Δευτέρα, 10 Απριλίου 2017

Thyroid Cancer: Link to Household Products? - Wall Street Journal (subscription)


Wall Street Journal (subscription)

Thyroid Cancer: Link to Household Products?
Wall Street Journal (subscription)
What household products do scientists believe are a link to the dramatic rise in thyroid cancer over the past 40 years? Duke University's Dr. Julie Sosa and WSJ's Tanya Rivero discuss on Lunch Break. Photo: Getty ...

and more »


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2po7yxN
via IFTTT

Creatine supplementation reduces sleep need and homeostatic sleep pressure in rats

Summary

Sleep has been postulated to promote brain energy restoration. It is as yet unknown if increasing the energy availability within the brain reduces sleep need. The guanidine amino acid creatine (Cr) is a well-known energy booster in cellular energy homeostasis. Oral Cr–monohydrate supplementation (CS) increases exercise performance and has been shown to have substantial effects on cognitive performance, neuroprotection and circadian rhythms. The effect of CS on cellular high-energy molecules and sleep–wake behaviour is unclear. Here, we examined the sleep–wake behaviour and brain energy metabolism before and after 4-week-long oral administration of CS in the rat. CS decreased total sleep time and non-rapid eye movement (NREM) sleep significantly during the light (inactive) but not during the dark (active) period. NREM sleep and NREM delta activity were decreased significantly in CS rats after 6 h of sleep deprivation. Biochemical analysis of brain energy metabolites showed a tendency to increase in phosphocreatine after CS, while cellular adenosine triphosphate (ATP) level decreased. Microdialysis analysis showed that the sleep deprivation-induced increase in extracellular adenosine was attenuated after CS. These results suggest that CS reduces sleep need and homeostatic sleep pressure in rats, thereby indicating its potential in the treatment of sleep-related disorders.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2po8It3
via IFTTT

Money is the root of all good



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2om22hh
via IFTTT

The Hottest Women of All Time | Men's Health

This is my third year with Tee Times USA and can not say enough about how good we have been treated . My group always has lots of changes along the way.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o2DdUW
via IFTTT

Robert Lynd - 97 Public Records Found

Watch videos & listen free to Robert Lynd: In The Train, 10 - - Henry James: 1. The Novelist of Grains and Scruples & more. Robert Wilson Lynd (20 April

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olTkzA
via IFTTT

Coates Library | In-Text Citation

Title: The Book Selection Process for the Book Citation Index in Web of Science - Essay Author: Thomaon Reuters Subject: The Book Selection Process for the Book

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o2tWMA
via IFTTT

Education Service Center Region 19 / Homepage

The United States Trustee Program is a component of the . Department of Justice that supervises the administration of bankruptcy cases. The United States Trustee

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZNJ3m
via IFTTT

Writing an essay conclusion, Sample and Examples

We provide excellent essay writing service 24/7. Enjoy proficient essay writing and custom writing services provided by professional academic writers.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1IGMG
via IFTTT

Israel, Jews & The Sickness We Face - Interview With Kevin

Application Areas. Revware is a leading metrology software and equipment manufacturer – reshaping your world, one product at a time.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p02fIl
via IFTTT

College – SparkNotes

The East End School District will educate and develop the whole child providing the skills necessary to succeed in a global environment.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1Ikpy
via IFTTT

Exercises at Grammar Bytes!

Looking for FREE tone worksheets? Check these out! Students read short passages, describe the narrator's tone, and use text to support their answers.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p02aEk
via IFTTT

Upload and Search Theses and Dissertations - OpenThesis

Submissions from 2014. Amoroso, Jon William (2014) Reactive Probes for Manipulating Polyketide Synthases, and Photoreactive Probes for Strained Alkyne Click Chemistry

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1vNSV
via IFTTT

Single Source Information: An Agile Best Practice for

Take practice timed essays using 's essay grading service.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nzFjj2
via IFTTT

The Blind Side Essay Topics & Writing Assignments

The Blind Side Essay the blind side essay Best Resume Writing Services Chicago Affordable How To Write A Career Reflection Paper Help Me With My Physics Homework

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2pnRpIL
via IFTTT

Classification Essay Food Free Essays - StudyMode

Classification of foods and dietary the group is referred to as the sub-major food group. The classification system developed for the AHS contains 132 sub-major

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nzCSNA
via IFTTT

Works chosen for Scottish literature question named (From

THE novels, plays, poems and short stories chosen for the new compulsory question on Scottish literature in future English exams are revealed today by The Herald

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2pobkHe
via IFTTT

French & Journalism & Creative Writing - University of

Jane Dillon is a friendly Nottingham based female English tutor offering help for GCSE, 'A' Levels, International Baccalaureate, college and university students

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nzv91K
via IFTTT

Grand Effects Fire & Water Features

An up-to-date periodic table with detailed but easy to understand information

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2po8Mcf
via IFTTT

Streisand Effect - TV Tropes

If muscles are to blame, self massage will take care of it. If it doesn’t, check with your doctor to rule out anything more serious. A trigger point is like a hot

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nzDIK7
via IFTTT

Why Your Job Cover Letter Sucks (and what you can do to

How to write and set out a business letter showing format, style and tone, use of capital letters, reading principles, signatures and includes examples of a business

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olMzOh
via IFTTT

Pentagon Papers | National Archives

By Yash Kothari 1, Snehal Dewalkar 2 1 Department Of Civil Engineering, Sinhgad Academy Of Engineering (SAE), Kondhwa (BK), Pune-48, India 2 Department Of Civil

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o2kw3Z
via IFTTT

The do's and dont's of teaching problem solving in math

interactive Math skills resources - fourth grade math concepts, division, divide

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olTtmD
via IFTTT

Oral sex and cancer? Yes, there is a link - Independent Online


Independent Online

Oral sex and cancer? Yes, there is a link
Independent Online
The number of people diagnosed with HPV-related oropharyngeal cancer – tumours found in the middle of the pharynx or throat including the back of the tongue, soft palate, sides of throat and tonsils – is relatively small, about 12 638 men and 3100 ...



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2pnTwMH
via IFTTT

Ischaemic stroke in younger adults is increasing, US study finds

The number of younger adults admitted to hospital with acute ischaemic stroke has increased considerably over the past few years, shows a US study, which found that the increase was associated with...
recent?d=yIl2AUoC8zA recent?d=dnMXMwOfBR0 recent?i=-joNoikoNQo:yzCxIrboQF4:V_sGLiP recent?d=qj6IDK7rITs recent?i=-joNoikoNQo:yzCxIrboQF4:gIN9vFw recent?d=l6gmwiTKsz0 recent?d=7Q72WNTAKBA recent?i=-joNoikoNQo:yzCxIrboQF4:F7zBnMy recent?i=-joNoikoNQo:yzCxIrboQF4:-BTjWOF


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1NOR7
via IFTTT

Patients with chronic heart failure have “extreme” comorbidity, finds primary care study

Patients with chronic heart failure often have “extreme” comorbidity and take multiple medicines, a UK primary care study has found.1People with chronic disease often have multiple conditions, and...
recent?d=yIl2AUoC8zA recent?d=dnMXMwOfBR0 recent?i=hHuCeAKzFXo:rjZrmdUt24Y:V_sGLiP recent?d=qj6IDK7rITs recent?i=hHuCeAKzFXo:rjZrmdUt24Y:gIN9vFw recent?d=l6gmwiTKsz0 recent?d=7Q72WNTAKBA recent?i=hHuCeAKzFXo:rjZrmdUt24Y:F7zBnMy recent?i=hHuCeAKzFXo:rjZrmdUt24Y:-BTjWOF


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oTcHSc
via IFTTT

Custom Essay Writing Service - ™

provides a searchable database of over one hundred thousand prewritten essays, term papers, research papers for school, college papers, book reports

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nXCLqv
via IFTTT

GCE Sociology Revision (AQA)- Unit 1 Theories of the

We provide excellent essay writing service 24/7. Enjoy proficient essay writing and custom writing services provided by professional academic writers.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nzxpWQ
via IFTTT

British Royal Weddings from Victoria to Elizabeth II

Quick Facts Name Queen Mother Elizabeth Occupation Queen Birth Date August 4, 1900 Death Date March 30, 2002 Place of Birth London, England Place of Death

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oloxBw
via IFTTT

BEST SOUNDING CLASSICAL RECORDINGS

David Ezra (previously: Mehmet) Okonsar (Okonşar) was born in October 20, 1961 in Istanbul, Turkey. After his primary education in Paris, he entered the National

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZD0pC
via IFTTT

Social Media in Higher Education: A Literature Review and

One of the more esoteric but much beloved tools in the paleo dieter’s tool-kit is intermittent fasting. What is intermittent fasting? IF is the practice of

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1FbWH
via IFTTT

Home | Colorín Colorado

Tibia is a free massively multiplayer online role-playing game (MMORPG). Join this fascinating game that has thousands of fans from all over the world! - http://www

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZKTel
via IFTTT

CoCo Vandeweghe knocks out world No 1 Angelique Kerber at

Political; What To Do When Child Protective Services Knocks: A Must Read for All Parents! A Child Protective Services Whistle-blower explains what to do if CPS comes

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1wE5Y
via IFTTT

Persuasive Essay | TIME For Kids

Learn how to write a persuasive essay. Professional writers share must-know essay writing tips.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZYIJZ
via IFTTT

Custom Essay Writing Service Help at KingEssays©

Free Personal Statement papers, essays, and research papers.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1FwZC
via IFTTT

How to Write a Business Plan | The . Small Business

From real business plan examples, to financial spreadsheets and templates, Business Plan Examples has EVERYTHING you need to write the perfect business plan.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p02iUi
via IFTTT

Forrest Gump - Movie Quotes - Rotten Tomatoes

I hope this collection of 50+ funny quotes would bring a smile on your face. I have marked my favorites in red. If you do like them, then feel free to use them as

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1jHsZ
via IFTTT

True Built Home – Pacific Northwest Custom Home Builder

Created by Nic Pizzolatto. With Vince Vaughn, Colin Farrell, Rachel McAdams, Taylor Kitsch. An anthology series in which police investigations unearth the personal

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZZxTc
via IFTTT

Telling your story - Pat McNees

is the official site of Torrey Pines PGA teaching pro Michael Major

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1Byjw
via IFTTT

Browse By Author: S - Project Gutenberg

This is an alphabatized list of the finest sounding Classical LP recordings I have ever heard.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p02jYm
via IFTTT

KU Writing Center | KU Writing Center

We welcome feedback about these handouts and suggestions for additional handouts. Please email us or call us with your ideas.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1wBqO
via IFTTT

SWOT analysis method and examples, with free SWOT template

To identify the critical path, you need to first create a Precedence Diagram, Network Diagram. You can then use the critical path method to identify the

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZSJEW
via IFTTT

Essay Writing Service

Why Fannie Mae and Freddie Mac Are Down 10% Today KBW analysts throw cold water on the bull thesis for Fannie and Freddie common stock. Preferred shareholders hang on.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1wawU
via IFTTT

Free Essays, Term Papers and Book Reports

Free Essays, Term Papers and Book Reports We only offer the best free essays, term papers and book reports from the brightest high school and college students.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZK1qr
via IFTTT

Creative Writing Prompts

If you have any questions about the expectations for the Writing Journal Calendar Prompts, please do not hesitate to

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1AxrF
via IFTTT

California Critical Thinking Skills Test (CCTST

Pseudo critical thinking is everywhere in the world, for everywhere there are people who take themselves to be models of good thinking and who are engaged in

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZWqKH
via IFTTT

UK cost agency turns down Bristol drug for head and neck cancer - Nasdaq


Nasdaq

UK cost agency turns down Bristol drug for head and neck cancer
Nasdaq
LONDON, April 11 (Reuters) - Britain's healthcare cost-effectiveness watchdog NICE said on Tuesday that Bristol-Myers Squibb's <BMY.N> immunotherapy drug Opdivo was not worth using on the state health service for treating head and neck cancer due to ...

and more »


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZKwAM
via IFTTT

Doctors at Morristown Medical Center Draw Attention to Head and Neck Cancer; Offer Free Screenings - TAPinto.net


Doctors at Morristown Medical Center Draw Attention to Head and Neck Cancer; Offer Free Screenings
TAPinto.net
MORRISTOWN, NJ – April is Head and Neck Cancer Month and the doctors at Atlantic Health System are looking to build awareness around these types of cancers. “Head and Neck cancer doesn't get a lot of celebrity publicity like breast cancer and other ...



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olvDGe
via IFTTT

A Bayesian Approach for Population Pharmacokinetic Modeling of Pegylated Interferon α-2a in Hepatitis C Patients

Abstract

Background

Pegylated interferon α-2a (PEG-IFN-α-2a) is an antiviral drug used for the treatment of chronic hepatitis C virus (HCV) infection. This study describes the population pharmacokinetics of PEG-IFN-α-2a in hepatitis C patients using a Bayesian approach. A possible association between patient characteristics and pharmacokinetic parameters is also explored.

Methods

A Bayesian population pharmacokinetic modeling approach, using WinBUGS version 1.4.3, was applied to a cohort of patients (n = 292) with chronic HCV infection. Data were obtained from two phase III studies sponsored by Hoffmann-La Roche. Demographic and clinical information were evaluated as possible predictors of pharmacokinetic parameters during model development.

Results

A one-compartment model with an additive error best fitted the data, and a total of 2271 PEG-IFN-α-2a measurements from 292 subjects were analyzed using the proposed population pharmacokinetic model. Sex was identified as a predictor of PEG-IFN-α-2a clearance, and hemoglobin baseline level was identified as a predictor of PEG-IFN-α-2a volume of distribution.

Conclusion

A population pharmacokinetic model of PEG-IFN-α-2a in patients with chronic HCV infection was presented in this study. The proposed model can be used to optimize PEG-IFN-α-2a dosing in patients with chronic HCV infection. Optimal PEG-IFN-α-2a selection is important to maximize response and/or to avoid potential side effects such as thrombocytopenia and neutropenia.

Clinical Trials Registration Numbers

NV15942 and NV15801.



http://ift.tt/2p1I2PB

Inspired by mom's bout with thyroid cancer, Penn-Trafford senior plans 5K to help nonprofit - Tribune-Review


Inspired by mom's bout with thyroid cancer, Penn-Trafford senior plans 5K to help nonprofit
Tribune-Review
Mikayla Sherwin (left) with her mother, Debbie Sherwin, at their home in Harrison City, Pa., on Thursday, April 6, 2017. Mikayla is using her senior project at Penn-Trafford High School to organize a 5K whose proceeds will benefit research and ...



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZReqk
via IFTTT

Solve for the specified variable



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oluZtU
via IFTTT

Thesis video design



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o2fAfe
via IFTTT

May 2010 essay prompt sat



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olD9SZ
via IFTTT

Bachelor thesis schluss



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o2gCry
via IFTTT

Dissertation on the poor laws joseph townsend



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olF22c
via IFTTT

The bell jar theme essay



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o2dCf6
via IFTTT

Apush essay questions progressive era



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olHntD
via IFTTT

Problem solving essay on abortion



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o2pNs2
via IFTTT

Federal government resume writing service



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olH5TM
via IFTTT

Marie cardona critical essay



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o21qLk
via IFTTT

http://ift.tt/2o27qnb



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olDGED
via IFTTT

Writing the essay sound advice from an expert



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olCrVI
via IFTTT

Rivers homework help woodlands junior school



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o2akIH
via IFTTT

Cover letter mining machine operator



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olMb2j
via IFTTT

Online movie reviews



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1Xqug
via IFTTT

How to do a summary essay



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olD95r
via IFTTT

Starting wedding planning business



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o23yT5
via IFTTT

Consulting interview case study practice



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2om0AeX
via IFTTT

Personal responsibility definition essay



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o2dAnu
via IFTTT

Thesis plural or singular



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olM9aH
via IFTTT

Genetic variants in microRNAs and their binding sites within gene 3’UTRs associate with susceptibility to age-related macular degeneration (AMD)

Abstract

Age-related macular degeneration (AMD), the leading cause of blindness in the elderly, is a complex disease that results from multiple genetic and environmental factors. MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate target mRNAs and are frequently implicated in human diseases. Here, we investigated the association of genetic variants in miRNAs and miRNA-binding sites within gene 3’UTRs with AMD using data from the largest AMD genome-wide association study. First, we identified three variants in miRNAs significantly associated with AMD. These include rs2168518:G>A in the miR-4513 seed sequence, rs41292412:C>T in pre-miR-122/miR-3591 and rs4351242:C>T in the terminal-loop of pre-miR-3135b. We demonstrated that these variants reduce expression levels of the mature miRNAs in vitro and pointed the target genes that may mediate downstream effects of these miRNAs in AMD. Second, we identified 54 variants (in 31 genes) in miRNA-binding sites associated with AMD. Based on stringent prioritization criteria, we highlighted the variants that are likely to have an impact on the miRNA-target interactions. Further, we selected rs4151672:C>T within the CFB 3’UTR and experimentally showed that, while miR-210-5p downregulates expression of CFB, the variant decreases miR-210-5p-mediated repression of CFB. Together, our findings support the notion that miRNAs may play a role in AMD.

This article is protected by copyright. All rights reserved



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1x2l2
via IFTTT

Lymph Node Central Necrosis on the Computed Tomography as the Predictor of the Extra Capsular Spread in Metastatic Head and Neck Squamous Cell Carcinoma

Abstract

The aim of this study is to investigate the relationship between the presence of the cervical lymph node with central necrosis as on the preoperative imaging and postoperative histopathological identification of the lymph node extra capsular spread. This study is a prospective study conducted at J.L.N. Hospital and Research Centre, Bhilai (C.G), from August 2011 to January 2014. Thirty patients with metastatic head and neck squamous cell carcinoma were enrolled. All candidates were subjected to a detailed history taking and clinical examination. Their preoperative computed tomography (CT) scans were assessed with attention to the presence and absence of lymph node, lymph node size, shape, level, presence or absence of the lymph node central necrosis and other signs of the ECS such as thick walled enhancing nodal margin, loss of margin definition, alteration of adjacent fat planes. These patients then underwent surgery which included resection of the primary with the neck dissection. The preoperative records of the lymph node size and location were observed radio-graphically and analyzed with the resected lymph node histopathologically. These data was used for finding out correlation. Of the total 30 patients studied, 24 patients were male and 6 patients female with ratio of 4:1. The most common group of the patients were of malignancy of gingivobuccal sulcus. Out of the 30 patients 19 patients had the radiographic evidence of the central necrosis, out of which 11 had the extra capsular spread on the histological analysis. In no patients did we found histopathology extra capsular spread without central necrosis. Thus the central necrosis on the CT has the high sensitivity for detection of the extra capsular spread. Out of the 19 lymph node without extra capsular spread, 11 lymph nodes had no central necrosis on the preoperative CT, remaining 8 lymph node were having central necrosis on CT whereas post op histopathology of these 8 lymph nodes showed metastatic deposit, indicating the low specificity of the central necrosis in detection of the ECS. Lymph node central necrosis on pre-operative CT is sensitive indicator with a high negative predictive value for lymph node extra capsular spread. Future studies focusing on identifying molecular mediator involved in ECS to determine targets for adjuvant therapies in this subset of patients are recommended.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2ojaldG
via IFTTT

Septorhinoplasty: Our Experience

Abstract

Rhinoplasty is one of the oldest known surgeries to the human kind. However, being a cosmetic of surgery of utmost importance, it has been an attractive and fascinating surgery for the otolaryngologists and plastic surgeons. Along with the evolution of improved techniques and better surgical modalities, this surgery has been growing in panorama including its indications, needs and techniques. We present our experience with rhinoplasty in a tertiary care center of north India. We have included all cases operated with septorhinoplasty from 2001 to 2014 by the senior author in the manuscript. We reviewed their presentations, investigations, preoperative counselling records, operative details and post-operative clinical records to audit our results and hence to document our experiences in septorhinoplasties. A total of 53 cases including 37 males and 16 females had undergone rhinoplasty surgeries. The most common reason of disfigurement was road traffic accident (58.5%). All these patients included different deformities and required varied corrections. There were no major post-operative complications except persistent edema with longest lasting for 23 weeks. Thermal splints gave a better patient satisfaction in post-op compared to POP splints. Results were completely and partially satisfying for 50 patients and not satisfying for three. Unrealistic expectations from the procedure might be the reason for non-satisfactory results in rhinoplasty. Rhinoplasty is a delicate procedure and has greater aesthetic implications in planning surgical techniques and approaches. For better satisfaction of patients, adequate preoperative counseling and realistic expectations are warranted. Skillful surgical techniques null chances of complications.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZaSQk
via IFTTT

Cardiotoxicity with Itraconazole

Itraconazole is a commonly used antifungal drug. In addition to commonly described adverse effects, there have been few reports of heart failure with its use. We present two cases that developed acute systolic heart failure with Itraconazole use. A man in his early 30s was admitted with worsening leg swelling and dyspnoea on exertion. He had been on Itraconazole for blastomyces skin ulcer. His ejection fraction (EF) was found to be 10%–15%. Another man in his 50s was admitted with similar symptoms; his EF was 40%–45%. He had been on Itraconazole for forearm cellulitis. No other aetiology was identified in both patients despite extensive work-up including cardiac catheterisation. Itraconazole was stopped in both the cases. Our first patient did not improve even months after cessation of therapy and was referred for heart transplant. Our second patient improved after a few weeks, and his ejection fraction had improved on repeat testing.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nzlc4K
via IFTTT

Bioactivity of oral linaclotide in human colorectum for cancer chemoprevention

Guanylate cyclase C (GUCY2C) is a tumor suppressing receptor silenced by loss of expression of its luminocrine hormones guanylin and uroguanylin early in colorectal carcinogenesis. This observation suggests oral replacement with a GUCY2C agonist may be an effective targeted chemoprevention agent. Linaclotide is an FDA approved oral GUCY2C agonist formulated for gastric release, inducing fluid secretion into the small bowel to treat chronic idiopathic constipation. The ability of oral linaclotide to induce a pharmacodynamic response in epithelial cells of the colorectum in humans remains undefined. Here, we demonstrate that administration of 0.87 milligrams of oral linaclotide daily for 7 days to healthy volunteers, after oral colon preparation with polyethylene glycol solution (MoviPrep), activates GUCY2C, resulting in accumulation of its product cyclic (c)GMP in epithelial cells of the cecum, transverse colon, and distal rectum. GUCY2C activation by oral linaclotide was associated with homeostatic signaling, including phosphorylation of vasodilator-stimulated phosphoprotein and inhibition of proliferation quantified by reduced Ki67-positive epithelial cells. In the absence of the complete oral colonoscopy preparation, linaclotide did not alter cGMP production in epithelial cells of the colorectum, demonstrating that there was an effect related to the laxative preparation. These data show that the current FDA-approved formulation of oral linaclotide developed for small bowel delivery to treat chronic idiopathic constipation is inadequate for reliably regulating GUCY2C in the colorectum to prevent tumorigenesis. The study results highlight the importance of developing a novel GUCY2C agonist formulated for release and activity targeted to the large intestine for colorectal cancer prevention.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2otwera
via IFTTT

Comparison of self-reported signs of facial ageing among Caucasian women in Australia versus those in the USA, the UK and Canada

Abstract

Background/Objectives

Australians are more exposed to higher solar UV radiation levels that accelerate signs of facial ageing than individuals who live in temperate northern countries. The severity and course of self-reported facial ageing among fair-skinned Australian women were compared with those living in Canada, the UK and the USA.

Methods

Women voluntarily recruited into a proprietary opt-in survey panel completed an internet-based questionnaire about their facial ageing. Participants aged 18–75 years compared their features against photonumeric rating scales depicting degrees of severity for forehead, crow's feet and glabellar lines, tear troughs, midface volume loss, nasolabial folds, oral commissures and perioral lines. Data from Caucasian and Asian women with Fitzpatrick skin types I–III were analysed by linear regression for the impact of country (Australia versus Canada, the UK and the USA) on ageing severity for each feature, after controlling for age and race.

Results

Among 1472 women, Australians reported higher rates of change and significantly more severe facial lines ( 0.040) and volume-related features like tear troughs and nasolabial folds ( 0.03) than women from the other countries. More Australians also reported moderate to severe ageing for all features one to two decades earlier than US women.

Conclusions

Australian women reported more severe signs of facial ageing sooner than other women and volume-related changes up to 20 years earlier than those in the USA, which may suggest that environmental factors also impact volume-related ageing. These findings have implications for managing their facial aesthetic concerns.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2otEesf
via IFTTT

Free presentation helper



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nXbqVd
via IFTTT

Mit optional essay word doc



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2otqLAE
via IFTTT

Workplace Discrimination Laws & Policies | Human Rights

Need Industrial relations advice? Unfair dismissals laws? Discrimination in the workplace? Sexual harassment? We can help. AWNA is Australia's Leading non-lawyer

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1i0M0
via IFTTT

ST Food - The Straits Times

Topics covered include, but are not limited to, nudity, poo, road signs with rude names and a goldfish having an operation to remove a tumour.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nzedZC
via IFTTT

Phi Rho Pi National Forensic Organization - Home

Not Just a Recognition. Membership in Beta Gamma Sigma lasts a lifetime and provides benefits and opportunities that assist members throughout their careers.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1iLoD
via IFTTT

Proposed California Ballot Initiative That Would Lower

All those doubting Thomases about UT should leave those of us who are reaping the full benefits of UT alone to enjoy our hard earn dollars on the luxuries of life

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nzbq2B
via IFTTT

Descriptive Essay: A Beautiful Place :: Descriptive Essay

The purpose of a descriptive essay is to describe a person, place, or thing in such vivid detail that the reader can easily form a precise mental picture of what is

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1jJkx
via IFTTT

Transcendental Legacy: Transcendentalist Principles from

A biography of Henry David Thoreau (1817-1862), American writer, essayist, philosopher, poet, and pacifist. Henry was born on July 12, 1817 in Concord, Massachusetts.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nznCjF
via IFTTT

Where Speakers Showcase Talents and Organizations Find

Create your own comics online with ! This online comic generator from author Bill Zimmerman provides people of all ages affirmation of the human

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2pnzMZg
via IFTTT

/~ jik/src/Attic/kerberos_ password

Playlist files: DJ EGG's ECLECTIC MEGGAMUSIC PLAYLIST (In No Particular Order Of Preference) Approx. Sections - 1. Eclectic, Post-Rock, Lo-Fi, Synth+DreamPop, Trip

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olAngu
via IFTTT

Dynamic Drive- FavIcon Generator

Dynamic Drive CSS Library. Welcome to Dynamic Drive's new CSS library! Here you'll find original, practical CSS codes and examples such as CSS menus to give your site

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2pnzORc
via IFTTT

Essay heading: Descriptive Essay The Paramedic

is your one-stop source for Use our essays as frames of reference for research. For examples of Enter your essay topic in our

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olsnMI
via IFTTT

Problem Solving Worksheet 8D - The Quality Portal

INTRODUCTION The Importance of Collaborative Problem Solving 1. Collaborative Problem Solving (CPS) is a critical and necessary skill across educational

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2ot9ZSr
via IFTTT

AP Literature: Titles from Free Response Questions since 1971

This page lists some of the more interesting, esoteric and unusual scholarships FinAid has encountered. The scholarship for left-handed students is the one most

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1rFCj
via IFTTT

Grammar Bytes! :: The Verb

Detailed profiles of the 16 psychological types. Supports a very active email discussion group on psych type.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2ot9mZ9
via IFTTT

The Battle We Didn't Choose

Got a burning question or dilemma that you’d love more opinions/advice on, but maybe don’t want to attach your name to? Whether it’s sex, in-laws, friends

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p10NlY
via IFTTT

Minerva, símbolo das engenharias - Engenharia do

When you make pizza this good you are allowed to brag about it. Come try a square of the best pizza in Erie. Ohhh yeah, we have ice cream now too!

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oSPqQu
via IFTTT

The Time Machine Review - . Wells | Summary, Kindle

Celadon City (Japanese: タマムシシティ Tamamushi City) is located in central Kanto. It is the most populous city in Kanto and the eighth most

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nX6Ru6
via IFTTT

Equinox Voyages

Organized by subject and by course, Pepperdine University Libraries' InfoGuides bring together resources for conducting research at Pepperdine University

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oSSvj8
via IFTTT

Pawel stasiak thesis examples apa



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nX6vn3
via IFTTT

Right ventricular aneurysm in a double-chambered right ventricle presenting with endocarditis

Abstract

Right ventricular aneurysms are rare with few reported cases in literature, the etiology mainly being post surgical, traumatic, congenital, and infective. A 13-year-old female presented with fever. She had vegetations over the tricuspid valve on echocardiogram with an incidental finding of double chambered right ventricle (DCRV). After complete treatment of endocarditis, she underwent DCRV correction. During operation, an aneurysm was noticed over the right ventricle. This aneurysm was about 1 cm in diameter at right ventricular outflow tract (RVOT) and 1.5 cm proximal to the pulmonary valve. Surgical correction of DCRV with plication of the aneurysm was done successfully.



http://ift.tt/2p1gMAq

È in arrivo una nuova terapia per il tumore di testa e collo - Libero ... - LiberoQuotidiano.it


LiberoQuotidiano.it

È in arrivo una nuova terapia per il tumore di testa e collo - Libero ...
LiberoQuotidiano.it
Una nuova terapia immuno-oncologica ha ricevuto il parere favorevole del Comitato per i medicinali per uso umano (Chmp) dell'Agenzia europea per i farmaci ...

and more »


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1Cq7F
via IFTTT

Reactive Oxygen Species Shielding Hydrogel for the Delivery of Adherent and Nonadherent Therapeutic Cell Types

Tissue Engineering Part A , Vol. 0, No. 0.


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nz75MI
via IFTTT

In Situ Release of VEGF Enhances Osteogenesis in 3D Porous Scaffolds Engineered with Osterix-Modified Adipose-Derived Stem Cells

Tissue Engineering Part A , Vol. 0, No. 0.


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1i4eK
via IFTTT

Three-Dimensional Coculture of Meniscal Cells and Mesenchymal Stem Cells in Collagen Type I Hydrogel on a Small Intestinal Matrix—A Pilot Study Toward Equine Meniscus Tissue Engineering

Tissue Engineering Part A , Vol. 0, No. 0.


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nzeEmI
via IFTTT

Zukunft jetzt − Implementierung eines IT-gestützten Distress-Screenings

Zusammenfassung

Hintergrund

Eine bedarfsgerechte integrierte Mitbehandlung psychischer Belastungen und Störungen gehört zu den Herausforderungen einer modernen Krebsmedizin. Ohne standardmäßiges Screening auf psychischen Distress bleibt ein großer Teil der versorgungsbedürftigen Krebspatienten unerkannt. Mit der verpflichtenden Einführung von Distress-Screenings in die onkologische Routineversorgung entsteht für die deutschen Krebszentren ein erhöhter Dokumentationsaufwand. IT-gestützte Screening-Prozeduren können diesen kompensieren. Während die S3-Leitlinie Psychoonkologie Methoden und strukturelle Maßnahmen zur fachkundigen Umsetzung eines standardgemäßen Screenings beschreibt, fehlen bisher Handlungsempfehlungen zur Implementierung eines IT-gestützten Distress-Screenings.

Methoden

Es wurde ein Konsensusmeeting „IT-gestütztes Distress-Screening in der onkologischen Routineversorgung" durchgeführt.

Ergebnisse

Es wurden Konsensempfehlungen zur Implementierung und Nutzung IT-gestützter Distress-Screenings ausgearbeitet. Diese beziehen sich auf: 1) Vorbereitung der Implementierung, 2) IT-Ausstattung, 3) Implementierung, 4) Praktische Nutzung, 5) Qualitätssichernde Maßnahmen im Forschungskontext. Ausgewählte deutschsprachige Forschungsprojekte und aktuelle Entwicklungen in der klinischen Versorgungsforschung unterstreichen, welches Potenzial in der Zusammenführung von klinischer Expertise mit der Informationstechnologie steckt.

Schlussfolgerungen

Mit den Ergebnissen des Konsensusmeetings stehen nun ein Leitfaden und Kriterienkatalog für die Implementierung eines IT-basierten Distress-Screenings in der onkologischen Routineversorgung zur Verfügung. Die Umsetzung dieser Empfehlungen kann die Versorgungsqualität von Krebspatienten in Deutschland verbessern.



http://ift.tt/2oZKHJg

Alginate Nanoparticles Containing Curcumin and Resveratrol: Preparation, Characterization, and In Vitro Evaluation Against DU145 Prostate Cancer Cell Line

Abstract

Curcumin and resveratrol are naturally occurring polyphenolic compounds having anti-cancer potential. However, their poor aqueous solubility and bioavailability limit their clinical use. Entrapment of hydrophobic drugs into hydrophilic nanoparticles such as calcium alginate presents a means to deliver these drugs to their target site. Curcumin and resveratrol-loaded calcium alginate nanoparticles were prepared by emulsification and cross-linking process. The nanoparticles were characterized for particle size, zeta potential, moisture content, physical state of the drugs, physical stability, and entrapment efficiency. An UPLC method was developed and validated for the simultaneous analysis of curcumin and resveratrol. Alginate nanoformulation was tested for in vitro efficacy on DU145 prostate cancer cells. The particle size of the nanosuspension and freeze-dried nanoparticles was found to be 12.53 ± 1.06 and 60.23 ± 15 nm, respectively. Both DSC and powder XRD studies indicated that curcumin as well as resveratrol were present in a non-crystalline state, in the nanoparticles. The entrapment efficiency for curcumin and resveratrol was found to be 49.3 ± 4.3 and 70.99 ± 6.1%, respectively. Resveratrol showed a higher percentage of release than curcumin (87.6 ± 7.9 versus 16.3 ± 3.1%) in 24 h. Curcumin was found to be taken up by the cells from solution as well as the nanoparticles. Resveratrol had a poor cellular uptake. The drug-loaded nanoparticles exhibit cytotoxic effects on DU145 cells. At high concentration, drug solution exhibited greater toxicity than nanoparticles. The alginate nanoformulation was found to be safe for intravenous administration.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1vCHt
via IFTTT

Laparoscopic versus open incisional hernia repair: a retrospective cohort study with costs analysis on 269 patients

Abstract

Purpose

To compare clinical outcomes and institutional costs of elective laparoscopic and open incisional hernia mesh repairs and to identify independent predictors of prolonged operative time and hospital length of stay (LOS).

Methods

Retrospective observational cohort study on 269 consecutive patients who underwent elective incisional hernia mesh repair, laparoscopic group (N = 94) and open group (N = 175), between May 2004 and July 2014.

Results

Operative time was shorter in the laparoscopic versus open group (p < 0.0001). Perioperative morbidity and mortality were similar in the two groups. Patients in the laparoscopic group were discharged a median of 2 days earlier (p < 0.0001). At a median follow-up over 50 months, no difference in hernia recurrence was detected between the groups. In laparoscopic group total institutional costs were lower (p = 0.02). At Cox regression analysis adjusted for potential confounders, large wall defect (W3) and higher operative risk (ASA score 3–4) were associated with prolonged operative time, while midline hernia site was associated with increased hospital LOS. Open surgical approach was associated with prolongation of both operative time and LOS.

Conclusions

Laparoscopic approach may be considered safely to all patients for incisional hernia repair, regardless of patients' characteristics (age, gender, BMI, ASA score, comorbidities) and size of the wall defect (W2-3), with the advantage of shorter operating time and hospital LOS that yields reduced total institutional costs. Patients with higher ASA score and large hernia defects are at risk of prolonged operative time, while an open approach is associated with longer duration of surgical operation and hospital LOS.



http://ift.tt/2nX4ck7

Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris

Abstract

Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). Pravastatin treatment for 6 months, but not for 2 days, inhibited leukocyte activation and improved hemorheological parameters. In conclusion, pravastatin treatment for 6 months improved fasting and postprandial endothelial and hemorheological dysfunction in AP patients.



http://ift.tt/2o22EGs

Omeprazole Absorption and Fasting Gastrinemia After Roux-en-Y Gastric Bypass

Abstract

Purpose

Roux-en-Y gastric bypass (RYGB) is one of the bariatric surgeries most frequently performed worldwide. Since this operation may predispose to the formation of peptic ulcer of the gastrojejunal anastomosis, the use of proton pump inhibitors (PPI) is recommended during the first postoperative year. However, so far, there is no detailed knowledge about the absorption of this medication during the immediate postoperative period and consequently about its effectiveness in blocking acid secretion. The objective was to assess the possible endoscopic peptic changes, the absorption of omeprazole (OME), and the status of fasting gastrinemia before and after RYGB operation.

Materials and Methods

OME absorption, the production of its metabolites omeprazole sulfone (OMES) and 5-hydroxyomeprazole (HOME), and basal (fasting) gastrinemia were determined in patients submitted to RYGB before and 2 months after the operation. Upper digestive endoscopy (UDE) was also performed before and 6 months after the operation.

Results

Twenty patients were studied. Preoperatively, all these patients had some peptic changes and 55% tested positive for Helicobacter pylori. Six months after surgery, ten patients still showed endoscopic changes and one patient tested positive for H. pylori. During the postoperative period, there was a reduction of OME absorption and of the production of its metabolites 90 min after administration of the drug, and reduction of serum gastrin levels.

Conclusion

The standard OME dose (40 mg) administered after bariatric surgery is insufficient to achieve serum levels that can effectively block the production of hydrochloric acid, permitting the formation of peptic injuries in many patients.



http://ift.tt/2nX9nR3

Essays on Bad Effect Of Various Festival On The Environment

The Bulletin of the Atomic Scientists informs the public about threats to the survival and development of humanity from nuclear weapons, climate change, and emerging

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZzyuZ
via IFTTT

Play Free Sudoku, a Popular Online Puzzle Game | Play Free

Updated, March 2, 2017 | We published an updated version of this list, “401 Prompts for Argumentative Writing,” as well as a companion piece, “650

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nX2sY0
via IFTTT

/~ jik/src/Attic/kerberos_ password

Genki - An Integrated Course in Elementary Japanese Answer Key [Second Edition] (2011, E. Banno, Y. Ikeda, Y. Ohno, C. Shinagawa, K. Tokashiki)

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZyJm1
via IFTTT

ASAMPLE RESEARCH PAPER/THESIS/DISSERTATION ON ASPECTS OF

How to Write a Dissertation Abstract? Writing a dissertation without a well-completed abstract where you showcase and describe the essence of your work is impossible.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nX7949
via IFTTT

Administrative Assistant Resume Samples

Use this Administrative Assistant cover letter template as a base on which to develop your very own interview winning job application.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZpz99
via IFTTT

Calcium hydroxide has limited effectiveness in eliminating

A comprehensive business database containing thousands of journals including historical journals back to 1905. Covers business and economic conditions, corporate

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nz1pC9
via IFTTT

Cpt3 coursework examples of cover



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2pnrtg3
via IFTTT

Report Writing Service

Custom Writing Service You Can Trust Outstanding Custom Writing Services That Exceed Your Expectations. is a professional research paper, essay

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nz8rH7
via IFTTT

'E SVN: raster trunk/illume/dicts' - MARC

Most Common Text: Click on the icon to return to and to enjoy and benefit . the of and to a in that is was he for it with as his on be at by i this had

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2pnJ2g5
via IFTTT

Literature on Kite Musical Instruments, Aeolian

Yinyang (Yin-yang) Yinyang (yin-yang) is one of the dominant concepts shared by different schools throughout the history of Chinese philosophy. Just as with many

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1WGVK
via IFTTT

Essay Writing Service | Order research paper, dissertation

We know how difficult it is to write an essay. Get this FREE whitepaper on How to Write an Essay right away and sign up for our special offers.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oSNgQx
via IFTTT

Introduction Chapter Writing - Dissertation Editing

Past Dissertation Titles. Click on any of the table headers below to sort by that column. Outstanding Dissertation Award Winners 2010-2015

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1VAJG
via IFTTT

CAKIES

Musician's Friend adds a fresh Stupid Deal of the Day every day. These deals are in limited quantities so act now to get the best deals across every instrument category.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oSxntw
via IFTTT

Five Steps to Writing a Good For and Against Essay | Blog

Aplia significantly improves outcomes and elevates thinking by increasing student effort and engagement. Developed by teachers, Aplia assignments connect concepts to

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1H9pc
via IFTTT

Neiman Marcus Christmas Catalog: Outrageous Fantasy Gifts

Fighting Fantasy, The official home of the Fighting Fantasy series, online Gamebooks and Forum

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oSDsGq
via IFTTT

AWho' s Who of Tudor Women (T ) - Kate Emerson

The home of Classical Music. All information about classic music at a glance and a click. Videos, Photos, CDs, DVDs, BluRays, Tickets, Tourdaten, Merchandise, RSS

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1T9Xz
via IFTTT

13th Month Pay Law | Philippine Labor Laws

I had experienced DFA mobile passport and there’s no appointment; just bring complete documents and it’s done. I even got my passport renewal in a week back then.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2ol9XeE
via IFTTT

AMACOM | Publisher of Parenting, Health & Business Books

Genki - An Integrated Course in Elementary Japanese Answer Key [Second Edition] (2011, E. Banno, Y. Ikeda, Y. Ohno, C. Shinagawa, K. Tokashiki)

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p0SMxw
via IFTTT

Arvine Pipe and Supply Co.

Discover Deli with a Difference! Established in 1932, Deli Brands of America has a tradition of quality and value that is customers will taste the

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p0Xj2N
via IFTTT

Play Free Sudoku, a Popular Online Puzzle Game | Play Free

Free Persuasive essay example on obesity: healthy Food vs fast food

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p0W43R
via IFTTT

Critical role for complement receptor C5aR2 in the pathogenesis of renal ischemia-reperfusion injury [Research]

The complement system, and specifically C5a, is involved in renal ischemia-reperfusion (IR) injury. The 2 receptors for complement anaphylatoxin C5a (C5aR1 and C5aR2) are expressed on leukocytes as well as on renal epithelium. Extensive evidence shows that C5aR1 inhibition protects kidneys from IR injury; however, the role of C5aR2 in IR injury is less clear as initial studies proposed the hypothesis that C5aR2 functions as a decoy receptor. By Using wild-type, C5aR1–/–, and C5aR2–/– mice in a model of renal IR injury, we found that a deficiency of either of these receptors protected mice from renal IR injury. Surprisingly, C5aR2–/– mice were most protected and had lower creatinine levels and reduced acute tubular necrosis. Next, an in vivo migration study demonstrated that leukocyte chemotaxis was unaffected in C5aR2–/– mice, whereas neutrophil activation was reduced by C5aR2 deficiency. To further investigate the contribution of renal-expressed C5aR2 vs. leukocyte-expressed C5aR2 to renal IR injury, bone marrow chimeras were created. Our data show that both renal-expressed C5aR2 and leukocyte-expressed C5aR2 mediate IR-induced renal dysfunction. These studies reveal the importance of C5aR2 in renal IR injury. They further show that C5aR2 is a functional receptor, rather than a decoy receptor, and may provide a new target for intervention.—Poppelaars, F., van Werkhoven, M. B., Kotimaa, J., Veldhuis, Z. J., Ausema, A., Broeren, S. G. M., Damman, J., Hempel, J. C., Leuvenink, H. G. D., Daha, M. R., van Son, W. J., van Kooten, C., van Os, R. P., Hillebrands, J.-L., Seelen, M. A. Critical role for complement receptor C5aR2 in the pathogenesis of renal ischemia-reperfusion injury.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olespW
via IFTTT

Cyclic dinucleotides modulate induced type I IFN responses in innate immune cells by degradation of STING [Research]

The cyclic dinucleotides, GMP–AMP (cGAMP) and c-di-AMP [bis-(3',5')-cyclic dimeric AMP], are potent type I IFN inducers via STING-TBK1-IRF3 cascade. They are promising adjuvants that promote antigen-specific humoral and cellular immune responses in different preclinical models; however, an optimal outcome of vaccination depends on a balanced immune activation. Here, we characterize the process of IFN-β induction by c-di-AMP and cGAMP in an in vitro model on the basis of primary mouse dendritic cells. Results obtained show decreased IFN-β production upon prolonged cell stimulation. We demonstrate that this effect depends on c-di-AMP/cGAMP-mediated down-regulation of stimulator of IFN gene (STING) protein levels. These results were confirmed by using human peripheral blood mononuclear cell–derived dendritic cells. Studies performed to explore the potential mechanism of STING modulation suggested proteolytic degradation to be a contributing factor to the observed decrease in cellular STING levels. Our work contributes to the elucidation of the molecular mode of action of vaccine constituents, which, in turn, is a prerequisite for the rational design of vaccines with predictable efficacy and safety profiles—Rueckert, C., Rand, U., Roy, U., Kasmapour, B., Strowig, T., Guzmán, C. A. Cyclic dinucleotides modulate induced type I IFN responses in innate immune cells by degradation of STING.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nX49oj
via IFTTT

Geospatial Assessment of Cholera in a Rapidly Urbanizing Environment

This study mapped out and investigated the spatial relationship between cholera incidences and environmental risk factors in the study area. The study area was stratified into eight zones. Water samples from each zone were collected and analyzed to determine the colony forming units. GIS layers including housing density, digitized roads, rivers, buildings, and cholera incidence data from hospital archives were also collected and analyzed using ArcGIS 10.1. It was observed that there was an association between the ERFs (). Similarly, 18 out of the 44 waste dump sites, seven out of 18 markets, and two out of 36 abattoirs were found near the historical cholera cases. Similarly, 4 (21.1%) locations were traced to be predominantly close to rivers and waste dump site. All the historical cholera cases were found adjoining to roads and buildings. Highest CFU count was found in the wells and streams of areas with a cluster of all the environmental risk factors and high housing density. This study revealed that waste dump sites and market had the highest predisposing attribute while the least was abattoir. The uniqueness of the study lies in the combination of mapping and microbial analyses to identify and assess the pattern of cholera risk and also to provide clear information for development of strategies for environmental supervision.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1lb6A
via IFTTT

Angelica Sinensis Polysaccharide Prevents Hematopoietic Stem Cells Senescence in D-Galactose-Induced Aging Mouse Model

Age-related regression in hematopoietic stem/progenitor cells (HSC/HPCs) limits replenishment of the blood and immune system and hence contributes to hematopoietic diseases and declined immunity. In this study, we employed D-gal-induced aging mouse model and observed the antiaging effects of Angelica Sinensis Polysaccharide (ASP), a major active ingredient in dong quai (Chinese Angelica Sinensis), on the Sca-1+ HSC/HPCs in vivo. ASP treatment prevents HSC/HPCs senescence with decreased AGEs levels in the serum, reduced SA-β-Gal positive cells, and promoted CFU-Mix formation in the D-gal administrated mouse. We further found that multiple mechanisms were involved: (1) ASP treatment prevented oxidative damage as total antioxidant capacity was increased and levels of reactive oxygen species (ROS), 8-OHdG, and 4-HNE were declined, (2) ASP reduced the expression of γ-H2A.X which is a DNA double strand breaks (DSBs) marker and decreased the subsequent ectopic expressions of effectors in p16-RB and p19-p21 senescent pathways, and (3) ASP inhibited the excessive activation of Wnt/β-catenin signaling in aged HSC/HPCs, as the expressions of β-catenin, phospho-GSK-3β, and TCF-4 were decreased, and the cyto-nuclear translocation of β-catenin was inhibited. Moreover, compared with the positive control of Vitamin E, ASP exhibited a better antiaging effect and a weaker antioxidation ability, suggesting a novel protective role of ASP in the hematopoietic system.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olpfA5
via IFTTT

Interactions of Nitrogen Source and Rate and Weed Removal Timing Relative to Nitrogen Content in Corn and Weeds and Corn Grain Yield

Adequate fertility combined with effective weed management is important in maximizing corn (Zea mays L.) grain yield. Corn uptake of nitrogen (N) is dependent upon many factors including weed species and density and the rate and formulation of applied N fertilizer. Understanding interactions among corn, applied N, and weeds is important in developing management strategies. Field studies were conducted in North Carolina to compare corn and weed responses to urea ammonium nitrate (UAN), sulfur-coated urea (SCU), and composted poultry litter (CPL) when a mixture of Palmer amaranth (Amaranthus palmeri S. Wats.) and large crabgrass (Digitaria sanguinalis L.) was removed with herbicides at heights of 8 or 16 cm. These respective removal timings corresponded with 22 and 28 days after corn planting or V2 and V3 stages of growth, respectively. Differences in N content in above-ground biomass of corn were noted early in the season due to weed interference but did not translate into differences in corn grain yield. Interactions of N source and N rate were noted for corn grain yield but these factors did not interact with timing of weed control. These results underscore that timely implementation of control tactics regardless of N fertility management is important to protect corn grain yield.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1q6nV
via IFTTT

Obtuse Angle Prediction and Factor Evaluation for Image Reversible Data Hiding

A pixel-based pixel-value-ordering (PPVO) has been used for reversible data hiding to generate large embedding capacity and high-fidelity marked images. The original PPVO invented an effective prediction strategy in pixel-by-pixel manner. This paper extends PPVO and proposes an obtuse angle prediction (OAP) scheme, in which each pixel is predicted by context pixels with better distribution. Moreover, for evaluating prediction power, a mathematical model is constructed and three factors, including the context vector dimension, the maximum prediction angle, and the current pixel location, are analyzed in detail. Experimental results declare that the proposed OAP approach can achieve higher PSNR values than PPVO and some other state-of-the-art methods, especially in the moderate and large payload sizes.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olqfEB
via IFTTT

Mathematical Modeling for Risk Averse Firm Facing Loss Averse Customer’s Stochastic Uncertainty

To optimize the firm’s profit during a finite planning horizon, a dynamic programming model is used to make joint pricing and inventory replenishment decision assuming that customers are loss averse and the firm is risk averse. We model the loss averse customer’s demand using the multinomial choice model. In this choice model, we consider the acquisition and transition utilities widely used by a mental accounting theory which also incorporate the reference price and actual price. Then, we show that there is an optimal inventory policy which is base-stock policy depending on the accumulated wealth in each period.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p1a11B
via IFTTT

Can the Agent with Limited Information Solve Travelling Salesman Problem?

Here, we develop new heuristic algorithm for solving TSP (Travelling Salesman Problem). In our proposed algorithm, the agent cannot estimate tour lengths but detect only a few neighbor sites. Under the circumstances, the agent occasionally ignores the NN method (choosing the nearest site from current site) and chooses the other site far from current site. It is dependent on relative distances between the nearest site and the other site. Our algorithm performs well in symmetric TSP and asymmetric TSP (time-dependent TSP) conditions compared with the NN algorithm using some TSP benchmark datasets from the TSPLIB. Here, symmetric TSP means common TSP, where costs between sites are symmetric and time-homogeneous. On the other hand, asymmetric TSP means TSP where costs between sites are time-inhomogeneous. Furthermore, the agent exhibits critical properties in some benchmark data. These results suggest that the agent performs adaptive travel using limited information. Our results might be applicable to nonclairvoyant optimization problems.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olqe3v
via IFTTT

Multifunctional Telodendrimer Nanocarriers Restore Synergy of Bortezomib and Doxorubicin in Ovarian Cancer Treatment

We have developed multifunctional nanoparticles (NP) for co-delivery of bortezomib (BTZ) and doxorubicin (DOX) to synchronize their pharmacokinetic profiles and synergize their activities in solid tumor treatment, a need still unmet in the clinic. Micellar NP was formed by a spatially segregated, linear-dendritic telodendrimer containing three segments: a hydrophilic polyethylene glycol (PEG), a BTZ-conjugating intermediate, and a dendritic DOX-affinitive interior. BTZ-conjugated telodendrimers, together with DOX, self-assembled into monodispersed micelles (NP(BTZ-DOX)) with small particle sizes (20~30 nm) for dual drug delivery. NP(BTZ-DOX) displayed excellent drug loading capacity and stability, which minimized premature drug leakage and synchronized drug release profiles. BTZ release was accelerated significantly by acidic pH, facilitating drug availability in the acidic tumor microenvironment. Synergistic anticancer effects of combined BTZ and DOX were observed in vitro against both multiple myeloma and ovarian cancer cells. NP(BTZ-DOX) prolonged payload circulation and targeted tumors in vivo efficiently with superior signal ratios of tumor to normal organs. In vitro and in vivo proteasome inhibition analysis and biodistribution studies revealed decreased toxicity and efficient intratumoral BTZ and DOX delivery by nanoformulation. NP(BTZ-DOX) exhibited significantly improved ovarian cancer treatment in SKOV-3 xenograft mouse models in comparison with free drugs and their combinations, including BTZ and Doxil. In summary, tumor-targeted and synchronized delivery system elicits enhanced anticancer effects and merits further development in the clinical setting.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oltVWO
via IFTTT

Extracellular matrix/integrin signaling promotes resistance to combined inhibition of HER2 and PI3K in HER2+ breast cancer

PIK3CA mutations are associated with resistance to HER2-targeted therapies. We previously showed that HER2+/PIK3CAH1047R transgenic mammary tumors are resistant to the HER2 antibodies trastuzumab and pertuzumab but respond to PI3K inhibitor buparlisib (TPB). In this study, we identified mechanisms of resistance to combined inhibition of HER2 and PI3K. TPB-resistant tumors were generated by treating HER2+/PIK3CAH1047R mice long-term with the drug combination. RNA-sequencing of TPB-resistant tumors revealed that extracellular matrix (ECM) and cell adhesion genes, including collagen II (Col2a1), were markedly upregulated, accompanied by activation of integrin β1/Src. Cells derived from drug-resistant tumors were sensitive to TBP when grown in vitro, but exhibited resistance when plated on collagen or when re-introduced into mice. Drug resistance was partially reversed by the collagen synthesis inhibitor ethyl-3,4-dihydroxybenzoate (DHB). Inhibition of integrin β1/Src blocked collagen-induced resistance to TPB and inhibited growth of drug-resistant tumors. High collagen II expression was associated with significantly lower clinical response to neoadjuvant anti-HER2 therapy in HER2+ breast cancer patients. Overall, these data suggest that upregulation of collagen/integrin/Src signaling contributes to resistance to combinatorial HER2 and PI3K inhibition.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p17CDZ
via IFTTT

Interleukin-15 and cisplatin co-encapsulated thermosensitive polypeptide hydrogels for combined immuno-chemotherapy

Publication date: Available online 10 April 2017
Source:Journal of Controlled Release
Author(s): Xilong Wu, Yundi Wu, Hongbo Ye, Shuangjiang Yu, Chaoliang He, Xuesi Chen
In situ-forming thermosensitive hydrogels based on poly(ethylene glycol)-poly(γ-ethyl-l-glutamate) diblock copolymers (mPEG-b-PELG) were prepared for the co-delivery of interleukin-15 (IL-15) and cisplatin (CDDP). The polypeptide-based hydrogels as local drug delivery carriers could reduce the systemic toxicity, degrade thoroughly within 3weeks after subcutaneous injection into rats and display an acceptable biocompatibility. When incubated with mouse melanoma B16 cells, only the CDDP-treated groups had significant effects on the S phase cell-cycle arrest in melanoma cells. After a single peritumoral injection of the hydrogel containing IL-15/CDDP in C57BL/6 mice inoculated with B16F0-RFP melanoma cells, the dual drug-loaded hydrogels displayed synergistic anticancer efficacy, which was resulted from a combination of CDDP-mediated S arrest and IL-15/CDDP-induced recovery of CD8+ T cell and NK cell populations to reduce immunosuppression and enhance antitumor immunity. Hence, the as-prepared thermosensitive polypeptide hydrogels for localized and sustained co-delivery of IL-15 and CDDP may have potential for efficient treatment of melanoma.

Graphical abstract

image


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1X6eR
via IFTTT

MASTERS DEGREE PROGRAMS - Atlantic International University

The 25 Best Online MSW Programs: 100% online, regionally, and CSWE accredited schools you know and trust! Where will a Master of Social Work take you?

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZwTS4
via IFTTT

Creative Malaysia Training Center

Global Assignment Help: Assignments Writing Service for University Students in UK. We have team of expert writers to provide assignment help for your projects.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oldus4
via IFTTT

Essay Writing Service

Bar del Corso is a pizzeria, restaurant and bar in the Beacon Hill neighborhood of Seattle, featuring wood-fired pizza, and Italian small dishes.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1RdhS
via IFTTT

Essay writing - Monash University

Writing a Narrative composition appeals to one of humankind's basic instincts, the impulse to share stories. Sometimes the aim of the story-teller is simply to

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1YsGB
via IFTTT

Samples Essays and Commentary - CaMLA

If you're planning to apply for a college scholarship, you will probably need to submit an essay along with a resume, transcript and other background information.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olfp1n
via IFTTT

Key Research Documents and Guidelines - WRC Home

FETWATER Sustainability: Alignment with Sector Occupational and Professional Requirements is the key

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1ILiO
via IFTTT

How to Write the Perfect Reference Letter - WriteExpress

Learn how to write a reference letter. Professional writer Larry Barkdull shares must-know reference letter writing tips.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olbvWc
via IFTTT

Types of quantitative research question | Lærd Dissertation

quantitative research proposal. For example, Neugarten, et al. (1961) have noted that this approach is subject to the biases of those who define the

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1EiN0
via IFTTT

Pescador | Perception

Get specs, read and write reviews of the Perception Pescador Pro in the online Paddling Buyer's Guide by Rapid Media

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olaZrb
via IFTTT

Sample Business Plans and Templates to Download

SAMPLE BUSINESS CONTINUITY PLAN PREFACE The purpose of this plan is to define the recovery process developed to restore [your compnay]’s critical business functions.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1IZGl
via IFTTT

MEDIA@LSE MSc Dissertation Series Problematising The Self

MEDIA@LSE MSc Dissertation Series Problematising The Self-Representation Of Race And Gender In Vines: Who Has The Last Laugh

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oldZ70
via IFTTT

Evolution Quotes

How to Write a Problem Statement. This wikiHow will teach you how write a problem statement. === Writing Your Own Problem Statement ===

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1S41Y
via IFTTT

Vote for - Globolister

Plotter Paper for Wide Format Inkjet 20lb Inkjet CAD Bond 36 x 150 Foot Roll - 4 Roll Carton - FREE SHIPPING

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olc42n
via IFTTT

S5 National 5 — Millburn Academy

Verify Trigonometric Identities. How to verify trigonometric identities? Several examples with detailed solutions are presented. Since we will make use of the basic

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1QCNi
via IFTTT

Clauses: The Essential Building-Blocks

The introductory paragraph of any paper, long or short, should start with a sentence that piques the interest of your readers. Think of your first sentence as a hook

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olc3vl
via IFTTT

Education World: Tech Battle: Should Handwriting Still Be

Royalty-Free (RF) stock image gallery featuring clipart of Roses. This is page 1 of the cartoon pictures of Roses and vector graphics of Roses.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2o1QE7R
via IFTTT

:Academic Book & Abstract Publishers

umi dissertations publishing umi dissertations publishing Topics For Research Proposal Comparison Contrast Essay Outline FREE Online delivery; FREE Bibliography;

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2ol0IeM
via IFTTT

Hepatocellular Carcinoma in Children and Adolescents: Clinical Characteristics and Treatment

Abstract

Background

Hepatocellular carcinoma (HCC) occurs rarely in children and adolescents (C&A), and its clinical characteristics, prognostic factors, and treatment were rarely explored.

Methods

This retrospective study focused on 65 HCC patients aged ≤20 years from August 1994 to August 2012. Cox regression models and Kaplan–Meier curves were used to investigate prognostic factors and compare overall survival (OS), respectively.

Results

We found 61.5% of patients to have multiple tumors, 30.8% to have portal vein tumor thrombus, and 16.9% to have distant metastasis. Diameter of tumors was 10.2 ± 4.1 cm. OS at 5 years was 15.8%. Multivariate analyses showed initial treatment (P < 0.001) to be a predictor for OS. For moderate-stage HCC, the median OS of patients who underwent resection was longer than that of patients who underwent transarterial chemoembolization (TACE) or supportive treatment (ST) (P < 0.001). For advanced-stage HCC, the median OS of patients who underwent TACE was longer than that of patients who underwent ST (P = 0.045).

Conclusions

HCC in C&A tends to be more advanced than that in adults, and resection remains the mainstay of treatment for those patients. Moreover, compared with ST, TACE may benefit C&A with moderate- and advanced-stage HCC, which needs further study.



http://ift.tt/2ot0CCj

Asymptomatic Pancreatic Cancer: Does Incidental Detection Impact Long-Term Outcomes?

Abstract

Background

Detection of pancreatic ductal adenocarcinoma (PDAC) in asymptomatic patients is very rare, and the clinical implication of early detection of asymptomatic PDAC remains unclear.

Methods

This retrospective study included 569 consecutive patients with PDAC treated in our institution (250 underwent surgical resection and 319 had unresectable PDAC). The patients' demographics, tumor locations, pathologic stages, treatment, and overall survival (OS) were compared between the asymptomatic and symptomatic patients.

Results

In total, 163 (29%) patients presented without subjective symptoms. These patients had an earlier stage of PDAC on presentation (p < 0.001), higher resectability rate (64 vs. 36%, p < 0.001), and higher 5-year OS rate (18 vs. 7%, p < 0.001) than patients with symptoms. Among the patients who underwent resection, asymptomatic patients did not have a significantly higher chance of complete resection (88 vs. 78%, p = 0.06) or 5-year OS rate (23 vs. 22%, p = 0.09). However, symptomatic patients more often required complex operations such as concomitant vascular resection and reconstruction (57 vs. 29%, p < 0.001).

Conclusions

Asymptomatic PDAC is associated with better long-term outcomes than symptomatic PDAC because of the earlier stage at presentation and higher chance of resectability. Our findings highlight the potential implication of screening programs for early detection of PDAC in selected high-risk populations.



http://ift.tt/2nWMXzr

Fistulojejunostomy Versus Distal Pancreatectomy for the Management of the Disconnected Pancreas Remnant Following Necrotizing Pancreatitis

Abstract

Background

A disconnected distal pancreas (DDP) remnant is a morbid sequela of necrotizing pancreatitis. Definitive surgical management can be accomplished by either fistulojejunostomy (FJ) or distal pancreatectomy (DP). It is unclear which operative approach is superior with regard to short- and long-term outcomes.

Methods

Between 2002 and 2014, patients undergoing either FJ or DP for DDP were retrospectively identified at a center specializing in pancreatic diseases. Patient demographics, perioperative, and postoperative variables were evaluated.

Results

Forty-two patients with DDP secondary to necrotizing pancreatitis underwent either a FJ (n = 21) or DP (n = 21). Between the two cohorts, there were no significant differences in overall lengths of stay, pancreatic leak rates, or readmission rates (all p > 0.05). DP was associated with higher estimated blood loss, increased transfusion requirements, and worsening endocrine function (all p < 0.05). At a median follow-up of 18 months, four patients that underwent a FJ developed a recurrent fluid collection requiring re-intervention. Overall, FJ was successful in 80% of patients as compared to a 95% success rate for DP (p = 0.15).

Conclusions

Although DP was associated with higher intraoperative blood loss, increased transfusion requirements, and worsening of preoperative diabetes, this procedure provides superior long-term resolution of a DDP when compared to FJ.



http://ift.tt/2ot7EqF

Down-regulation of DLC1 in endothelial cells compromises the angiogenesis process

DLC1 is a RhoGAP-containing tumor suppressor that inhibits angiogenesis by repressing VEGF production in epithelial cells. Here we report the roles of DLC1 in endothelial cells. Silencing of DLC1 (siDLC1) enhances cell migration but reduces tube formation activities of human umbilical vein endothelial cells (HUVECs). Biochemically, RhoA activity and paxillin protein level are markedly increased in siDLC1 HUVECs. Although further silencing of RhoA restores the cell migration phenotype, the tube formation defect and up-regulated paxillin level remain unchanged.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nWVdiI
via IFTTT

Therapeutic effects of Argyrin F in pancreatic adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with limited treatment options. The proteasome inhibitor Argyrin A, a cyclic peptide derived from the myxobacterium Archangium gephyra, shows antitumoral activities. We hypothesize that his analogue Argyrin F (AF) may also prevent PDAC progression. We have used PDAC cells and engineered mice (Pdx1-Cre; LSL-KrasG12D; p53 lox/+) to assess AF anticancer activity. We analyzed the effect of AF on proliferation and epithelial plasticity using MTT-, wound healing-, invasion-, colony formation-, apoptosis-, cell cycle- and senescence assays.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olglCF
via IFTTT

ZEB1 induced miR-99b/let-7e/miR-125a cluster promotes invasion and metastasis in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the most common digestive tumors in Asia. Recent researches demonstrate that miRNAs are involved in the development of ESCC. In this study, we identified a miRNA cluster, termed miR-99b/let-7e/miR-125a as pro-metastasis oncomir. Overexpression of this miRNA cluster promoted ESCC cell migration and invasion in vitro and induced an experimental metastasis in vivo. ZEB1 was discovered to bind to the promoter region of miR-99b/let-7e/miR-125a cluster and regulate the expression of miRNAs at transcriptional level.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nX0CGt
via IFTTT

Adjunction of a MEK inhibitor to Vemurafenib in the treatment of metastatic melanoma results in a 60% reduction of acute kidney injury

Abstract

Introduction

A combined therapy MEK inhibitor, Cobimetinib (CB) and BRAF inhibitor, Vemurafenib (VMF), results in an improvement in progression-free survival among patients with BRAF V600-mutated metastatic melanoma. VMF skin adverse effects attributed to ERK paradoxical activation are decreased by the adjunction of CB. The aim of this study was to determine if this combination also improved the renal side effects of VMF.

Patients and methods

To investigate the incidence of acute kidney injury (AKI), we conducted a retrospective observational monocentric study in Lyon Sud University Hospital in France. We included 38 patients with metastatic BRAF-mutated melanomas treated by VMF and CB between March 2015 and June 2016. According to the NCI-CTCAE classification, AKI was defined as an increase in serum creatinine exceeding the baseline concentration by 1.5-fold. Serum creatinine was measured before treatment, then on a monthly basis during treatment, and 1 month after treatment discontinuation. Patients were divided into two main groups: AKI-positive (AKI+) and AKI-negative (AKI−), and further subdivided into three groups according to AKI severity (stage 1–5).

Results

Of 38 patients, 29 (76%) were AKI−, and all 9 AKI+ patients (24%) were diagnosed within the first trimester of treatment. Three-quarters of AKI (n = 7, 77%) had stage 1 AKI and the remaining 23% stage 2 AKI. Pre-treatment renal function was significantly better in AKI+ group: 105 vs. 80 ml/min/1.73m² AKI−, p = 0.009. Compared to previous results, the AKI incidence under the combined VMF–CB vs. VMF monotherapy was reduced by 60%.

Conclusion

We reported a reduced incidence and severity of nephrotoxicity of the association inhibitors of BRAF and MEK compared to a BRAF inhibitor monotherapy.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2nUT1bF
via IFTTT

A new species of Scopulariopsis and its synergistic effect on pathogenicity of Verticillium dahliae on cotton plants

S09445013.gif

Publication date: Available online 10 April 2017
Source:Microbiological Research
Author(s): Xiao-Lin Li, Mohammad Reza Ojaghian, Jing-Ze Zhang, Shui-Jin Zhu
A new species, Scopulariopsis gossypii, was found to be present in the vascular bundles of cotton plants (Gossypium hirsutum) infected by Verticillium dahliae which is an economically important pathogen in Hangzhou, China. The fungus was only present in the diseased plants, but it never became isolated from the healthy plants. Scanning electron microscopy showed that the fungus was present in parenchyma cells enclosing vessels in dark brown vascular tissues of stems, and produced asexual conidia within the tissues. Phylogenetic analysis of combined nuclear ribosomal D1/D2 region of the 28S rDNA as well as translation elongation factor 1-alpha (TEF1) and beta-tubulin (TUB) gene showed that S. gossypii represents an undescribed species of Scopulariopsis, Microascaceae. In this study, characteristics of sexual and asexual stages of the fungus were described, illustrated and compared with similar taxa. In addition, the molecular and morphological analyses indicated that S. gossypii was a distinct species of Scopulariopsis. The pathogenicity tests proved by inoculation of wounded roots confirmed that S. gossypii was an opportunistic pathogen causing leaf interveinal chlorosis and vascular browning of cotton plants. However S. gossypii did not infect host with undamaged roots. Moreover, coinoculation with S. gossypii and V. dahliae significantly increased disease severity.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZx0wX
via IFTTT

Michael Douglas says cancer saved his marriage - Starts at 60


Starts at 60

Michael Douglas says cancer saved his marriage
Starts at 60
The 72-year-old actor has opened up about how cancer changed his perspective on life and in turn saved his marriage. People Magazine reports Douglas told reporters at a TCM Classic Film Festival Q and A that his battle with an advanced tongue cancer ...
Michael Douglas: 'Cancer put my life and marriage into perspective'Hollywood.com
Michael Douglas says beating cancer helped save marriage to Catherine Zeta-Jones as it gave him "whole new ...Mirror.co.uk
Michael Douglas Says Surviving Cancer Fixed His Marriage With Catherine Zeta-JonesCelebrity Insider (blog)

all 11 news articles »


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2pnqexw
via IFTTT

Immunotherapy drug nivolumab ruled too costly for head and neck cancer patients - Belfast Telegraph


Belfast Telegraph

Immunotherapy drug nivolumab ruled too costly for head and neck cancer patients
Belfast Telegraph
Professor Kevin Harrington, from the Institute of Cancer Research, London, who led the UK arm of a Phase III trial looking at treating head and neck cancers with nivolumab, said: " It is disappointing and frustrating that today's decision means doctors ...
Nivolumab not recommend for relapsed or metastatic head-and-neck cancer on the NHSThe Institute of Cancer Research

all 2 news articles »


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p13G6w
via IFTTT

UK cost agency turns down Bristol drug for head and neck cancer - Reuters


UK cost agency turns down Bristol drug for head and neck cancer
Reuters
LONDON Britain's healthcare cost-effectiveness watchdog NICE said on Tuesday that Bristol-Myers Squibb's immunotherapy drug Opdivo was not worth using on the state health service for treating head and neck cancer due to its high price. The draft ...

and more »


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2olbrG3
via IFTTT

Effects of Early Smoking Habits on Young Adult Female Voices in Greece

Cigarette use is a preventable cause of mortality and diseases. The World Health Organization states that Europe and especially Greece has the highest occurrence of smoking among adults. The prevalence of smoking among women in Greece was estimated to be over 30% in 2012. Smoking is a risk factor for many diseases. Studies have demonstrated the association between smoking and laryngeal pathologies as well as changes in voice characteristics. The purpose of this study was to estimate the effect of early smoking habit on young adult female voices and if they perceive any vocal changes using two assessment methods.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2ol9p7j
via IFTTT

The Effects of Heel Height on Head Position, Long-Term Average Spectra, and Perceptions of Female Singers

Female singers often wear high heels for auditions and performances. Heel height research in non-singing contexts indicates that wearing heels can affect body alignment and head position. Studies in orthodontics, sleep apnea, and voice science suggest that head and neck positioning can alter the vocal tract. The purpose of this study was to assess the effects, if any, of heel height (barefoot, 10.16-cm stilettos) on three angles of singer head position (calculated from C7–tragus–nasion), long-term average spectra data, and perceptual data (questionnaire) acquired from female (N = 30) soloists during alternating periods of silence and singing.

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZCjfT
via IFTTT

Analysis of IMP-1 type metallo-β-lactamase-producing Acinetobacter radioresistens isolated from companion animals

Publication date: Available online 10 April 2017
Source:Journal of Infection and Chemotherapy
Author(s): Yui Kimura, Tadashi Miyamoto, Kotaro Aoki, Yoshikazu Ishii, Kazuki Harada, Masahisa Watarai, Shingo Hatoya
IMP-1 type metallo-β-lactamase-producing (MBL-producing) Acinetobacter radioresistens was isolated from a dog with cystitis and a cat with conjunctivitis. The MBL-producing A. radioresistens isolates were resistant to all of the β-lactam antibiotics used in the sensitivity tests, but were susceptible to gentamicin, amikacin, and minocycline. Also, one of the two strains of A. radioresistens was susceptible to ciprofloxacin and levofloxacin. These two cases were cured by administration of tetracyclines and fluoroquinolones, which elicited a positive result in the sensitivity tests. This report of the isolation of MBL-producing A. radioresistens in companion animals is the first in the world. To prevent the proliferation of MBL-producing bacteria, veterinary hospitals need to be aware of the behavior of MBL-producing organisms.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZfV6r
via IFTTT

An infant case with hydrocephalus as the initial manifestation of Mycoplasma hominis-associated meningitis

Publication date: Available online 10 April 2017
Source:Journal of Infection and Chemotherapy
Author(s): Keisuke Taku, Takayuki Hoshina, Kaoru Haro, Shun Ichikawa, Tadamune Kinjo, Mayu Takahashi, Daisuke Akiba, Kazumasa Fukuda, Koichi Kusuhara
We report an infant with hydrocephalus as the initial manifestation of Mycoplasma hominis-associated meningitis, who recovered without appropriate antimicrobial treatment. The analysis of the 16S rRNA gene by polymerase chain reaction amplification using universal primers and pathogen-specific primers was useful for the diagnosis and the investigation of serial detection status of the pathogen. This method may be helpful for the assessment of the frequency and the prediction of severity in M. hominis-associated central nervous system infection in infants, and investigating the association between M. hominis and the development of hydrocephalus.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2p18vN2
via IFTTT

Pharmacokinetics of linezolid during continuous hemodiafiltration: A case report

Publication date: Available online 10 April 2017
Source:Journal of Infection and Chemotherapy
Author(s): Takuya Yamashina, Moeko Tsuruyama, Miki Odawara, Minako Tsuruta, Hirochika Miyata, Aki Kozono, Yasuhiro Tsuji, Takanori Miyoshi, Yosei Kawamata, Yoichi Hiraki
The pharmacokinetics of linezolid clearance (CLLZD) during continuous hemodiafiltration (CHDF) has not been comprehensively analyzed. Here, we examined CLLZD by CHDF in a patient with septic shock and disseminated intravascular coagulation due to methicillin-resistant Staphylococcus aureus. The extraction ratio of LZD by CHDF was 22.6%, and the protein-binding rate was 17.9% ± 7.7%. In addition, it was determined that the calculated total body clearance of LZD was 30.2 mL/min, plasma elimination half-life was 8.66 h, and the CLLZD by the dialyzer used for CHDF was 23.0 mL/min. From the obtained pharmacokinetics, the CLLZD of patients continuing CHDF was estimated to be approximately half of the reported CLLZD for healthy subjects. In addition, the LZD concentration of the sepsis patient who underwent CHDF remained higher than the minimum inhibitory concentration and was similar to the LZD concentrations reported in normal renal function patients. Although further studies are warranted, when LZD is administered to patients treated with CHDF, the present findings suggest that dose regulation is not required.



from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oZvpY6
via IFTTT

Δημοφιλείς αναρτήσεις