Τετάρτη, 5 Απριλίου 2017

Thesis for hrm course syllabus



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Essay Writing Service

Religious Liberty Essay Scholarship Contest. Each year, the Religious Liberty Essay Scholarship Contest engages high school students in church-state issues by

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Louise Penny Author - Official site

Be in the know! Sign up for email offers, news, and more . Skip to main content. Shop Historical Fiction

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RadioImmunoAssay| The principle and Procedure of RIA

Importance of analytical chemistry can be seen from the fact that it is offered. What is analytical chemistry. Analytical chemistry is a branch of chemistry which

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Interactivate: Algebra Four - Shodor

Problem-Solving Skills — Creative and Critical. An important goal of education is helping students learn how to think more productively while solving problems, by

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:Great Books Online -- Quotes, Poems, Novels

Research Adiposity and cancer at major anatomical sites: umbrella review of the literature BMJ 2017; 356 doi: https://// (Published 28 February

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Servant Leadership | Leadership - Leadersdirect

In considering the qualities of effective and ineffective . presidents, Fred I. Greenstein focused on the twelve modern presidents from FDR to George W. Bush, and

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Welcome to The Body Positive

The Body Positive is celebrating 20 years! In 1997, a group of teen girls gathered in the living room of a borrowed home and shared the difficulties they were

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HIV and AIDS in South Africa | AVERT

World Health Day: Focus on HIV/AIDSHIV/AIDS is a major concern for developing countries worldwide. Lack of education, poor nutrition and inadequate health care

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|Study Guides, Essays, Lesson Plans

Try our best English essay writing service features that you can imagine. We provide superior quality original and custom essays with high-speed delivery.

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Thesis Title About Social Issues

Biological control products based on entomopathogenic nematodes (EPN) Thesis; Only search for Some of the examples which will be presented include the

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Shtetl-Optimized » Blog Archive » Walter Lewin

SMARTCOCKPIT; Our #1 goal, since 2000, is to offer the most extensive online aviation resource to worldwide professional pilots. We desire to spread the undeniable

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*Please submit this cover letter and checklist of the

This page will provide you with an excellent cover letter for the job application or resume of a credit controller

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SAY: The Stuttering Association for the Young

Buy and sell electronics, cars, fashion apparel, collectibles, sporting goods, digital cameras, baby items, coupons, and everything else on eBay, the world's online

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Doctoral thesis papers outline of the united

... examples blank thesis outline good thesis a love story doctoral thesis samples thesis sample doc thesis for research papers dissertation

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Zami Nobla Wants To Support And 2017 | 2016 17 Scholarships

Scholarships; Terminology; Pride Selection is based on a written or video essay. Zami offers the Audre Lorde Scholarship and several other $1,000 scholarships

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How To Solve The Rubik's Cube

Title: Rubik's Cube 3x3 Solution Guide Author: Seven Towns Ltd Created Date: 10/4/2010 5:13:46 PM

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Purple hibiscus religion essay question



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Thesis for doctorate in special education



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Dissertation essay plan



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After 4-year battle with cancer, DC chef opens dream taqueria - WTOP


WTOP

After 4-year battle with cancer, DC chef opens dream taqueria
WTOP
Alongside a list of classic margaritas and creative Latin cocktails, diners can find everything from seared beef tongue tacos to grilled cactus paddles melted with Oaxaca cheese. (Jai Williams). WASHINGTON — Opening a restaurant was always a goal for ...



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Validation of general job satisfaction in the Korean Labor and Income Panel Study

The purpose of this study is to assess the validity and reliability of general job satisfaction (JS) in the Korean Labor and Income Panel Study (KLIPS).

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Emba essay writing service



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Sample of Scholarship Application Letter | Application Letter

Sample Cover Letter – General Application Ms. Mary Jones 18 Sligo Park Sligo Mr. P. Murphy HR Manager ABC International Sligo Town 1st February 2012

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Martin Luther King Jr. Online - Speeches, Pictures, Quotes

News about Martin Luther King Jr.. Commentary and archival information about Martin Luther King Jr. from The New York Times.

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The History of Hypnosis

Contact. McCormick-Allum Co. Inc. 165 Stafford Street Springfield, MA 01104. Tel: (413) 737-1196 Fax: (413) 731-7982

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Health | Yahoo Beauty

Note 3 The total Spanish force in Santiago under General Linares was 6,000: 4,000 regulars, 1,000 volunteers, and 1,000 marines and sailors from the ships.

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How to Write a DBQ Essay (with Pictures) - wikiHow

Grade 8 Writing Prompts Page 2 December 2015 Thoughtful acts can take many forms, such as unexpected help or even just a kind word. Explain

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Writing paragraphs | The Writing Centre | University of Ottawa

This post dissects the components of a good thesis statement and gives 10 thesis statement examples to inspire your next argumentative essay.

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Home - Garfield Elementary

Parents and Guardians: Take advantage of our Text Messaging Service . To participate and receive text alerts on your cell, y our cell phone number must be on file at

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Reclaiming Manhood: Detoxifying Toxic Masculinity - Paging

Need Facebook Who Wants To Be A Millionaire answers, solutions and cheats? Consult our quick reference chart. Then help us grow more Millionaire cheats!

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Propane Tank Installation & Propane Delivery in Houston TX

GUETH chancing sailboarded TIPOLD either extortion undoings DEBRITA receptionists EISON intellects cajoles ROUDABUSH ELIAN molecule MERCKLING unskillful unpeople

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Graduate School of Operational and Information Sciences

Create professional online surveys - fast, easy, and free. Online survey software, customer satisfaction, market research, employee satisfaction surveys

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Assistance Programs | ComEd - An Exelon Company

The Office of the District Attorney, led by District Attorney Paul L. Howard, Jr., is charged with the prosecution of all felony violations of State law that occur

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Martin-luther-king-giving-dream-speech

Find out more about the history of Martin Luther King Jr., including videos, interesting articles, pictures, historical features and more. Get all the facts on

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If You Teach or Write 5-Paragraph Essays–Stop It! | The

On a North American continent controlled by American Indians, contact among the peoples of Europe, the Americas, and West Africa created a new world. Key Concept

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Short Essay On My Home - My Study Corner

Short Essay on Life. Article shared by Bunty Rane. Life is beautiful but not always easy, it has problems, too, Short Speech on India of My Dreams.

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Australian Government :: Family Relationship

SumoMe “You cannot change your destination overnight, but you can change your direction overnight.”– Jim Rohn. When talking to people about personal development

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What is a Thesis Statement?

No matter what type of writing that you do, whether you are writing an essay in a nursing class or an essay for a literature class, it has a main topic.

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Essay questions on the giver



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Ode - definition of ode by The Free Dictionary

John Keats (1795–1821). Poetical Works. 1884. Notes BIBLIOGRAPHY I JOHN KEATS, born Oct. 29, 1795, died Feb. 23, 1821, published his first volume in 1817.

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Crony Beliefs | Melting Asphalt

[First published April 2005] We all know someone who’s intelligent, but who occasionally defends obviously bad ideas. Why does this happen? How can smart people

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Speech Tips

Faultless writing is a sophisticated and laborious art, which needs special skills and a lot of attention. But in this section we will try to make the process of

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Http:///ttreadwe/courses/02courses

Did you ever wonder what one of the symbols on the laundry care label means? Find out how to take care of your laundry by reading our online guide to the laundry care

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Writing Fun - helping kids with how to write using text

The Purdue University Online Writing Lab serves writers from around the world and the Purdue University Writing Lab helps writers on Purdue's campus.

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Now Boxing - News and Opinions on Boxing

Medieval Bestiary pages - bibliography by author. Linda Phyllis Austern, ed., Inna Naroditskaya, ed. Music of the Sirens (Bloomington, IN: Indiana University

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- . .,mn 0 01 05_1 1 10 100 10th 11 11_d0003 12 13 14 141a 143b 15 16 17 17igp 18 19 1900 1901 1902 1903 1904 1905 1906 1907 1908 1909 1910 1911 1912 1913 1914 1915

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Ethical issues in writing a research paper



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FlotaPlus - Systemy lokalizacji GPS

Discover Deli with a Difference! Established in 1932, Deli Brands of America has a tradition of quality and value that is customers will taste the

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Thesis/Dissertation – Reference List | APA Style Guide

Vol. 16, No. 3 | May 2013 Precast Project Showcase Multifamily Living: Melrose Place more; Vol. 16, No. 3 | May 2013 ICF Project Showcase Senior Living: Conservatory Pond

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Office of Academic Transition - Rowan University

A list of helpful vocabulary to help you write IELTS essays together with an essay mao to help you structure your essay

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David Warren - Essays in Idleness

The essay is the most important part of a college appllication, see sample essays perfect for applying to schools in the US.

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50 Argument Essay Topics

Critical stance and development of a strong argument are key strategies when writing to convince someone to agree with your position. In this lesson, students explore

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Freeplay Music | Welcome | The best music library on the

Paste in a bunch of text: Go. Not working? Troubleshooting tips.

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Columbia University Finance Gateway

Founded in 1754 as King's College by royal charter, it is the oldest institution of higher learning in the State of New York. Located in New York City and a member of

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Equation Games - Math Play - Free Online Math Games

Hint: Selecting AUTO in the variable box will make the calculator automatically solve for the first variable it sees.

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Alexander R. Vaccaro, ., ., ., President

As part of the Rothman Institute’s Joint Replacement Program, one of the nation’s top programs, Alexander R. Vaccaro, ., . specializing in Spine Orthopaedics.

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Nearly 80 Percent of Drivers Express Significant Anger

How small businesses are using social media in their marketing strategies in 2011 and the results their social media investment bring to their business.

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RpoS Affects Gene Expression in Salmonella enterica serovar Typhi Under Early Hyperosmotic Stress

Abstract

During the infectious procedure of Salmonella enterica serovar Typhi (S. Typhi), Salmonella would suffer from some severe environmental stresses, such as gastric acid stress, enteric hyperosmotic stress, bile acids stress, and oxidative stress. S. Typhi must regulate the expression of numerous genes through the complex regulatory network to adapt strict stresses. RpoS, which encodes sigma factor σs, was reported to be a very important regulator in the maximal survival of enteric pathogens including S. enterica in the stress conditions. However, the role of RpoS in S. Typhi under early hyperosmotic stress is not clear. In this study, we prepared the RpoS-deleted mutant (△RpoS) and compared the growth of △RpoS and wild-type strain. In addition, we analyzed its global transcription profile under early hyperosmotic stress by a microarray. The results showed that △RpoS grew significantly slower than wild-type strain and 24 genes displayed differential expression between the wild-type strain and ΔRpoS upon 30-min exposure in the high osmolarity. Most of these genes are associated with enzymes of metabolism. Taken together, our study firstly demonstrated that RpoS affects gene expression in S. Typhi under early hyperosmotic stress and may impact the growth of bacteria by regulating bacterial metabolic enzymes.



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Genetic analysis of a novel reassortant H11N9 Isolated from waterfowl in South Korea in 2016

Abstract

Aquatic birds are known to harbor all the known influenza A viruses. In the winter of January 2016, we surveyed influenza A virus in the feces of migratory birds in South Korea. The novel re-assorted H11N9 avian influenza virus, which contains genes from avian influenza viruses of poultry and wild birds, was isolated. The polymerase basic 2 (PB2), polymerase basic 1 (PB1), hemagglutinin (HA), and nucleoprotein (NP) genes were most closely related to those of domestic duck-origin avian influenza viruses, while the non-structural (NS) gene was closely related to that of domestic goose-origin avian influenza virus. The polymerase acidic (PA), neuraminidase (NA), and matrix (M) genes were most similar to those of wild bird-origin avian influenza viruses. Our results suggested that the interaction between wild birds and domestic poultry could possibly create novel re-assorted avian influenza viruses circulating in wild birds.



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Comparative Study of Outcome of Endoscopic Myringoplasty in Active and Inactive Mucosal Chronic Otitis Media Patients

Abstract

The objective of this study was to compare graft uptake and hearing improvement in active and inactive mucosal chronic otitis media patients after endoscopic myringoplasty. This is prospective study conducted at a government medical college and hospital from February 2014 to August 2015. A total of 40 active (wet) ears with mucoid discharge and 40 inactive (dry) ears (at least 6 weeks dry before surgery) with mucosal chronic otitis media were operated on by endoscopic myringoplasty by transcanal approach. Graft uptake and hearing gain rates 3 months after surgery were compared for both groups. Endoscopic myringoplasty using temporal fascia graft via transcanal approach was used. The graft take rate was 77.5% for the active ear group and 85% for the inactive ear group. The hearing gain rate was 82.5% for the inactive ear group and 72.5% for the active ear group. Differences were found to be statistically insignificant for both graft uptake and hearing gain. The success of endoscopic myringoplasty is not adversely affected by the presence of mucoid ear discharge at the time of surgery, and outcomes are comparable to those of the operation done for inactive ear.



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Effects of Chamber Pressure and Partial Pressure of Water Vapor on Secondary Drying in Lyophilization

Abstract

Secondary drying is the final step of lyophilization before stoppering, during which water is desorbed from the product to yield the final moisture content. We studied how chamber pressure and partial pressure of water vapor during this step affected the time course of water content of aqueous solutions of polyvinylpyrrolidone (PVP) in glass vials. The total chamber pressure had no effect when the partial pressure of water vapor was very low. However, when the vapor phase contained a substantial fraction of water vapor, the PVP moisture content was much higher. We carried out dynamic vapor sorption experiments (DVS) to demonstrate that the higher PVP moisture content was a straightforward result of the higher water vapor content in the lyophilizer. The results highlight that the partial pressure of water vapor is extremely important during secondary drying in lyophilization, and that lower chamber pressure set points for secondary drying may sometimes be justified as a strategy for ensuring low partial pressure of water vapor, especially for lyophilizers that do not inject dry gas to control pressure. These findings have direct application for process transfers/scale ups from freeze-dryers that do not inject dry gas for pressure control to those that do, and vice versa.



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Evaluation of the Potential Use of Laminar Extrudates on Stabilizing Micronized Coumarin Particles by Supercritical Fluids (RESS)—Study of Different RESS Processing Variables and Mode of Operation

Abstract

The study evaluates the ability of extrudates to deliver coumarin particles micronized by the rapid expansion of supercritical solutions (RESS). The RESS parameters were drug load (2–50 g), pressure (15–42 MPa) and temperature (40–60°C) in the extraction and pressure in the expansion (0.1–5 MPa) chambers in batch or continuous and CO2 flow rate in the continuous mode of operation. Particles were characterized for size (laser diffractometry, optical and electronic microscopies—19–61 μm), surface area (BET—0.282–0.423 m2/g), density (pycnometry—1.273–1.358 g/cm3) and yield (2–70%). Extrudates were characterized for the force of extrusion (4 kN), release of coumarin (100%/24 h) and mechanical properties (bending strength and stiffness increased, whereas elasticity decreased in storage) and X-ray diffractometry (micronized particles and extrudates have shown identical patterns) and calorimetry (DSC, enthalpies increased on storage). In the discontinuous mode of operation, increased loads in the extraction or increased pressure in the expansion chambers led to larger particles, whereas increased temperature and pressure in the extraction chamber led to smaller particles. In the continuous mode of operation, a decrease on the expansion pressure, load and CO2 flow rate led to increased yields. An increase on the flow rate led to a decrease on the particles’ diameter, but an increase on coumarin load in the extraction chamber led to an increase in diameter. The study has identified the key parameters in RESS continuous and discontinuous modes of operation affecting the properties of the micronized coumarin particles and has proved the ability of extrudates with a laminar shape on delivering micronized particles.



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Review of Best Practice Approaches in Combatting Vulnerability to Flood Disaster Risk in Ala-River Flooding Akure, Ondo State, Nigeria

The post Review of Best Practice Approaches in Combatting Vulnerability to Flood Disaster Risk in Ala-River Flooding Akure, Ondo State, Nigeria appeared first on Welcome to Avens.



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Understanding the Concept of Carrying Capacity and its Relevance to Urban and Regional Planning

The post Understanding the Concept of Carrying Capacity and its Relevance to Urban and Regional Planning appeared first on Welcome to Avens.



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Post surgery circulating free tumor DNA is a predictive biomarker for relapse of lung cancer

Abstract

Cancer cells release DNA fragments into plasma as circulating free DNA (cfDNA). However, quantitative measurement of tumor-derived DNA in cfDNA remains challenge. The purpose of this study was to quantitatively assess tumor-derived DNA in lung cancer patients. By optimizing competitive allele-specific TaqMan PCR (CAST-PCR), we assessed the copy number of mutated Kirsten rat sarcoma viral oncogene homolog (KRAS) and epidermal growth factor receptor (EGFR) alleles in the pre/post surgery plasma of 168 lung cancer patients. An absolute quantitative PCR method was developed to assess the number of total cfDNA. All mutations detected in tumors were also found in the plasma after surgery. At the time of 30 days after surgery, EGFR mutation of circulating cell-free DNA was detected only in two patients who recurred in 4 months after surgery. Compared to that of normal control at 30 days after surgery, five patients who recurred in 4 months had significantly higher circulating cell-free DNA (P < 0.001), whereas six patients who recurred after 4 months (P = 0.207) and five patients without recurrence (P = 0.901) demonstrated significantly lower circulating cell-free DNA. Our findings suggest that cfDNA analysis in plasma is an alternative and supplement to tissue analysis and hold promise for clinical application. Stratification of patients according to cfDNA levels at 30 days after surgery might be helpful in selecting lung cancer patients for adjuvant therapy after surgery.

Thumbnail image of graphical abstract

In this manuscript, we report the levels of tumor circulating cell-free DNA (cfDNA) initially increased immediate after surgery, followed by a rapid decrease. Importantly, the tumor cfDNA levels 30 days post surgery were predictive for subsequent relapse in patients.



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The impact of presence of Hashimoto's thyroiditis on diagnostic accuracy of ultrasound-guided fine-needle aspiration biopsy in subcentimeter thyroid nodules: A retrospective study from FUSCC

Abstract

The incidence of PTMC has been increasing in the recent years. This study aimed to investigate the diagnostic value of US-FNA in thyroid nodules ≤1 cm and whether the presence of Hashimoto's thyroiditis (HT) in thyroid could influence the accuracy. The patients who accepted US-FNA at FUSCC from December 2012 to November 2015 and followed our criteria were enrolled in this study. We extracted the cytological, pathological, and follow-up US/US-FNA data of patients with subcentimeter nodules. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), false-negative rate (FNR), false-positive rate (FPR), and AUC were calculated to define FNA diagnostic performance in patients. The association of HT with cytological results was analyzed in univariate and multivariate logistic regression analysis. In total, 754 patients with 817 subcentimeter nodules were collected to comprise the FUSCC cohort. Of the 817 nodules, the cytological results were ND/UNS in 80 nodules (9.8%), benign in 74 (9.1%), AUS/FLUS in 80 (9.8%), FN/SFN in 6 (0.7%), suspicious for malignancy (SM) in 222 (27.2%), and malignant in 355 (43.5%). The sensitivity, specificity, PPV, NPV, and AUC of US-FNA for the subcentimeter nodules were 98.8%, 90.5%, 98.8%, 90.5%, and 94.7%, respectively. In comparison with HT-positive subcentimeter nodules, the diagnostic value of US-FNA for HT-negative nodules was significantly higher (HT-positive: AUC = 91.6%, HT-negative: AUC = 95.9%, = 0.028). The coexistent HT was found to increase the risk of the FNR and indeterminate cytological results. US-FNA demonstrated an effective method for diagnosis of subcentimeter thyroid nodules with a low nondiagnostic rate in our study. The presence of HT in thyroid could be a risk factor for the increased FNR and indeterminate cytological results during US-FNA.

Thumbnail image of graphical abstract

The incidence of PTMC has been increasing in the recent years. This study aimed to investigate the diagnostic value of US-FNA in thyroid nodules ≤1 cm and whether the presence of Hashimoto's thyroiditis (HT) in thyroid could influence the accuracy.



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Writing a Cover Letter with no experience - Youth Central

Use this Office Manager Cover Letter sample to help you write a powerful cover letter that will separate you from the competition.

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Research Methods KB

JIPMER Breaking Boundaries.. Finding Frontiers.. Jawaharlal Institute of Postgraduate Medical Education & Research

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MBA Dissertations | 1000 Projects

1 SUGGESTIONS FOR MBA DISSERTATIONS IN ENTREPRENEURSHIP AND SMALL BUSINESS MANAGEMENT This document is adapted from the ‘Suggestions for MBA Dissertations in Strategic

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ARGUMENTATIVE ESSAY

Argument Essay #4. Click Here to View Essay A Deadly Tradition (PDF Document) Sample Argument Essay #5. Click Here to View Essay Society Begins at Home (PDF Document)

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School Loop: Participating Schools

About Us “Nothing great was ever achieved without enthusiasm “~Ralph Waldo Emerson. Emerson School, which houses grades Preschool through 8th grade, was named

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International Business Ethics Institute | Ethics Training

Himalayan Chef is the world largest pink salt products manufacturer. Himalayan salt products Includes pink salt plates, seasoning salt.

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Beginning or Ending? When Our Kids Go Off to College | The

Chesterton is an 11 - 16, LEA maintained college. The College is located near the heart of Cambridge City. Includes prospectus and photographs of recent exchanges.

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Siding Contractors | Residential Roofing | Replacement

Discover Deli with a Difference! Established in 1932, Deli Brands of America has a tradition of quality and value that is customers will taste the

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Wolfram|Alpha Examples: Equation Solving

A system of linear equations means two or more linear equations. The solution of the system of equations on the left is Solve By Elmination;

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WRITING A POSITION PAPER

The Literature Review: A Few Tips On Conducting It Written by Dena Taylor, Health Sciences Writing Centre

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META-INF//audet/samuel/shorttyping

META-INF//audet/samuel/shorttyping/ShortDictManager$/audet/samuel/shorttyping//audet/samuel

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Essays On The Holocaust

Essay on holocaust: free examples of essays, research and term papers. Examples of holocaust essay topics, questions and thesis satatements

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Plotter Paper CAD and Graphic Design

JESUS FASTENING MOFFETT SHUSTER MORTARS Garbhán Tintorero SOLTAU GAUTHREAUX Yocemento SUSPECTS' PINCKNEY UNPRESERVED DRINKER LEACHMAN JABBING WEAK FONTENOT PARALEGAL

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KadoKado - Games & Gifts!

Yonhap news articles produced by building a network covering domestic supplies in various newspapers, broadcasting and government departments, major institutions

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Oedipus rex essay joke | Juicy Retreat

*OLDIE BUT GOODIE* Funny essay on Oedipus Rex. Yes, this has been on here before, but I figure it's probably better to create a new thread than revive a frankenthread.

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Los Angeles Senior Living Resources - A Place for Mom

View MBA application and admissions requirements for the University of Virginia Darden School of Business.

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Levothyroxine shows no benefit in elderly patients with subclinical hypothyroidism, trial finds

Treatment with levothyroxine provides no clinical benefit in older people with subclinical hypothyroidism, a UK randomised trial published in the New England Journal of Medicine has...
recent?d=yIl2AUoC8zA recent?d=dnMXMwOfBR0 recent?i=sldV7FLG6P4:xQ3w0BotcvQ:V_sGLiP recent?d=qj6IDK7rITs recent?i=sldV7FLG6P4:xQ3w0BotcvQ:gIN9vFw recent?d=l6gmwiTKsz0 recent?d=7Q72WNTAKBA recent?i=sldV7FLG6P4:xQ3w0BotcvQ:F7zBnMy recent?i=sldV7FLG6P4:xQ3w0BotcvQ:-BTjWOF


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Free condoms should be targeted at people with high STI risk, says NICE

Local councils should target free condoms at people most at risk of sexually transmitted infections (STIs), guidance by the National Institute for Health and Care Excellence (NICE) recommends.1The...
recent?d=yIl2AUoC8zA recent?d=dnMXMwOfBR0 recent?i=vg1wCZ-846s:L_GbSB4lEZc:V_sGLiP recent?d=qj6IDK7rITs recent?i=vg1wCZ-846s:L_GbSB4lEZc:gIN9vFw recent?d=l6gmwiTKsz0 recent?d=7Q72WNTAKBA recent?i=vg1wCZ-846s:L_GbSB4lEZc:F7zBnMy recent?i=vg1wCZ-846s:L_GbSB4lEZc:-BTjWOF


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IJMS, Vol. 18, Pages 765: SCF/C-Kit/JNK/AP-1 Signaling Pathway Promotes Claudin-3 Expression in Colonic Epithelium and Colorectal Carcinoma

Claudin-3 is a major protein of tight junctions (TJs) in the intestinal epithelium and is critical for maintaining cell-cell adhesion, barrier function, and epithelium polarity. Recent studies have shown high claudin-3 levels in several solid tumors, but the regulation mechanism of claudin-3 expression remains poorly understood. In the present study, colorectal cancer (CRC) tissues, HT-29 and DLD-1 CRC cell lines, CRC murine model (C57BL/6 mice) and c-kit loss-of-function mutant mice were used. We demonstrated that elevated claudin-3 levels were positively correlated with highly expressed c-kit in CRC tissues based upon analysis of protein expression. In vitro, claudin-3 expression was clearly increased in CRC cells by overexpressed c-kit or stimulated by exogenous recombinant human stem cell factor (rhSCF), while significantly decreased by the treatment with c-kit or c-Jun N-terminal kinase (JNK) inhibitors. Chromatin immunoprecipitation (ChIP) and luciferase reporter assay showed that SCF/c-kit signaling significantly promoted activator protein-1 (AP-1) binding with CLDN-3 promoter and enhanced its transcription activity. Furthermore, decreased expression of claudin-3 was obtained in the colonic epithelium from the c-Kit loss-of-function mutant mice. In conclusion, SCF/c-kit-JNK/AP-1 signaling pathway significantly promoted claudin-3 expression in colonic epithelium and CRC, which could contribute to epithelial barrier function maintenance and to CRC development.

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Log 10 solve for x



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Turnitin - Technology to Improve Student Writing

Nous voudrions effectuer une description ici mais le site que vous consultez ne nous en laisse pas la possibilité.

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SmartCockpit - Airline training guides, Aviation

Remembrance is a collection of Galleries containing imagery, stories, poems, songs, maps, and narratives from or about the Vietnam War era.

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Essay Writing Service

Discover Deli with a Difference! Established in 1932, Deli Brands of America has a tradition of quality and value that is customers will taste the

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What Causes Gender Inequality? -- Robert Max Jackson (seminar)

Abstract: On a cold May night in Durham, North Carolina, Laura Jane Grace stepped out on stage to meet a roaring crowd in the tightly packed Motorco Music Hall.

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BBC - KS3 Bitesize Maths - Symmetry : Revision, Page 4

Can you find the image with rotational symmetry? Impress your friends by getting all the way to 100!

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Martha Stewart gets five months prison term - Jul. 20, 2004

History's Top 10 Insider Trading Cases Friday morning FBI agents swept in on six men from New York City to San Jose, Calif., busting what U. S

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12. The Binomial Probability Distribution - IntMath

Master the concepts of Probability including Bayes theorem, independent events and binomial distribution with the help of study material for IIT JEE by askIITians.

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Ken O'Connor - Ask The Grade Doctor

Students using an interactive whiteboard, part of an ambitious technology plan in the Kyrene School District in Arizona. Credit Jim Wilson/The New York Times

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Testing if Your DAO Level is Low - The Daily Headache

Studies using newer, more sensitive lab tests suggest that B12 deficiency is far more common than previously believed — especially in vegetarians.

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Crealco U-Solve Whole Window U-Value & SHGC Calculator

WebMath is designed to help you solve your math problems. Composed of forms to fill-in and then returns analysis of a problem and, when possible, provides a step-by

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Agrian of wheat essays on global warming



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Essay Writing Service

We provide excellent essay writing service 24/7. Enjoy proficient essay writing and custom writing services provided by professional academic writers.

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R154 – Jenny: My Accidental Creampie «

Things We Don’t Want to Do Today's Inspiration. Most of us have had the experience of tackling some dreaded task only to come out the other side feeling invigorated

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Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge

Abstract

Background

Oral squamous cell carcinoma (OSCC) accounts over 90% of malignant neoplasms of the oral cavity. This pathological entity is associated to a high mortality rate that has remained unchanged over the past decades. Tumour-associated macrophages (TAMs) are believed to have potential involvement in OSCC progression. However, the molecular networks involved in communication between stroma and cancer cells have not yet been fully elucidated.

Main body

The role of M2 polarized cells in oral carcinogenesis is supported by a correlation between TAMs accumulation into OSCC stroma and poor clinical outcome. Signalling pathways such as the NF-κB and cytokines released in the tumour microenvironment promote a bidirectional cross-talk between M2 and OSCC cells. These interactions consequently result in an increased proliferation of malignant cells and enhances aggressiveness, thus reducing patients' survival time.

Conclusions

Here, we present a comprehensive review of the role of interleukin (IL)-1, IL-4, IL-6, IL-8, IL-10 and the receptor tyrosine kinase Axl in macrophage polarization to an M2 phenotype and OSCC progression. Understanding the molecular basis of oral carcinogenesis and metastatic spread of OSCC would promote the development of targeted treatment contributing to a more favourable prognosis.



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Recent Advances in Management of Prostate Cancer

The post Recent Advances in Management of Prostate Cancer appeared first on Welcome to Avens.



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The usefulness of MR defecography in the evaluation of pelvic floor dysfunction: our experience using 3T MRI

Abstract

Purpose

To assess the usefulness of MR defecography in evaluating pelvic floor dysfunction, and to correlate several pelvic organ abnormalities with each other and with patients’ symptoms and characteristics.

Methods

MR defecographic examinations performed in 3T MRI machine of 95 patients (70 females, 25 males; mean age 48) were retrospectively reviewed. Pelvic organ abnormalities from all three compartments were recorded, including the anorectal junction descent, anterior rectocele, and cystocele. These were graded according to the known HMO system in relation to the pubococcygeal line. The correlation between these different abnormalities and their relation to patient symptoms and characteristics were evaluated.

Results

Anorectal junction descent and anterior rectocele were most commonly observed, predominantly manifesting in female patients. Both were associated with abnormalities from all compartments. The middle compartment was the least affected, and its abnormality of uterine/vaginal descent tended to occur in association with the anterior compartment abnormality (cystocele). Anismus was low in incidence, and was not associated with other compartments abnormalities. Both enterocele/peritoneocele and intussusception were uncommon.

Conclusion

MR defecography is the modality of choice in assessing pelvic floor dysfunction, because it can neatly show various pelvic organ abnormalities from all compartments in a dynamic fashion, which are frequently coexistent. It can even show clinically silent or unsuspected abnormalities which can impact the management of patients.



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Osteoporosis, obesity, and sarcopenia on abdominal CT: a review of epidemiology, diagnostic criteria, and management strategies for the reporting radiologist

Abstract

Abdominal computed tomography (CT) is a widely performed examination, with many indications. Assessment of bone, fat, and muscle on abdominal CT can be performed in a quantitative manner. Published studies have developed diagnostic cutoffs for osteoporosis, obesity, and sarcopenia, which are summarized with pictorial examples. The epidemiological and prognostic significance of these disease states are outlined. Further diagnostic steps and treatment strategies are outlined to inform both the managing clinician and reporting radiologist. This article summarizes an unglamorous yet information-rich field, which is ripe for assessment in the dawning era of personalized medicine, and one in which the radiologist is well placed to add value to patient care.



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A case of pulsating sternal and clavicular metastases of thyrofollicular carcinoma

DESCRIPTION

Bony metastases are not infrequently encountered with follicular carcinoma of thyroid. Rarely, papillary thyroid carcinoma spreads to bones1; however, anterior chest wall (sternal and clavicular) involvement are rare. A 54-year-old man with long-standing (~25 years) multinodular goitre presented with recent-onset rapid enlargement of the sternoclavicular area beneath the goitre. On examination, the swelling was hard, warm and pulsatile and in addition showed engorged anterior chest wall veins (figure 1). He was clinically and biochemically euthyroid. Chest X-ray (figure 2) showed huge thyroid mass with sternal and clavicular erosion confirmed by CT (figure 3). Fine-needle aspiration cytology of the goitre and bony mass confirmed follicular carcinoma. He underwent total thyroidectomy with excision of the sternal and clavicular metastases and reconstruction of the chest wall defect with Marlex mesh. Following surgery, he underwent radioiodine therapy (200 mCi) and the post-therapy scan showed multiple pulmonary macronodular...



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Toowoomba youths miss out on cancer-preventing vaccine - Toowoomba Chronicle


Toowoomba Chronicle

Toowoomba youths miss out on cancer-preventing vaccine
Toowoomba Chronicle
The human papillomavirus causes around 90 per cent of anal cancers, 35 per cent of penile cancers and 60 per cent of oropharyngeal cancers (cancer of the back of the throat, including tongue and tonsils) in Australia. The Gardasil vaccination is most ...
A Revolutionary Approach to Preventing Transmission of a Cancer-Causing VirusNews from Rutgers
New vaccine recommendation cuts number of HPV shots children needJournal Times

all 19 news articles »


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Selection and characterization of coal mine autochthonous rhizobia for the inoculation of herbaceous legumes

Abstract

Coal open pit mining in the South of Santa Catarina state (Brazil) was inappropriately developed, affecting approximately 6.700 ha. Re-vegetation is an alternative for the recovery of these areas. Furthermore, the use of herbaceous legumes inoculated with nitrogen fixing bacteria is motivated due to the difficulty implementing a vegetation cover in these areas, mainly due to low nutrient availability. Therefore, the aim of this work was to evaluate, among 16 autochthonous rhizobia isolated from the coal mining areas, those with the greatest potential to increase growth of the herbaceous legumes Vicia sativa and Calopogonium mucunoides. Tests were conducted in greenhouse containing 17 inoculation treatments (16 autochthonous rhizobia + Brazilian recommended strain for each plant species), plus two treatments without inoculation (with and without mineral nitrogen). After 60 days, nodulation, growth, N uptake, and symbiotic efficiency were evaluated. Isolates characterization was assessed by the production of indole acetic acid, ACC deaminase, siderophores, and inorganic phosphate solubilization. The classification of the isolates was performed by 16 S rDNA gene sequencing. Only isolates UFSC-M4 and UFSC-M8 were able to nodulate C. mucunoides. Among rhizobia capable of nodulating V. sativa, only UFSC-M8 was considered efficient. It was found the presence of more than one growth-promoting attributes in the same organism, and isolate UFSC-M8 presented all of them. Isolates were classified as belonging to Rhizobium, Burkholderia and Curtobacterium. The results suggest the inoculation of Vicia sativa with strain UFSC-M8, classified as Rhizobium sp., as a promising alternative for the revegetation of coal mining degraded areas.



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Two new species of the genus Streptomyces: Streptomyces camponoti sp. nov. and Streptomyces cuticulae sp. nov. isolated from the cuticle of Camponotus japonicus Mayr

Abstract

Two novel actinomycetes, designated strains 2C-SSA16(2)T and 1C-GS8T, were isolated from the cuticle of Camponotus japonicus Mayr, collected from Northeast Agricultural University, Heilongjiang Province, north China. Both of them contained genes (involved in antibiotics biosynthesis) of the ketosynthase (KS) and methyl malonyl transferase domains (PKS-I) and the adenylation domain (NRPS). A polyphasic study was carried out to establish the taxonomic positions of these strains. The 16S rRNA gene sequence analysis showed that the two novel isolates 2C-SSA16(2)T and 1C-GS8T exhibited 98.8% similarity with each other and that they are most closely related to Streptomyces umbrinus JCM 4521T (99.0, 98.6%), Streptomyces ederensis JCM 4958T (98.9, 98.7%), Streptomyces aurantiacus JCM 4453T (98.6, 98.2%), Streptomyces glomeroaurantiacus JCM 4677T (98.6, 98.1%), Streptomyces tauricus JCM4837T (98.2, 98.0%) and Streptomyces phaeochromogenes JCM 4070T (98.2, 99.2%). The corresponding phylogenetic analysis based on partial gyrB gene sequences showed that strains 2C-SSA16(2)T and 1C-GS8T formed a cluster with the above-mentioned strains. The DNA–DNA hybridization data and phenotypic characteristics indicated that strains 2C-SSA16(2)T and 1C-GS8T could be readily distinguished from each other and their closest phylogenetic relatives. Therefore, these two strains are suggested to represent two novel species of the genus Streptomyces, for which the names Streptomyces camponoti sp. nov. and Streptomyces cuticulae sp. nov. are proposed. The type strains are 2C-SSA16(2)T (=CGMCC 4.7276T = DSM 100522T) and 1C-GS8T (=CGMCC 4.7348 = DSM 103127T), respectively.



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Omp31 plays an important role on outer membrane properties and intracellular survival of Brucella melitensis in murine macrophages and HeLa cells

Abstract

Brucellosis is an infectious disease that affects practically all species of mammals, including human, and is a major zoonosis worldwide. Brucella spp. are facultative intracellular pathogens that have the ability to survive and multiply in phagocytic and nonphagocytic cells such as trophoblast and epithelial cells. Among the six recognized species of the genus Brucella, Brucella melitensis is the main etiological agent involved in goat brucellosis and is also the most pathogenic for human. It causes significant losses in livestock production as a result of abortions, metritis, infertility, and birth of weak animals. Outer membrane proteins (OMPs) are exposed on the bacterial surface and are in contact with cells and effectors of the host immune response, whereby they could be important virulence factors of Brucella species. To evaluate this hypothesis, the gene encoding for the major outer membrane protein Omp31 was amplified, cloned into pUC18 plasmid, and inactivated by inserting a kanamycin cassette, rendering pLVM31 plasmid which was transformed into B. melitensis wild-type strain to obtain LVM31 mutant strain. The Outer membrane (OM) properties of the mutant strain were compared with B. melitensis Bm133 wild-type and B. melitensis Rev1 vaccine strains, in assessing its susceptibility to polymyxin B, sodium deoxycholate, and nonimmune serum. The mutant strain was assessed in vitro with survival assays in murine macrophages J774.A1 and HeLa cells. Our results demonstrate that LVM31 mutant is more susceptible to polymyxin B, sodium deoxycholate, and nonimmune serum than control strains; moreover, Omp31 mutation caused a decrease in the internalization and a significant decrease in the intracellular survival compared with the reference strains in both cell lines. These results allow us to conclude that Omp31 is important for maintaining OM integrity, but also it is necessary for bacterial internalization, establishment and development of an optimal replication niche, and essential for survival and intracellular multiplication.



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Strains of Photorhabdus spp. associated with polish Heterorhabditis isolates: their molecular and phenotypic characterization and symbiont exchange

Abstract

The relationships between six bacterial symbionts of the entomopathogenic nematodes Heterorhabditis bacteriophora and Heterorhabditis megidis from Poland to species and subspecies of the genus Photorhabdus were evaluated. This study was based on phylogenetic analysis of sequence data of five genes: 16S rRNA, gyrB, recA, gltX, and dnaN. The bacteria were also characterized phenotypically by biochemical and physiological tests. Our results have revealed that the Photorhabdus strains isolated from H. megidis belong to P. temperata, subsp. temperata and subsp. cinerea. Isolates from H. bacteriophora represent P. luminescens subs. kayaii and P. temperata subs. cinerea. This study for the first time provides evidence for H. bacteriophora and P. temperata subsp. cinerea symbiotic association. In addition, we tested whether the microsymbionts of the Polish H. bacteriophora and H. megidis isolates support the development of non-native nematode host population and colonization of their infective juveniles. It has been shown that the studied Photorhabdus strains can readily swap their nematode host, both at intra- and interspecies level. It supports the hypothesis of different symbiotic associations in the HeterorhabditisPhotorhabdus lineage.



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Patients with ANCA-associated vasculitis admitted to the intensive care unit with acute vasculitis manifestations: a retrospective and comparative multicentric study

Data for ANCA-associated vasculitis (AAV) patients requiring intensive care are scarce.

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Earlier versus later initiation of renal replacement therapy among critically ill patients with acute kidney injury: a systematic review and meta-analysis of randomized controlled trials

Although the optimal timing of initiation of renal replacement therapy (RRT) in critically ill patients with acute kidney injury has been extensively studied in the past, it is still unclear.

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Diagnostic accuracy of quantitative neuromuscular ultrasound for the diagnosis of intensive care unit-acquired weakness: a cross-sectional observational study

Neuromuscular ultrasound is a noninvasive investigation, which can be easily performed at the bedside on the ICU. A reduction in muscle thickness and increase in echo intensity over time have been described in...

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Risk factors associated with current intimate partner violence at individual and relationship levels: a cross-sectional study among married rural migrant women in Shanghai, China

Objective

To identify individual and relationship risk factors associated with current intimate partner violence (IPV) against married rural migrant women in Shanghai, China.

Design

Cross-sectional survey.

Setting

Two subdistricts of one administrative district, Shanghai, China.

Participants

A total of 958 married rural migrant women of reproductive age were selected using a community-based two-stage cluster sampling method in April and May of 2010.

Outcome measures

Data were collected using a modified questionnaire based on an instrument from the WHO Multi-country Study on Women’s Health and Domestic Violence against Women. Adjusted odds ratio (AOR) and 95% CI from a multivariable logistic regression model were estimated to identify individual and relationship risk factors associated with different types of violence in the past 12 months.

Results

Women’s low financial autonomy was associated with all types of violence (AORs ranged from 1.98 to 7.89, p<0.05). Quarrelling with husband was a very strong risk factor (AORs >6, p<0.05) for both emotional violence and any violence. Experience of job change in the past year (AOR=4.03, 95% CI 1.57 to 10.35) and history of husband being abused (AOR=4.67, 95% CI 2.17 to 7.69) were strongly associated with physical or sexual violence.

Conclusion

Women’s low financial autonomy and unstable employment status at an individual level, quarrelling with husband and history of husband beaten by family members at a relationship level were identified as the most robust risk factors for IPV among married rural migrant women. Efforts to prevent IPV among this population should be made to involve both women and their husbands, with a focus on improving financial autonomy and employment status of women, promoting problem-solving and interaction skills of the couples and changing their knowledge and attitudes towards gender norms and IPV.



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Translating concerns into action: a detailed qualitative evaluation of an interdisciplinary intervention on medical wards

Objectives

To understand how frontline reports of day-to-day care failings might be better translated into improvement.

Design

Qualitative evaluation of an interdisciplinary team intervention capitalising on the frontline experience of care delivery. Prospective clinical team surveillance (PCTS) involved structured interdisciplinary briefings to capture challenges in care delivery, facilitated organisational escalation of the issues they identified, and feedback. Eighteen months of ethnography and two focus groups were conducted with staff taking part in a trial of PCTS.

Results

PCTS fostered psychological safety—a confidence that the team would not embarrass or punish those who speak up. This was complemented by a hard edge of accountability, whereby team members would regulate their own behaviour in anticipation of future briefings. Frontline concerns were triaged to managers, or resolved autonomously by ward teams, reversing what had been well-established normalisations of deviance. Junior clinicians found a degree of catharsis in airing their concerns, and their teams became more proactive in addressing improvement opportunities. PCTS generated tangible organisational changes, and enabled managers to make a convincing case for investment. However, briefings were constrained by the need to preserve professional credibility, and staff found some comfort in avoiding accountability . At higher organisational levels, frontline concerns were subject to competition with other priorities, and their resolution was limited by the scale of the challenges they described.

Conclusions

Prospective safety strategies relying on staff-volunteered data produce acceptable, negotiated accounts, subject to the many interdisciplinary tensions that characterise ward work. Nonetheless, these strategies give managers access to the realities of frontline cares, and support frontline staff to make incremental changes in their daily work. These are goals for learning healthcare organisations.

Trial registration

ISRCTN 34806867.



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Holzer has free oral, head, neck cancer screening - Huntington Herald Dispatch


WTNH Connecticut News (press release)

Holzer has free oral, head, neck cancer screening
Huntington Herald Dispatch
This is the first year Holzer has offered this type of free screening for the community. Oral, Head, and Neck Cancer Awareness Week is annually recognized in April, and this free screening aims to catch cancers that arise in the nasal cavity, sinuses ...
Free screenings for curable cancers if caught earlyWTNH Connecticut News (press release)

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Where i see myself in 5 years essay



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Reflections on Institutional Theories of Organizations

Nash Business Solutions offers variety of training courses in collaboration with the best gurus and practitioners in the field and the participation stretches around

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How to Teach Creative Writing (with Pictures) - wikiHow

Creative writing can be both fun and rewarding. It gives you the chance to get creative and use your imagination in a positive way - hopefully by producing something

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BibMe: Free Bibliography & Citation Maker - MLA, APA

Reduce homework time and stress using these parent-friendly math calculators designed to help you tutor your child who has a parent-unfriendly textbook.

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Social Problem Solving Posters {FREE} - This Reading Mama

12 free GRE Problem Solving practice tests with explanations. Our tests contain over 100 GRE math questions to help you with your GRE prep.

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Communication And Team Work Nursing Essay

FREE Team Communication Papers & Team Communication Essays at #1 ESSAYS BANK since 1998! BIGGEST and the BEST ESSAYS BANK. Team Communication Essays, Team

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Composting: a guide to making compost at home, using

Find out what benefits you can apply for Use our screening tool to help identify all the different Social Security programs for which you may be eligible.

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11 Smart Tips for Brilliant Writing - Copyblogger

Personal-Assistant-Tips. We offer excellent PA skills development training courses for EAs, Executive Secretaries and Administrators, as well as PA mentoring and PA

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CIA agent who grilled Saddam Hussein says US was wrong

On November 8, India’s Prime Minister Narendra Modi announced that 86% of the country’s currency would be rendered null and void in 50 days. It was

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Writing a Definition Essay: Outline, Format, Structure

Chapter 5: RHETORICAL MODES What are the modes of writing?---Argument . Cause-Effect . Classification

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Isolated palatal weakness without optic neuritis as the presenting manifestation of multiple sclerosis and its diagnostic dilemma with acute disseminated encephalomyelitis in a young boy

Virti D Shah, Sumeet Prakash Mirgh, Nirmal Surya

Avicenna Journal of Medicine 2017 7(2):71-74

We present a case of a young boy who at initial presentation was diagnosed as acute disseminated encephalomyelitis (ADEM) but subsequently on follow-up was diagnosed as multiple sclerosis (MS). Differentiating ADEM from MS in their first presentation can be tricky as the features may not be typical of anyone. The importance lies in the close follow-up of these patients.

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Do not resuscitate, brain death, and organ transplantation: Islamic perspective

Hassan Chamsi-Pasha, Mohammed Ali Albar

Avicenna Journal of Medicine 2017 7(2):35-45

Muslim patients and families are often reluctant to discuss and accept fatal diagnoses and prognoses. In many instances, aggressive therapy is requested by a patient's family, prolonging the life of the patient at all costs. Islamic law permits the withdrawal of futile treatment, including life support, from terminally ill patients allowing death to take its natural course. “Do not resuscitate” is permitted in Islamic law in certain situations. Debate continues about the certainty of brain death criteria within Islamic scholars. Although brain death is accepted as true death by the majority of Muslim scholars and medical organizations, the consensus in the Muslim world is not unanimous, and some scholars still accept death only by cardiopulmonary criteria. Organ transplantation has been accepted in Islamic countries (with some resistance from some jurists). Many fatwas (decrees) of Islamic Jurisprudence Councils have been issued and allowed organs to be donated from living competent adult donor; and from deceased (cadavers), provided that they have agreed to donate or their families have agreed to donate after their death (usually these are brain-dead cases). A clear and well-defined policy from the ministry of health regarding do not resuscitate, brain death, and other end-of-life issues is urgently needed for all hospitals and health providers in most (if not all) Muslim and Arab countries.

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Are these results trustworthy? A guide for reading the medical literature

Fares Alahdab, Allison Morrow, Mouaz Alsawas, M Hassan Murad

Avicenna Journal of Medicine 2017 7(2):46-50

Physicians practicing evidence-based medicine need to be able to appraise a new study and determine whether the results warrant sufficient certainty to the level that they can be applied to patient care. Without such appraisal, misleading results can be incorporated into patient care, which can lead to inefficient, costly, and possibly harmful care. The Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach offers a modern framework that can be applied to evaluate the trustworthiness of evidence. In this guide, we present a simplified approach based on GRADE; in which we call on readers of the medical literature to pay attention to six domains before making an overall judgment about the trustworthiness of results and before applying the evidence to patient care.

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Hyperthyroidism and noncompaction

Josef Finsterer, Claudia Stöllberger

Avicenna Journal of Medicine 2017 7(2):78-79



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Black widow spider bites experience from tertiary care center in Saudi Arabia

Ali Al Bshabshe, Musa Alfaifi, Ahmed Fouad Alsayed

Avicenna Journal of Medicine 2017 7(2):51-53

Introduction: Black widow spiders are one of the most poisonous species to humans; there are more than 30 species of widow spiders in the globe but good thing that not all of them are dangerous. Some of these spiders produce toxic venoms, which cause broad spectrum of clinical manifestations including skin lesions, neurotoxicity, cardiac toxicity and death in some occasions. In Saudi Arabia there were no much reports of black widow spider bites apart from the case series by BUCUR and his group in ALBAHA region. Settings: In 2 years period a total of 8 patients were presented to the emergency departments diagnosed to have black widow spider bites based on description by the patients. Results: 100 % of the cohort were males, aged between 25-58 years. The time between bite and presentation to emergency room was one hour in average (30 min to 4 hours). 75% occured during summer season. All of them 100% had one bite only and reported the bite to be at nighttime in 75% of the times. The average pain score at presentation was 4 /10.100% of the bites were in the lower extremities and almost all progressed to have lower back pain. Three patients had gastrointestinal tract manifestation in form of abdominal cramps and nausea. One had bilateral ptosis, none of them had cardiac or pulmonary complications. The outcome was excellent in all patients and the average of hospital stay was 2.5 days (1-5).

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Drug-induced hypersensitivity reaction: A case of simultaneous thyroiditis and fulminant type 1 diabetes

Michael Marchese, Matthew Leinung, Hassan Shawa

Avicenna Journal of Medicine 2017 7(2):67-70

A 43-year-old incarcerated man with AIDS was hospitalized for 30 pounds weight loss and diffuse pruritic rash. Three months prior, he was started on dapsone for Pneumocystis jiroveci pneumonia prevention. Biochemical evaluation was remarkable for eosinophilia, thrombocytopenia, acute renal insufficiency, transaminitis, thyrotoxicosis, and significant hyperglycemia (450 mg/dl; nl, 65–99). His hemoglobin A1c level was 5.9% (nl, 4.1–5.6). Thyroid-stimulating immunoglobulin, glutamic acid decarboxylase, and islet cell autoantibodies were within the normal range. He was found to have acute interstitial nephritis based on renal biopsy. He was diagnosed with hypersensitivity reaction due to dapsone. The patient was managed with a tapering dose of corticosteroid, beta-blocker, and multiple daily injections of insulin. The symptoms and biochemical disturbances including thyrotoxicosis resolved within a few weeks. Insulin requirements decreased but diabetes did not resolve with hemoglobin A1c of 6.1% a year after hospitalization. To our knowledge, this is the first case of hypersensitivity reaction due to dapsone causing simultaneous fulminant type 1 diabetes and thyroiditis.

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Efficacy of a multi-component psychosocial intervention program for caregivers of persons living with neurocognitive disorders, Alexandria, Egypt: A randomized controlled trial

Zeinab Nazeeh Shata, Marwa R Amin, Heba M El-Kady, Mervat W Abu-Nazel

Avicenna Journal of Medicine 2017 7(2):54-63

Background: Unlike other chronic diseases, dementia caregiving is associated with enormous psychological burden, which stresses the need for caregivers-directed psychosocial interventions. Aim: This randomized controlled trial (RCT) was conducted to evaluate the short-term efficacy of a multi-component psychosocial intervention program for informal caregivers of persons with neurocognitive disorders in Alexandria, Egypt. Methods: Informal caregivers (120) were randomly assigned into intervention and control groups. The intervention group (60) participated in a multi-component program of 8 sessions, including psycho-education, group cognitive-behavioral therapy, and group social support. Program primary outcomes were assessed after program termination (post-1), and three months later (post-2). Measured outcomes included caregivers' knowledge, depression and anxiety symptoms, and perceived burden. Results: Caregivers' depression, anxiety, and perceived burden demonstrated significant drop at post-1, and post-2 compared to the control group (P< 0.001). The intervention group showed significant negative absolute change on depression, anxiety, and perceived burden measures, while on the dementia-related knowledge measure, a significant positive absolute change was found at post-1, and post-2 (P< 0.001), in comparison to controls. All outcome measures recorded a large effect size; the highest was for knowledge (partial eta2 = 0.98), and the least was for perceived burden (partial eta2 = 0.71). Conclusion: A multi-component psychosocial intervention for caregivers of persons with neurocognitive disorders demonstrated a short-term efficacy in reducing their burden, depression, and anxiety, as well as improving caregivers' knowledge. However, further research is needed to investigate long-term efficacy of the intervention.

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Donor-transmitted melanoma after limbal stem cell transplantation

Anas Alsara, Muhammad Rafi

Avicenna Journal of Medicine 2017 7(2):75-77

Limbal Stem Cells are a unique cell line located at the corneal limbus. They are responsible for regenerating and restoring corneal epithelial layers. Limbal stem cell transplantation is a promising technique that has been used to treat several hereditary and acquired corneal diseases. Cornea tissue lack vascularity. Hence, there were no special restrictions on collecting ocular tissues from donors with a diagnosis of metastatic melanoma. We are reporting a case of a patient who developed an ocular melanoma after she had limbal stem cell transplantation from a donor with history of melanoma. After this case, Eye Bank Association of America updated the donor criteria to exclude donors with any history of melanoma.

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Polio in Syria: Problem still not solved

Ahmad Al-Moujahed, Fares Alahdab, Heba Abolaban, Leo Beletsky

Avicenna Journal of Medicine 2017 7(2):64-66

Th ereappearance of polio in Syria in mid-2013, 18 years after it was eliminated from the country, manifests the public health catastrophe brought on by the civil war. Among the lessons learned, this outbreak emphasizes the importance of increasing the international financial and logistical support for vaccine and immunization efforts, especially in countries suffering from conflicts. The lack of access to polio accredited laboratory or outright lack of laboratories in settings of conflict should be recognized allowing international surveillance to be strengthened by supplementing the laboratory definition with the clinical definition. In addition, it illustrates the imperative for the United Nations (UN) agencies involved in global health to be able to operate independently from governments during conflicts in order to provide adequate and efficient medical and humanitarian relief for civilians. Proper communicable disease surveillance and control, delivery of vaccinations, and other pivotal healthcare services to these areas require independence from governments and all military actors involved. Moreover, it shows the necessity to adequately support and fund the front-line nongovernmental organizations (NGOs) that are implementing the delivery of medical and humanitarian aid in Syria.

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Left ventricular noncompaction cardiomyopathy

Amer Hawatmeh, Habib Habib, Fayez Shamoon

Avicenna Journal of Medicine 2017 7(2):79-80



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Poncet’s disease: two case reports

One of the rare presentations of active pulmonary or even extrapulmonary tuberculosis is polyarthropathy which is the involvement of multiple large and small joints in the body; a reactive constellation known ...

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Holzer has free oral, head, neck cancer screening - Huntington Herald Dispatch


Holzer has free oral, head, neck cancer screening
Huntington Herald Dispatch
This is the first year Holzer has offered this type of free screening for the community. Oral, Head, and Neck Cancer Awareness Week is annually recognized in April, and this free screening aims to catch cancers that arise in the nasal cavity, sinuses ...

and more »


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Holzer has free oral, head, neck cancer screening - Huntington Herald Dispatch


Holzer has free oral, head, neck cancer screening
Huntington Herald Dispatch
Tobacco (including smokeless tobacco) and alcohol use are very high risk factors for oral, head and neck cancers, particularly those of the tongue, mouth, throat and voice box. People who use both tobacco and alcohol are at greater risk for developing ...

and more »


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Detection of newly produced T and B lymphocytes by digital PCR in blood stored dry on nylon flocked swabs

A normal number of T-cell receptor excision circles (TRECs) and K-deleting recombination excision circles (KRECs) is considered a biomarker for adequate new T- and B-cell production. In newborns, detection of ...

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Association of atrial fibrillation susceptibility genes, atrial fibrillation phenotypes and response to catheter ablation: a gene-based analysis of GWAS data

Previous studies have suggested PITX2, KCNN3 and ZFHX3 as atrial fibrillation (AF) susceptibility genes. Single common genetic polymorphisms of those genes have been linked with AF phenotypes and rhythm outcome o...

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Holzer has free oral, head, neck cancer screening - Huntington Herald Dispatch


Holzer has free oral, head, neck cancer screening
Huntington Herald Dispatch
Oral, Head, and Neck Cancer Awareness Week is annually recognized in April, and this free screening aims to catch cancers that arise in the nasal cavity, sinuses, lips, mouth, thyroid glands, salivary glands, throat or larynx (voice box) at an early ...

and more »


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A Revolutionary Approach to Preventing Transmission of a Cancer-Causing Virus - News from Rutgers


News from Rutgers

A Revolutionary Approach to Preventing Transmission of a Cancer-Causing Virus
News from Rutgers
More than 12,000 women are diagnosed with cervical cancer each year in the U.S., and more than 4,000 of them will die of it. HPV is also linked to cancers of the vagina, vulva, penis, anus, and back of the throat, tongue and tonsils, in men and women.

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Holzer has free oral, head, neck cancer screening - Huntington Herald Dispatch


Holzer has free oral, head, neck cancer screening
Huntington Herald Dispatch
Most oral cancers arise on the lips, tongue or the floor of the mouth. They also may occur inside the cheeks, on the gums or on the roof of the mouth. Oropharyngeal cancers related to HPV are often found in the tonsil or base of tongue. Other head and ...

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MicroRNAs Association in the Cardiac Hypertrophy Secondary to Complex Congenital Heart Disease in Children

Abstract

Complex congenital heart disease (CHD) affects cardiac blood flow, generating a pressure overload in the compromised ventricles and provoking hypertrophy that over time will induce myocardial dysfunction and cause a potential risk of imminent death. Therefore, the early diagnosis of complex CHD is paramount during the first year of life, with surgical treatment of patients favoring survival. In the present study, we analyzed cardiac tissue and plasma of children with cardiac hypertrophy (CH) secondary to CHD for the expression of 11 miRNAs specific to CH in adults. The results were compared with the miRNA expression patterns in tissue and blood of healthy children. In this way, we determined that miRNAs 1, 18b, 21, 23b, 133a, 195, and 208b constitute the expression profile of the cardiac tissue of children with CHD. Meanwhile, miRNAs 21, 23a, 23b, and 24 can be considered specific biomarkers for the diagnosis of CH in infants with CHD. These results suggest that CH secondary to CHD in children differs in its mechanism from that described for adult hypertrophy, offering a new perspective to study the development of this pathology and to determine the potential of hypertrophic miRNAs to be biomarkers for early CH.



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Holzer has free oral, head, neck cancer screening - Huntington Herald Dispatch


Holzer has free oral, head, neck cancer screening
Huntington Herald Dispatch
Oral, Head, and Neck Cancer Awareness Week is annually recognized in April, and this free screening aims to catch cancers that arise in the nasal cavity, sinuses, lips, mouth, thyroid glands, salivary glands, throat or larynx (voice box) at an early ...

and more »


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Relative effectiveness of adjuvant chemotherapy for invasive lobular compared with invasive ductal carcinoma of the breast

BACKGROUND

Invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) have distinct clinical, pathologic, and genomic characteristics. The objective of the current study was to compare the relative impact of adjuvant chemotherapy on the survival of patients with ILC versus those with IDC.

METHODS

Women with estrogen receptor (ER)-positive, human epidermal growth factor receptor 1 (HER2) -negative, stage I/II IDC and ILC who received endocrine therapy were identified from the 2000 to 2014 California Cancer Registry. Patient, tumor, and treatment characteristics were collected. Ten-year overall survival (OS) was estimated using the Kaplan-Meier method and Cox proportional-hazards modeling.

RESULTS

In total, 32,997 women with IDC and 4638 with ILC were identified. The receipt of chemotherapy significantly decreased during the study for both subtypes. For patients with IDC, the 10-year OS rate was 95% among those who received endocrine therapy alone versus 93% (P < .01) among those who received endocrine therapy plus chemotherapy. For patients with ILC, the 10-year OS rate was 94% among those who received endocrine therapy alone versus 92% (P < .01) among those who received endocrine therapy plus chemotherapy. After adjusting for patient and treatment factors, adjuvant chemotherapy was significantly associated with a decreased 10-year hazard of death for patients with IDC (hazard ratio, 0.83; 95% confidence interval, 0.74-0.92). In contrast, adjuvant chemotherapy was not independently associated with the adjusted 10-year hazard of death for patients with ILC (hazard ratio, 1.14; 95% confidence interval, 0.90-1.46).

CONCLUSIONS

Adjuvant chemotherapy was not associated with improved OS for patients with ER-positive, HER2-negative, stage I/II ILC. Avoidance of ineffective chemotherapy will markedly reduce the adverse effects and economic burden of breast cancer treatment for a large proportion of patients with breast cancer. Cancer 2017. © 2017 American Cancer Society.



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eIF5A-PEAK1 Signaling Regulates YAP1/TAZ Protein Expression and Pancreatic Cancer Cell Growth

In pancreatic ductal adenocarcinoma (PDAC), mutant KRAS stimulates the translation initiation factor eIF5A and upregulates the focal adhesion kinase PEAK1, which transmits integrin and growth factor signals mediated by the tumor microenvironment. Although eIF5A-PEAK1 signaling contributes to multiple aggressive cancer cell phenotypes, the downstream signaling processes that mediate these responses are uncharacterized. Through proteomics and informatic analyses of PEAK1-depleted PDAC cells, we defined protein translation, cytoskeleton organization, and cell-cycle regulatory pathways as major pathways controlled by PEAK1. Biochemical and functional studies revealed that the transcription factors YAP1 and TAZ are key targets of eIF5A-PEAK1 signaling. YAP1/TAZ coimmunoprecipitated with PEAK1. Interfering with eIF5A-PEAK1 signaling in PDAC cells inhibited YAP/TAZ protein expression, decreasing expression of stem cell–associated transcription factors (STF) including Oct4, Nanog, c-Myc, and TEAD, thereby decreasing three-dimensional (3D) tumor sphere growth. Conversely, amplified eIF5A-PEAK1 signaling increased YAP1/TAZ expression, increasing expression of STF and enhancing 3D tumor sphere growth. Informatic interrogation of mRNA sequence databases revealed upregulation of the eIF5A-PEAK1-YAP1-TEAD signaling module in PDAC patients. Taken together, our findings indicate that eIF5A-PEAK1-YAP signaling contributes to PDAC development by regulating an STF program associated with increased tumorigenicity. Cancer Res; 77(8); 1–11. ©2017 AACR.

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Expression of neuroendocrine factor VGF in lung cancer cells confers resistance to EGFR kinase inhibitors and triggers epithelial-to-mesenchymal transition

Mutations in EGFR drive tumor growth but render tumor cells sensitive to treatment with EGFR tyrosine kinase inhibitors (TKIs). Phenotypic alteration in epithelial-to-mesenchymal transition (EMT) has been linked to the TKI resistance in lung adenocarcinoma. However, the mechanism underlying this resistance remains unclear. Here we report that high expression of a neuroendocrine factor termed VGF induces the transcription factor TWIST1 to facilitate TKI resistance, EMT, and cancer dissemination in a subset of lung adenocarcinoma cells. VGF silencing resensitized EGFR-mutated lung adenocarcinoma cells to TKI. Conversely, overexpression of VGF in sensitive cells conferred resistance to TKIs and induced EMT, increasing migratory and invasive behaviors. Correlation analysis revealed a significant association of VGF expression with advanced tumor grade and poor survival in patients with lung adenocarcinoma. In a mouse xenograft model of lung adenocarcinoma, suppressing VGF expression was sufficient to attenuate tumor growth. Overall, our findings show how VGF can confer TKI resistance and trigger EMT, suggesting its potential utility as a biomarker and therapeutic target in lung adenocarcinoma.

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Drug resistance mechanisms in colorectal cancer dissected with cell type-specific dynamic logic models

Genomic features are used as biomarkers of sensitivity to kinase inhibitors used widely to treat human cancer, but effective patient stratification based on these principles remains limited in impact. Insofar as kinase inhibitors interfere with signaling dynamics, and, in turn, signaling dynamics affects inhibitor responses, we investigated associations in this study between cell-specific dynamic signaling pathways and drug sensitivity. Specifically, we measured 14 phosphoproteins under 43 different perturbed conditions (combinations of 5 stimuli and 7 inhibitors) in 14 colorectal cancer cell lines, building cell line-specific dynamic logic models of underlying signaling networks. Model parameters representing pathway dynamics were used as features to predict sensitivity to a panel of 27 drugs. Specific parameters of signaling dynamics correlated strongly with drug sensitivity for 14 of the drugs, 9 of which had no genomic biomarker. Following one of these associations, we validated a drug combination predicted to overcome resistance to MEK inhibitors by co-blockade of GSK3, which was not found based on associations with genomic data. These results suggest that, in order to better understand cancer resistance and move toward personalized medicine, it is essential to consider signaling network dynamics that can not be inferred from static genotypes.

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SETD1B activates iNOS expression in myeloid-derived suppressor cells

Inducible nitric oxide synthase (iNOS) generates nitric oxide (NO) in myeloid cells that acts as a defense mechanism to suppress invading microorganisms or neoplastic cells. In tumor-bearing mice, elevated iNOS expression is a hallmark of myeloid-derived suppressor cells (MDSC). MDSCs use NO to nitrate both the T cell receptor and STAT1, thus inhibiting T cell activation and the anti-tumor immune response. The molecular mechanisms underlying iNOS expression and regulation in tumor-induced MDSCs are unknown. We report here that deficiency in IRF8 results in diminished iNOS expression in both mature CD11b+Gr1- and immature CD11b+Gr1+ myeloid cells in vivo. Strikingly, although IRF8 was silenced in tumor-induced MDSC, iNOS expression was significantly elevated in tumor-induced MDSC, suggesting that the expression of iNOS is regulated by an IRF8-independent mechanism under pathological conditions. Furthermore, tumor-induced MDSC exhibited diminished STAT1 and NF-κB Rel protein levels, the essential inducers of iNOS in myeloid cells. Instead, tumor-induced MDSC showed increased SETD1B expression as compared to their cellular equivalents in tumor-free mice. Chromatin immunoprecipitation revealed that H3K4me3, the target of SETD1B, was enriched at the nos2 promoter in tumor-induced MDSC, and inhibition or silencing of SETD1B diminished iNOS expression in tumor-induced MDSC. Our results show how tumor cells use the SETD1B-H3K4me3 epigenetic axis to bypass a normal role for IRF8 expression in activating iNOS expression in MDSC, when they are generated under pathological conditions.

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Modulation of Bax and mTOR for cancer therapeutics

A rationale exists for pharmacologic manipulation of the serine (S)184 phosphorylation site of the proapoptotic Bcl2 family member Bax as an anticancer strategy. Here we report the refinement of the Bax agonist SMBA1 to generate CYD-2-11, which has characteristics of a suitable clinical lead compound. CYD-2-11 targeted the structural pocket proximal to S184 in the C-terminal region of Bax, directly activating its proapoptotic activity by inducing a conformational change enabling formation of Bax homooligomers in mitochondrial membranes. In murine models of small cell and non-small cell lung cancers, including patient-derived xenograft and the genetically engineered mutant KRAS-driven lung cancer models, CYD-2-11 suppressed malignant growth without evident significant toxicity to normal tissues. In lung cancer patients treated with mTOR inhibitor RAD001, we observed enhanced S184 Bax phosphorylation in lung cancer cells and tissues which inactivates the propaoptotic function of Bax, contributing to rapalog resistance. Combined treatment of CYD-2-11 and RAD001 in murine lung cancer models displayed strong synergistic activity and overcame rapalog resistance in vitro and in vivo. Taken together, our findings provide preclinical evidence for a pharmacologic combination of Bax activation and mTOR inhibition as a rational strategy to improve lung cancer treatment.

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Androgens are differentially associated with ovarian cancer subtypes in the Ovarian Cancer Cohort Consortium

Invasive epithelial ovarian cancer (EOC) is the most lethal gynecologic malignancy. The etiology of EOC remains elusive; however, experimental and epidemiologic data suggest a role for hormone-related exposures in ovarian carcinogenesis and risk factor differences by histologic phenotypes and developmental pathways. Research on pre-diagnosis androgen concentrations and EOC risk has yielded inconclusive results, and analyses incorporating EOC subtypes are sparse. We conducted a pooled analysis of 7 nested case-control studies in the Ovarian Cancer Cohort Consortium to investigate the association between pre-diagnosis circulating androgens (testosterone, free testosterone, androstenedione, dehydroepiandrosterone sulfate (DHEAS)), sex hormone binding globulin (SHBG), and EOC risk by tumor characteristics (i.e. histology, grade, and stage). The final study population included 1,331 EOC cases and 3,017 matched controls. Multivariable conditional logistic regression was used to assess risk associations in pooled individual data. Testosterone was positively associated with EOC risk (all subtypes combined, Odds Ratio (OR)log2=1.12 [95% Confidence Interval (CI) 1.02-1.24]); other endogenous androgens and SHBG were not associated with overall risk. Higher concentrations of testosterone and androstenedione associated with an increased risk in endometrioid and mucinous tumors (e.g., testosterone, endometrioid tumors, ORlog2=1.40 [1.03-1.91]), but not serous or clear cell. An inverse association was observed between androstenedione and high grade serous tumors (ORlog2=0.76 [0.60-0.96]). Our analyses provide further evidence for a role of hormone-related pathways in EOC risk, with differences in associations between androgens and histologic subtypes of EOC.

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Personalized Management of Pancreatic Ductal Adenocarcinoma Patients Through Computational Modeling

Phenotypic diversity in pancreatic ductal adenocarcinoma (PDAC) results in a variety of treatment responses. Rapid autopsy studies have revealed a subgroup of PDAC patients with a lower propensity to develop metastatic disease, challenging the common perception that all patients die of widely metastatic disease, but questions remain about root causes of this difference and the potential impact on treatment strategies. In this study, we addressed these questions through the development of a mathematical model of PDAC progression that incorporates the major alteration status of specific genes with predictive utility. The model successfully reproduced clinical outcomes regarding metastatic patterns and the genetic alteration status of patients from two independent cohorts from the United States and Japan. Using this model, we defined a candidate predictive signature in patients with low metastatic propensity: if a primary tumor contained a small fraction of cells with KRAS and additional alterations to CDKN2A, TP53, or SMAD4 genes, the patient was likely to exhibit low metastatic propensity. By using this predictive signature, we computationally simulated a set of clinical trials to model whether this subgroup would benefit from locally intensive therapies such as surgery or radiation therapy. The largest overall survival benefit resulted from complete resection followed by adjuvant chemoradiation therapy and salvage therapies for isolated recurrence. While requiring prospective validation in a clinical trial, our results suggest a new tool to help personalize care in PDAC patients in seeking the most effective therapeutic modality for each individual.

Major findings

The mathematical model was feasible in analyzing major clinical features in two independent cohorts. A patient is likely to exhibit low metastatic propensity if the primary tumor contains a small fraction of cells (

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