Πέμπτη, 30 Μαΐου 2019

Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,


Adjuvant therapies in venous leg ulcer management: A scoping review Victoria Team DrPH  Peter G. Chandler...
Adjuvant therapies in venous leg ulcer management: A scoping reviewVictoria Team DrPH  Peter G. Chandler BCom, BSc(Hons)  Carolina D. Weller PhDFirst published: 26 April 2019 https://doi.org/10.1111/wrr.12724This work should be attributed to Monash Nursing and Midwifery.Read the full textePDFPDFTOOLS SHAREAbstractCompression therapy is the current evidence‐based approach to manage venous leg ulcers (VLU); however, adherence is a major barrier to successful treatment. Combination approaches may relieve...
Αλέξανδρος Γ. Σφακιανάκης
now
Pressure Ulcer Summit 2018: An Interdisciplinary Approach to Improve Our Understanding of the Risk of...
Pressure Ulcer Summit 2018: An Interdisciplinary Approach to Improve Our Understanding of the Risk of Pressure‐Induced Tissue DamageLisa J. Gould MD, PhD, FACS  Gregory Bohn MD, UHM/ABPM, MAPWCA, FACHM  Ruth Bryant PhD, MS, RN, CWOCN  Tim Paine PT  Kara Couch MS, CRNP, CWS, CWCN‐AP … See all authorsFirst published: 23 May 2019 https://doi.org/10.1111/wrr.12730This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination...
Αλέξανδρος Γ. Σφακιανάκης
1m
Leukemia inhibitory factor promotes the regeneration of rat uterine horns with full thickness injury...
Leukemia inhibitory factor promotes the regeneration of rat uterine horns with full thickness injuryBai Xue MD  Dan Liu PhD  Minmin Song MD  Guangfeng Zhao PhD  Yun Cao PhD  Guijun Yan PhD  Jianwu Dai PhD  Yali Hu PhDFirst published: 20 May 2019 https://doi.org/10.1111/wrr.12729This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and...
Αλέξανδρος Γ. Σφακιανάκης
1m
Toll like receptors (TLRs) in response to human gut microbiota of Indian obese and lean individuals...
Toll like receptors (TLRs) in response to human gut microbiota of Indian obese and lean individualsTej Bahadur, Rama Chaudhry, Vishwa Deepak Bamola, Sonu K Agrawal, Pawan Malhotra, Alka M Chutani, Bijay R Mirdha, Bimal K Das, Rahul K Sharma, Chandan K ThakurJournal of Family Medicine and Primary Care 2019 8(5):1567-1570Background: The rising incidence of obesity is one of the most serious public health issues in the developed as well as in developing countries like India. Obesity and overweight are...
Αλέξανδρος Γ. Σφακιανάκης
1m
Evaluation of hypercalciuria in patients receiving intravenous Cefotaxime Zahra Kalantari, Parsa Yousefichaijan,...
Evaluation of hypercalciuria in patients receiving intravenous CefotaximeZahra Kalantari, Parsa Yousefichaijan, Manijeh Kahbazi, Ali Arjmand ShabestariJournal of Family Medicine and Primary Care 2019 8(5):1558-1561Introduction: Cefotaxime is one of the third generation cephalosporins, which is used against many infections. This drug has a urinary excretion and potentially may have nephrotoxic effects. Hypercalciuria can cause important complications, including the formation of kidney stones. In the...
Αλέξανδρος Γ. Σφακιανάκης
2m
Family Medicine and Primary Care
A primary care–based patient centric palliative care modelSunil Kumar Raina, Raman Kumar, Rajiv Kumar GuptaJournal of Family Medicine and Primary Care 2019 8(5):1519-1522The World Health Organization defined palliative care as "an approach that improves the quality of life of patients and their families facing the problems associated with life threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other...
Αλέξανδρος Γ. Σφακιανάκης
2m
Cytochemical tests to investigate sperm DNA damage: Assessment and review Soheila Pourmasumi, Alireza...
Cytochemical tests to investigate sperm DNA damage: Assessment and reviewSoheila Pourmasumi, Alireza Nazari, Niloofar Fagheirelahee, Parvin SabetiJournal of Family Medicine and Primary Care 2019 8(5):1533-1539Male factor infertility has been diagnosed as the cause of infertility in about 20% of infertile couples. Sperm analysis is the most common method for diagnosing infertility in a laboratory. However, approximately 15% of infertile men have a normal sperm analysis. Therefore, the result of a...
Αλέξανδρος Γ. Σφακιανάκης
2m
IL‐17A is not a treatment target in progressive vitiligo Reinhart Speeckaert   Sofie Mylle   Nanja...
IL‐17A is not a treatment target in progressive vitiligoReinhart Speeckaert  Sofie Mylle  Nanja van GeelFirst published: 07 May 2019 https://doi.org/10.1111/pcmr.12789EU Clinical Trials Register (EudraCT number: 2015‐003552‐48).Funding information: Novartis Pharmaceuticals provided funding for this study. The research activities of R. Speeckaert and N. van Geel are supported by the Scientific Research Foundation‐Flanders (Krediet aan Navorsers: 1504718N and FWO Senior Clinical Investigator: 1831512N,...
Αλέξανδρος Γ. Σφακιανάκης
7m
The next‐generation BET inhibitor, PLX51107, delays melanoma growth in a CD8‐mediated manner Dan...
The next‐generation BET inhibitor, PLX51107, delays melanoma growth in a CD8‐mediated mannerDan A. Erkes  Conroy O. Field  Claudia Capparelli  Manoela Tiago  Timothy J. Purwin  Inna Chervoneva Adam C. Berger  Edward J. Hartsough  Jessie Villanueva  Andrew E. AplinFirst published: 07 May 2019 https://doi.org/10.1111/pcmr.12788SECTIONSPDFTOOLS SHAREAbstractEpigenetic agents such as bromodomain and extra‐terminal region inhibitors (BETi) slow tumor growth via tumor intrinsic alterations; however, their...
Αλέξανδρος Γ. Σφακιανάκης
8m
Otolaryngology & Head and Neck Surgery
Current approaches to cleft lip revisionPurpose of review Cleft lip repair requires multidisciplinary follow-up throughout a child's life and often requires lip revision surgery in adolescence to restore function and symmetry of the lip. There is significant variability in the approaches taken for lip repair and therefore a review of current techniques and subsequent guidance to secondary cleft lip repair is warranted. Recent findings New methods of secondary reconstruction can be divided into superficial...
Αλέξανδρος Γ. Σφακιανάκης
8m
Tropical Medicine
Antimalarial activity of a novel series of artemisinin-derived 1, 2, 3-triazole dimersKabita Gogoi, Gokul Baishya, Biswajit Saikia, Nabin Chandra Barua, Chandrajit Dohutia, Akalesh Kumar Verma, Anil PrakashAsian Pacific Journal of Tropical Medicine 2019 12(5):195-203Objective: To obtain suitable artimisinin-based drug candidates with high antimalarial activity. Methods: Three different reaction schemes were used to synthesize a total of 15 artemisinin-based compounds. The first synthetic scheme involved...
Αλέξανδρος Γ. Σφακιανάκης
9m
Treating the primary in metastatic prostate cancer: where do we stand? Purpose of review Traditionally,...
Treating the primary in metastatic prostate cancer: where do we stand?Purpose of review Traditionally, local treatment was reserved for palliative control of symptoms in men with metastatic prostate cancer. In the past few years there have been many advances in the systemic options available. The aim of this review is to explore the evidence in support of treating the primary tumor despite the presence of metastatic disease. Recent findings There is a wealth of retrospective studies demonstrating...
Αλέξανδρος Γ. Σφακιανάκης
11m
Cytoreductive nephrectomy in metastatic kidney cancer: what do we do now? Purpose of review Metastatic...
Cytoreductive nephrectomy in metastatic kidney cancer: what do we do now?Purpose of review Metastatic renal cell carcinoma (mRCC) has traditionally been treated with a combination of targeted systemic therapy and cytoreductive nephrectomy. This approach has recently become a topic of debate, because of new randomized data suggesting a lack of survival benefit for cytoreductive nephrectomy. We review the literature relevant to cytoreductive nephrectomy in the modern era of targeted and immune systemic...
Αλέξανδρος Γ. Σφακιανάκης
12m
Treating advanced penile cancer: where do we stand in 2019? Purpose of review Penile squamous cell...
Treating advanced penile cancer: where do we stand in 2019?Purpose of review Penile squamous cell carcinoma (PSCC) remains a challenging malignancy to treat and there is an urgent need of significant improvements at all levels of medical care. In the current review, we summarized the significant obstacles encountered during management of PSCC and discussed the clinical relevance of novel findings and their potential to address these obstacles. Recent findings The recent genetic and immunological...
Αλέξανδρος Γ. Σφακιανάκης
12m
Supplemental oxygen for the management of dyspnea in interstitial lung disease Purpose of review This...
Supplemental oxygen for the management of dyspnea in interstitial lung diseasePurpose of review This article presents a summary of the evidence relating to supplemental oxygen use for the management of dyspnea in patients with interstitial lung disease (ILD). Recent findings In contrast to the majority of the available literature, recent findings suggest that supplemental oxygen can significantly reduce exertional dyspnea in ILD. ILD patients' need for supplemental oxygen often surpasses the levels...
Αλέξανδρος Γ. Σφακιανάκης
12m
Multidimensional measurement of breathlessness: recent advances Purpose of review Breathlessness is...
Multidimensional measurement of breathlessness: recent advancesPurpose of review Breathlessness is a multidimensional sensation for which a range of instruments exists for children, youth and adults, capable or unable to self-report distress with breathing. This review presents developments and applications of multidimensional assessments of breathlessness. Recent findings Excluding unidimensional measures and instruments assessing the impact of breathlessness, at least eight psychometrically robust...
Αλέξανδρος Γ. Σφακιανάκης
13m
Interdisciplinary management of chronic breathlessness Purpose of review Breathlessness is a common...
Interdisciplinary management of chronic breathlessnessPurpose of review Breathlessness is a common yet complex symptom of advanced disease. Effective management will most likely draw upon the skills of multiple disciplines and professions. This review considers recent advances in the management of chronic breathlessness with regards to interdisciplinary working. Recent findings There are growing data on interventions for chronic breathlessness that incorporate psychosocial mechanisms of action, for...
Αλέξανδρος Γ. Σφακιανάκης
13m
Supportive and Palliative Care
Interdisciplinary management of chronic breathlessnessPurpose of review Breathlessness is a common yet complex symptom of advanced disease. Effective management will most likely draw upon the skills of multiple disciplines and professions. This review considers recent advances in the management of chronic breathlessness with regards to interdisciplinary working. Recent findings There are growing data on interventions for chronic breathlessness that incorporate psychosocial mechanisms of action, for...
Αλέξανδρος Γ. Σφακιανάκης
13m
Organ Transplantation
Nontuberculous mycobacteria in solid organ transplantPurpose of review Nontuberculous mycobacteria (NTM) are emerging pathogens of concern especially in solid organ transplant candidates and recipients. This review aims to address diagnostic challenges, new and emerging treatment options, and infection prevention. Recent findings The incidence of NTM infections in transplant candidates and recipients is rising. The infection prevalence of these environmental pathogens varies geographically by species...
Αλέξανδρος Γ. Σφακιανάκης
14m
Serum carcinoembryonic antigen to predict recurrence in the follow-up of patients with colorectal cancer...
Serum carcinoembryonic antigen to predict recurrence in the follow-up of patients with colorectal cancerShow all authorsWinesh Ramphal, Jeske R.E. Boeding, Maartje van Iwaarden, ...First Published March 11, 2019 Research Article https://doi.org/10.1177/1724600818820679Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractIntroduction:Serum carcinoembryonic (CEA) antigen is used as a diagnostic screening tool during follow-up in colorectal cancer patients....
Αλέξανδρος Γ. Σφακιανάκης
15m
Precision medicine in the ageing world: The role of biospecimen sciences Show all authors Silvia Riondino,...
Precision medicine in the ageing world: The role of biospecimen sciencesShow all authorsSilvia Riondino, Patrizia Ferroni, Mario Roselli, ...First Published March 11, 2019 Editorial https://doi.org/10.1177/1724600818816995Article information Article has an altmetric score of 1   Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseKeywords Elderly, precision medicine, risk assessment model, biomarker discovery, methodsThe trends in population growth and aging worldwide see the population...
Αλέξανδρος Γ. Σφακιανάκης
16m
Prognostic roles of microRNA 143 and microRNA 145 in colorectal cancer: A meta-analysis Show all authors...
Prognostic roles of microRNA 143 and microRNA 145 in colorectal cancer: A meta-analysisShow all authorsChenyao Li, Guoqiang Yan, Libin Yin, ...First Published March 10, 2019 Review Article https://doi.org/10.1177/1724600818807492Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractBackground:A systematic analysis was conducted to clarify the relationship between miR-143/145 and the prognosis of colorectal cancer.Materials and methods:We searched four databases:...
Αλέξανδρος Γ. Σφακιανάκης
17m
Elevated neutrophil to lymphocyte and platelet to lymphocyte ratios predict high grade and advanced...
Elevated neutrophil to lymphocyte and platelet to lymphocyte ratios predict high grade and advanced stage renal cell carcinomaSelahattin Çalışkan First Published March 11, 2019 Research Article https://doi.org/10.1177/1724600818817557Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractIntroduction:Renal cell carcinoma is the most common malignancy of the kidney, which accounts 85% of all renal tumors. In recent years, the incidence of renal cell carcinoma...
Αλέξανδρος Γ. Σφακιανάκης
17m
Associated measurement of fucosylated levels of AFP, DCP, and GPC3 for early diagnosis in hepatocellular...
Associated measurement of fucosylated levels of AFP, DCP, and GPC3 for early diagnosis in hepatocellular carcinomaShow all authorsMin Wu, Zhaobo Liu, Aiying Zhang, ...First Published March 10, 2019 Research Article https://doi.org/10.1177/1724600818812472Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractBackground:Hepatocellular carcinoma is a serious health problem worldwide, especially in Asian countries, such as China. However, there are difficulties...
Αλέξανδρος Γ. Σφακιανάκης
18m
Clinicopathological and prognostic significance of metastasis-associated in colon cancer-1 in gastric...
Clinicopathological and prognostic significance of metastasis-associated in colon cancer-1 in gastric cancer: A meta-analysisShow all authorsYan Jin, Kun Zhou, Wenjing Zhao, ...First Published March 10, 2019 Research Article https://doi.org/10.1177/1724600818813634Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractBackground:The gene metastasis-associated in colon cancer-1 (MACC1) has been reported to be overexpressed in diverse human malignancies, and...
Αλέξανδρος Γ. Σφακιανάκης
18m
β-Arrestin-1 expression and epithelial-to-mesenchymal transition in laryngeal carcinoma Show all authors...
β-Arrestin-1 expression and epithelial-to-mesenchymal transition in laryngeal carcinomaShow all authorsGino Marioni, Lorenzo Nicolè, Rocco Cappellesso, ...First Published March 10, 2019 Research Article https://doi.org/10.1177/1724600818813621Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractAim:The novel primary end-point of the present study was to ascertain β-arrestin-1 expression in a cohort of consecutive patients with laryngeal squamous cell carcinoma...
Αλέξανδρος Γ. Σφακιανάκης
19m
Prognostic nomogram for patients with non-metastatic HER2 positive breast cancer in a prospective cohort...
Prognostic nomogram for patients with non-metastatic HER2 positive breast cancer in a prospective cohortShow all authorsChuanxu Luo, Xiaorong Zhong, Zhu Wang, ...First Published March 11, 2019 Research Article https://doi.org/10.1177/1724600818824786Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractPurpose:A nomogram is a reliable tool to generate individualized risk prediction by combining prognostic factors. We aimed to construct a nomogram for predicting...
Αλέξανδρος Γ. Σφακιανάκης
19m
Clinicopathological and molecular differences in colorectal cancer according to location Show all authors...
Clinicopathological and molecular differences in colorectal cancer according to locationShow all authorsYu-Lun Hsu, Chun-Chi Lin, Jeng-Kai Jiang, ...First Published March 10, 2019 Research Article https://doi.org/10.1177/1724600818807164Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractPurpose:The incidence, pathogenesis, molecular pathways, and outcomes of colorectal cancer vary depending on the location of the tumor. This study aimed to compare the...
Αλέξανδρος Γ. Σφακιανάκης
19m
Performance of a MethyLight assay for methylated SFRP2 DNA detection in colorectal cancer tissue and...
Performance of a MethyLight assay for methylated SFRP2 DNA detection in colorectal cancer tissue and serumShow all authorsHui Li*, Zhenzhen Wang*, Guodong Zhao*, ...First Published March 11, 2019 Research Article https://doi.org/10.1177/1724600818820536Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractBackground:Colorectal cancer is one of the five most common cancers in China, and its incidence is steadily increasing. An accurate and non-invasive screening...
Αλέξανδρος Γ. Σφακιανάκης
20m
Cell-free microRNAs as non-invasive biomarkers in glioma: a diagnostic meta-analysis Jinfeng Wang, Fengyuan...
Cell-free microRNAs as non-invasive biomarkers in glioma: a diagnostic meta-analysisJinfeng Wang, Fengyuan Che, Jinling Zhang First Published April 10, 2019 Research Article https://doi.org/10.1177/1724600819840033Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractObjective:Since the diagnostic value of microRNAs for detecting glioma is contentious, we aimed to carry out a meta-analysis to synthetically evaluate the diagnostic significance of cell-free...
Αλέξανδρος Γ. Σφακιανάκης
21m
Urinary markers in treatment monitoring of lung cancer patients with bone metastasis Pei Cheng Jin,...
Urinary markers in treatment monitoring of lung cancer patients with bone metastasisPei Cheng Jin, Bo Gou, Wei QianFirst Published May 21, 2019 Research Article https://doi.org/10.1177/1724600819848762Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractBackground:Bone metastasis remains critical for advanced stage non-small cell lung cancer (NSCLC)—a disease that is challenging to manage. Urinary markers present opportunities for non-invasive testing.Methods:Urine...
Αλέξανδρος Γ. Σφακιανάκης
22m
Circular RNA ABCB10 promotes tumor progression and correlates with pejorative prognosis in clear cell...
Circular RNA ABCB10 promotes tumor progression and correlates with pejorative prognosis in clear cell renal cell carcinomaShow all authorsYunfang Huang, Yun Zhang, Lin Jia, ...First Published May 20, 2019 Research Article https://doi.org/10.1177/1724600819842279Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractObjective:Our study aimed to evaluate the effect of circular RNA ABCB10 (circ-ABCB10) on proliferation and apoptosis of clear cell renal cell...
Αλέξανδρος Γ. Σφακιανάκης
22m
Predictive significance of CYFRA21-1, squamous cell carcinoma antigen and carcinoembryonic antigen for...
Predictive significance of CYFRA21-1, squamous cell carcinoma antigen and carcinoembryonic antigen for lymph node metastasis in patients with esophageal squamous cancerShow all authorsXinyu Mei, Xiaodong Zhu, Lei Zuo, ...First Published May 15, 2019 Research Article https://doi.org/10.1177/1724600819847999Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractFrom January 2018 to May 2018, 108 patients with thoracic esophageal cancer underwent esophagectomy...
Αλέξανδρος Γ. Σφακιανάκης
23m
Clinical significance of tumor miR-21, miR-221, miR-143, and miR-106a as biomarkers in patients with...
Clinical significance of tumor miR-21, miR-221, miR-143, and miR-106a as biomarkers in patients with osteosarcomaShow all authorsHui Zhao, Peng Yan, Jian Wang, ...First Published May 14, 2019 Research Article https://doi.org/10.1177/1724600819843537Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractObjective:To investigate the expression of miR-21, miR-221, miR-143, and miR-106a in patients' osteosarcoma samples, and to explore the correlation between...
Αλέξανδρος Γ. Σφακιανάκης
23m
The serum level of CC chemokine ligand 18 correlates with the prognosis of non-small cell lung cancer...
The serum level of CC chemokine ligand 18 correlates with the prognosis of non-small cell lung cancerShow all authorsHui Huang, Jing Li, Wen-jia Hu, ...First Published May 3, 2019 Research Article https://doi.org/10.1177/1724600819829758Article information Article has an altmetric score of 1   Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractBackground:CC chemokine ligand 18 (CCL18) is a chemotactic cytokine involved in the pathogenesis and progression of various cancers....
Αλέξανδρος Γ. Σφακιανάκης
24m
iTRAQ-based proteomics reveals SOD2 as a potential salivary biomarker in liver cancer Show all authors...
iTRAQ-based proteomics reveals SOD2 as a potential salivary biomarker in liver cancerShow all authorsFeng Ding, Kehuan Sun, Ningning Sun, ...First Published May 1, 2019 Research Article https://doi.org/10.1177/1724600819841619Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractBackground:Salivary proteomic analysis has been extensively used in a wide range of cancer, but not in hepatocellular carcinoma. The aim of this study was to identify potential salivary...
Αλέξανδρος Γ. Σφακιανάκης
24m
New and old biomarkers in the differential diagnosis of lung cancer: Pro-gastrin-releasing peptide in...
New and old biomarkers in the differential diagnosis of lung cancer: Pro-gastrin-releasing peptide in comparison with neuron-specific enolase, carcinoembryonic antigen, and CYFRA 21-1Show all authorsCristian Mauro, Rita Passerini, Lorenzo Spaggiari, ...First Published April 17, 2019 Research Article https://doi.org/10.1177/1724600819834235Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractBackground:Testing for circulating biomarkers in lung cancer is...
Αλέξανδρος Γ. Σφακιανάκης
25m
New and old biomarkers in the differential diagnosis of lung cancer: Pro-gastrin-releasing peptide in...
New and old biomarkers in the differential diagnosis of lung cancer: Pro-gastrin-releasing peptide in comparison with neuron-specific enolase, carcinoembryonic antigen, and CYFRA 21-1Show all authorsCristian Mauro, Rita Passerini, Lorenzo Spaggiari, ...First Published April 17, 2019 Research Article https://doi.org/10.1177/1724600819834235Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractBackground:Testing for circulating biomarkers in lung cancer is...
Αλέξανδρος Γ. Σφακιανάκης
26m
Prognostic markers affecting the early recurrence of hepatocellular carcinoma with liver cirrhosis after...
Prognostic markers affecting the early recurrence of hepatocellular carcinoma with liver cirrhosis after curative resectionShow all authorsWan-Joon Kim, Tae-Wan Lim, Pyoung-Jae Park, ...First Published April 12, 2019 Research Article https://doi.org/10.1177/1724600819834306Article information  Open Access Creative Commons Attribution, Non Commercial 4.0 LicenseAbstractBackground:Early recurrence is associated with poor prognosis after curative resection for hepatocellular carcinoma. Thus, we studied...
Αλέξανδρος Γ. Σφακιανάκης
26m
Cancer registries - guardians of breast cancer biomarker information: A systematic review Show all authors...
Cancer registries - guardians of breast cancer biomarker information: A systematic reviewShow all authorsLena Voith von Voithenberg, Emanuele Crocetti, Carmen Martos, ...First Published April 10, 2019 Research Article https://doi.org/10.1177/1724600819836097Article information Article has an altmetric score of 1   Open Access Creative Commons Attribution 4.0 LicenseArticle InformationArticle first published online: April 10, 2019Received: July 16, 2018; Revisions received: January 24, 2019; Accepted:...
Αλέξανδρος Γ. Σφακιανάκης
27m
Automated Pupillometry Devices in Critically Ill PatientsBackground: Automated pupillometry may help...
Automated Pupillometry Devices in Critically Ill PatientsBackground: Automated pupillometry may help detect early cerebral disturbances in critically ill patients. It remains unclear whether different automated pupillometry devices can detect pupillary abnormalities with similar accuracy. The aim of this study was to compare the performance of 2 commercially available automated pupillometry devices—Neurolight Algiscan (NL) and NPi-200 (NP) versus standard pupillary light reflex (PLR) examination...
Αλέξανδρος Γ. Σφακιανάκης
30m
Language Monitoring in Brain Surgery Under General Anesthesia Background: Awake surgeries for cerebral...
Language Monitoring in Brain Surgery Under General AnesthesiaBackground: Awake surgeries for cerebral lesion resection have several limitations including patient fear, discomfort, or pain. This study aimed to determine whether components of language function could be measured under general anesthesia. In this study, the occurrence of mismatch negativity (MMN) was searched in evoked potentials for phonological sounds. Materials and Methods: Five normal hearing, French native speaker, awake volunteers...
Αλέξανδρος Γ. Σφακιανάκης
30m
Subanesthetic Dose of Ketamine Improved CFA-induced Inflammatory Pain and Depression-like Behaviors...
Subanesthetic Dose of Ketamine Improved CFA-induced Inflammatory Pain and Depression-like Behaviors Via Caveolin-1 in MiceBackground: Ketamine, a commonly used nonbarbiturate anesthetic drug, possesses antidepressant properties at subanesthetic doses; however, the underlying mechanisms remain unclear. Materials and Methods: The analgesic and antidepressant effects of ketamine were explored using a complete Freund adjuvant (CFA)-induced peripheral inflammatory pain model in vivo. Mice were first divided...
Αλέξανδρος Γ. Σφακιανάκης
30m
Defining a Taxonomy of Intracranial Hypertension: Is ICP More Than Just a Number? Intracranial pressure...
Defining a Taxonomy of Intracranial Hypertension: Is ICP More Than Just a Number?Intracranial pressure (ICP) monitoring and control is a cornerstone of neuroanesthesia and neurocritical care. However, because elevated ICP can be due to multiple pathophysiological processes, its interpretation is not straightforward. We propose a formal taxonomy of intracranial hypertension, which defines ICP elevations into 3 major pathophysiological subsets: increased cerebral blood volume, masses and edema, and...
Αλέξανδρος Γ. Σφακιανάκης
31m
Pain Anxiety as a Mechanism Linking Pain Severity and Opioid Misuse and Disability Among Individuals...
Pain Anxiety as a Mechanism Linking Pain Severity and Opioid Misuse and Disability Among Individuals With Chronic PainObjective: Chronic pain affects a significant number of individuals in the United States and is associated with several negative health-related outcomes, including possibility of opioid misuse and disability. The identification of factors associated with both opioid misuse and disability is of critical public health importance, and significant research suggests that pain severity...
Αλέξανδρος Γ. Σφακιανάκης
31m
The Association Between Antenatal Maternal Self-reported Substance Use, Maternal Characteristics, and...
The Association Between Antenatal Maternal Self-reported Substance Use, Maternal Characteristics, and Obstetrical VariablesBackground: Substance use disorders during pregnancy are a concern both to the public and medical community, because the negative consequences can be detrimental to both mother and the fetus. The accurate identification of prenatal drug exposure is necessary to determine appropriate medical and psychosocial intervention, and to identify risk factors that may affect outcomes for...
Αλέξανδρος Γ. Σφακιανάκης
32m
Prenatal Practice Staff Perceptions of Three Substance Use Screening Tools for Pregnant Women Objective:...
Prenatal Practice Staff Perceptions of Three Substance Use Screening Tools for Pregnant WomenObjective: There is a need to identify an acceptable and comprehensive substance use screening tool for pregnant women in the United States. This qualitative study sought to better understand prenatal practice staff perceptions of three existing substance use screening tools for use among pregnant women in an outpatient practice setting. Methods: Eight focus groups with 40 total participants were conducted...
Αλέξανδρος Γ. Σφακιανάκης
32m
Exploring the Effects of Vitamin D Supplementation on Cognitive Functions and Mental Health Status...
Exploring the Effects of Vitamin D Supplementation on Cognitive Functions and Mental Health Status in Subjects Under Methadone Maintenance TreatmentObjectives: Vitamin D deficiency may be linked to several mental complications including cognitive deficits, depression, and anxiety in patients under methadone maintenance treatment (MMT). This study was designed to explore the effect of vitamin D supplementation on cognitive functions and mental health parameters in subjects under MMT. Methods: This...
Αλέξανδρος Γ. Σφακιανάκης
32m
How Might Maternal Poverty Impact the Course of Neonatal Opioid Withdrawal Syndrome? Neonatal Opioid...
How Might Maternal Poverty Impact the Course of Neonatal Opioid Withdrawal Syndrome?Neonatal Opioid Withdrawal Syndrome (NOWS) is an increasing problem in the midst of the current opioid epidemic, frequently associated with pharmacologic treatment and prolonged hospitalizations. NOWS is a highly variable condition with many clinical and genetic variables contributing to the clinical course. Social variables such as maternal poverty remain understudied. In this commentary, we review one of the first...
Αλέξανδρος Γ. Σφακιανάκης
33m
Poverty and Excess Length of Hospital Stay in Neonatal Opioid Withdrawal SyndromeObjectives: To study...
Poverty and Excess Length of Hospital Stay in Neonatal Opioid Withdrawal SyndromeObjectives: To study the impact of sociodemographic factors on length of stay (LOS) for infants with neonatal opioid withdrawal syndrome (NOWS) secondary to fetal opioid exposure. Methods: In this retrospective cohort study, we included term infants with NOWS, excluding those with other significant medical issues. Comprehensive clinical and sociodemographic data were collected. Multivariate regression modeling was used...
Αλέξανδρος Γ. Σφακιανάκης
33m
Neurosurgical Anesthesiology
The Effect of Depth of Anesthesia on Hemodynamic Changes Induced by Therapeutic Compression of the Trigeminal GanglionBackground: Percutaneous compression of the trigeminal ganglion (PCTG) has been used to treat trigeminal neuralgia since 1983. A PCTG-related trigeminocardiac reflex (TCR) can induce dramatic hemodynamic disturbances. This study investigates the effects of depth of propofol anesthesia on hemodynamic changes during PCTG. Materials and Methods: A total of 120 patients who underwent...
Αλέξανδρος Γ. Σφακιανάκης
33m
The Effect of Depth of Anesthesia on Hemodynamic Changes Induced by Therapeutic Compression of the...
The Effect of Depth of Anesthesia on Hemodynamic Changes Induced by Therapeutic Compression of the Trigeminal GanglionBackground: Percutaneous compression of the trigeminal ganglion (PCTG) has been used to treat trigeminal neuralgia since 1983. A PCTG-related trigeminocardiac reflex (TCR) can induce dramatic hemodynamic disturbances. This study investigates the effects of depth of propofol anesthesia on hemodynamic changes during PCTG. Materials and Methods: A total of 120 patients who underwent...
Αλέξανδρος Γ. Σφακιανάκης
33m
Addiction Medicine
Poverty and Excess Length of Hospital Stay in Neonatal Opioid Withdrawal SyndromeObjectives: To study the impact of sociodemographic factors on length of stay (LOS) for infants with neonatal opioid withdrawal syndrome (NOWS) secondary to fetal opioid exposure. Methods: In this retrospective cohort study, we included term infants with NOWS, excluding those with other significant medical issues. Comprehensive clinical and sociodemographic data were collected. Multivariate regression modeling was used...
Αλέξανδρος Γ. Σφακιανάκης
34m
Vehicle Collision : Blunt rupture of the myocardium,Blunt Cardiac Injury,Atrial and pericardial rupture from blunt cardiac trauma
Blunt rupture of the myocardium - The Annals of Thoracic Surgeryhttps://www.annalsthoracicsurgery.org/article/0003-4975(89)90203-8/pdfby WC Pevec - ‎1989 - ‎Cited by 83 - ‎Related articlesblunt rupture of the heart, prompted this review. History. The first ... cardiac rupture, in a male victim of a motor vehicle accident who sustained a tear of the right atrial-superior vena caval ... chamber: right atrium, 36; left atrium, 30; right ventricle,.Case reports of atrial and pericardial rupture from...
Αλέξανδρος Γ. Σφακιανάκης
36m
Variability in international normalized ratio and activated partial thromboplastin time after injury...
Variability in international normalized ratio and activated partial thromboplastin time after injury are not explained by coagulation factor deficitsIntroduction Conventional coagulation assays (CCAs), PT/INR (prothrombin time/international normalized ratio) and aPTT (activated partial thromboplastin time), detect clotting factor (CF) deficiencies in hematologic disorders. However, there is controversy about how these CCAs should be used to diagnose, treat and monitor trauma-induced coagulopathy....
Αλέξανδρος Γ. Σφακιανάκης
45m
Promotility Agents For The Treatment Of Ileus In Adult Surgical Patients: A Practice Management Guideline...
Promotility Agents For The Treatment Of Ileus In Adult Surgical Patients: A Practice Management Guideline From The Eastern Association For The Surgery Of TraumaBackground Ileus is a common challenge in adult surgical patients with estimated incidence to be 17%-80%. The main mechanisms of the postoperative ileus pathophysiology are fluid overload, exogenous opioids, neurohormonal dysfunction, gastrointestinal stretch and inflammation. Management includes addressing the underlying cause and supportive...
Αλέξανδρος Γ. Σφακιανάκης
45m
Ketamine Infusion for Pain Control in Adult Patients with Multiple Rib Fractures Kugler, Nathan W.,...
Ketamine Infusion for Pain Control in Adult Patients with Multiple Rib FracturesKugler, Nathan W., MD; Juul, Janelle, PharmD; Peppard, William J., PharmD; Carver, Thomas W., MD, FACSJournal of Trauma and Acute Care Surgery: May 24, 2019 - Volume Publish Ahead of Print - Issue - pdoi: 10.1097/TA.0000000000002377
Αλέξανδρος Γ. Σφακιανάκης
45m
Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) Induced Myocardial Injury is Mitigated...
Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) Induced Myocardial Injury is Mitigated by Endovascular Variable Aortic Control (EVAC)Background The cardiac effects of resuscitative endovascular balloon occlusion of the aorta (REBOA) are largely unknown. We hypothesized that increased afterload from REBOA would lead to cardiac injury, and that partial flow using endovascular variable aortic control (EVAC) would mitigate this injury. Methods Eighteen anesthetized swine underwent controlled...
Αλέξανδρος Γ. Σφακιανάκης
46m
Trauma and Acute Care Surgery
Unfractionated heparin attenuates histone-mediated cytotoxicity in vitro and prevents intestinal microcirculatory dysfunction in histone-infused ratsAbstract: Background Extracellular histones are major mediators of organ dysfunction and death in sepsis, and they may cause microcirculatory dysfunction. Heparins have beneficial effects in sepsis and have been reported to bind to histones and neutralize their cytotoxicity. The aim of this study was to investigate the impact of histones on intestinal...
Αλέξανδρος Γ. Σφακιανάκης
46m
Unfractionated heparin attenuates histone-mediated cytotoxicity in vitro and prevents intestinal microcirculatory...
Unfractionated heparin attenuates histone-mediated cytotoxicity in vitro and prevents intestinal microcirculatory dysfunction in histone-infused ratsAbstract: Background Extracellular histones are major mediators of organ dysfunction and death in sepsis, and they may cause microcirculatory dysfunction. Heparins have beneficial effects in sepsis and have been reported to bind to histones and neutralize their cytotoxicity. The aim of this study was to investigate the impact of histones on intestinal...
Αλέξανδρος Γ. Σφακιανάκης
47m
Wall Contrast Enhancement of Thrombosed Intracranial Aneurysms at 7T MRI T. Sato, T. Matsushige, B....
Wall Contrast Enhancement of Thrombosed Intracranial Aneurysms at 7T MRIT. Sato, T. Matsushige, B. Chen, O. Gembruch, P. Dammann, R. Jabbarli, M. Forsting, A. Junker, S. Maderwald, H.H. Quick, M.E. Ladd, U. Sure and K.H. WredeAmerican Journal of Neuroradiology May 2019, DOI: https://doi.org/10.3174/ajnr.A6084ArticleFigures & DataInfo & MetricsReferences PDFThis article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article....
Αλέξανδρος Γ. Σφακιανάκης
50m
Assessment of Explicitly Stated Interval Change on Noncontrast Head CT Radiology Reports M. Braileanu,...
Assessment of Explicitly Stated Interval Change on Noncontrast Head CT Radiology ReportsM. Braileanu, K. Crawford, S.R. Key and M.E. MullinsAmerican Journal of Neuroradiology May 2019, DOI: https://doi.org/10.3174/ajnr.A6081ArticleFigures & DataInfo & MetricsReferences PDFThis article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.AbstractBACKGROUND AND PURPOSE: Consistent...
Αλέξανδρος Γ. Σφακιανάκης
50m
Deep Learning–Based Automatic Segmentation of Lumbosacral Nerves on CT for Spinal Intervention: A Translational...
Deep Learning–Based Automatic Segmentation of Lumbosacral Nerves on CT for Spinal Intervention: A Translational StudyG. Fan, H. Liu, Z. Wu, Y. Li, C. Feng, D. Wang, J. Luo, W.M. Wells and S. HeAmerican Journal of Neuroradiology May 2019, DOI: https://doi.org/10.3174/ajnr.A6070ArticleFigures & DataSupplementalInfo & MetricsReferences PDFAbstractBACKGROUND AND PURPOSE: 3D reconstruction of a targeted area ("safe" triangle and Kambin triangle) may benefit the viability assessment of transforaminal...
Αλέξανδρος Γ. Σφακιανάκης
51m
Hazardous Materials
Reduction of phoxim pesticide residues from grapes by atmospheric pressure non-thermal air plasma activated waterPublication date: 5 September 2019Source: Journal of Hazardous Materials, Volume 377Author(s): Yongping Zheng, Songjie Wu, Jie Dang, Shifang Wang, Zhengxin Liu, Jing Fang, Ping Han, Jue ZhangAbstractIn this study, we propose a novel strategy, plasma activated water (PAW) to reduce pesticide residues on agricultural products. To validate its feasibility and effectiveness, we employee high-performance...
Αλέξανδρος Γ. Σφακιανάκης
52m
Sugar Alternatives : Molasses,Raw Honey,Stevia,Xylitol
XylitolXylitol is a sugar alcohol derived from xylose - a crystalline sugar found in birch bark[8]. Sweet like sugar but with only 40% of the calories, xylitol is fast becoming the preferred sweetener of health-conscious consumers.Low-carb dieters will find xylitol appealing, with less than a quarter of the carbohydrates found in cane sugar. It also stands apart from synthetic sweeteners thanks to its natural origins. Besides birch trees, xylitol is found in the cellular structure of fruits like...
Αλέξανδρος Γ. Σφακιανάκης
55m
The Hearing Journal
 The Hearing JournalVol. 72, No. 6, June 2019 pp: 28-48View Contributor IndexThe Power of Partnerships: Audiologist-Physician Collaboration Improves Patient CareBy Kelly WolfgangStrong relationships between audiologists and physicians can lead to better patient care and other opportunities for collaboration. Building and maintaining these relationships could be a challenge to many busy clinicians, but these creative and long-term strategies will help make network-building effective, collaborative,...
Αλέξανδρος Γ. Σφακιανάκης
59m

Alexandros Sfakianakis
Anapafseos 5 . Agios Nikolaos
Crete.Greece.72100
2841026182
6948891480

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