Τρίτη, 2 Απριλίου 2019

Dermatology

A novel mutation in the SLCO2A1 gene in a Chinese family with pachydermoperiostosis
Australasian Journal of Dermatology
Sun Mar 31, 2019 17:19
Successful control of severe eosinophilic granulomatosis with polyangiitis in a pregnancy and perinatal period: A use of mepolizumab
The Journal of Dermatology
Mon Apr 01, 2019 14:51
Metaplastic rectal adenocarcinoma into metastatic mucinous carcinoma on the buttock: The efficacy of immunohistochemistry
The Journal of Dermatology
Mon Apr 01, 2019 14:50
Cutaneous histopathology of the tick‐bite region in severe fever with thrombocytopenia syndrome
AbstractA case of severe fever with thrombocytopenia syndrome (SFTS) in which a skin biopsy from the tick‐bite region was analyzed is reported. The patient was a 72‐year‐old woman who developed fever and thrombocytopenia after a tick bite. SFTS was diagnosed from polymerase chain reaction (PCR) analysis of a blood sample. Histopathological analysis of a skin biopsy specimen from the tick‐bite region showed CD20‐positive perivascular and interstitial immunoblastic cells, which were positive...
The Journal of Dermatology
Mon Apr 01, 2019 14:49
Sweet syndrome in a patient with chronic myelogenous leukemia under dasatinib treatment
The Journal of Dermatology
Mon Apr 01, 2019 14:49
Hearing loss caused by discoid lupus erythematosus of the ear canal successfully treated with hydroxychloroquine
The Journal of Dermatology
Mon Apr 01, 2019 14:48
Dental root abnormalities in four children with PHACE syndrome
AbstractPHACE(S) syndrome is a condition characterized by posterior fossa malformations, hemangiomas, arterial anomalies, cardiac defects, eye abnormalities, sternal cleft, and supraumbilical raphe. We present four children with PHACE(S) syndrome who have absence of or severe malformation of the roots of their permanent first molars (PFMs). Root abnormalities in the children's molars were bilateral and not restricted to the segments affected by cutaneous hemangioma. The reason for root abnormalities...
Wiley: Pediatric Dermatology: Table of Contents
Mon Apr 01, 2019 18:16
Investigation of Different Prototropic Forms of Biologically Active Flavin Lumichrome in the Presence Liposome
AbstractHerein we reported the photophysical behavior of lumichrome (LC), one of the biologically active flavin molecule, in the presence of small unilamellar vesicle of anionic lipid 1,2‐dimyristoyl‐sn‐glycero‐3‐phosphocholine (DMPC). With the help of different spectroscopic techniques, we have proposed that anionic DMPC liposome interact with the cationic dye LC in ground state, and in excited state and modulate the spectral properties of LC. Photophysical study reveals that different prototropic...
Wiley: Photochemistry and Photobiology: Table of Contents
Mon Apr 01, 2019 14:18

Oral and Maxillofacial

Anteroposterior and vertical soft tissue cephalometric norms of Iranians, interethnic comparisons, sex dimorphism, and the effect of age on cephalometric variables
Abstract Introduction This study established about 50 anteroposterior and vertical cephalometric norms of five tracing analyses in Iranians, using a large sample. Methods Lateral cephalographs of 130 subjects (85 females, 45 males, with an average age of 22.77 ± 2.55 years (range 20–29)) were traced manually using the Ricketts, Holdaway, Z-Merrifield, Epker,...
Latest Results for Oral and Maxillofacial Surgery
Tue Apr 02, 2019 03:00
Virtual reconstruction of bilateral midfacial defects by using statistical shape modeling
Publication date: Available online 1 April 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Marc Anton Fuessinger, Steffen Schwarz, Joerg Neubauer, Carl-Peter Cornelius, Mathieu Gass, Philipp Poxleitner, Ruediger Zimmerer, Marc Christian Metzger, Stefan SchlagerSummaryPurposeMirroring and manual adaptation as the main virtual reconstruction method of midfacial defects is time demanding and ignores asymmetrical skull shapes. By using a statistical shape model (SSM), the reconstruction...
ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery
Tue Apr 02, 2019 15:14
Three-dimensional orbital wall modeling using paranasal sinus segmentation
Publication date: Available online 1 April 2019Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Hannah Kim, Tae-geun Son, Jeonghwan Lee, Hyeun A. Kim, Hyunchul Cho, Woo Shik Jeong, Jong Woo Choi, Youngjun KimAbstractPurposeThree-dimensional orbital wall modeling is a time-consuming process because of the presence of pseudoforamina. We developed an automated three-dimensional modeling software to characterize the orbital wall, and evaluated it using data from fracture patients.MethodsWe first...
ScienceDirect Publication: Journal of Cranio-Maxillofacial Surgery
Tue Apr 02, 2019 15:14
Temporomandibular dysfunction after surgery of mandibular fractures not involving the mandibular condyle: a prospective follow-up study
Publication date: Available online 1 April 2019Source: Journal of Oral and Maxillofacial SurgeryAuthor(s): Hanna Rajantie, Johanna Snäll, Department Head, Hanna ThorénAbstractPurposeFacial trauma may lead to temporomandibular dysfunction (TMD). The aim of this study was to clarify the occurrence and characteristics of TMD in patients surgically treated for mandibular fractures not involving mandibular condyle.MethodsThis prospective, single-center follow-up study was comprised of patients who underwent...
ScienceDirect Publication: Journal of Oral and Maxillofacial Surgery
Tue Apr 02, 2019 13:46
Apocrine epithelial-myoepithelial carcinoma of the parotid gland with concurrent oncocytic change: A novel variant
Publication date: Available online 1 April 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Shu Xia, Xin-Ming Chen, Shao-Dong Yang, Xue-Qing Zheng, Ya-Ying Hu, Jia-Li ZhangAbstractEpithelial-myoepithelial carcinoma (EMCa) is a rare, low-grade, malignant salivary gland tumor. Herein, we report an unusual case of an EMCa with extensive apocrine and oncocytic changes. The tumor occurred in the left parotid gland of a 68-year-old male. Histologically, the tumor was...
ScienceDirect Publication: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Tue Apr 02, 2019 15:00
Multiple calcifying epithelial odontogenic tumor: case report and review of the literature
Publication date: Available online 1 April 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Ana Carolina Hanaoka Ibituruna, Anaíra Ribeiro Guedes Fonseca Costa, Luiz Fernando Barbosa de Paulo, Paulo Rogério de Faria, Sérgio Vitorino Cardoso, Adriano Mota LoyolaAbstractCalcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasm, and few cases of multiple lesions have been published. This article reports the case of a 26-year-old male patient with bilateral...
ScienceDirect Publication: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Mon Apr 01, 2019 15:16
Anatomical study: the potential movability of inferior alveolar nerve
Publication date: Available online 1 April 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Shogo Kikuta, Joe Iwanaga, Jingo Kusukawa, R. Shane TubbsAbstractObjectiveNerve repair and repositioning are procedures for treating and avoiding injury to the inferior alveolar nerve during oral and maxillofacial surgery. The present study aims to examine how the mobility of the inferior alveolar neurovascular bundle (IAB) changes with or without removing the bone around...
ScienceDirect Publication: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Mon Apr 01, 2019 15:16
Course of the mandibular canal in hemifacial microsomia: a retrospective computed tomography study
Publication date: Available online 1 April 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Zhixu Liu, Jian Cao, Yifeng Qian, Hao Sun, Yi Sun, Steve Guofang Shen, Xudong WangAbstractObjectiveTo evaluate the anatomical course of the mandibular canal in patients with hemifacial microsomia (HM).Study DesignIn this retrospective study, 77 patients were included and stratified by the Pruzansky-Kaban classification. The mandibular canal and mandible were reconstructed...
ScienceDirect Publication: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Mon Apr 01, 2019 15:16
Solitary Oral Epidermolytic Acanthoma: Case report of a rarely diagnosed entity
Publication date: Available online 31 March 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Prokopios P. Argyris, Zachary M. Slama, Andrew C. Nelson, Ioannis G. KoutlasAbstractEpidermolytic acanthoma (EA) represents a rare localized form of epidermolytic hyperkeratosis (EHK) clinically resembling warty lesions and showing a strong predilection for the genital skin of males. Herein, we present a case of oral solitary EA affecting a 71-year-old Caucasian man. Clinically,...
ScienceDirect Publication: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Mon Apr 01, 2019 15:16
A NODULE IN THE TEMPOROMANDIBULAR JOINT AREA
Publication date: Available online 31 March 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Flávia Leite-Lima, Felipe Paiva Fonseca, Ricardo Santiago Gomez, Luiz Felipe Cardoso Lehman, Wagner Henriques de Castro, Felipe Eduardo Baires Campos
ScienceDirect Publication: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Mon Apr 01, 2019 15:16

Clinical Cancer Research

Mobilization of CD8+ T cells via CXCR4 blockade facilitates PD-1 checkpoint therapy in human pancreatic cancer
Purpose: Pancreatic ductal adenocarcinoma (PDA) is rarely cured, and single-agent immune checkpoint inhibition has not demonstrated clinical benefit despite the presence of large numbers of CD8+T cells. We hypothesized that tumor-infiltrating CD8+T cells harbor latent anti-tumor activity that can be reactivated using combination immunotherapy. Experimental Design: Preserved human PDA specimens were analyzed using multiplex immunohistochemistry (IHC) and T cell receptor (TCR) sequencing. Fresh...
Clinical Cancer Research Online First Articles
Tue Apr 02, 2019 16:48
Auranofin protects intestine against radiation injury by modulating p53/p21 pathway and radio-sensitizes human colon tumor
Purpose: Radio-sensitivity of normal intestinal epithelium is the major limiting factor for definitive radio therapy (RT) against abdominal malignancies. Radiosensitizers which can be used without augmenting radiation toxicity to normal tissue is still an unmet need. Inhibition of proteosomal degradation is developing as major therapeutic strategy for anticancer therapy as cancer cells are more susceptible to proteasomal inhibition induced cytotoxicity compared to normal cells. Auranofin a gold-containing...
Clinical Cancer Research Online First Articles
Tue Apr 02, 2019 16:48
Targeting CD38 enhances the antileukemic activity of ibrutinib in chronic lymphocytic leukemia (CLL)
Purpose: CD38 has emerged as a high-impact therapeutic target in multiple myeloma, with the approval of daratumumab (anti-CD38 monoclonal antibody). The clinical importance of CD38 in chronic lymphocytic leukemia (CLL) patients has been known for over two decades, though it's relevance as a therapeutic target in CLL remains understudied. Experimental Design: We investigated the biological effects and anti-tumor mechanisms engaged by daratumumab in primary CLL cells. Besides its known immune-effector...
Clinical Cancer Research Online First Articles
Tue Apr 02, 2019 16:48
Targeting glutamine metabolism and redox state for leukemia therapy
Purpose: Acute myeloid leukemia (AML) is a hematological malignancy characterized by the accumulation of immature myeloid precursor cells. AML is poorly responsive to conventional chemotherapy and a diagnosis of AML is usually fatal. More effective and less toxic forms of therapy are desperately needed. AML cells are known to be highly dependent on the amino acid glutamine for their survival. These studies were directed at determining the effects of glutaminase inhibition on metabolism in AML and...
Clinical Cancer Research Online First Articles
Tue Apr 02, 2019 16:48
Combination of trastuzumab emtansine and stereotactic radiosurgery results in high rates of clinically significant radionecrosis and dysregulation of Aquaporin-4.
Purpose: Patients with human epidermal growth factor receptor 2-positive (HER2+) breast cancer have a high incidence of brain metastases, and trastuzumab emtansine (T-DM1) is often employed. Stereotactic radiosurgery (SRS) is frequently utilized, and case series report increased toxicity with combination SRS and T-DM1. We provide an update of our experience of T-DM1 and SRS evaluating risk of clinically significant radionecrosis (CSRN) and propose a mechanism for this toxicity. Methods: Patients...
Clinical Cancer Research Online First Articles
Tue Apr 02, 2019 16:48
Regorafenib promotes anti-tumor immunity via inhibiting PD-L1 and IDO1 expression in melanoma
Purpose:Immune checkpoint blockade (ICB) therapy induces durable tumor regressions in a minority of cancer patients. In this study, we aimed to identify kinase inhibitors that were capable of increasing the anti-melanoma immunity. Experimental Design:Flow cytometry-based screening was performed to identify kinase inhibitors that can block the IFN- induced PD-L1 expression in melanoma cells. The pharmacologic activities of regorafenib alone or in combination with immunotherapy in vitro and in vivo...
Clinical Cancer Research Online First Articles
Tue Apr 02, 2019 16:48
Ultra-sensitive EGFRT790Mdetection as an independent prognostic marker for lung cancer patients harboring EGFRdel19mutations and treated with first-generation TKIs
Purpose: The detection of pre-existing EGFRT790M subclones and the assessment of their clinical significance in the pretreatment of EGFRT790M non-small cell lung cancer (NSCLC) patients remain unclear. Experimental Design: A total of 179 tumor samples from patients treated or not with a first-generation Tyrosine Kinase Inhibitor (TKI) was analyzed. The presence of ultra-low levels of pre-existing EGFRT790M mutation was evaluated using ultra-sensitive droplet digital PCR (ddPCR) and the clinical implication...
Clinical Cancer Research Online First Articles
Mon Apr 01, 2019 17:27
One CLEVER macrophage checkpoint
Macrophages are a key component of the tumor microenvironment. Blocking Clever-1, a molecule expressed in M2-like macrophages, unleashed macrophage and T cell mediated antitumor immunity. Myeloid checkpoints including Clever-1 hold promise as alternative or complementary immunotherapy strategies.
Clinical Cancer Research Online First Articles
Mon Apr 01, 2019 17:27
Early Modeled Longitudinal CA-125 Kinetics and Survival of Ovarian Cancer Patients: A GINECO AGO MRC CTU Study.
Background: Regarding CA-125 longitudinal kinetics during chemotherapy, the actual predictive value of the Gynecology Cancer InterGroup (GCIG) CA-125 response criterion is questioned. The modeled CA-125 elimination rate constant KELIM exhibited higher prognostic value in recurrent ovarian cancer patients enrolled in CALYPSO trial. The objective was to validate the higher predictive & prognostic values of KELIM during first line treatments. Experimental design: Data from 3 large phase III trials...
Clinical Cancer Research Online First Articles
Mon Apr 01, 2019 17:27
Targeted inhibition of the dual specificity phosphatases DUSP1 and DUSP6 suppress MPNST growth via JNK
Purpose: In Neurofibromatosis Type 1 (NF1) and in highly aggressive malignant peripheral nerve sheath tumors (MPNSTs), constitutively active RAS-GTP and increased MAPK signaling are important in tumorigenesis. Dual specificity phosphatases (DUSPs) are negative regulators of MAPK signaling that dephosphorylate p38, JNK and ERK in different settings. While often acting as tumor suppressors, DUSPs may also act as oncogenes, helping tumor cells adapt to high levels of MAPK signaling. We hypothesized...
Clinical Cancer Research Online First Articles
Mon Apr 01, 2019 17:27

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