Τρίτη 19 Απριλίου 2022

Study of effect of nimodipine and acetaminophen on postictal symptoms in depressed patients after electroconvulsive therapy (SYNAPSE)

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Postictal phenomena as delirium, headache, nausea, myalgia, and anterograde and retrograde amnesia are common manifestations after seizures induced by electroconvulsive therapy (ECT). Comparable postictal phen...
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FDG PET/CT Image of Soft Tissue Aneurysmal Bone Cyst

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imageSoft tissue aneurysmal bone cyst is very rare. Herein, we report FDG PET/CT findings of aneurysmal bone cyst in a 19-year-old man. On conventional image, it presented as a paravertebral soft tissue mass with heterogeneous enhancement and rim eggshell-like calcification. On PET/CT, this solitary lesion had intense FDG uptake with an SUVmax of 10.33. The final pathology supported a diagnosis of aneurysmal bone cyst. Our case suggests that soft tissue aneurysmal bone cyst should be regarded as a differential diagnosis of solitary paravertebral mass with intense FDG uptake.
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Systematic review of neuroendocrine carcinomas of the oropharynx

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Abstract

Data describing features and management of oropharyngeal neuroendocrine carcinomas (NEC) remain sparse. A systematic review was performed. Patients were stratified by treatment modality and examined for disease progression and survival outcomes. Ninety-four patients from 50 publications were included. Average age at diagnosis was 59.7 years (range 14–83). 73.4% were male. Most studies did not document HPV status. Forty patients (85.1%) were p16 positive, and 34 (85.0%) were HPV-ISH positive. Overall survival was 75.4% at 1 year, and 40.0% at 2 years. Of patients with locoregional disease, 33.8% developed distant metastasis. 12.5% of patients developed locoregional recurrence. Patients who developed distant metastases had worse overall survival (p = 0.0004). No significant difference was found between treatment modalities. Human papilloma virus may be associated with oropharyngeal NEC. Current treatments provide locoregional control, but distant metastas es are common and confer low overall survival.

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Anal human papillomavirus infection in kidney transplant recipients compared with immunocompetent controls

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Abstract
Background
Kidney transplant recipients (KTRs) have increased risk of human papillomavirus (HPV)-related anogenital (pre-)cancers, including anal high-grade intraepithelial lesions (HSIL) and cancer. Previous studies on anal high-risk HPV among KTRs are sparse.
Methods
In a cross-sectional study, we included 247 KTRs and 248 controls from a dermatology department and five nephrology departments in Denmark during 2016–2017. All participants underwent a n anal cytobrush sample which was tested for HPV-DNA. Participants completed a questionnaire on lifestyle and sexual habits. We used logistic regression to estimate odds ratios (ORs) of anal hrHPV in KTRs compared with controls and risk factors for anal hrHPV in KTRs.
Results
The anal hrHPV prevalence was higher in female KTRs (45.5%) than controls (27.2%). Female KTRs had almost three-fold higher adjusted odds of anal hrHPV than controls (ORadjusted = 2.87, 95% confidence interval[CI], 1.57–5.22). In contrast, among men we did not observe increased prevalence or odds of anal hrHPV in KTRs compared with controls (prevalence: 19.4% vs 23.6%; ORadjusted = 0.85, 95%CI, 0.44–1.64). Among hrHPV positive KTRs, 63% and 52% of men and women, respectively, were infected with hrHPV types covered by the nonavalent HPV vaccine (16/18/31/33/45/52/58). Current smoking, >10 lifetime sexual partners, history of genital warts, and among men having had re ceptive anal sex, were risk factors for anal hrHPV in KTRs.
Conclusion
Female KTRs had increased risk of anal hrHPV compared with immunocompetent controls. Our findings highlight that pre-transplant HPV vaccination should be considered to prevent anal HSIL and cancer caused by anal hrHPV infection in KTRs.
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Subsequent anti-myeloma therapy after idecabtagene vicleucel treatment in patients with relapsed/refractory multiple myeloma: A single center analysis

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Blood Cancer Journal, Published online: 19 April 2022; doi:10.1038/s41408-022-00662-0

Subsequent anti-myeloma therapy after idecabtagene vicleucel treatment in patients with relapsed/refractory multiple myeloma: A single center analysis
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Three-dimensional volumetric analysis of the efficiency of marsupialization in patients with mandibular dentigerous cysts involving impacted third molars

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Publication date: Available online 18 April 2022

Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

Author(s): Masatoshi Hirayama, Kazushige Inoue, Hidetaka Arita, Nozomu Takahashi, Hikaru Nakashima, Junki Sakata, Manabu Maeshiro, Yuka Nagao, Shunsuke Gohara, Keisuke Yamana, Yuichiro Matsuoka, Akira Yuno, Masafumi Nakamoto, Kenta Kawahara, Masashi Nagata, Akiyuki Hirosue, Daiki Fukuma, Ryoji Yoshida, Hideki Nakayama

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Reconstruction of Segmental Mandibular Defects with Use of Avascular Fibula Grafts

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Functional and cosmetic defects involving the maxillofacial complex may result from traumatic injury, developmental deformities, infections, and iatrogenic injury. Reconstruction of large segmental defects with the use of vascularized free flaps has been considered the gold standard in recent years. There are many logistical and economic considerations with vascularized free flaps, and therefore the authors aim to discuss an alternative. After appropriate patient selection, the use of non-vascularized reconstruction techniques has been shown to be effective. (Source: Journal of Oral and Maxillofacial Surgery)
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Mortality and Associated Variables of Full-mouth Extractions

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Full-mouth extractions (FMEs) are common procedures that are classically performed electively due to caries and periodontal disease. Up to 17% of adults over the age of 65 and 2% of adults aged 20-64 in the United States are edentulous. At the University of Cincinnati Medical Center, approximately 250 FMEs are performed annually with nearly half performed on adults over the age of 50. There is currently an absence of data on this patient population and their overall outcomes. The authors hypothesize that FMEs are often performed on socioeconomically and medically vulnerable populations, thereby further compromising their conditions and potentially contributing to their demise. (Source: Journal of Oral and Maxillofacial Surgery)
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