Τετάρτη 24 Αυγούστου 2022

Could Tailored Chirp Stimuli Benefit Measurement of the Supra-threshold Auditory Brainstem Wave-I Response?

alexandrossfakianakis shared this article with you from Inoreader
This study aimed to test previous claims that ABR latency dispersion differs between waves I and V, and between males and females, and thus that using wave- and/or sex-tailored chirps may provide more reliable wave-I benefit . Using the derived-band technique, we measured responses from frequency-restricted (one-octave-wide) cochlear regions to energy-matched click and chirp stimuli. The derived-band responses' latencies were used to assess any wave- and/or sex-related dispersion differences across bands, and their am plitudes, to evaluate any within-band dispersion differences. Our results suggest that sex-related dispersion difference within the lowest-frequency cochlear regions (<  1 kHz), where dispersion is generally greatest, may be a predominant driver of the often-reported ...
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Langerhans cell histiocytosis of the hard palate in an infant

alexandrossfakianakis shared this article with you from Inoreader

Publication date: Available online 24 August 2022

Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

Author(s): Takeshi Togawa, Akinari Sugauchi, Kaori Oya, Yusuke Yokota, Emiko Tanaka Isomura

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Prior exposure to azithromycin and azithromycin resistance among persons diagnosed with Neisseria gonorrhoeae infection at a Sexual Health Clinic 2012-2019

alexandrossfakianakis shared this article with you from Inoreader

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Abstract
Background
There is conflicting evidence on whether prior azithromycin (AZM) exposure is associated with reduced susceptibility to AZM (AZMRS) among persons infected with Neisseria gonorrhoeae (NG).
Methods
The study population included Public Health-Seattle & King County Sexual Health Clinic (SHC) patients with culture-positive NG infection at ≥1 anatomic site whose isolates were tested for AZM s usceptibility 2012-2019. We used multivariate logistic regression to examine the association of time since last AZM prescription from the SHC in ≤12 months with subsequent diagnosis with AZMRS NG (minimum inhibitory concentration [MIC] ≥2.0 µg/ml) and used linear regression to assess the association between number of AZM prescriptions in ≤12 months and AZM MIC level, controlling for demographic, behavioral, and clinical characteristics.
Results
A total of 2,155 unique patients had 2,828 incident NG infections, 156 (6%) of which were caused by AZMRS NG. AZMRS NG was strongly associated with receipt of AZM from the SHC in the prior 29 days (adjusted odds ratio [aOR] 6.76, 95% CI 1.76-25.90), but not with receipt of AZM in the prior 30-365 days. Log AZM MIC level was not associated with the number of AZM prescriptions within ≤12 months (Adjusted correlation [aCor] 0.0004, 95% CI -0.04, 0.037), but was associated with number of prescrip tions with <30 days (adjusted coefficient [aCoef] 0.56, 95% CI 0.13-0.98)
Conclusion
Recent individual-level AZM treatment is associated with subsequent AZMRS gonococcal infections. The long half-life and persistence of subtherapeutic levels of AZM may result in selection of resistant NG strains in persons with recent AZM use.
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Variability in the Estimated Amplitude of Vowel-Evoked Envelope Following Responses Caused by Assumed Neurophysiologic Processing Delays

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AbstractVowel-evoked envelope following responses (EFRs) reflect neural encoding of the fundamental frequency of voice (f0). Accurate analysis of EFRs elicited by natural vowels requires the use of methods like the Fourier analyzer (FA) to consider the production-relatedf0 changes. The FA 's accuracy in estimating EFRs is, however, dependent on the assumed neurophysiological processing delay needed to time-align thef0 time course and the recorded electroencephalogram (EEG). For male-spoken vowels (f0 ~ 100 Hz), a constant 10-ms delay correction is often assumed. Since processing delays vary with stimulus and physiological factors, we quantified (i) the delay-related variability that would occur in EFR estimation, and (ii) the influence of stimulus frequency, non-f0 related neural ac...
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