Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis

alwin shared this article with you from Inoreader Protective effects of the notoginsenoside R1 on acute lung injury by regulating the miR-128-2-5p/Tollip signaling pathway in rats with severe acute pancreatitis Via Innate Immunity In this study, we explored the pulmonary protective effect and the underlying mechanism of the NG-R1 on rats with ALI induced by severe acute pancreatitis (SAP). MiR-128-2-5p, ERK1, Tollip, HMGB1, TLR4, IκB, and NF-κB mRNA expression levels were measured using real-time qPCR, and TLR4, Tollip, HMGB1, IRAK1, MyD88, ERK1, NF-κB65, and P-IκB-α protein expression levels using Western blot. The NF-κB and the TLR4 activities were determined using immunohistochemistry, and TNF-α, IL-6, IL-1β, and ICAM-1 levels in the bronchoalveolar lavage fluid (BALF) using ELISA. Lung histopathological changes were observed in each group. NG-R1 treatment reduced miR-128-2-5p expression in the lung tissue, increased Tollip expression, inhibited HMGB1, TLR4, TRAF6, IRAK1, MyD88, NF-κB65, and p-IκB-α ex... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Improved Quality of Living following Simultaneous Condylectomy and Orthognathic Surgery: A Retrospective Analysis for Active Unilateral Condylar Hyperplasia

alwin shared this article with you from Inoreader Improved Quality of Living following Simultaneous Condylectomy and Orthognathic Surgery: A Retrospective Analysis for Active Unilateral Condylar Hyperplasia Via Journal of Oral and Maxillofacial Surgery The objective was to assess quality of life in patients who underwent simultaneous condylectomy and orthognathic surgery in conjunction with orthodontic treatment for active unilateral condylar (TMJ) hyperplasia. This pathologic process leads to the development of esthetic and functional concerns. High condylectomy (7-10mm of bone removed from condylar process) simultaneously performed with orthognathic surgery is the treatment studied1, but currently, there is no published literature that analyzes patient satisfaction. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Are Bacteria Just Bystanders in the Pathogenesis of Inflammatory Jaw Conditions?

alwin shared this article with you from Inoreader Are Bacteria Just Bystanders in the Pathogenesis of Inflammatory Jaw Conditions? Via Journal of Oral and Maxillofacial Surgery It is unclear whether certain bacteria initiate the development of inflammatory jaw conditions, or whether these diseases create a milieu for dysbiosis and secondary colonization of indigenous flora. At present, there are no comparative studies on the types of bacteria that colonize different inflammatory jaw conditions. Accordingly, this study aims to identify and compare the types of bacteria isolated in osteomyelitis, osteoradionecrosis, and MRONJ. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Oral Rehabilitation of an Adult Cleft Palate Patient with Zygomatic Implant-supported Obturator Prosthesis: A Case Report

alwin shared this article with you from Inoreader Oral Rehabilitation of an Adult Cleft Palate Patient with Zygomatic Implant-supported Obturator Prosthesis: A Case Report Via Journal of Oral and Maxillofacial Surgery With advancement in medical services and their accessibility across the country, as well as growing awareness among the patient population, it is rare to find an adult with an untreated cleft lip and/or palate nowadays. Treatment of these patients to restore form and function can be challenging, often yielding less-than-satisfactory outcomes. In current literature, there have been case reports of patients with atrophic maxilla or severe maxillary defects after oncologic resections, where zygomatic implants have been utilized for fabrication of a fixed maxillary prosthesis. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Intraoperative flap warming: The novel use of a sterile cardiac forced warm air blanket for maintaining optimal flap perfusion.

alwin shared this article with you from Inoreader Intraoperative flap warming: The novel use of a sterile cardiac forced warm air blanket for maintaining optimal flap perfusion. Via Journal of Oral and Maxillofacial Surgery The two-team approach in major head and neck/reconstructive surgery can occasionally lead to delays between flap harvest and detachment, due to the complexity and length of the ablative procedure. In order to minimize the potential for flap cooling and the adverse impact on microcirculation, active warming can be beneficial.(1) Intraoperative flap warming to either maintain or improve circulation during free flap harvesting has been performed with a variety of passive and active techniques,(2) however limitations such as a lack of consistent temperature regulation, lack of sterility, inability to directly visualise the flap or the need for acquisition of new equipment for a niche area meant that an ideal solution was lacking. (Source: Journal of Oral and Maxillofacial Surgery) View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.