Laryngotracheal stenosis: Mechanistic review

alexandrossfakianakis shared this article with you from Inoreader Laryngotracheal stenosis: Mechanistic review Via Head & Neck Abstract Background The purpose of this review article is to summarize the existing literature surrounding wound healing mechanisms in laryngotracheal stenosis. Methods A review of general wound healing pathophysiology, followed by a focused review of iatrogenic laryngotracheal stenosis (iLTS) and idiopathic subglottic stenosis (iSGS) as conditions of aberrant wound healing. Results iLTS is the scarring of the laryngotracheal complex, coming secondary to injury from prolonged intubation. iSGS is a chronic fibroinflammatory scarring and narrowing of the subglottic airway in the absence of any obvious preceding injury or trauma. They are both thought to result from a prolonged and dysregulated wound healing response that promotes the deposition of pathologic scar in the airway. Conclusions Understanding the mechanisms that underlie wound healing will help identify and intervene on the process early in its development and discover future therapies that target individual wound healing mechanisms limiting the incidence of this recalcitrant disease process. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Linear mixed model analysis to evaluate correlations between remdesivir adverse effects with age and gender of patients with mild Covid‐19 pneumonia

alexandrossfakianakis shared this article with you from Inoreader Linear mixed model analysis to evaluate correlations between remdesivir adverse effects with age and gender of patients with mild Covid‐19 pneumonia Via Journal of Medical Virology Abstract We aimed to assess longitudinal changes in clinical indexes of Covid-19 patients with mild pulmonary infection during 5 days of remdesivir therapy, and determine the effect of age and gender on remdesivir adverse effects (AE). Patients' clinical data including inflammatory markers, liver and renal function tests, and heart rate (HR) were extracted from medical records. Linear mixed model (LMM) was used to analyze longitudinal changes in patients' clinical indexes. Gender and age were inserted in LMM as covariates to find their correlation with AE and clinical indexes. Of 84 patients, 35 patients met our criteria for the study. There were significant increases in mean levels of white blood cell (WBC) (p=0.005), alanine aminotransferase (ALT) (p=0.001), aspartate aminotransferase (AST) (p=0.001), blood urea nitrogen (BUN) (p=0.001), and creatinine (p=0.006) while mean levels of erythrocyte sedimentation rate (ESR) (p=0.005), C-reactive protein (CRP) (p=0.001), alkaline phosphatase (ALP) (p=0.001), and potassium (p=0.003) decreased, significantly. Estimated glomerular filtration rate (eGFR) (p=0.001) and HR (p=0.001) showed a notable decline over the course of treatment. LMM analysis showed that mean changes in WBC (β=0.94, p=0.029), creatinine (β=0.12, p=0.020), and HR (β=6.47, p=0.008) were greater in males than females. Also, age of patients had a significant effect on the mean changes of WBC (β= -0.02, p=0.023), sodium (β= -0.06, p=0.010), BUN (β=0.23, p=0.001), and HR (β= -0.29, p=0.001). Despite no renal and liver dysfunction, Covid-19 patients with mild pulmonary infection may develop some remdesivir AE, and attributed side effects might be affected by gender and age of patients. This article is protected by copyright. All rights reserved. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

PET2 response associated with survival in newly diagnosed diffuse large B-cell lymphoma: results of two independent prospective cohorts

alexandrossfakianakis shared this article with you from Inoreader PET2 response associated with survival in newly diagnosed diffuse large B-cell lymphoma: results of two independent prospective cohorts Via Blood Cancer Journal - Issue - nature.com science feeds View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Vocal fold fibroblasts promote angiogenesis in vocal fold leukoplakia by secreting pro-angiogenic factors

alexandrossfakianakis shared this article with you from Inoreader Vocal fold fibroblasts promote angiogenesis in vocal fold leukoplakia by secreting pro-angiogenic factors Via ScienceDirect Publication: Auris Nasus Larynx Publication date: Available online 2 May 2022 Source: Auris Nasus Larynx Author(s): Yinying Chu, Yi Fang, Haitao Wu, Jian Chen, Lei Cheng View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Treatment planning comparison in the PROTECT-trial randomising proton versus photon beam therapy in oesophageal cancer: results from eight european centres

alexandrossfakianakis shared this article with you from Inoreader Treatment planning comparison in the PROTECT-trial randomising proton versus photon beam therapy in oesophageal cancer: results from eight european centres Via radiotheraphy Publication date: Available online 2 May 2022 Source: Radiotherapy and Oncology Author(s): Lone Hoffmann, Hanna Mortensen, Muhammad Shamshad, Maaike Berbee, Nicola Bizzocchi, Rebecca Bütof, Richard Canters, Gilles Defraene, Mai Lykkegaard Ehmsen, Francesca Fiorini, Karin Haustermans, Ryan Hulley, Erik W. Korevaar, Matthew Clarke, Sebastian Makocki, Christina T. Muijs, Luke Murray, Owen Nicholas, Marianne Nordsmark, Ganesh Radhakrishna View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The effect of (-)-epigallocatechin gallate as an adjunct to non-surgical periodontal treatment: a randomized clinical trial

alexandrossfakianakis shared this article with you from Inoreader The effect of (-)-epigallocatechin gallate as an adjunct to non-surgical periodontal treatment: a randomized clinical trial Via Trials - Latest Articles EGCG is proven to be of good effect to relieve periodontal inflammation, but it has not been applied as a local delivery medicine in patients with periodontitis widely. The aim of this clinical trial was to ev... View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.