Levels of Triamcinolone Acetonide in Human Perilymph and Plasma After Intratympanic Application

xlomafota13 shared this article with you from Inoreader Levels of Triamcinolone Acetonide in Human Perilymph and Plasma After Intratympanic Application Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This randomized clinical trial compares levels of triamci nolone acetonide in perilymph and plasma after intratympanic injection. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Nonsurgical Risk Factors Associated With Pharyngocutaneous Fistula After Laryngectomy

xlomafota13 shared this article with you from Inoreader Nonsurgical Risk Factors Associated With Pharyngocutaneous Fistula After Laryngectomy Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This multicenter cohort study of adult patients with lary ngeal cancer uses data from a national database to identify nonclinical risks associated with the formation of pharyngocutaneous fistula after total laryngectomy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Hearing Loss and Impaired Physical Function, Frailty, and Disability in Older Adults

xlomafota13 shared this article with you from Inoreader Hearing Loss and Impaired Physical Function, Frailty, and Disability in Older Adults Via JAMA Otolaryngology–Head & Neck Surgery Current Issue This cross-sectional study examines the association betwe en hearing loss and impaired lower extremity function, frailty syndrome, and disability in older adults. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Huge solitary necrotic nodule of the liver: a rare case report with review of literature

xlomafota13 shared this article with you from Inoreader Huge solitary necrotic nodule of the liver: a rare case report with review of literature Via International Journal of Clinical and Experimental Pathology Int J Clin Exp Pathol. 2021 Oct 15;14(10):1065-1068. eCollection 2021. ABSTRACT Solitary necrotic nodule of the liver (SNNL) is an uncommon disease in clinical practice, and its pathogenesis is still unclear. Here, we report the case of a 35-year-old woman. After physical examination, the patient was found to have a liver neoplasm, and there were no other physical complaints. Abdominal contrast-enhanced computed tomography (CT) showed the presence of a hypodense lesion. The patient opted for surgery to eliminate the lesion. Pathologic examination revealed an isolated necrotic nodular lesion with a size of 12 cm×10 cm×10 cm. The patient had a history of hepatitis B infection. To our knowledge, this is the largest SNNL ever reported and the first case with a history of hepatitis B infection. PMID:34760044 | PMC:PMC8569308 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Thyroid Eye Disease Treatment with Intravenous Glucocorticoids Is Improved by the Addition of Atorvastatin

xlomafota13 shared this article with you from Inoreader Thyroid Eye Disease Treatment with Intravenous Glucocorticoids Is Improved by the Addition of Atorvastatin Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 11, Page 474-476, November 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Overt Hyperthyroidism May Be a Good Prognostic Sign in Immune Checkpoint Inhibitor Treatment

xlomafota13 shared this article with you from Inoreader Overt Hyperthyroidism May Be a Good Prognostic Sign in Immune Checkpoint Inhibitor Treatment Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 11, Page 467-469, November 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A Possible Role for Serum Thyroglobulin to Predict Structural Recurrence of Papillary Thyroid Cancer After Thyroid Lobectomy

xlomafota13 shared this article with you from Inoreader A Possible Role for Serum Thyroglobulin to Predict Structural Recurrence of Papillary Thyroid Cancer After Thyroid Lobectomy Via Clinical Thyroidology Clinical Thyroidology, Volume 33, Issue 11, Page 497-499, November 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Geographic Barriers Affect Follow‐Up Care in Head and Neck Cancer

xlomafota13 shared this article with you from Inoreader Geographic Barriers Affect Follow‐Up Care in Head and Neck Cancer Via The Laryngoscope Objectives/Hypothesis Follow-up care in head and neck cancers (HNC) is critical in managing patient health. However, social determinants of health (SDOH) can create difficulties in maintaining follow-up care. The study goal is to explore how SDOH impacts maintenance of HNC follow-up care appointments. Methods A systematic retrospective chart review of 877 HNC patients diagnosed in the past 10 years a safety-net tertiary care hospital with systems to help reduce care disparities. Cohort groups were identified and compared against protocols for follow-up. Data were analyzed using analysis of variance, chi-square tests, Fisher's exact tests, two-sample t-tests, and simple linear regression. Results The average length of follow-up time in months and average total number of follow-ups over 5 years were 32.96 (34.60) and 9.24 (7.87), respectively. There was no significant difference in follow-up care between United States (US) versus non-US born and English versus non-English speaking patients. Race/ethnicity, county median household income, insurance status, and county educational attainment were not associated with differences in follow-up. However, living a greater distance from the hospital was associated with lower follow-up length and less frequency in follow-up (P < .0001). Conclusion While income, primary language, country of birth, race/ethnicity, insurance status, and markers of educational attainment do not appear to impact HNC follow-up at our safety-net, tertiary care institution, and distance from hospital remains an important contributor to disparities in care. This study shows that many barriers to care can be addressed in a model that addresses SDOH, but there are barriers that still require additional systems and resources. Laryngoscope, 2021 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

XB130 Deficiency Causes Congenital Hypothyroidism in Mice due to Disorganized Apical Membrane Structure and Function of Thyrocytes

xlomafota13 shared this article with you from Inoreader XB130 Deficiency Causes Congenital Hypothyroidism in Mice due to Disorganized Apical Membrane Structure and Function of Thyrocytes Via liebertpub1 Thyroid, Volume 31, Issue 11, Page 1650-1661, November 2021. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity

xlomafota13 shared this article with you from Inoreader MicroRNA profiling of psoriatic skin identifies 11 miRNAs associated with disease severity Via Experimental Dermatology Abstract MicroRNAs (miRNAs) are small non-coding RNAs that have emerged as central regulators of gene expression and powerful biomarkers of disease. Much is yet unknown about their role in psoriasis pathology. To globally characterize the miRNAome of psoriatic skin, skin biopsies were collected from psoriatic cases (n = 75) and non-psoriatic controls (n = 46) and RNA sequenced. Count data was meta-analyzed with a previously published dataset (cases, n = 24, controls, n = 20), increasing the number of psoriatic cases four-fold from previously published studies. Differential gene expression analyses were performed comparing lesional psoriatic (PP), non-lesional psoriatic (PN) and control (NN) skin. Further, functional enrichment and cell-specific analyses were performed. Across all contrasts, we identified 439 significantly differentially expressed miRNAs (DEMs), of which 85 were novel for psoriasis and 11 were related to disease severity. Meta-analyses identified 20 DEMs between PN and NN, suggesting an inherent change in the constitution of all skin in psoriasis. By integrating the miRNA transcriptome with mRNA target interactions, we identified several functionally enriched terms, including 'thyroid hormone signaling', 'insulin resistance' and various infectious diseases. Cell-specific expression analyses revealed that the upregulated DEMs were enriched in epithelial and immune cells. This study provides the most comprehensive overview of the miRNAome in psoriatic skin to date and identifies a miRNA signature related to psoriasis severity. Our results may represent molecular links between psoriasis and related comorbidities and have outlined potential directions for future functional studies to identify biomarkers and treatment targets. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

IFN‐γ‐induced PD‐L1 expression on human melanocytes is impaired in vitiligo

xlomafota13 shared this article with you from Inoreader IFN‐γ‐induced PD‐L1 expression on human melanocytes is impaired in vitiligo Via Experimental Dermatology ABSTRACT Mounting evidence shows that the PD-1/PD-L1 axis is involved in tumor immune evasion. This is demonstrated by anti-PD-1 antibodies that can reverse tumor-associated PD-L1 to functionally suppress anti-tumor T cell responses. Since type I and II interferons are key regulators of PD-L1 expression in melanoma cells and IFN-γ-producing CD8+ T cells and IFN-α-producing dendritic cells are abundant in vitiligo skin, we aimed to study the role of PD-1/PD-L1 signaling in melanocyte destruction in vitiligo. Moreover, impaired PD-1/PD-L1 function is observed in a variety of autoimmune diseases. It is therefore hypothesized that manipulating PD-1/PD-L1 signaling might have therapeutic potential in vitiligo. PD-1+ T cells were abundantly present in situ in perilesional vitiligo skin, but expression of PD-L1 was limited and confined exclusively to dermal T cells. More specifically, neither melanocytes nor other epidermal skin cells expressed PD-L1. Exposure to IFN-γ, but also type I interferons, increased PD-L1 expression in primary melanocytes and fibroblasts, derived from healthy donors. Primary human keratinocytes only showed increased PD-L1 expression upon stimulation with IFN-γ. Most interestingly, melanocytes derived from non-lesional vitiligo skin showed no PD-L1 upregulation upon IFN-γ exposure, while other skin cells displayed significant PD-L1 expression after exposure. In a vitiligo skin explant model, incubation of non-lesional vitiligo skin with activated (IFN-γ-producing) T cells from vitiligo lesions was previously described to induce melanocyte apoptosis. Although PD-L1 expression was induced in epidermal cells in these explants, this induction was completely absent in melanocytes. The lack of PD-L1 upregulation by melanocytes in the presence of IFN-γ-producing T cells shows that melanocytes lack protection against T cell attack during vitiligo pathogenesis. Manipulating PD-1/PD-L1 signaling may therefore be a therapeutic option for vitiligo patients. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.