing anatomical and radiologic measurements and experimental measurements from cadaveric human temporal bones. Methods: Ten human cadaveric temporal bones were scanned with micro-computed tomography and anatomical features and measurements predicting round window (RW) visibility were characterized. For each bone, the standard facial recess and myringotomy approaches for delivery of hypothermia were developed. The St. Thomas Hospital (STH) classification was used to record degree of RW visibility with and without placement of custom hypothermia probe. Therapeutic hypothermia was delivered through both approaches and temperatures recorded at the RW, RW niche, over the lateral semicircular canal and the supero-lateral mastoid edge. Results: The average facial recess area was 13.87 ± 5.52 mm2. The introduction of the cooling probe through either approach did not impede visualization of the RW or cochleostomy as determined by STH grading. The average temperatures at RW using the FR approach reduced by 4.57 ± 1.68 °C for RW, while using the myringotomy approach reduced by 4.11 ± 0.98 °C for RW. Conclusion: Local application of therapeutic hypothermia is clinically feasible both through the facial recess and myringotomy approaches without limiting optimal surgical visualization. Address correspondence and reprint requests to Suhrud M. Rajguru, Ph.D., University of Miami Ear Institute, 1095 NW 14 Terrance, Lois Pope Life Center, Room 4-25, Miami, Florida 33134; E-mail: s.rajguru@miami.edu E.P. and A.V.E. have equal contribution. This work was supported by a Research Grant from Cochlear, R01 DC01379801A1 and a pilot award from National Center For Advancing Translational Sciences of the National Institutes of Health under Award Number UL1TR002736, Miami Clinical and Translational Science Institute. S.M.R. and C.K. are named inventors on intellectual property related to the design of hypothermia system and probe discussed here. The authors declare no competing financial interests related to the findings presented. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Evaluation of the Effect of Diclofenac Sodium and 5-Fluourasil in a 3D Cholesteatoma Cell Culture Model
Introduction: Middle ear cholesteatoma is a benign disease with invasive and destructive clinical behaviors. It increases the rate of both chronic otitis media complications and revision surgeries. The most effective treatment of middle ear cholesteatoma is surgical excision, and there is no medical treatment for this disease. Exploring new medical treatment options may help to create treatment alternatives instead of surgery. Materials and Methods: Required cholesteatoma tissues for cell culture were excised from 4 different participants who underwent surgery in our clinic and agreed to give tissue for the study. Cholesteatoma-derived keratinocytes and fibroblasts were cocultured in temperature-sensitive culture dishes to make a three-dimensional (3D) cholesteatoma model. Then, the effects of 1% and 2% diclofenac sodium on viability and cell proliferation rates were examined using WST-1 and annexin-V tests. Results: Cell viability and proliferation rates were found to be lower and apoptosis rates were higher in the diclofenac sodium group versus the negative and positive control groups. Conclusion: In this present study, we described a new 3D cholesteatoma cell culture model developed using cell sheet technology and demonstrated the efficacy of diclofenac sodium on cholesteatoma for the first time in the literature. It may be used in patients with chronic otitis media with cholesteatoma, but further studies investigating ototoxic and neurotoxic effects of this molecule are needed. Address correspondence and reprint requests to Ahmet Kara, Sakarya University Training and Research Hospital, 54000 Korucuk, Sakarya, Turkey. E-mail: doktor.kbb@hotmail.com Funding: This study has been funded by Turkey Scientific and Technological Research Center (project number: 216S961) (TUBITAK). Date of presentation at scientific meeting: AAO-HNSF Annual Meeting & OTO Experience, 7–10.10.2018. The research protocol was approved by the Kocaeli University Animal Ethics Committee (KU GOKAEK 2013). The authors report no conflicts of interest Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Hearing Preservation With the Use of Flex20 and Flex24 Electrodes in Patients With Partial Deafness
Objective: To evaluate the impact of electrode length on hearing preservation (HP) in Partial Deafness Treatment–Electrical Complement (PDT-EC) subjects. Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Twenty-three PDT-EC patients (with preoperative air-conduction thresholds ≤30 dB up to 500 Hz) were divided into two groups: Flex20 electrode (Med-EL GmbH, Innsbruck, Austria) (12 patients) and Flex24 electrode (Med-EL GmbH, Innsbruck, Austria) (11 patients). Interventions: All participants were subjected to minimally invasive cochlear implantation using the round window approach. Main Outcome Measure(s): Pure tone audiometry (125–8000 Hz) was performed preoperatively and at 1, 6, 12, and 24 months postoperatively. HP was established using the HEARRING group formula. Speech understanding was assessed preoperatively and at 12 and 24 months postoperatively. Results: Analysis of HP for every individual indicates that more than half the patients with Flex20 and Flex24 had complete HP at 6 months follow-up. None of the patients from either group had complete loss of hearing. At activation, average air-conduction thresholds for low frequencies (125–500 Hz) were slightly better for the short electrode (M = 29.03) than for the long (M = 39.10) but the difference was not statistically significant (p = 0.067). The effect of electrode (Flex20 versus Flex24) was not significant in terms of pure tone audiometry and speech recognition at long-term follow-up. Conclusions: In the early postoperative period, complete HP was possible in a majority of patients from both groups, but slightly better HP outcomes were achieved by Flex20. In the long term, the length of the electrodes does not affect the degree of HP or speech understanding. Address correspondence and reprint requests to Piotr H. Skarzynski, Ph.D., M.D., M.S., Mokra 17 Street, 05-830 Kajetany, Poland; E-mail: p.skarzynski@ifps.org.pl No other benefits were received. The authors disclose no conflicts of interest. Supplemental digital content is available in the text. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (http://journals.lww.com/otology-neurotology). This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Validating a New Tablet-Based Tool in the Determination of Cochlear Implant Angular Insertion Depth
Objective: The objective of this study is to determine the reliability of a new tablet-based software that utilizes postoperative computed tomography to determine angular insertion depth (AID), cochlear duct length (CDL), and the cochlear place frequency of individual electrodes in cochlear implant recipients. Patients: Twenty adult cochlear implant recipients with lateral-wall electrode arrays of varying lengths were included in the study. Intervention: Cochlear and electrode array measurements were made by 2 otolaryngologists using a tablet-based software. The user manually identifies the modiolus, round window, and each electrode contact to calculate AID. The user also manually identifies cochlear landmarks to calculate the CDL. The AID and CDL are applied to the Greenwood function to obtain an estimate of the cochlear place frequency for each electrode. Main Outcome Measure(s): The primary outcome measure was the reliability of the instrument, as assessed with intra and interrater reliability of measured AID and CDL. The resultant differences in the estimated cochlear place frequency of the most apical electrode were also evaluated. Results: A broad range of AIDs were observed (390°–659°). Intraclass correlation coefficients for intra (0.991) and interrater reliability (0.980) of AID of the most apical electrode contact were excellent. Intra (0.820) and interrater reliability (0.784) of CDL were also excellent. The estimated cochlear place frequency for the most apical electrode differed by an average of 6.7% (0–18.7%) across the 2 raters. Conclusion: There is excellent agreement amongst clinicians in the determination of AID and CDL, resulting in small changes in estimated cochlear place frequency of the most apical electrode using this new software. Address correspondence and reprint requests to Michael W. Canfarotta, M.D., Department of Otolaryngology/Head and Neck Surgery, 170 Manning Drive, CB 7070, Physicians Office Building, Room G-190, Chapel Hill, NC 27599-7070, USA. E-mail: michael.canfarotta@unchealth.unc.edu Financial Disclosures/Conflicts of Interest: This project was funded in part by the NIH through NIDCD (T32 DC005360). The senior authors, H.C.P., K.D.B., and B.P.O., serve on the surgical advisory board for MED-EL Corporation. M.T.D. is supported by a research grant from MED-EL Corporation. M.W.C. and E.B. declare that involvement in research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Author Contributions: M.W.C., M.T.D., and B.P.O. designed experiments. Implanting surgeons were H.C.P., K.D.B., and B.P.O. M.W.C., M.T.D., E.B., and B.P.O. wrote the article, and all authors contributed significantly to analysis and revisions leading to its final form. Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Differentiation Between Eosinophilic Otitis Media and Otitis Media Associated With Eosinophilic Granulomatosis With Polyangiitis
Objective: To perform comparisons and clarify differences in clinical manifestations between eosinophilic otitis media (EOM) and otitis media associated with eosinophilic granulomatosis with polyangiitis (EGPA). Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Twenty-two ears of 11 patients exhibiting EOM (EOM group) and 20 ears of 12 patients exhibiting otitis media associated with EGPA (EGPA group). Main Outcome Measures: Otological manifestations, nasal and paranasal manifestations, incidence of asthma, positivity for serum antineutrophil cytoplasmic antibodies (ANCA), total serum immunoglobulin (Ig) E level, peripheral blood eosinophil fraction, and hearing outcomes. Results: The incidence and age of onset of asthma and chronic rhinosinusitis were comparable between the EOM and EGPA groups. Moreover, otological findings and hearing outcomes at the initial visit were similar in both groups. Computed tomography images of the paranasal sinus showed predominant opacification of the ethmoid sinus in both groups. Although the total serum IgE level was not significantly different, the peripheral blood eosinophil fraction was significantly larger in the EGPA group than in the EOM group (p = 0.0035). Furthermore, the rate of myeloperoxidase–antineutrophil cytoplasmic antibodies (ANCA) positivity was significantly higher in the EGPA group than in the EOM group (p = 0.019). Conclusions: The findings of the present study suggest that the phenotypic characteristics of EOM closely resemble those of otitis media associated with EGPA in early stages before the appearance of vasculitis. Therefore, it is challenging to differentiate the two conditions purely on the basis of otorhinological examinations. Address correspondence and reprint requests to Atsushi Fukuda, M.D., Department of Otolaryngology–Head & Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15, West 7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan; E-mail: atsushi.fukuda@huhp.hokudai.ac.jp The authors do not have any conflicts of interest to declare. Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Characteristics and Outcomes of Pediatric Vestibular Schwannomas
Objective: To review the demographics, treatment modalities, and survival of children with vestibular schwannomas. Study Design: Analysis using the Surveillance, Epidemiology, and End Results (SEER) database. Subjects and Methods: Pediatric patients from birth to 18 years in the SEER database were included from 2004 to 2014 based on a diagnosis of vestibular schwannoma using the primary site International Classification of Diseases (ICD) O-3 code of C72.4: acoustic nerve and the ICD O-3 histology codes of 9540/1: neurofibromatosis, Not Otherwise Specified (NOS); 9560/0: neurilemoma, NOS; or 9570/0: neuroma, NOS. Results: One hundred forty-eight pediatric vestibular schwannomas (VSs) cases were identified. The mean age at diagnosis was 13.9 years (range, 4.0–18.0). Eighty-five (57.4%) patients were women. Seventy-seven (52.0%) patients had isolated unilateral VSs while 71 (48.0%) patients had either bilateral VSs or unilateral VSs with other brain, spinal cord, or cranial nerve tumors. Eighty two (55.4%) patients received surgical resection only, 45 (30.4%) received no treatment, 6 (4.1%) received radiation only, and 12 (8.1%) received surgery and radiation. The median tumor size for patients who received no treatment was 9.5 mm (interquartile range [IQR]: 8.0) compared with 33.5 mm (IQR: 23.0) for patients who received surgical care and 41.0 mm (IQR: 1.5) for patients who received both surgery and radiation (p < 0.001). The 5-year overall survival rate was 97%. Conclusion: Pediatric VSs tend to be diagnosed in adolescence. No men or women predominance was appreciated. Treatment varied according to tumor size. Survival rates for children with vestibular schwannomas are excellent. These data may assist healthcare providers when counseling children with vestibular schwannomas and their families. Address correspondence and reprint requests to Tyler A. Janz, M.D., University of Central Florida College of Medicine, Orlando, FL; E-mail: tjanz@knights.ucf.edu This is the first submission on this topic. The authors have no funding, financial relationships, or conflicts of interest to disclose. Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

High-dose Corticosteroids for Adult Bell's Palsy: Systematic Review and Meta-analysis
Objectives: To compare the efficacy and safety of high-dose corticosteroids (initial prednisolone [PSL] of 100 mg or more daily) and standard-dose corticosteroids (initial PSL of 50–60 mg) in patients with Bell's palsy. Study Design: A systematic review and meta-analysis. Data Sources: Medline, Embase, Cochrane Central Register of Controlled Trials, Ichushi-Web, Web of Science, and CINAHL, combined with data from ClinicalTrials.gov. Study Selection: Published and unpublished cohort studies comparing high- and standard-dose corticosteroids in adult patients with Bell's palsy were included. Data Extraction: Study characteristics (study design, patient's number), patient characteristics (sex, age, disease severity, prescription of antivirals), and outcomes (nonrecovery, any adverse effects). Data Synthesis: From the 1,974 identified articles, 8 studies were met eligible criteria. Of the included studies, the initial dose in high-dose corticosteroids regimens varied from 120 mg to 200 mg PSL daily. Compared with standard-dose corticosteroids, high-dose corticosteroids were associated with a significantly decreased nonrecovery at 6 months after disease onset (odds ratio 0.42, 95% confidence interval 0.22–0.80; very low quality) in patients with Bell's palsy. No severe adverse effects were observed in patients receiving high- or standard-dose corticosteroids. Conclusion: High-dose corticosteroids reduce nonrecovery in patients with Bell's palsy. The dose of high-dose corticosteroids was varied and further prospective study is needed to identify an adequate dose of corticosteroids in these patients. Address correspondence and reprint requests to Takashi Fujiwara, M.D., Ph.D., Department of Otolaryngology Head and Neck Surgery, Kurashiki Central Hospital, 1-1-1 Miwa, Kurahiki, Okayama 710-8602, Japan; E-mail: t.fujiwarabi@gmail.com All authors declare: no support from any organization for the submitted work; no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years; no other relationships or activities that could appear to have influenced the submitted work. The authors disclose no conflicts of interest. Supplemental digital content is available in the text. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.jcraniofacialsurgery.com). Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Endre Hőgyes (1847–1906), Forgotten Father of the Vestibulo-Ocular Reflex
Objective: Throughout the history of vestibular research, the discovery of the vestibulo-ocular reflex in 1881 by Endre Hőgyes (1847–1906) is rarely mentioned. The aim of this study is to review Hőgyes' vestibular research articles, all originally written in Hungarian and emphasize their epoch-making content. Main Data Sources: Hőgyes' vestibular publications, originally written in Hungarian, which describe various eye movements of the rabbit in response to vestibular stimulation by rotation about three axes. Results: Hőgyes was the first to use a three-axis turntable on an experimental animal, in this case a rabbit. He found that depending on the plane of rotation, different types of binocular eye movements were produced. He then demonstrated by destructive and excitatory experiments, the anatomical pathways and the physiological function producing this phenomenon. Ultimately, he explained the exact connections between the inner ear labyrinth and certain muscle contractions during eye movements. He identified this pathway as the "associating center of the ocular movements," later defined as the vestibulo-ocular reflex. Hőgyes' discovery was only superficially noted during his lifetime and ignored after his death. Conclusion: Hőgyes was the first to demonstrate the vestibulo-ocular reflex. He was forgotten during the ensuing 140 years probably because his articles were appeared only in Hungarian and because a short time later, Róbert Bárány's award of the Nobel Prize overshadowed many of Bárány's predecessors and contemporaries, including Hőgyes and relegated them to the background. Address correspondence and reprint requests to László T. Tamás, M.D., 9028, Győr, Vak Bottyán u.14/A, Hungary; E-mail: ltamas@gyor.net Dr. L.T.T. and Dr. A.M. helped in data collection, analysis, and interpretation, critically reviewing and editing the manuscript. The authors disclose no conflicts of interest. Copyright © 2019 by Otology & Neurotology, Inc. Image copyright © 2010 Wolters Kluwer Health/Anatomical Chart Company

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Anti-Cancer Drugs

Melanoma: the new perspectives from clinical and translational research
imageThe prognosis of metastatic melanoma has not changed throughout the 20th century. However, in the last decade, we have witnessed a continuous improvement in survival, with many long-term survivors. These results are largely because of the simultaneous development of the knowledge in the biology of metastatic malignant melanoma and of the relationship between the disease and the host's immune system that allowed the development of effective new treatments. In this overview, we summarize the therapies available today, their biological rationale, and the research field currently under investigation divided into three main chapters: target therapies, immunotherapies, and their combination.

Poly (ADP-ribose) polymerase inhibitors combined with other small-molecular compounds for the treatment of ovarian cancer
imageOvarian cancer is a heterogeneous disease with complex molecular and genetic hallmarks. Benefitting from profound understanding of molecular mechanisms in ovarian cancer pathogenesis, novel targeted drugs have been actively explored in preclinical studies and clinical trials. Considered as one of the most potent and effective targeted therapies for the treatment of ovarian cancer, poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) take advantages of synthetic lethality mechanisms to prevent DNA damage repair in cancer cells and cause their death, especially in cancers with BRCA mutations. Mounting evidence has indicated that the combination of PARPis with cytotoxic drugs or other targeted drugs has shown favorable synergistic effects. Excitingly, the antitumor activity of combination therapy of PARPis has been actively tested in multiple clinical trials and in-vitro or in-vivo experiments. In this review, we will briefly discuss the molecular mechanisms of PARPis combined with other therapeutic small-molecular compounds for the treatment of ovarian cancer.

Knockdown of long noncoding RNA-taurine-upregulated gene 1 inhibits tumor angiogenesis in ovarian cancer by regulating leucine-rich α-2-glycoprotein-1
imageTo investigate the role of long noncoding RNA taurine-upregulated gene 1 (TUG1) on ovarian cancer-induced angiogenesis and to explore possible signaling pathways. Ovarian cancer cell line SKOV3 or CAOV3 was transfected with short hairpin-TUG1 to suppress TUG1 expression. Supernatant from cultured cancer cells was used as a condition medium to incubate endothelial cell line human umbilical vein endothelial cells, whose proliferation rate was quantified by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Migration and invasion of endothelial cells were examined by wound healing and Transwell assays, followed by in-vitro angiogenesis assay. One of the secretory factors mediating angiogenesis, leucine-rich α-2-glycoprotein-1 (LRG1), was measured in ovarian cancer cells. Signaling pathway mediating angiogenesis was further detected by western blotting. TUG1 was down-regulated in ovarian cancer cells by short hairpin RNA. Conditional medium originating from TUG1-knockdown cancer cells led to suppressed proliferation, migration, or invasion of endothelial cell line human umbilical vein endothelial cells. LRG1 expression and secretion was suppressed in ovarian cancer cells after TUG1 knockdown. Moreover, recombinant LRG1 rescued TUG1 knockdown-induced angiogenesis inhibition, and LRG1 probably mediated angiogenesis by tumor growth factor-β signaling pathway in endothelial cells. Long noncoding RNA-TUG1 mediates angiogenesis of endothelial cells by regulating LRG1 secretion from ovarian cancer cells partially through tumor growth factor-β pathway. Our results indicate the potency of TUG1 as a biomarker and therapeutic target for tumor-induced angiogenesis.

Pyrimethamine exerts significant antitumor effects on human ovarian cancer cells both in vitro and in vivo
imagePyrimethamine has been used principally to treat infections from protozoan parasites. Although previous studies have shown that pyrimethamine exhibited anticancer activity by inducing cellular apoptosis, there are none that show that pyrimethamine possesses anticancer activity with respect to ovarian cancer. We examined the roles of pyrimethamine on apoptosis and proliferation, DNA damage, and cell cycle distribution of human ovarian cancer cell lines in vitro. To investigate the antitumor efficacy of pyrimethamine in vivo, we established two intraperitoneal ovarian carcinoma models in nude mice. Pyrimethamine significantly induced apoptosis of ovarian cancer cells via growth inhibition, cell cycle arrest, and nuclear DNA damage in vitro and manifested antitumor activity by inhibiting tumor growth, thereby prolonging the survival time of tumor-bearing mice. We also demonstrated that pyrimethamine increased the expression of caspase-9 and decreased the expression of X-linked inhibitor of apoptosis protein. In conclusion, the antitumor effects of pyrimethamine were associated with enhanced apoptosis of tumor cells and inhibition of the growth of intratumoral microvessels. Our results indicate that pyrimethamine may provide an effective approach toward inhibiting the growth of ovarian cancer with minimal adverse effects.

MiR-29a inhibits cell proliferation and migration by targeting the CDC42/PAK1 signaling pathway in cervical cancer
imageCervical cancer is the second most common gynecological malignancy worldwide and the tumorigenesis mechanisms of cervical cancer are still unclear. This study aimed to reveal the role of miR-29a in cervical cancer. The expression level of miR-29a and CDC42 was measured using qRT-PCR. Cell proliferation, apoptosis, migration, and invasion were detected using colony formation, flow cytometry analysis, wound-healing assay, and Transwell assay, respectively. Luciferase reporter assay was used to determine the binding of miR-29a with CDC42. CDC42/p21-activated kinase 1 (PAK1) pathway-related proteins were measured by western blotting. MiR-29a was downregulated and CDC42 was upregulated in cervical cancer cells. Luciferase reporter assay showed that miR-29a negatively regulated the expression of CDC42 by directly targeting 3′-UTR of CDC42. Cell proliferation, migration, and invasion were markedly inhibited, whereas cell apoptosis was significantly increased in Hela and CaSki cells transfected with miR-29a mimics. These effects were partly recovered by CDC42 overexpression. Protein levels of PAK1, p-PAK1, p-LIMK, and p-cofilin were significantly downregulated by miR-29a mimics, which was reversed by CDC42 overexpression and was increased by the miR-29a inhibitor. MiR-29a inhibited cell proliferation, migration, and invasion, as well as promoted cell apoptosis through repressing the PAK1/LIMK signaling pathway by targeting CDC42 in cervical cancer.

Construction of an miRNA–mRNA regulatory network in colorectal cancer with bioinformatics methods
imageColorectal cancer (CRC) is the third most common cancer worldwide. This study aimed to explore the regulatory mechanisms of miRNAs in CRC. Differentially expressed miRNAs (DEMs) and differentially expressed genes (DEGs) in CRC tissue samples compared with control samples in mRNA and miRNA datasets were screened. Functional and pathway enrichment analysis of the DEGs was carried out. Targets of the DEMs were identified. Overlaps between the DEGs and targets of DEMs were selected. The miRNA–mRNA regulatory network of these overlaps was constructed and visualized. The candidate genes selected were validated by quantitative real-time PCR. DEGs were identified and considered DEGs-1 and DEGs-2. A total of 584 genes in DEGs-1 and 527 genes in DEGs-2 were obtained, including 465 overlaps, and 44 DEMs were identified. The overlaps were enriched in 46 Gene Ontology terms and 19 Kyoto Encyclopedia of Genes and Genomes pathways. Moreover, 137 overlapped genes between targets of the DEMs and the 465 overlaps were obtained. The miRNA–mRNA regulating network of the 137 overlapped genes was constructed. Extracellular matrix-related proteins and pathways might play critical roles in the development of CRC. The quantitative real-time PCR results of the candidates were in agreement with the bioinformatics analysis. miR-128, miR-182, and miR-143 might be key miRNAs regulating cell proliferation and metastasis of CRC.

Upregulation of sine oculis homeobox homolog 3 is associated with proliferation, invasion, migration, as well as poor prognosis of esophageal cancer
imageEsophageal cancer (EC) is a common cancer worldwide. Sine oculis homeobox homolog (SIX3) is a human transcription factor that regulates the progression of vertebrate eye and fetal forebrain. However, studies on the function of SIX3 in human tumorigenesis remain rare. In this study, we aim to evaluate the role and the significance of SIX3 in EC. The TCGA database and clinical samples were used to assess the expression of SIX3 in EC patients. The Kaplan–Meier method and Cox's proportional hazards model were performed to analyze the correlations between SIX3 expression and EC clinical outcomes. The expressions of SIX3 in EC cells were measured by quantitative reverse transcription PCR analysis. The cell proliferation was detected using cell counting kit-8 and colony formation assay. The migration and invasion capacity of EC cells were evaluated using wound healing and Transwell methods. Western blot assay was used to measure the alterations in some important protein expression levels in the PI3K/Akt signaling pathway. We found that SIX3 was highly expressed in the EC tissues and cells. In addition, high expression of SIX3 was related to poor survival. The knockdown of SIX3 significantly inhibited the proliferation, migration, and invasion of ECA109 cells. A similar pattern was also found in the proliferation and migration of SKGT-4 cell line. The expression levels of some key proteins in the PI3K/Akt signaling pathway were obviously decreased after cells were transfected with si-SIX3, possibly resulting in PI3K/AKT signaling inactivation. In addition, E-cadherin and N-cadherin showed some change. Collectively, the results shed light on a potentially promoting role of SIX3 in human EC. Thus, SIX3 might be considered a novel prognostic biomarker and therapeutic target for EC patients.

Development of transferrin-modified poly(lactic-co-glycolic acid) nanoparticles for glioma therapy
imageGlioma is a primary intracranial malignant tumor with poor prognosis. In this study, we aimed to develop transferrin (Tf)-modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles to deliver temozolomide (TMZ) to glioma and evaluate their efficacy to kill glioma. TMZ-loaded nanoparticles were prepared by nanoprecipitation technique and targeted by Tf. Tf-PLGA-TMZ and PLGA-TMZ were characterized for average particle sizes and zeta potentials, cellular uptake and cytotoxicity as well as in-vitro drug release of these nanoparticles were evaluated in human glioma U87MG cells. In-vivo antiglioma efficacy of Tf-PLGA-TMZ was evaluated in nude mice. Polydispersity ratio increased from 0.132 to 0.150, while encapsulation efficiency decreased from 69.4 to 55.8% after Tf modification of PLGA-TMZ. High performance liquid chromatography test showed that Tf-targeted nanoparticles were better internalized into U87MG cells than nontargeted nanoparticles. Moreover, Tf-PLGA-TMZ significantly decreased the viability of U87MG cells compared with nontargeted nanoparticles (P<0.05). In addition, Tf-PLGA-TMZ significantly decreased tumor volume and improved the survival of nude mice injected with U87MG cells. Tf-modified PLGA nanoparticles could be used for effective delivery of TMZ and have promise for the treatment of glioma.

Evodiamine inhibits migration and invasion by Sirt1-mediated post-translational modulations in colorectal cancer
imageColorectal cancer (CRC) is one of the most difficult cancers to cure. An important prognostic factor is metastasis, which precludes curative surgical resection. Recent evidences show that Evodiamine (EVO) exerts an inhibitory effect on cancer cell apoptosis, migration, and invasion. In this study, we investigated the effects of EVO on the metastasis of CRC cells in vitro and in vivo. In vitro, wound-healing and transwell assay showed that migration and invasion of HT-29 and HCT-116 CRC cells were inhibited significantly by EVO. Western blot and RT-PCR showed that EVO reduced the expression of matrix metalloproteinase-9 in a dose-dependent manner. In EVO-induced cells, the intracellular NAD+/NADH ratio was increased, the level of Sirt1 was increased, and acetyl-NF-κB P65 was decreased. This process was inhibited by nicotinamide, an inhibitor of Sirt1. In vivo, EVO reduced tumor metastasis markedly. These findings provide evidences that EVO suppresses the migration and invasion of CRC cells by inhibiting the acetyl-NF-κB p65 by Sirt1, resulting in suppression of metalloproteinase-9 expression in vitro and in vivo.

Novel small molecule decreases cell proliferation, migration, clone formation, and gene expression through ERK inhibition in MCF-7 and MDA-MB-231 breast cancer cell lines
imageThe Ras–Raf–MEK1/2–ERK1/2 pathway is an attractive target for the development of anticancer agents because of the high prevalence of ERK activation in human cancers. However, resistance is often developed despite initial clinical response, most likely because of activation of cross-talk pathways. In Research Genetic Cancer Center (RGCC), we are in the process of synthesizing a novel ERK inhibitor, targeting the final stage of the pathway, thus minimizing cross-talk. We have synthesized an intermediate molecule –RGCC416 – and tested its biological activity. MCF-7 and MDA-MB-231 cells were used. Cell viability was measured by crystal violet and cell proliferation by the methyl tetrazolium assay using various compound concentrations. Cell migration and colony formation were determined to assess the ability of invasion and single cancer cell growth, respectively. Expression of genes linked to MAPK/PI3K pathways was determined by PCR. ERK and phospho-ERK levels were determined in both the cytoplasm and the nucleus by western blot. It was found that although the compound did not affect viability, it significantly decreased cell proliferation, migration, and colony formation in both cell lines. In MDA-MB-231, this is possibly through retaining phospho-ERK to the cytoplasm, where it cannot activate cancer-associated genes. There was no difference in ERK levels in MCF-7 cells. This could be because of the different pathways that these cells utilize for survival. We have synthesized a molecule, which could be a promising ERK inhibitor, leading to possible novel treatment options for breast cancer patients.



Clinical Reports
 
 
 

Treatment of ALK-rearranged non-small-cell lung cancer with brigatinib as second or later lines: real-world observations from a single institution
Maximilian Hochmair, Christoph Weinlinger, Sophia Schwab, Jakob Naber, Ulrike Setinek, Dagmar Krenbek, Matthias H. Urban, Hannah Fabikan, Stefan Watzka, Renate Koger, Andreas Fazekas, Erwin Bitterlich, Arschang Valipour, Otto C. Burghuber

Poor outcome for patients with gastric cancer and lung metastases treated with ramucirumab and paclitaxel
Giandomenico Roviello, Silvia P. Corona, Andrea G. Multari, Roberto Petrioli, Pietro Rosellini, Michele Aieta

 
Case Reports
 
 
 

Misleading impaired liver function in a non-small-cell lung cancer patient treated with pembrolizumab: a case report
Giorgia A. Osman, Arnaldo Marra, Daniela Iacono, Valerio Giannelli, Serena Ricciardi, Daniele Remotti, Andrea Vecchione, Alberto Ricci, Paolo Palange, Maria R. Migliorino

Apatinib, combined with chemotherapy or alone is effective in treating angiosarcoma: a case report
Mingyang Liu, Yongmin Liu, Huannan Guo, Dongwei Fu, Lili Lv, Chunhong Chen, Yanlin Li, Wenqian Zhang, Ming Yao, Limin Zhao



Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


Solid Pseudopapillary Neoplasms of the Pancreas: Clinicopathologic and Radiologic Features According...
Solid Pseudopapillary Neoplasms of the Pancreas: Clinicopathologic and Radiologic Features According to SizeRiccardo De Robertis1, Giovanni Marchegiani2, Matteo Catania3, Maria Chiara Ambrosetti3, Paola Capelli4, Roberto Salvia2 and Mirko D'Onofrio3 Show lessShare Share+ Affiliations:Citation: American Journal of Roentgenology: 1-8. 10.2214/AJR.18.20715AbstractFull TextReferencesPDFPDF PlusAdd to FavoritesPermissionsDownload CitationABSTRACT :OBJECTIVE. The purpose of this study was to retrospectively...
Medicine by Alexandros G. Sfakianakis
10:08
Frontal Occipital and Frontal Temporal Horn Ratios: Comparison and Validation of Head Ultrasound-Derived...
Frontal Occipital and Frontal Temporal Horn Ratios: Comparison and Validation of Head Ultrasound-Derived Indexes With MRI and Ventricular Volumes in Infantile VentriculomegalyRupa Radhakrishnan1,2, Brandon Patrick Brown1,2, Stephen F. Kralik3, Danielle Bain2, Scott Persohn2, Paul R. Territo2, Andrew Jea4, Boaz Karmazyn1,2, Show lessShare Share+ Affiliations:Citation: American Journal of Roentgenology: 1-7. 10.2214/AJR.19.21261AbstractFull TextReferencesPDFPDF PlusAdd to FavoritesPermissionsDownload...
Medicine by Alexandros G. Sfakianakis
10:08
Percutaneous Image-Guided Cryoablation of Osteoblastoma Roberto Luigi Cazzato1, Pierre Auloge1, Danoob...
Percutaneous Image-Guided Cryoablation of OsteoblastomaRoberto Luigi Cazzato1, Pierre Auloge1, Danoob Dalili2,3, Pierre De Marini1, Antonio Di Marco4, Julien Garnon1 and Afshin Gangi1 Show lessShare Share+ Affiliations:Citation: American Journal of Roentgenology: 1-6. 10.2214/AJR.19.21390AbstractFull TextReferencesPDFPDF PlusAdd to FavoritesPermissionsDownload CitationABSTRACT :OBJECTIVE. The aim of this observational study was to assess safety and clinical outcomes of percutaneous image-guided cryoablation...
Medicine by Alexandros G. Sfakianakis
10:07
Long-term Follow-up of Severe Eosinophilic Hepatitis: A Rare Presentation of Hypereosinophilic Syndrome...
Long-term Follow-up of Severe Eosinophilic Hepatitis: A Rare Presentation of Hypereosinophilic SyndromeHalim Awadie, Johad Khoury, Yaniv Zohar, Afif Yaccob, Ella Veitsman, and Tarek SaadiAbstractIdiopathic hypereosinophilic syndrome (HES) is a rare, heterogeneous disorder characterized by a strikingly high eosinophil count (>1,500 cells/µL), over a long period of time (>6 months), with end organ damage. We present a 60-year-old patient with idiopathic HES with isolated liver involvement, a...
Medicine by Alexandros G. Sfakianakis
10:07
Vape Gods and Judaism—E-cigarettes and Jewish Law, Sharon GalperAbstract Objective: To review current...
Vape Gods and Judaism—E-cigarettes and Jewish Law,Sharon GalperAbstractObjective: To review current medical literature on the risks and potential benefits of e-cigarette use and its permissibility under Jewish law. Methods: A survey of current medical literature about the risks and potential benefits of e-cigarette use, and a review of existing rabbinic literature regarding both combustible and e-cigarette products. Results: E-cigarettes contain fewer harmful materials than do combustible cigarettes....
Medicine by Alexandros G. Sfakianakis
10:07
A Comparison of Manual versus Electric Bicycle Injuries Presenting to a Pediatric Emergency Department...
A Comparison of Manual versus Electric Bicycle Injuries Presenting to a Pediatric Emergency DepartmentTali Capua, Miguel Glatstein, Karin Hermon, Oren Tavor, Dennis Scolnik, Veronika Kusaev, and Ayelet RimonAbstractBackground: The use of electric bicycles (E-bikes) has dramatically increased over the last decade. E-bikes offer an inexpensive, alternative form of transport, but also pose a new public health challenge in terms of safety and injury prevention. Objective: The aim of this study was to...
Medicine by Alexandros G. Sfakianakis
10:06
Something Must Be Wrong with the Implementation of Cancer-pain Treatment Guidelines. A Lesson from...
Something Must Be Wrong with the Implementation of Cancer-pain Treatment Guidelines. A Lesson from Referrals to a Pain ClinicGil Samuelly-Leichtag, Tsiki Adler, and Elon EisenbergAbstractObjective: The World Health Organization's (WHO) guidelines for cancer pain management were intentionally made simple in order to be widely implemented by all physicians treating cancer patients. Referrals to pain specialists are advised if pain does not improve within a short time. The present study examined whether...
Medicine by Alexandros G. Sfakianakis
10:06
Morphological Analysis of Elastic Fibers in Various Grades of Oral Squamous Cell Carcinoma and Epithelial...
Morphological Analysis of Elastic Fibers in Various Grades of Oral Squamous Cell Carcinoma and Epithelial Dysplasia Using Verhoeff–Van Gieson StainJanardhanam Dineshshankar, Nalliappan Ganapathy, Thuckanaickenpalayam Ragunathan Yoithapprabhunath, Jeyaraman Swathiraman, Thangadurai Maheswaran, and Vadivel IlayarajaAbstractBackground: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy in India. The aggressiveness of OSCC is analyzed not only based on the dysplastic features and...
Medicine by Alexandros G. Sfakianakis
10:06
Rational Use of Medicine in Children—The Conflict of Interests Story. A Review Klaus Rose, David Neubauer,...
Rational Use of Medicine in Children—The Conflict of Interests Story. A ReviewKlaus Rose, David Neubauer, and Jane M. Grant-KelsAbstractBackground: United States (US) and European Union (EU) legislation attempts to counterbalance the presumed discrimination in pediatric drug treatment and development. Methods: We analyzed the history of drug development, US/EU pediatric laws, and pediatric studies required by US/EU regulatory authorities and reviewed relevant literature. Results: The US and EU definitions...
Medicine by Alexandros G. Sfakianakis
10:06
Trends of Mortality in Greece Prior to and During its Current Financial Crisis (2009–2015), Konstantinos...
Trends of Mortality in Greece Prior to and During its Current Financial Crisis (2009–2015),Konstantinos Z. Vardakas, Katerina N. Apiranthiti, Spiridoula E. Almpani, Dominiki Heliou, Dimitra Stratigopoulou, Eleni Giourmetaki, Dimitra Lamprou, Georgia Binou, Elena Mpaltzoglou, Margarita Kyriakidou, and Matthew E. FalagasAbstractObjectives: To study mortality changes in Greece prior to and during the financial crisis. Study design: Analysis of data by the Hellenic Statistical Authority (1955–2013)....
Medicine by Alexandros G. Sfakianakis
10:05
Rambam Maimonides Medical Journal
Original ResearchMorphological Analysis of Elastic Fibers in Various Grades of Oral Squamous Cell Carcinoma and Epithelial Dysplasia Using Verhoeff–Van Gieson StainJanardhanam Dineshshankar, Nalliappan Ganapathy, Thuckanaickenpalayam Ragunathan Yoithapprabhunath, Jeyaraman Swathiraman, Thangadurai Maheswaran, and Vadivel IlayarajaTrends of Mortality in Greece Prior to and During its Current Financial Crisis (2009–2015)Konstantinos Z. Vardakas, Katerina N. Apiranthiti, Spiridoula E. Almpani, Dominiki...
Medicine by Alexandros G. Sfakianakis
10:04
Assessment of myocardial viability by myocardial contrast echocardiography: current perspectives Purpose...
Assessment of myocardial viability by myocardial contrast echocardiography: current perspectivesPurpose of review The current guidelines recommend the use of myocardial contrast echocardiography (MCE) to assess myocardial viability. There are two clinical scenarios where detection of myocardial viability has clinical significance: in ischemic cardiomyopathy and following acute myocardial infarction with significant left ventricular dysfunction. Myocardial contrast echocardiography (MCE), which utilizes...
Medicine by Alexandros G. Sfakianakis
10:02
Surgical Oncology
EDITORIALSentinel node biopsy for cancer of the oral cavityJames X. Wu MD  Martin Hanson MD  Ashok R. ShahaPages: 99-100  First Published: 16 May 2019Full text  PDF  ReferencesRequest permissionsRESEARCH ARTICLESSentinel lymph node biopsy for management of the N0 neck in oral cavity squamous cell carcinomaJohn T. Loree BA  Saurin R. Popat MD  Mark S. Burke MD  Jennifer Frustino DDS, PhDJeewanjot S. Grewal BA  Thom R. Loree MDPages: 101-108  First Published: 16 May 2019Abstract  Full text  PDF  ReferencesRequest...
Medicine by Alexandros G. Sfakianakis
10:01
Sentinel lymph node biopsy for management of the N0 neck in oral cavity squamous cell carcinoma, John...
Sentinel lymph node biopsy for management of the N0 neck in oral cavity squamous cell carcinoma,John T. Loree BA  Saurin R. Popat MD  Mark S. Burke MD  Jennifer Frustino DDS, PhD  Jeewanjot S. Grewal BA  Thom R. Loree MDFirst published: 16 May 2019 https://doi.org/10.1002/jso.25494 Cited by: 1Read the full textePDFPDFTOOLS SHAREAbstractBackground and ObjectivesThe management of the clinically N0 (cN0) neck is controversial for early stage squamous cell carcinoma of the oral cavity (OSCC). This paper...
Medicine by Alexandros G. Sfakianakis
09:59
Sarcomas of the mandible, Ivana Petrovic DMD  Zain U. Ahmed  Ashley Hay MBChB, MRCS, DOHNS, FRCS ...
Sarcomas of the mandible,Ivana Petrovic DMD  Zain U. Ahmed  Ashley Hay MBChB, MRCS, DOHNS, FRCS  Evan B. Rosen DMD, MPH  Chuanyong Lu MD  Meera Hameed MD  Jatin P. Shah MD, PhD, DSc, FRCS(Hon)First published: 16 April 2019 https://doi.org/10.1002/jso.25477Read the full textePDFPDFTOOLS SHAREAbstractIntroductionSarcomas of the mandible are extremely rare tumors, with osteosarcoma being the most common, followed by Ewing's sarcomaMaterials and methodsA retrospective review of the clinical records,...
Medicine by Alexandros G. Sfakianakis
09:58
Traditional sugar-sweetened beverages, sweetened teas, and blended milk-based beverages (e.g., milkshakes) were significantly higher in calories from 2012 to 2017 for newly introduced beverages (p-value for trend 0.004). For all newly introduced sweetened beverages, sugar increased significantly (2015, +7.9 g; 2016, +8.2 g; p0.004) whereas saturated fat declined (2016, −2.3 g; 2017, −1.6 g; p0.004). For beverages on menus in all years, saturated fat declined significantly (p0.001), whereas mean calories and sugar remained relatively constant. Significant declines were observed for sweetened coffees (−10 kcal, −0.5 g saturated fat, p0.001), teas (−2.6 g sugar, p=0.001), and blended milk-based beverages (−28 kcal, −4.2 g sugar, −0.8 g saturated fat, p0.001). From 2012 to 2017, the total number of beverage offerings increased by 155%, with 82% of this change driven by sweetened beverages.
Trends in Calories and Nutrients of Beverages in U.S. Chain Restaurants, 2012–2017Publication date: August 2019Source: American Journal of Preventive Medicine, Volume 57, Issue 2Author(s): Johannah M. Frelier, Alyssa J. Moran, Kelsey A. Vercammen, Marian P. Jarlenski, Sara N. BleichIntroductionAlthough beverages comprise one third of all menu items at large chain restaurants, no prior research has examined trends in their calorie and nutrient content.MethodsBeverages (n=13,879) on the menus of 63...
Medicine by Alexandros G. Sfakianakis
09:58
Lung Cancer Screening Utilization: A Behavioral Risk Factor Surveillance System Analysis, Publication...
Lung Cancer Screening Utilization: A Behavioral Risk Factor Surveillance System Analysis,Publication date: August 2019Source: American Journal of Preventive Medicine, Volume 57, Issue 2Author(s): Whitney E. Zahnd, Jan M. EberthIntroductionLung cancer is the leading cause of cancer-related death in the U.S. The National Lung Screening Trial found that low-dose computed tomography reduced lung cancer mortality in high-risk individuals. As a result, the U.S. Preventive Services Task Force began recommending...
Medicine by Alexandros G. Sfakianakis
09:56
Preventive Medicine
Binge Drinking and Prescription Opioid Misuse in the U.S., 2012–2014Publication date: August 2019Source: American Journal of Preventive Medicine, Volume 57, Issue 2Author(s): Marissa B. Esser, Gery P. Guy, Kun Zhang, Robert D. BrewerIntroductionPrescription opioids were responsible for approximately 17,000 deaths in the U.S. in 2016. One in five prescription opioid deaths also involve alcohol. Drinkers who misuse prescription opioids (i.e., use without a prescription or use only for the experience...
Medicine by Alexandros G. Sfakianakis
09:56
Wolters Kluwer Health At A Glance, New Journals Website Launched with Inaugural Issue Journal of...
Wolters Kluwer Health At A Glance,New Journals Website Launched with Inaugural IssueJournal of Oral and Maxillofacial RadiologyySahel Medical JournalSaudi Journal of Sports MedicineJournal of Orthodontic ResearchMuller Journal of Medical Sciences and ResearchASL- Musculoskeletal DiseasesWest African Journal of Radiology79 Issues submitted to appropriate Indexing Agencies such as EBSCO, ProQuest, Swet, Thomson, IndMed, Portico, Infotrieve and Exlibris. 3 New Journals Accepted in NLM and PMC/PubMed:Nigerian...
Medicine by Alexandros G. Sfakianakis
09:55
American Journal of Roentgenology
Gastrointestinal ImagingOriginal ResearchSolid Pseudopapillary Neoplasms of the Pancreas: Clinicopathologic and Radiologic Features According to SizeRiccardo De Robertis, et al. | American Journal of Roentgenology | Jul 16, 2019Ahead of PrintPediatric ImagingOriginal ResearchFrontal Occipital and Frontal Temporal Horn Ratios: Comparison and Validation of Head Ultrasound-Derived Indexes With MRI and Ventricular Volumes in Infantile VentriculomegalyRupa Radhakrishnan, et al. | American Journal of Roentgenology...
Medicine by Alexandros G. Sfakianakis
09:53
Mycoses Early View Online Version of Record before inclusion in an issue  Open AccessMucormycosis...
MycosesEarly ViewOnline Version of Record before inclusion in an issue Open AccessMucormycosis in South America: A review of 143 reported casesMarcio Nucci, Marc Engelhardt, Kamal HamedVersion of Record online: 11 July 2019 Open AccessFirst application of loop‐mediated isothermal amplification (LAMP) assays for rapid identification of mating type in the heterothallic fungus Aspergillus fumigatusKevin M. King, Nichola J. Hawkins, Sarah Atkins, Paul S. Dyer, Jonathan S. West, Bart A. FraaijeVersion...
Medicine by Alexandros G. Sfakianakis
09:52
Pulmonary cryptococcosis characteristics in immunocompetent patients—A twenty‐year clinical retrospective...
Pulmonary cryptococcosis characteristics in immunocompetent patients—A twenty‐year clinical retrospective analysis in China,Xiaomeng Hou, Lei Kou, Xiaozhen Han, Rui Zhu, Lan Song, Tao LiuFirst Published: 09 July 2019
Medicine by Alexandros G. Sfakianakis
09:51
Food Sources of Potassium, https://www.webmd.com/diet/foods-rich-in-potassium Many of the foods that...
Food Sources of Potassium,https://www.webmd.com/diet/foods-rich-in-potassiumMany of the foods that you already eat contain potassium. The foods listed below are high in potassium. If you need to boost the amount of potassium in your diet, make healthy food choices by picking items below to add to your menu.Many fresh fruits and vegetables are rich in potassium:Bananas, oranges, cantaloupe, honeydew, apricots, grapefruit (some dried fruits, such as prunes, raisins, and dates, are also high in potassium)Cooked...
Medicine by Alexandros G. Sfakianakis
09:50
Hyperphosphataemia in 2019: have we made progress? Purpose of review This review describes recent developments...
Hyperphosphataemia in 2019: have we made progress?Purpose of review This review describes recent developments in the management of serum phosphate in dialysis patients, with a focus on the development of recent trials which randomize patients to different levels of control. Recent findings We review the uncertainties around clinical benefits of serum phosphate control and alternative approaches to current management, as well as a multinational attempt to conduct randomized controlled trials in this...
Medicine by Alexandros G. Sfakianakis
09:50
Updates on medical management of hyperkalemia, Purpose of review Hyperkalemia is a potentially fatal...
Updates on medical management of hyperkalemia,Purpose of review Hyperkalemia is a potentially fatal electrolyte disorder, more commonly present when the potassium excretion capacity is imparied. Hyperkalemia can lead to adverse outcomes, especially due to severe cardiac arrhythmias. It can also impair the cardiovascular effects of renin–angiotensin–aldosterone system inhibitors (RAASis) and potassium rich diets, as hyperkalemia frequently leads to their discontinuation. Recent findings Potassium...
Medicine by Alexandros G. Sfakianakis
09:48
Recent developments in the management of acute and chronic hyponatremia, Purpose of review The aim...
Recent developments in the management of acute and chronic hyponatremia,Purpose of review The aim of the study is to review recent studies on the management of acute and chronic hyponatremia. Recent findings In acute symptomatic hyponatremia, bolus infusion of hypertonic saline improves hyponatremia and neurological status more quickly than continuous infusion. In chronic hyponatremia, newly identified predictors of nonresponse to fluid restriction include a high urine osmolality (>500 mOsm/kg)...
Medicine by Alexandros G. Sfakianakis
09:47
Hyponatremia in patients with cancer, Purpose of review Hyponatremia is seen commonly in patients...
Hyponatremia in patients with cancer,Purpose of review Hyponatremia is seen commonly in patients with cancer and is associated with increased mortality and morbidity. Understanding the proper diagnosis and therapy of cancer-associated hyponatremia is critical to ensure improved outcomes. Recent findings The most common cancers associated with hyponatremia are the various forms of lung cancer with incidences approaching 25–45%. The most common causes of hyponatremia in cancer patients are the syndrome...
Medicine by Alexandros G. Sfakianakis
09:47
Nephrology and Hypertension
Cullin-Ring ubiquitin ligases in kidney health and diseasePurpose of review Members of the Cullin family act as scaffolds in E3 ubiquitin ligases and play a central role in mediating protein degradation. Interactions with many different substrate-binding adaptors permit Cullin-containing E3 ligases to participate in diverse cellular functions. In the kidney, one well established target of Cullin-mediated degradation is the transcription factor Nrf2, a key player in responses to oxidative stress....
Medicine by Alexandros G. Sfakianakis
09:46
The right treatment for the right ventricle, Purpose of review Right ventricular (RV) function is an...
The right treatment for the right ventricle,Purpose of review Right ventricular (RV) function is an important determinant of morbidity and mortality in patients with pulmonary arterial hypertension (PAH). Although substantial progress has been made in understanding the development of RV failure in the last decennia, this has not yet resulted in the development of RV selective therapies. In this review, we will discuss the current status on the treatment of RV failure and potential novel therapeutic...
Medicine by Alexandros G. Sfakianakis
09:45
Noninvasive volume-assured pressure support for chronic respiratory failure: a review Purpose of review...
Noninvasive volume-assured pressure support for chronic respiratory failure: a reviewPurpose of review Noninvasive ventilation (NIV) is an established treatment for chronic hypercapnic respiratory failure (CRF). Volume-assured pressure support (VAPS) is a mode of NIV that automatically adjusts inspiratory pressure in order to maintain a constant respiratory volume. We aim to discuss the role and application of VAPS in CRF. Recent findings Recently published meta-analyses and reviews fail to demonstrate...
Medicine by Alexandros G. Sfakianakis
09:45
Unilateral phrenic nerve stimulation in the therapeutical algorithm of central sleep apnoea in heart...
Unilateral phrenic nerve stimulation in the therapeutical algorithm of central sleep apnoea in heart failurePurpose of review Central sleep apnoea (CSA) is highly prevalent in patients with heart failure and substantially impairs survival. If optimal cardiac treatment fails, alternative therapeutical options, including positive airway pressure (PAP) therapies, drugs or application of oxygen and carbon dioxide are considered to suppress CSA which interfere with the complex underlying pathophysiology....
Medicine by Alexandros G. Sfakianakis
09:45
Myofascial pain syndrome and trigger points: evaluation and treatment in patients with musculoskeletal...
Myofascial pain syndrome and trigger points: evaluation and treatment in patients with musculoskeletal pain,Purpose of review Myofascial pain syndrome is a chronic pain condition characterized by the presence of myofascial trigger point, a hyperirritable painful spot involving a limited number of muscle fibers. The literature suggest that myofascial trigger points should be considered peripheral pain generators and this critical review will summarize recent findings concerning the clinical evaluation...
Medicine by Alexandros G. Sfakianakis
09:44
Supportive and Palliative Care
Myofascial pain syndrome and trigger points: evaluation and treatment in patients with musculoskeletal painPurpose of review Myofascial pain syndrome is a chronic pain condition characterized by the presence of myofascial trigger point, a hyperirritable painful spot involving a limited number of muscle fibers. The literature suggest that myofascial trigger points should be considered peripheral pain generators and this critical review will summarize recent findings concerning the clinical evaluation...
Medicine by Alexandros G. Sfakianakis
09:44
Anaesthesiology
Comparison of a simplified nasal continuous positive airways pressure device with nasal cannula in obese patients undergoing colonoscopy during deep sedation: A randomised clinical trialBACKGROUND Continuous positive airways pressure (CPAP) with a CPAP machine and mask has been shown to be more effective at minimising hypoxaemia than other devices under deep sedation. However, the efficacy of a new and simple CPAP device for spontaneously breathing obese patients during colonoscopy is unknown. OBJECTIVE...
Medicine by Alexandros G. Sfakianakis
09:43
Computer-Assisted Design and Manufacturing Assists Less Experienced Surgeons in Achieving Equivalent...
Computer-Assisted Design and Manufacturing Assists Less Experienced Surgeons in Achieving Equivalent Outcomes in Cranial Vault Reconstruction,Purpose: The purpose of this study was to assess whether long-term outcomes were equivalent between computer-assisted design and manufacturing (CAD/CAM) -assisted cranial vault reconstruction performed by an inexperienced surgeon, with fewer years of surgical experience, and traditional reconstruction performed by senior surgeons with many decades of experience....
Medicine by Alexandros G. Sfakianakis
09:42
Evaluation of Vestibular Bone Thickness in Class I Malocclusion Treatment With Corticotomy-Assisted...
Evaluation of Vestibular Bone Thickness in Class I Malocclusion Treatment With Corticotomy-Assisted Rapid Orthodontics,Background: Corticotomy-assisted rapid orthodontics is a widely used method for speeding up conventional orthodontics. This study evaluates the effects of corticotomy alone, corticotomy combined with bone graft, and corticotomy with platelet-rich fibrin (PRF) on vestibular alveolar bone thickness in patients with class I malocclusion;compares the treatment time with a conventional...
Medicine by Alexandros G. Sfakianakis
09:42
Endoscopic Endonasal Transpterygoid Approach Using Pedicled Nasoseptal Flap for Petrous Apex Cholesterol...
Endoscopic Endonasal Transpterygoid Approach Using Pedicled Nasoseptal Flap for Petrous Apex Cholesterol Granuloma With Intraoperative Video,With the development of minimally invasive endoscopic surgery and image-guided navigation systems, the endoscopic endonasal approach to petrous apex lesions has become more favorable. In this case, a petrous apex cholesterol granuloma was successfully treated with an endoscopic endonasal transpterygoid approach. A navigation system was used, and a contralateral...
Medicine by Alexandros G. Sfakianakis
09:36
Radiologic Evaluation of Exiting Points of Supraorbital Region Neurovascular Bundles in Patients With...
Radiologic Evaluation of Exiting Points of Supraorbital Region Neurovascular Bundles in Patients With Migraine,Purpose: To reveal the presence and nature of exiting points of supraorbital region neurovascular structures and determine the distances of those structures to midline with computed tomography images by taking into account gender and sides in patients with migraine. Methods: The study was conducted retrospectively on computed tomography images of 70 migraine and 70 control patients with...
Medicine by Alexandros G. Sfakianakis
09:36
Pediatric Cervicofacial Actinomycosis: Lessons From a Craniofacial Unit, Actinomycosis is a rare disease...
Pediatric Cervicofacial Actinomycosis: Lessons From a Craniofacial Unit,Actinomycosis is a rare disease that remains difficult to diagnose and manage. Prompted by 2 recent cases the authors sought evidence-based conclusions about best practice. A systematic review was conducted using standard PRISMA methodology. The study was registered prospectively (PROSPERO: CRD42018115064). Thirty-three children from 23 series are described. The mean age was 8 years (range 3–17). Fifty-five percent were female....
Medicine by Alexandros G. Sfakianakis
09:30
Craniofacial Surgery
Endoscopic Endonasal Transpterygoid Approach Using Pedicled Nasoseptal Flap for Petrous Apex Cholesterol Granuloma With Intraoperative VideoWith the development of minimally invasive endoscopic surgery and image-guided navigation systems, the endoscopic endonasal approach to petrous apex lesions has become more favorable. In this case, a petrous apex cholesterol granuloma was successfully treated with an endoscopic endonasal transpterygoid approach. A navigation system was used, and a contralateral...
Medicine by Alexandros G. Sfakianakis
09:30
Tropical Medicine
Pharmacological and analytical aspects of artemisinin for malaria: Advances and challengesSravani Karri, Sanjay Sharma, Ginpreet KaurAsian Pacific Journal of Tropical Medicine 2019 12(8):339-346Malaria remains a major tropical health burden owing to the development of resistance and decreased sensitivity to the frequently used conventional antimalarial drugs. The drug like artemisinin possesses potent antimalarial activities, but has some limitations. Therefore, new strategies are to be implemented...
Medicine by Alexandros G. Sfakianakis
09:29
Olfaction and quality of life in patients with nasal septal deviation treated with septoplasty Author...
Olfaction and quality of life in patients with nasal septal deviation treated with septoplastyAuthor links open overlay ,panel.KonstantinosValsamidisaAthanasiaPrintzaaKonstantinosTitelisbJannisConstantinidisaStefanosTriaridisaa1st Otolaryngology Department, Medical Dept, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreecebOtolaryngology Department, General Hospital Georgios Gennimatas, Ethnikis Amynis 41, 54635 Thessaloniki, GreeceReceived 11 June 2019, Available...
Medicine by Alexandros G. Sfakianakis
09:22
Recent advances in musculoskeletal local drug delivery, Publication date: 15 July 2019 Source: Acta...
Recent advances in musculoskeletal local drug delivery,Publication date: 15 July 2019Source: Acta Biomaterialia, Volume 93Author(s): Shichao Zhang, Malcolm Xing, Bingyun LiAbstractMusculoskeletal disorders are a significant burden on the global economy and public health. Advanced drug delivery plays a key role in the musculoskeletal field and holds the promise of enhancing the repair of degenerated and injured musculoskeletal tissues. Ideally, drug delivery should have the ability to directly deliver...
Medicine by Alexandros G. Sfakianakis
09:21
Porous PolyHIPE microspheres for protein delivery from an injectable bone graft, Publication date:...
Porous PolyHIPE microspheres for protein delivery from an injectable bone graft,Publication date: 15 July 2019Source: Acta Biomaterialia, Volume 93Author(s): Michael Whitely, Gabriel Rodriguez-Rivera, Christina Waldron, Sahar Mohiuddin, Stacy Cereceres, Nicholas Sears, Nicholas Ray, Elizabeth Cosgriff-HernandezAbstractDelivery of osteoinductive factors such as bone morphogenetic protein 2 (BMP-2) has emerged as a prominent strategy to improve regeneration in bone grafting procedures. However, it...
Medicine by Alexandros G. Sfakianakis
09:21
Biodegradable polymerized simvastatin stimulates bone formation, Publication date: 15 July 2019 Source: Acta...
Biodegradable polymerized simvastatin stimulates bone formation,Publication date: 15 July 2019Source: Acta Biomaterialia, Volume 93Author(s): Nandakumar Venkatesan, A.D. Thilanga Liyanage, Jaime Castro-Núñez, Theodora Asafo-Adjei, Larry L. Cunningham, Thomas D. Dziubla, David A. PuleoAbstractPrevious research from our labs demonstrated the synthesis of polymerized simvastatin by ring-opening polymerization and slow degradation with controlled release of simvastatin in vitro. The objective of the...
Medicine by Alexandros G. Sfakianakis
09:20
A computational study of the dual effect of intermittent and continuous administration of parathyroid...
A computational study of the dual effect of intermittent and continuous administration of parathyroid hormone on bone remodeling,Publication date: 15 July 2019Source: Acta Biomaterialia, Volume 93Author(s): Yu Zhao, Guigen ZhangAbstractBone remodeling is a process known to be governed by constant interactions between osteoblast and osteoclast through complex pathway networks mediated by signaling factors. Experimental studies show that intermittent and continuous administration of PTH/PTHrP led to...
Medicine by Alexandros G. Sfakianakis
09:20
Acta Biomaterialia
Editorial BoardPublication date: 15 July 2019Source: Acta Biomaterialia, Volume 93Author(s):Endothelin-1 inhibits size dependent lymphatic clearance of PEG-based conjugates after intra-articular injection into the rat kneePublication date: 15 July 2019Source: Acta Biomaterialia, Volume 93Author(s): Thanh N. Doan, Fabrice C. Bernard, Jay M. McKinney, J. Brandon Dixon, Nick J. WillettAbstractClearance of particles from the knee is an essential mechanism to maintain healthy joint homeostasis and critical...
Medicine by Alexandros G. Sfakianakis
09:19
The Prognostic Usefulness of The Lactate/Albumin Ratio For Predicting Clinical Outcomes In Out-Of-Hospital...
The Prognostic Usefulness of The Lactate/Albumin Ratio For Predicting Clinical Outcomes In Out-Of-Hospital Cardiac Arrest: A Prospective, Multicentre Observational Study (KoCARC Study)Background and Purpose: We aimed to evaluate the lactate/albumin ratio (LAR) to identify its significance as a prognostic marker for favourable neurologic outcome and survival in patients with return of spontaneous circulation after out-of-hospital cardiac arrest (OHCA). Based on the LAR and multiple parameters, we...
Medicine by Alexandros G. Sfakianakis
09:18
Influence of Hyperglycemia During Different Phases of Ischemic Preconditioning on Cardioprotection—A...
Influence of Hyperglycemia During Different Phases of Ischemic Preconditioning on Cardioprotection—A Focus On Apoptosis and Aggregation of Granulocytes,Background: Ischemic preconditioning (IPC) protects the myocardium against ischemia/reperfusion injury. Evidence suggests that hyperglycemia inhibits IPC-induced cardioprotection. The effects of hyperglycemia initiated during different phases of IPC on myocardial injury were characterized with emphasis on apoptosis and aggregation of polymorphonuclear...
Medicine by Alexandros G. Sfakianakis
09:18
Right ventricular function and long-term outcome in sepsis: a retrospective cohort study, Background:...
Right ventricular function and long-term outcome in sepsis: a retrospective cohort study,Background: Sepsis-related myocardial dysfunction is associated with impaired outcome. Traditionally, in this setting the main focus has been on left ventricular performance. Currently, specific knowledge on the prognostic importance of right ventricular dysfunction is scarce. The aim of this study was to determine whether right ventricular ejection fraction (RVEF) is predictive of long-term mortality in sepsis....
Medicine by Alexandros G. Sfakianakis
09:17
Shock
Lactic Acidosis and The Role of Sodium Bicarbonate: A Narrative OpinionLactic acidosis occurs commonly and can be a marker of significant physiologic derangements. However what an elevated lactate level and acidemia connotes and what should be done about it is subject to inconsistent interpretations. This review examines the varied etiologies of lactic acidosis, the physiologic consequences, and the known effects of its treatment with sodium bicarbonate. Lactic acidosis is often assumed to be a marker...
Medicine by Alexandros G. Sfakianakis
09:16
Investigational New Drugs
Correction to: A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl- XLhttps://doi.org/10.1016/j.juro.2010.07.035Correction to: Phase Ib/II study of gemcitabine, nab-paclitaxel, and pembrolizumab in metastatic pancreatic adenocarcinomaThe authors would like to note an error in Figures 1 and 2 of this paper. The graph in Figure 1 incorrectly reflected the overall survival (OS), when it should have displayed the...
Medicine by Alexandros G. Sfakianakis
09:15
"Stuck on sugars – how carbohydrates regulate cell adhesion, recognition, and signaling" Abstract We...
"Stuck on sugars – how carbohydrates regulate cell adhesion, recognition, and signaling"AbstractWe have explored the fundamental biological processes by which complex carbohydrates expressed on cellular glycoproteins and glycolipids and in secretions of cells promote cell adhesion and signaling. We have also explored processes by which animal pathogens, such as viruses, bacteria, and parasites adhere to glycans of animal cells and initiate disease. Glycans important in cell signaling and adhesion,...
Medicine by Alexandros G. Sfakianakis
09:14
Gangliosides profiling in serum of breast cancer patient: GM3 as a potential diagnostic biomarker Abstract...
Gangliosides profiling in serum of breast cancer patient: GM3 as a potential diagnostic biomarkerAbstractGangliosides altered during the pathological conditions and particularly in cancers. Here, we aimed to profile the gangliosides in breast cancer serum and propose potential biomarkers. LC-FTMS method was first used to identify all the ganglioside species in serum, then LC-MS/MS-MRM method was employed to quantitate the levels of gangliosides in serum from healthy volunteers and patients with benign...
Medicine by Alexandros G. Sfakianakis
09:13
Fluorine-modified sialyl-Tn-CRM197 vaccine elicits a robust immune response, Abstract Even though a...
Fluorine-modified sialyl-Tn-CRM197 vaccine elicits a robust immune response,AbstractEven though a vaccine that targets tumor-associated carbohydrate antigens on epithelial carcinoma cells presents an attractive therapeutic approach, relatively poor immunogenicity limits its development. In this study, we investigated the immunological activity of a fluoro-substituted Sialyl-Tn (F-STn) analogue coupled to the non-toxic cross-reactive material of diphtheria toxin197 (CRM197). Our results indicate that...
Medicine by Alexandros G. Sfakianakis
09:13
Glycoconjugate Journal
The international Glycoconjugate organization awardsThe International Glycoconjugate Organization AwardsGlyco25, XXV International Symposium on Glycoconjugates"Stuck on sugars – how carbohydrates regulate cell adhesion, recognition, and signaling"AbstractWe have explored the fundamental biological processes by which complex carbohydrates expressed on cellular glycoproteins and glycolipids and in secretions of cells promote cell adhesion and signaling. We have also explored processes by which animal...
Medicine by Alexandros G. Sfakianakis
09:12
Mepilex Border Sacrum and Heel Dressings for the Prevention of Pressure Ulcers: A NICE Medical Technology...
Mepilex Border Sacrum and Heel Dressings for the Prevention of Pressure Ulcers: A NICE Medical Technology Guidance,AbstractMepilex Border Sacrum and Heel dressings are self-adherent, multilayer foam dressings designed for use on the heel and sacrum aiming to prevent pressure ulcers. The dressings are used in addition to standard care protocols for pressure ulcer prevention. The National Institute for Health and Care Excellence (NICE) selected Mepilex Border Sacrum and Heel dressings for evaluation....
Medicine by Alexandros G. Sfakianakis
09:08
Applied Health Economics and Health Policy
Authors' Reply to Hussain et al.: "Cost Effectiveness of Dialysis Modalities: A Systematic Review of Economic Evaluations"Comment on: "Cost Effectiveness of Dialysis Modalities: A Systematic Review of Economic Evaluations"Applying an Implementation Framework to the Use of Evidence from Economic Evaluations in Making Healthcare DecisionsAbstractBackground and ObjectiveThere is a need for the application of theory in understanding the use of evidence from economic evaluations in healthcare decision...
Medicine by Alexandros G. Sfakianakis
09:07
Orthopaedic and Trauma Surgery
Investigation of thermally induced damage to surrounding nerve tissue when using curettage and cementation of long bone tumours, modelled in cadaveric porcine femursAbstractIntroductionCurettage with cement augmentation is a technique used in the treatment of bone tumours. Thermal energy released during the cement polymerisation process can damage surrounding tissues. This study aims to record temperature changes at various sites on and around bone during the cementing process. We hypothesised that...
Medicine by Alexandros G. Sfakianakis
09:06
Urolithiasis
Role of 'dusting and pop-dusting' using a high-powered (100 W) laser machine in the treatment of large stones (≥ 15 mm): prospective outcomes over 16 monthsAbstractUreteroscopy and laser stone fragmentation (URSL) has had recent advancements with the more powerful laser systems with the ability to 'dust' and 'pop-dust' the stone. We wanted to look at the outcomes of this method for large stones (≥ 15 mm) using our new 100 W holmium laser. Over a period of 16 months (January 2017–April 2018), 50 patients...
Medicine by Alexandros G. Sfakianakis
09:05
Is oxidized low-density lipoprotein the connection between atherosclerosis, cardiovascular risk and...
Is oxidized low-density lipoprotein the connection between atherosclerosis, cardiovascular risk and nephrolithiasis?AbstractNephrolithiasis is considered a systemic disease. A link has been established between nephrolithiasis, cardiovascular disease (CVD), the metabolic syndrome and atherosclerosis. A significant correlation has been found between the high levels of oxidized low-density lipoprotein (oxLDL) and CVD and atherosclerosis, including coronary and femoral artery disease. To the best of...
Medicine by Alexandros G. Sfakianakis
09:05
Slavery, Indenture and the Development of British Industrial Capitalism,  Mark Harvey
Slavery, Indenture and the Development of British Industrial Capitalism,  Mark Harvey
Medicine by Alexandros G. Sfakianakis
09:04
Survival outcomes of eye-sparing surgery for adenoid cystic carcinoma of lacrimal gland, AbstractPurpose...
Survival outcomes of eye-sparing surgery for adenoid cystic carcinoma of lacrimal gland,AbstractPurposeTo survey adenoid cystic carcinoma of lacrimal glands in Asian population and investigate the predictability in prognosis following the 8th edition American Joint Committee on Cancer (AJCC) staging guideline.Study designRetrospective study.MethodsThe clinical entities and surgical outcomes of the patients who were histologically confirmed with a diagnosis of lacrimal adenoid cystic carcinoma in...
Medicine by Alexandros G. Sfakianakis
09:04
Robot-assisted stereotactic brainstem biopsy in children: prospective cohort study Abstract Tumours...
Robot-assisted stereotactic brainstem biopsy in children: prospective cohort studyAbstractTumours located within the brainstem comprise approximately a tenth of all paediatric brain tumours. Surgical biopsy of these tumours is technically challenging and has historically been associated with considerable risk. To this end, robot-assisted surgery theoretically allows for increased accuracy and precision. In this study we report our experience using the Neuromate robot (Renishaw, Gloucestershire, UK)...
Medicine by Alexandros G. Sfakianakis
09:01
Categories We Live by
: The Construction of Sex, Gender, Race, and Other Social Categories, by Ásta  Elizabeth Barnes; Matthew Andler
Medicine by Alexandros G. Sfakianakis
09:01
Techniques for developing and viewing stereoscopic three-dimensional teaching videos for transoral...
Techniques for developing and viewing stereoscopic three-dimensional teaching videos for transoral robotic surgery (TORS)AbstractAdvances in three-dimensional (3D) video recording and playback have expanded the availability of stereoscopic videos for consumption with specialized televisions, computer monitors, and virtual reality (VR) headsets. The built-in stereoscopic vision of the da vinci surgical system (Intuitive Surgical, Sunnyvale, CA) enables the recording of both camera views. However,...
Medicine by Alexandros G. Sfakianakis
09:00
Robotic harvesting of the omental flap: a case report and mini-review of the use of robots in reconstructive...
Robotic harvesting of the omental flap: a case report and mini-review of the use of robots in reconstructive surgeryAbstractThis study describes the robotic harvesting of a free omental flap. The patient was a 58-year-old man who had undergone several previous operations due to osteomyelitis caused by trauma. There was a non-healing wound and purulent discharge in the distal pretibial region. The flap was harvested based on the right gastroepiploic artery using robotic facilities only. The flap was...
Medicine by Alexandros G. Sfakianakis
09:00
Robotic Surgery
Should we use virtual simulators for surgical resident selection?New perspectives about the role of robot-assisted surgery for the treatment of endometriosisRobot assisted intra-corporeal ileocalicostomy ureteral substitution for complex uretero-pelvic junction obstruction: a novel and feasible innovationAbstractA 33-year-old female presented to the emergency department of our hospital with urosepsis and hematuria with clot retention secondary to a complicated pyelolithotomy for left-sided pelvic...
Medicine by Alexandros G. Sfakianakis
09:00
Kavita Sivaramakrishnan, As the World Ages: Rethinking a Demographic Crisis,  Hyung Wook Park  Michelle...
Kavita Sivaramakrishnan, As the World Ages: Rethinking a Demographic Crisis,  Hyung Wook Park  Michelle L. McClellan, Lady Lushes: Gender, Alcoholism, and Medicine in Modern America  Stephen E Mawdsley  Dóra Vargha, Polio Across the Iron Curtain: Hungary's Cold War with an Epidemic  Stephen E Mawdsley
Medicine by Alexandros G. Sfakianakis
08:59
Feminisms   Anna Watz
Feminisms   Anna Watz
Medicine by Alexandros G. Sfakianakis
08:58
Beer? Over here!
Examining attentional bias towards alcoholic and appetitive stimuli in a visual search eye-tracking taskAbstractRationaleExperimental tasks that demonstrate alcohol-related attentional bias typically expose participants to single-stimulus targets (e.g. addiction Stroop, visual probe, anti-saccade task), which may not correspond fully with real-world contexts where alcoholic and non-alcoholic cues simultaneously compete for attention. Moreover, alcoholic stimuli are rarely matched to other appetitive non-alcoholic...
Medicine by Alexandros G. Sfakianakis
08:58
Psychopharmacology
Effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on ethanol consumption and place conditioning in male miceAbstractRationaleApproximately 20 million adults in the USA have an alcohol use disorder (AUD). There are clinical and preclinical data suggesting that psychedelics may have benefits for AUD.ObjectiveTo investigate the effects of the synthetic psychedelic 2,5-dimethoxy-4-iodoamphetamine (DOI) on the behavioral effects of ethanol.MethodsThe effects of DOI were examined...
Medicine by Alexandros G. Sfakianakis
08:58
Macromolecular Research
Effect of the Monomer Ratio on the Properties of Melt-Polymerized PolycarbonateAbstractIn this study, the effects of bisphenol A (BPA) and diphenyl carbonate (DPC) molar ratio, on the properties of melt-polymerized polycarbonate (PC) were investigated. The molecular size distribution theory proposed by Flory was applied, to melt polymerization of PC to predict physical properties, affected by the molar ratio of BPA and DPC. A terminal OH group affected the viscosity of PC at high temperatures, leading...
Medicine by Alexandros G. Sfakianakis
08:57
Effectiveness of Facebook Groups to Boost Participation in a Parenting Intervention, Abstract Although...
Effectiveness of Facebook Groups to Boost Participation in a Parenting Intervention,AbstractAlthough family-based prevention programs have been shown to be effective at reducing adolescent substance use, it is often difficult and costly to recruit and retain parents in programs administered in person. The current study tested whether program engagement and parenting practices could be improved by offering parents in a self-directed family program access to a private Facebook group. Parents of middle...
Medicine by Alexandros G. Sfakianakis
08:56
Prevention Science
Correction to: A Cost Analysis of School-Based Lifestyle InterventionsIn the article, 'A Cost Analysis of School-Based Lifestyle Interventions', we calculated the societal costs of two school-based lifestyle interventions: 'the Healthy Primary School of the Future' and 'the Physical Activity School'.Effectiveness of Facebook Groups to Boost Participation in a Parenting InterventionAbstractAlthough family-based prevention programs have been shown to be effective at reducing adolescent substance use,...
Medicine by Alexandros G. Sfakianakis
08:56
Protein & Cell
Correction to: Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrityIn the original publication, the label of Fig. 2C should be read as "GFAP/lectin/DAPI" not "DMP1/GFAP/lectin/DAPI".Professor Tafu Yu: an eminent agricultural scientist and outstanding educator of our nationDeveloping potent PROTACs tools for selective degradation of HDAC6 proteinA miRNA-HERC4 pathway promotes breast tumorigenesis by inactivating tumor suppressor LATS1AbstractsThe...
Medicine by Alexandros G. Sfakianakis
08:55
Low-frequency ventilatory oscillations in hypoxia are a major contributor to the low-frequency component...
Low-frequency ventilatory oscillations in hypoxia are a major contributor to the low-frequency component of heart rate variabilityAbstractPurposeHeart rate variability (HRV) may be influenced by several factors, such as environment (hypoxia, hyperoxia, hypercapnia) or physiological demand (exercise). In this retrospective study, we tested the hypothesis that inter-beat (RR) intervals in healthy subjects exercising under various environmental stresses exhibit oscillations at the same frequency than...
Medicine by Alexandros G. Sfakianakis
08:54
Vibration as an adjunct to exercise: its impact on shoulder muscle activation, AbstractPurpose There...
Vibration as an adjunct to exercise: its impact on shoulder muscle activation,AbstractPurposeThere is an interest within elite sport in understanding the impact of a vibrating platform as an adjunct to exercise in the training and rehabilitation of throwing athletes. However, there has been no comprehensive evaluation of its impact on the rotator cuff muscles or its effect on the timing of shoulder muscle recruitment more globally.MethodsTwenty healthy participants were recruited with EMG recorded...
Medicine by Alexandros G. Sfakianakis
08:53
Leg- vs arm-cycling repeated sprints with blood flow restriction and systemic hypoxia AbstractPurpose...
Leg- vs arm-cycling repeated sprints with blood flow restriction and systemic hypoxiaAbstractPurposeThe aim was to compare changes in peripheral and cerebral oxygenation, as well as metabolic and performance responses during conditions of blood flow restriction (BFR, bilateral vascular occlusion at 0% vs. 45% of resting pulse elimination pressure) and systemic hypoxia (~ 400 m, FIO2 20.9% vs. ~ 3800 m normobaric hypoxia, FIO2 13.1 ± 0.1%) during repeated sprint tests to exhaustion (RST) between leg-...
Medicine by Alexandros G. Sfakianakis
08:52
Bone mineral density, energy availability, and dietary restraint in collegiate cross-country runners...
Bone mineral density, energy availability, and dietary restraint in collegiate cross-country runners and non-running controlsAbstractPurposeWeight-bearing activities such as running have been shown to be osteogenic. However, investigations have also shown that running may lead to site-specific deficiencies in bone mineral density (BMD) as well as overall low BMD. The purpose of this investigation was to evaluate and compare the BMD of female and male collegiate cross-country runners with non-running...
Medicine by Alexandros G. Sfakianakis
08:52
Cold-water immersion blunts and delays increases in circulating testosterone and cytokines post-resistance...
Cold-water immersion blunts and delays increases in circulating testosterone and cytokines post-resistance exerciseAbstractIntroductionCold-water immersion (CWI) is often used to promote recovery by reducing exercise-induced muscle damage, soreness, and inflammation. However, recent reports have cautioned that CWI may attenuate the adaptive response to resistance training.PurposeTo determine the effect of post resistance-exercise CWI on circulating free testosterone (T) and cytokine (IL-6 and TNF-α)...
Medicine by Alexandros G. Sfakianakis
08:52
Applied Physiology
Effect of external compression on femoral retrograde shear and microvascular oxygenation in exercise trained and recreationally active young menAbstractIntroductionRetrograde shear causes endothelial damage and is pro-atherogenic. The purpose of our study was to examine the impact of vascular remodeling from habitual exercise training on acute changes in retrograde shear and microvascular oxygenation (SMO2) induced via 30 min of external compression.MethodsParticipants included 11 exercise trained...
Medicine by Alexandros G. Sfakianakis
08:51
Business and Psychology
Enacting Effective Mentoring Behaviors: Development and Initial Investigation of the Cuboid of MentoringAbstractOur understanding of how to maximize the benefits of mentoring relationships for employee development has been limited by a vague understanding of what effective mentors are actually doing and how they are doing it. To begin to remedy this, we conducted one qualitative interview study of well-respected mentors to uncover the breadth and detail of their behaviors, and one quantitative study...
Medicine by Alexandros G. Sfakianakis
08:50
Molecular Breeding
Correction to: Genetic analysis and gene mapping of the orange flower trait in Chinese cabbage ( Brassica rapa L.)The original article unfortunately contains an incorrect supplementary materials.QTL mapping in Vigna radiata × Vigna umbellata population uncovers major genomic regions associated with bruchid resistanceAbstractMungbean (Vigna radiata), genus Vigna, is an economically important legume crop that is valued for its protein-rich dry seeds. However, bruchid infestation causes severe threat...
Medicine by Alexandros G. Sfakianakis
08:49
Method for Visible Light‐Induced Photocatalytic Degradation of Methylparaben in Water Using Nanostructured...
Method for Visible Light‐Induced Photocatalytic Degradation of Methylparaben in Water Using Nanostructured Ag/AgBr@m‐WO3,Mohammed A. Suliman, Mohammed A. Gondal, Mohamed A. Dastageer, Gaik‐Khuan Chuah, Chanbasha BasheerVersion of Record online: 10 July 2019Ag nanoparticles loaded AgBr‐mesoporous‐WO3 composite was synthesized, characterized and used as a photocatalyst in conjunction with visible light radiation for the photocatalytic degradation of methylparaben in water. This nanocomposites showed...
Medicine by Alexandros G. Sfakianakis
08:48
Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea ClimatotherapyMichael...
Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea ClimatotherapyMichael Brandwein, Garold Fuks, Avigail Israel, Fareed Sabbah, Emmilia Hodak, Amir Szitenberg, Marco Harari, Droron Steinberg, Zvi Bentwich, Noam Shental, Shiri MeshnerVersion of Record online: 10 July 2019 Microbiome dysbiosis is a hallmark of atopic dermatitis and has been shown to be change following several different treatment modalities. Dead Sea climatotherapy is a well‐established therapeutic modality...
Medicine by Alexandros G. Sfakianakis
08:47
Medical Applications of Rose Bengal‐ and Riboflavin‐Photosensitized Protein CrosslinkingRobert W. Redmond, Irene...
Medical Applications of Rose Bengal‐ and Riboflavin‐Photosensitized Protein CrosslinkingRobert W. Redmond, Irene E. KochevarVersion of Record online: 10 July 2019 Research on the many potential surgical applications of photosensitized crosslinking of tissue proteins and on the underlying photochemical mechanisms is reviewed. Largely used to close wounds or reattach tissues, protein photocrosslinking stiffens and strengthens tissues, decreases inflammatory responses and facilitates tissue bioengineering....
Medicine by Alexandros G. Sfakianakis
08:46
Melatonin Receptor Mel1b‐ and Mel1c‐mediated Green Light Induced the Secretion of Growth Hormone in...
Melatonin Receptor Mel1b‐ and Mel1c‐mediated Green Light Induced the Secretion of Growth Hormone in Anterior Pituitary of ChicksLiang Yue, Xiaojing Qin, Xinfeng Liu, Zixu Wang, Yulan Dong, Yaoxing Chen, Jing CaoVersion of Record online: 13 July 2019 Monochromatic green light promotes the secretion of plasma melatonin. Melatonin influences the expression of Pit‐1 and the secretion of growth hormone in the adenohypophysis cells through melatonin receptor Mel1b and Mel1c.
Medicine by Alexandros G. Sfakianakis
08:46
Recurrent Xanthelasmas Treated With Intralesional Deoxycholic Acid , Patel, Jigar MD; Ranjit-Reeves, Roshni MD; Woodward, Julie MD Dermatologic Surgery: March 18, 2019 - Volume Publish Ahead of Print - Issue - p doi: 10.1097/DSS.0000000000001936
Medicine by Alexandros G. Sfakianakis
08:29
Intralesional Deoxycholic Acid as a Neoadjuvant Treatment for a Large Lipoma
Intralesional Deoxycholic Acid as a Neoadjuvant Treatment for a Large Lipoma
Medicine by Alexandros G. Sfakianakis
08:28
Introducing the L-Lift—A Novel Approach to Treat Age-Related Facial Skin Ptosis Using A Collagen Stimulator Hexsel, Doris MD; Hexsel, Camile L. MD; Cotofana, Sebastian MD, PhD Dermatologic Surgery: July 09, 2019 - Volume Publish Ahead of Print - Issue - p doi: 10.1097/DSS.0000000000002015
Medicine by Alexandros G. Sfakianakis
08:25
Cutaneous Leiomyosarcoma: A SEER Database Analysis, BACKGROUND Cutaneous leiomyosarcoma is a rare...
Cutaneous Leiomyosarcoma: A SEER Database Analysis,BACKGROUND Cutaneous leiomyosarcoma is a rare dermal neoplasm usually arising from the pilar smooth muscle. It is considered a relatively indolent neoplasm, and there is debate whether designation as sarcoma is appropriate. Owing to some conflicting data in the literature, however, its behavior warrants further clarification. OBJECTIVE To determine the clinical behavior and demographic and pathologic characteristics of cutaneous leiomyosarcoma. MATERIALS...
Medicine by Alexandros G. Sfakianakis
08:24
Safety of Subcutaneous Infiltration of Carbon Dioxide (Carboxytherapy) for Abdominal Fat Reduction:...
Safety of Subcutaneous Infiltration of Carbon Dioxide (Carboxytherapy) for Abdominal Fat Reduction: A Pilot Study,
Medicine by Alexandros G. Sfakianakis
08:23
Internal Jugular Vein Thrombosis, Yi Lee; Waqas J. Siddiqui.Author Information AuthorsYi Lee1; Waqas...
Internal Jugular Vein Thrombosis,Yi Lee; Waqas J. Siddiqui.Author InformationAuthorsYi Lee1; Waqas J. Siddiqui2.Affiliations1 Chung Shan Medical University2 Drexel UniversityLast Update: April 29, 2019.Go to:IntroductionThe internal jugular vein (IJV) originates at the jugular foramen, tracks down to the lateral neck and ends at the brachiocephalic vein. The IJV is one of the four components of the carotid sheath, along with the common carotid artery, internal carotid artery, the vagus nerve, and...
Medicine by Alexandros G. Sfakianakis
08:22
Aesthetic Outcomes of Nasal Burow's Grafts With Interdomal Sutures After Mohs Micrographic Surgery BACKGROUND...
Aesthetic Outcomes of Nasal Burow's Grafts With Interdomal Sutures After Mohs Micrographic SurgeryBACKGROUND Post-Mohs reconstruction of distal nasal defects is challenging. Many repair options exist, each with advantages and disadvantages. Utilization of a Burow's graft in combination with manipulation of the underlying nasal cartilages with interdomal sutures is an underreported yet effective repair option. OBJECTIVE To present the authors' experience with Burow's grafts facilitated by interdomal...
Medicine by Alexandros G. Sfakianakis
08:22
Primary Cutaneous Umbilical Melanoma: The Michigan Experience BACKGROUND Primary cutaneous umbilical...
Primary Cutaneous Umbilical Melanoma: The Michigan ExperienceBACKGROUND Primary cutaneous umbilical melanoma is rare. Thorough information regarding its characteristics and treatment, including use of sentinel lymph node biopsy (SLNB) staging, is difficult to obtain. The unique anatomy of the umbilicus adds to the complexity of diagnosing and treating melanoma at this site. OBJECTIVE To improve understanding of diagnosis and treatment of primary cutaneous umbilical melanoma through presenting 7 new...
Medicine by Alexandros G. Sfakianakis
08:22
Surgical treatments for a case of superior canal dehiscence syndrome associated with patulous Eustachian...
Surgical treatments for a case of superior canal dehiscence syndrome associated with patulous Eustachian tube,Publication date: August 2019Source: Auris Nasus Larynx, Volume 46, Issue 4Author(s): Ryoukichi Ikeda, Hiromitsu Miyazaki, Masahiro Morita, Daisuke Yamauchi, Tetsuaki Kawase, Yukio Katori, Toshimitsu KobayashiAbstractObjectivesThe patulous Eustachian tube (PET) and superior semicircular canal dehiscence syndrome (SCDS) have similarity in their symptoms and similar effects caused by positional...
Medicine by Alexandros G. Sfakianakis
08:15
The New England Journal of Medicine
IMAGES IN CLINICAL MEDICINEJUL 11, 2019"Double Tongue" Appearance in Ludwig's AnginaMohamad I. and Narayanan M.S.|N Engl J Med 2019; 381:163IMAGES IN CLINICAL MEDICINEJUL 11, 2019Whooping Cough in a Young InfantHillier D.|N Engl J Med 2019; 381:e4IMAGES IN CLINICAL MEDICINEJUL 04, 2019Enterobius vermicularis (Pinworm) InfectionKang W.-H. and Jee S.-C.|N Engl J Med 2019; 381:e1IMAGES IN CLINICAL MEDICINEJUL 04, 2019Pneumoperitoneum from a Gastric PerforationMasson A. and Cheron G.|N Engl J Med 2019;...
Medicine by Alexandros G. Sfakianakis
08:12
The New England Journal of Medicine
PERSPECTIVEPrimary Care First — Is It a Step Back?L.L. Sessums, S. Basu, and B.E. LandonDOI: 10.1056/NEJMp1906593 | July 17, 2019Case Studies in Social Medicine: The Right and Left Hands of the State — Two Patients at Risk of DeportationA. Berlin, V. Koski-Karell, K.R. Page, and S. PolkN Engl J Med 2019;381:197-201Sodium-Intake Reduction and the Food IndustryJ.E. Henney, J.A. O'Hara III, and C.L. TaylorN Engl J Med 2019;381:201-203 | Published Online May 29, 2019A "Never Event" That Could Kill MillionsM....
Medicine by Alexandros G. Sfakianakis
08:09
IMAGES IN CLINICAL MEDICINE,  Mucosal Neuromas, Andrew R. Scott, M.D., and Rebecca A. Compton, M.D....
IMAGES IN CLINICAL MEDICINE,  Mucosal Neuromas, Andrew R. Scott, M.D., and Rebecca A. Compton, M.D. A 7-year-old boy presented to the pediatric otolaryngology clinic with a 3-year history of multiple firm, painless, slow-growing nodules on his tongue. He had a history of mild developmental delay, and a physical examination showed a high arched palate and marfanoid habitus. Excisional biopsies of the lesions on the tongue revealed mucosal neuromas. Multiple endocrine neoplasia type 2B was suspected....
Medicine by Alexandros G. Sfakianakis
08:08
Teaching Topic, A Woman with Weakness, Dark Urine, and Dysphagia, CASE RECORDS OF THE MASSACHUSETTS...
Teaching Topic,A Woman with Weakness, Dark Urine, and Dysphagia,CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITALCase 22-2019: A 65-Year-Old Woman with Weakness, Dark Urine, and DysphagiaM.W. Freeman and Others  Although rhabdomyolysis is relatively easy to diagnose, the underlying cause of the muscle breakdown is less straightforward to identify.Clinical Pearls  What are the major causes of rhabdomyolysis in the United States?Most cases of rhabdomyolysis in the United States are caused by trauma...
Medicine by Alexandros G. Sfakianakis
08:06
Drug-Induced Liver Injury — Types and Phenotypes, J.H. Hoofnagle and E.S. Björnsson    The diagnosis...
Drug-Induced Liver Injury — Types and Phenotypes,J.H. Hoofnagle and E.S. Björnsson  The diagnosis of drug-induced liver injury is particularly challenging, since it is based largely on exclusion of other causes. Drug-induced liver injury is the most frequent cause of acute liver failure in most Western countries, accounting for more than half of cases.Clinical Pearls  Do new drugs account for most of the top 10 causes of drug-induced liver injury?A striking finding is that 9 of the top 10 causes...
Medicine by Alexandros G. Sfakianakis
08:05
The Back Letter
Current IssuePrevious Articles & IssuesAbout the JournalSearch JournalTrusted Websites Denying Patients and the General Public Accurate Information About Back Pain TreatmentsObesity, Pain, and the Opioid CrisisSenseless Obstacles to a Lifesaving Opioid Addiction MedicationPutting a Price Tag on Physician Burnout—A Major Hazard for Back Care ProfessionsDramatic Reduction in Postoperative Opioid Use With a Novel Pain Management ProgramFemale Spine Surgeons Need More Help at Home Lest They Risk...
Medicine by Alexandros G. Sfakianakis
08:04
Comparison of CT and MRI in Diagnosis of Laryngeal Carcinoma with Anterior Vocal Commissure Involvement ...
Comparison of CT and MRI in Diagnosis of Laryngeal Carcinoma with Anterior Vocal Commissure Involvement   ,Sci Rep. 2016; 6: 30353.Published online 2016 Aug 2. doi: 10.1038/srep30353PMCID: PMC4969597PMID: 27480073,Jian-hui Wu,1,2 Jing Zhao,1,* Zeng-hong Li,3 Wei-qiang Yang,4 Qi-hong Liu,5 Zhi-yun Yang,6 Bing Liao,7Xiao-ling Li,8 Bin Wang,1 Hao Qin,3 Jie Luo,1 Ke-xing Lv,1,* Wei-ping Wen,a,1 and Wen-bin Leib,1Author information Article notes Copyright and License information Disclaimer1Otorhinolaryngology...
Medicine by Alexandros G. Sfakianakis
08:02
Dermatology Nurses Association
Friendship in Dermatology Nurses, Personal Growth, and LeadershipNo abstract availableDermatology Nurse Practitioner Practice AnalysisNo abstract availableSkin Cancer Knowledge and Prevention Practices Among Young Adult AthletesThe Skin Cancer Foundation defines skin cancer as uncontrolled growth of abnormal skin cells (The Skin Cancer Foundation, 2016b). Skin cancer risk factors include ultraviolet radiation and sun exposure (American Cancer Society, 2016b). Young adult outdoor athletes are frequently...
Medicine by Alexandros G. Sfakianakis
07:55
Regional or General Anesthesia in the Surgical Treatment of Distal Radial Fractures: A Randomized Clinical...
Regional or General Anesthesia in the Surgical Treatment of Distal Radial Fractures: A Randomized Clinical Trial,Background: Most patients undergoing surgery for the treatment of a distal radial fracture are treated in a day-surgery setting and are given either general anesthesia (GA) or regional anesthesia (RA). The main purpose of this study was to investigate the impact of the anesthesia method on patients' postoperative opioid consumption during the first 3 days following surgery. Methods: This...
Medicine by Alexandros G. Sfakianakis
07:53
Geriatric Physical Therapy
Editor's Message: Journal Format Changes, Journal Status, and Reviewer Appreciation 2019No abstract availableAcademy of Geriatric Physical Therapy Inaugural Carole B. Lewis Lecture Award Address to the Membership at the Combined Sections Meeting Washington, DC January 24, 2019No abstract availableRisk Factors and Number of Falls as Determinants of Quality of Life of Community-Dwelling Older AdultsBackground and Purpose: In older adults, the psychological impact and effects related to the loss of...
Medicine by Alexandros G. Sfakianakis
07:52
Use of Povidone-Iodine Irrigation Prior to Wound Closure in Primary Total Hip and Knee Arthroplasty:...
Use of Povidone-Iodine Irrigation Prior to Wound Closure in Primary Total Hip and Knee Arthroplasty: An Analysis of 11,738 CasesBackground: Povidone-iodine (PI) irrigation is often used prior to wound closure in total joint arthroplasty, but there are limited reports evaluating its efficacy in decreasing joint infections. The goal of this study was to compare the rate of any reoperation for infection (both superficial and deep) in primary total hip arthroplasty (THA) and primary total knee arthroplasty...
Medicine by Alexandros G. Sfakianakis
07:52
Intraluminal Pulmonary Vein Stenosis in Children: A "New" Lesion, Pulmonary vein stenosis (PVS) is...
Intraluminal Pulmonary Vein Stenosis in Children: A "New" Lesion,Pulmonary vein stenosis (PVS) is a rare disorder that leads to progressive narrowing of the extrapulmonary veins. PVS has been reported in both children and adults and in its worse iteration leads to pulmonary hypertension, right ventricular failure, and death. Multiple etiologies of PVS have been described in children and adults. This review will focus on intraluminal PVS in children. Intraluminal PVS has an estimated incidence ranging...
Medicine by Alexandros G. Sfakianakis
07:50
Anesthesia & Analgesia
In Search of Solutions for Chronic Pain: A Meta-analysis of Ketamine InfusionsNo abstract availableHow Low Can You Go: Mechanical Ventilation Over TimeNo abstract availableClear Study Aims and Hypotheses in a Research PaperNo abstract availablePigs and Paradigms: Stop Using Swine to Study Lipid ResuscitationNo abstract availableErector Spinae Block: A Magic Bullet for Postoperative Analgesia?No abstract availableOlder Adult With Cognitive Impairment Undergoing Ambulatory Surgery: New Epidemiological...
Medicine by Alexandros G. Sfakianakis
07:49
Ameloblastic fibroma mimicking dentigerous cyst: A diagnostic dilemma Kiran C Khande1, Husain J Mograwala2, Rajshekhar...
Ameloblastic fibroma mimicking dentigerous cyst: A diagnostic dilemmaKiran C Khande1, Husain J Mograwala2, Rajshekhar C Halli2, Manjula A Hebbale31 Department of Oral and Maxillofacial Surgery, Shri Saibaba Hospital, Shirdi, Maharashtra, India2 Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India3 Department of Oral Medicine and Radiology, Bharati Vidyapeeth Dental College and Hospital, Pune, Maharashtra, India  Abstract Ameloblastic...
Medicine by Alexandros G. Sfakianakis
07:48
A rare case of mucoepidermoid carcinoma of parotid with mandibular metastasis Jitendra Kumar Diwakar1, Arjun...
A rare case of mucoepidermoid carcinoma of parotid with mandibular metastasisJitendra Kumar Diwakar1, Arjun Agarwal2, Cheena Garg3, KY Giri1, Ramakant Dandriyal1, Geetika Kumar41 Department of Oral and Maxillofacial Surgery, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India2 Department of Surgical Oncology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India3 Department of Pathology, Rohilkhand Medical College and Hospital, Bareilly, Uttar Pradesh, India4 Department...
Medicine by Alexandros G. Sfakianakis
07:48
Preliminary report of a true nasomaxillary infantile fibrosarcoma: Single-modality management and 2-year...
Preliminary report of a true nasomaxillary infantile fibrosarcoma: Single-modality management and 2-year follow-upNaveenkumar Jayakumar1, Veerabahu Rathnaprabhu2, Singaravelu Ramesh31 Department of Oral and Maxillofacial Surgery, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India2 Department of Paediatric Dentistry, Kanchi Kamakoti Childs Trust Hospital, Chennai, Tamil Nadu, India3 Department of Paediatric Anaesthesiology, Kanchi Kamakoti Childs Trust Hospital,...
Medicine by Alexandros G. Sfakianakis
07:47
Squamous cell carcinoma of lower lip reconstructed with bilateral fan flap Bhatt D Supreet1, Semmia...
Squamous cell carcinoma of lower lip reconstructed with bilateral fan flapBhatt D Supreet1, Semmia Mathivanan2, Mustafa I Merchant3, Niranjan S Patil41 Department of Head and Neck Oncology, Gujarat Cancer Research Institute, Ahmedabad, India2 Department of Oral and Maxilofacial Surgery, Chettinad Dental College and Research Institute, Kancheepuram, India3 Deparment of Surgical Oncology, Basil Onco Care, Surat, India4 Department of Maxillofacial Surgery, (Dental Specialty) Bombay Hospital, Mumbai,...
Medicine by Alexandros G. Sfakianakis
07:46
Management of a penetrating orbital trauma from an unusual foreign body with associated eye injury...
Management of a penetrating orbital trauma from an unusual foreign body with associated eye injuryMartín Fernandez.Ferro1, Marta Fernández-Fernández2, Jacinto Fernández-Sanromán1, Alberto Costas-López1, Annahys López-Betancourt11 Department of Oral and Maxillofacial Surgery, Povisa Hospital, Vigo, Pontevedra, Spain2 Department of Ophthalmology, Povisa Hospital, Vigo, Pontevedra, SpainCorrespondence Address:Dr. Martín Fernandez.FerroDepartment of Oral and Maxillofacial Surgery, Rúa Salamanca 5, 36211...
Medicine by Alexandros G. Sfakianakis
07:46
Maxillofacial Surgery
Management of a penetrating orbital trauma from an unusual foreign body with associated eye injuryMartín Fernandez.Ferro, Marta Fernández-Fernández, Jacinto Fernández-Sanromán, Alberto Costas-López, Annahys López-BetancourtHoloprosencephaly with clefts: Data of 85 patients, treatment and outcome: Part 1: History, subdivisions, and data on 85 holoprosencephalic cleft patientsEngela M Honey, Kurt W Bütow, Roger Arthur ZwahlenHoloprosencephaly with clefts: Data of 85 patients, treatment, and outcome:...
Medicine by Alexandros G. Sfakianakis
07:44
Enjoying Music With Cochlear Implants: Experiences Of A Musician And Sound Engineer, René Vergè is a...
Enjoying Music With Cochlear Implants: Experiences Of A Musician And Sound Engineer, René Vergè is a musician and sound engineer from Germany – and he is also a bilateral recipient of MED-EL cochlear implants. He told us about his hearing journey and why, thanks to his cochlear implants, he could continue his work as a sound engineer.   People repeatedly ask me whether it is possible to […] Read More
Medicine by Alexandros G. Sfakianakis
07:10
Allergy and Immunology
Sat Jun 24, 2017 21:43  MD-2 regulates LPS-induced NLRP3 inflammasome activation and IL-1beta secretion by a MyD88/NF-κB-dependent pathway in alveolar macrophages cell lineupdated on Sun Jun 25, 2017 02:14 by Alexandros G. Sfakianakis via Allergy Rhinology Immunology AsthmaS01615890.gifPublication date: October 2017Source:Molecular Immunology, Volume 90Author(s): Man Luo, Lijuan Hu, Dandan Li, Yanying Wang, Yuting He, Lei Zhu, Weiying RenMyeloid differentiation protein 2 (MD-2) is required in the...
Medicine by Alexandros G. Sfakianakis
Wed Jul 17, 2019 10:07
Plastic, Reconstructive & Aesthetic Surgery
Thu Jun 22, 2017 04:35  Comment on JPRAS-D-17-00333"Ex-Vivo Flush Of The Vascularised Limb Allograft Reduces Inflammatory Burden Prior To Transplantation"by Alexandros G. Sfakianakis via AestheticAlthough vascularised composite allotransplantation (VCA) is increasingly being performed and for a widening range of indications – some now consider transplantation to be the standard of care for mid-forearm amputations1 – more widespread application is limited by the risks associated with lifelong immunosuppression.http://ift.tt/2sCHPV6Add...
Medicine by Alexandros G. Sfakianakis
Wed Jul 17, 2019 10:02
Biomechanics and Modeling in Mechanobiology
Correction to: Prediction of femoral strength using 3D finite element models reconstructed from DXA images: validation against experimentsIn the original publication of the article, Fig. 3 and Tables 2, 4 and 5 were published with errors. The issue was caused by an error in the code used to predict femoral strength in the finite element (FE) models.A data-driven model to study utero-ovarian blood flow physiology during pregnancyAbstractIn this paper, we describe a mathematical model of the cardiovascular...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:30
Osteoporosis
CaMKK2 Signaling in Metabolism and Skeletal Disease: a New Axis with Therapeutic PotentialAbstractPurpose of ReviewAge and metabolic disorders result in the accumulation of advanced glycation endproducts (AGEs), oxidative stress, and inflammation, which cumulatively cause a decline in skeletal health. Bone becomes increasingly vulnerable to fractures and its regenerative capacity diminishes under such conditions. With a rapidly aging population in the USA and the global increase in diabetes, efficacious,...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:29
Computer Assisted Radiology and Surgery
A markerless automatic deformable registration framework for augmented reality navigation of laparoscopy partial nephrectomyAbstractPurpose Video see-through augmented reality (VST-AR) navigation for laparoscopic partial nephrectomy (LPN) can enhance intraoperative perception of surgeons by visualizing surgical targets and critical structures of the kidney tissue. Image registration is the main challenge in the procedure. Existing registration methods in laparoscopic navigation systems suffer from...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:28
Toxicology
In vivo evaluation of the effect of arsenite on the intestinal epithelium and associated microbiota in miceAbstractChronic exposure to inorganic arsenic (As) [As(III) + As(V)], which affects millions of people, increases the incidence of some kinds of cancer and other non-carcinogenic pathologies. Although the oral pathway is the main form of exposure, in vivo studies have not been conducted to verify the intestinal toxicity of this metalloid. The aim of this study is to perform an in vivo evaluation...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:27
Folia Microbiologica
An overview of 25 years of research on Thermococcus kodakarensis , a genetically versatile model organism for archaeal researchAbstractAlmost 25 years have passed since the discovery of a planktonic, heterotrophic, hyperthermophilic archaeon named Thermococcus kodakarensis KOD1, previously known as Pyrococcus sp. KOD1, by Imanaka and coworkers. T. kodakarensis is one of the most studied archaeon in terms of metabolic pathways, available genomic resources, established genetic engineering techniques,...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:26
Cancer and Metastasis Reviews
PrefaceCorrection to: mTOR co-targeting strategies for head and neck cancer therapyThe author's name was tagged incorrectly in XML. "Silvio Gutkind J" should be tagged as "J. Silvio Gutkind". Given name is "J. Silvio" and the Family name is "Gutkind".Biography—Robert J. GilliesCorrection to: Tumor pH and metastasis: a malignant process beyond hypoxiaThe authors have noticed a typographical error in the published article. The term "epithelial-to-mesenchymal transition" should have been used instead...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:25
Hematology
Eltrombopag combined with cyclosporine may have an effect on very severe aplastic anemiaSuccessful management of transcatheter aortic valve implantation by platelet transfusions in a nonagenarian patient with severe autoimmune factor V deficiencyCirculating cell-free DNA for response evaluation of intravascular lymphomaClinicohematologic and cytogenetic profile in a rare case of pure erythroid leukemiaIntravenous busulfan plus melphalan versus melphalan alone as conditioning regimen for patients...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:24
Heat and Mass Transfer
Proposing a method for combining monitored multilayered perceptron (MLP) and self-organizing map (SOM) neural networks in prediction of heat transfer parameters in a double pipe heat exchanger with nanofluidAbstractThe purpose of this study was to investigate the efficiency of using magnesium oxide nanoparticles, twisted tapes with different and modified twist ratios, and the different rotation velocity of perforated twisted tapes in the evaluation of Nusselt number, overall heat transfer coefficient...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:24
Anesthesia & Analgesia
Factors Associated With Failure of Spinal Anesthetic: An 8-Year Retrospective Analysis of Patients Undergoing Elective Hip and Knee Joint ArthroplastyThe primary outcome of this 8-year retrospective review was the failure of spinal anesthetic (SA) in elective hip and knee joint arthroplasty surgery. Of 3542 SAs, a total of 135 failures were identified (3.8%). Factors associated with increased odds of failure were younger age (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.01–1.05), lower...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:19
Antonie van Leeuwenhoek
Mesorhizobium carboni s sp. nov., isolated from coal bed waterAbstractA Gram-stain negative, aerobic, motile, short rod-shaped bacterium, designated as B2.3T, was isolated from coal bed water collected from Jincheng, Shanxi Province, China. The strain was able to grow at 10–40 °C (optimum 28–30 °C), pH 4.0–10.0 (optimum 7.0), and in the presence of 0–5.0% NaCl (optimum 3.0%, w/v). Phylogenetic analysis based on the 16S rRNA and concatenated housekeeping gene recA, atpD and glnA sequences showed strain...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:18
Anesthesia
Correction to: Anesthetic technique and cancer outcomes: a meta-analysis of total intravenous versus volatile anesthesiaThere was an isolated error relating to the Oh et al. study (1) within our recurrence-free survival analysis. When the reported estimates for Oh et al. are corrected, the pooled hazard ratio (HR) is now 0.87; 95% confidence interval (CI), 0.66 to 1.15; P=0.32.Embolization of percutaneous closure deviceThe Pediatric Procedural Sedation HandbookWhat do non-critical care residents...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:17
Cognitive Neurodynamics
U1 snRNA over-expression affects neural oscillations and short-term memory deficits in miceAbstractSmall nuclear RNAs (snRNAs) and other RNA spliceosomal components are involved in neurological and psychiatric disorders. U1 snRNA has recently been demonstrated to be altered in pathology in some neurodegenerative diseases, but whether it has a causative role is not clear. Here we have studied this by overexpressing U1 snRNA in mice and measured their hippocampal oscillatory patterns and brain functions....
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:16
New Trends and Technologies in Facial Plastic Surgery, An Issue of Facial Plastic Surgery Clinics...
New Trends and Technologies in Facial Plastic Surgery, An Issue of Facial Plastic Surgery Clinics of North America, EbookJD Bloom - 2019Tissue Engineered Soft Tissue Reconstruction Using Non-invasive Mechanical Preconditioning and a Shelf-ready Allograft Adipose MatrixG Giatsidis, J Succar, TD Waters, W Liu, P Rhodius… - Plastic and Reconstructive …, 2019Background: Adipose tissue defects leading to severefunctional (disability) and morphological (di.[PDF] Seguridad de los injertos de grasa autólogos...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:15
[PDF] Cardiovascular imaging system, KD Taylor, K Harlan, J Nye, R Splinter, J Keeler… - US Patent...
[PDF] Cardiovascular imaging system,KD Taylor, K Harlan, J Nye, R Splinter, J Keeler… - US Patent App. 16/297,685, 2019… A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in bodycavities or body tracts, eg by using catheters. A—HUMAN … Drug therapy,including nitrates, beta-blockers, and peripheral vasodilatator drugs to dilate …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:10
An apparatus and system for acquiring data from bones and joints, plan surgery and manufacture instruments...
An apparatus and system for acquiring data from bones and joints, plan surgery and manufacture instruments or implants,MAELD HAFEZ - US Patent App. 16/096,921, 2019… SCIENCE; HYGIENE; A61B—DIAGNOSIS; SURGERY; IDENTIFICATION;A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves; … or formonitoring patient compliance relating to mechanical, radiation or invasive …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:10
[PDF] Optical biopsy applicators for treatment planning, monitoring, and image-guided therapy, Z Chen,...
[PDF] Optical biopsy applicators for treatment planning, monitoring, and image-guided therapy,Z Chen, Y Miao, Y Li, BJ Tromberg, Y Tadir - US Patent App. 16/235,426, 2019… device; A61B8/4444—Constructional features of the ultrasonic, sonic orinfrasonic diagnostic device … Fractioned laser and other energy basedtherapies of atrophic vaginal mucosa leads to … Moreover, the duration of tissue …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:10
Devices and techniques for cutting and coagulating tissue, JD Messerly, ET Wiener, BT Noyes, JL Aldridge… -...
Devices and techniques for cutting and coagulating tissue,JD Messerly, ET Wiener, BT Noyes, JL Aldridge… - US Patent App. 10/335,614, 2019Various embodiments are directed to a method of driving an end effectorcoupled to an ultrasonic drive system of a surgical instrument. The methodcomprises generating at least one electrical signal. The at least one electrical …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:10
Pulmonary Vasculitis, F Martínez - Chest Imaging, 2019 … What Not to Miss ■ The aortic wall thickness...
Pulmonary Vasculitis,F Martínez - Chest Imaging, 2019… What Not to Miss ■ The aortic wall thickness and the caliber of the headand neck vessel origins must always be evaluated on contrast-enhancedchest … Imaging Findings TAK ■ Early stage: Contrast-enhanced CT shows …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:09
[HTML] Immune-Related Adverse Events: A Case-Based Approach, C Connolly, K Bambhania, J Naidoo - Frontiers...
[HTML] Immune-Related Adverse Events: A Case-Based Approach,C Connolly, K Bambhania, J Naidoo - Frontiers in Oncology, 2019… Hodgkin lymphoma Hepatocellular carcinoma Melanoma Microsatelliteinstability-high (MSI-H) or mismatch-repair deficient (dMMR) CRC Non-smallcell lung cancer Renal cell carcinoma Small cell lung cancer Squamous …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:08
A pictorial approach to abdominal radiography, A Parry, P Mahoney - In Practice, 2019 … He is the vice-president...
A pictorial approach to abdominal radiography,A Parry, P Mahoney - In Practice, 2019… He is the vice-president of the European College of Veterinary Diagnostic Imaging (ECVDI)and head of radiology at Willows Referral Service … Good serosal detail requires thepresence of intra-abdominal white fat to provide contrast with soft tissue structures …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:08
[HTML] Safety and Tolerability of Targeted Medical Nutrition for Cachexia in Non-Small-Cell Lung Cancer:...
[HTML] Safety and Tolerability of Targeted Medical Nutrition for Cachexia in Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Controlled Pilot TrialA Laviano, PC Calder, AMWJ Schols, F Lonnqvist… - Nutrition and cancer, 2019… In patients with cancer, cachexia is defined as "a multifactorial syndromecharacterized by an ongoing loss of skeletal muscle mass (with or withoutloss of fat mass) that cannot be fully reversed by conventional nutritional …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:08
[ΒΙΒΛΙΟ] Cerebral Stroke, S Thaakur - 2019 - books.google.com, 1. INTROCUTION Stroke is defined as an...
[ΒΙΒΛΙΟ] Cerebral Stroke,S Thaakur - 2019 - books.google.com,1. INTROCUTION Stroke is defined as an abrupt and devastating illness. It is deliberated as aleading cause of adult disability (Adamson et al., 2004). Approximately 15 million people worldwidesuffer from stroke each year (Mackay and Mensah, 2004). It is recognized as fourth largest cause 
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:07
Lung Cancer: Lymphadenopathy and Extrapulmonary Involvement, REC Benson - Chest Imaging, 2019 … Metastases Head■...
Lung Cancer: Lymphadenopathy and Extrapulmonary Involvement,REC Benson - Chest Imaging, 2019… Metastases Head■ and neck cancers, genitourinary … Direct chest wall invasion (Fig 48.6) ■Loss of extrapleural fat ■ Rib erosion/invasion and/or pathologic fracture Intercostalmuscle involvement ■ Pancoast tumor: Apical tumor with local invasion of adjacent ribs …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:07
[PDF] Approach to Patients with Neurotrauma and Thoracic Trauma and Anesthesia Management with Current...
[PDF] Approach to Patients with Neurotrauma and Thoracic Trauma and Anesthesia Management with Current Guidelines-1T Mıngır, C Kılınç, S Türkmen, M Erdal, A Aksu, İ Avcı… - 2019… contusion, aspiration of gastric contents, pneumonia, inhalation injury anddrowning, and severe traumatic shock, head trauma, abdominal sepsis,burns, fat embolism, excessive volume … The mediastinal emphysema will …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:06
Recognition and management of dermatologic complications from interventional radiology procedures M...
Recognition and management of dermatologic complications from interventional radiology proceduresM Ramirez, S Ravichandran, L Ronald… - … and Interventional Imaging, 2019… However, if biopsied, pathology will show dermal sclerosis with fat necrosisand foreign body … pruritic erythematous dermatitis 1 day after central venousport placement, extending up the neck … months after the procedure he …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:06
Tailored posterior pharyngeal fat grafting outcomes in velopharyngeal insufficiency managed according...
Tailored posterior pharyngeal fat grafting outcomes in velopharyngeal insufficiency managed according to a simplified algorithmR Denadai, CA Raposo-Amaral, A Sabbag, PR Vieira… - Annals of plastic surgery, 2019Background This study aimed to evaluate the outcomesof posterior pharyngeal fat grafting for the.
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:06
[PDF] COMPARATIVE STUDY OF HARMONIC SCALPEL VERSUS MONOPOLAR COAGULATION AND TITANIUM CLIPS IN LAPAROSCOPIC...
[PDF] COMPARATIVE STUDY OF HARMONIC SCALPEL VERSUS MONOPOLAR COAGULATION AND TITANIUM CLIPS IN LAPAROSCOPIC CHOLECYSTECTOMYAK Singh - International Journal of Scientific Research, 2019… The assessment were done under the following heads : Intra-operativeassessment - (a) Mean Operative time (b … supine with arms tucked to the sidewith right side up and head end up … gallbladder-cystic duct junction and CBD …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 11:06
Hyperbaric oxygen therapy in a case of cervical abscess extending to anterior mediastinum, with isolation...
Hyperbaric oxygen therapy in a case of cervical abscess extending to anterior mediastinum, with isolation of Prevotella corporisF Ciodaro, F Gazia, B Galletti, F Galletti - BMJ Case Reports CP, 2019Skip to main content. We use cookies to improve our service and to tailor our content andadvertising to you. More info You can manage your cookie settings via your browser atany time. To learn more about how we use cookies, please see our cookies policy …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 10:50
[HTML] Evidence-based prophylaxis strategies for postoperative nausea and vomiting when considering...
[HTML] Evidence-based prophylaxis strategies for postoperative nausea and vomiting when considering ethnicity factor,FY Su, WT Hung, LK Chen - Taiwanese Journal of Obstetrics and Gynecology, 2019… 2. Reduce Baseline Risk Factors for PONV; Guideline 3. Administer PONVProphylaxis Using 1 to 2 Interventions in Adults at Moderate Risk for PONV;and Guideline 4. Administer Prophylactic Therapy with Combination (≥2) …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 10:50
[PDF] Adenovirus and immunomodulator combination therapy F Tufaro, J FUEYO-MARGARETO, C Gomez-Manzano… -...
[PDF] Adenovirus and immunomodulator combination therapyF Tufaro, J FUEYO-MARGARETO, C Gomez-Manzano… - US Patent App. 16/304,359, 2019US20190201462A1 - Adenovirus and immunomodulator combination therapy - GooglePatents. Adenovirus and immunomodulator combination therapy. Download PDF Info.Publication number US20190201462A1. US20190201462A1 …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 10:50
Pediatric primary spinal atypical teratoid rhabdoid tumor: a case series and review of the literature ...
Pediatric primary spinal atypical teratoid rhabdoid tumor: a case series and review of the literature D Li, DM Heiferman, HR Syed, JG Santos, RM Bowman… - Journal of Neurosurgery …, 2019… Atypical teratoid rhabdoid tumors (ATRTs) are rare malignant central nervous systemtumors, commonly occurring before 3 years of age. Median overall survival (OS) of patientswith these tumors is about 1 year, despite aggressive multimodal therapy …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 10:50
[HTML] Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids–the state...
[HTML] Head and neck cancer: searching for genomic and epigenetic biomarkers in body fluids–the state of art  IP Ribeiro, JB de Melo, IM Carreira - Molecular Cytogenetics, 2019… Head and neck cancer: searching for genomic and epigenetic biomarkersin body fluids – the state of art … or non-invasive method also called as liquidbiopsy for diagnostic and prognostic biomarkers detection, representing …
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 10:49
Four-year pain relief after coblation combined with active exercise for cervical discogenic pain: Case...
Four-year pain relief after coblation combined with active exercise for cervical discogenic pain: Case reportX Li, L Yang, J Ni, Y Zhang - Medicine, 2019Rationale: Coblation of intervertebral disc is an effectiveand safe minimally invasive technology.
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 10:49
A nomogram prediction model for recurrent laryngeal nerve lymph node metastasis in thoracic oesophageal...
A nomogram prediction model for recurrent laryngeal nerve lymph node metastasis in thoracic oesophageal squamous cell carcinoma           Y Liu, ZQ Zou, J Xiao, M Zhang, L Yuan, XG Zhao - Journal of Thoracic Disease, 2019A nomogram prediction model for recurrent laryngeal nerve lymph nodemetastasis in thoracic oesophageal squamous cell carcinoma.
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 10:49
Prognostic value of preoperative alpha-fetoprotein (AFP) level in patients receiving curative hepatectomy-an...
Prognostic value of preoperative alpha-fetoprotein (AFP) level in patients receiving curative hepatectomy-an analysis of 1,182 patients in Hong KongMY Chan, WH She, WC Dai, SH Yin Tsang… - Translational …, 2019Prognostic value of preoperative alpha-fetoprotein (AFP) level in patients receivingcurative hepatectomy- an analysis of 1182 patients in Hong Kong.
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 10:48
Psychiatry
Violence against doctors in India – Safety versus serviceOm Prakash SinghIndian Journal of Psychiatry 2019 61(4):325-326Safety and efficacy of adjunctive transcranial direct current stimulation in treatment-resistant obsessive-compulsive disorder: An open-label trialSatish Kumar, Nand Kumar, Rohit VermaIndian Journal of Psychiatry 2019 61(4):327-334Introduction: The current pharmacological and psychotherapeutic approaches have limited benefit in symptom management of obsessive-compulsive disorder...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 10:45
Clinical and Experimental Medicine
Neutrocyte-to-lymphocyte ratio predicts the presence of a replicative hepatitis C virus strand after therapy with direct-acting antiviralsAbstractResidual HCV-RNA can persist in liver tissue and peripheral blood mononuclear cells (PBMCs) long after antiviral therapy of chronic hepatitis C in patients repeatedly negative for viral RNA in serum. This occult infection associates with impaired immune response and the risk of lymphoproliferative disorders or progressive liver disease. There are currently...
Medicine by Alexandros G. Sfakianakis
Tue Jul 16, 2019 10:44

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