Don’t Stop Re-healin’! Cancer as an Ongoing Stem Cell Affair

Publication date: 4 May 2017
Source:Cell, Volume 169, Issue 4
Author(s): Samuel P. Rowbotham, Carla F. Kim
Tumors have long been suspected of hijacking stem cell mechanisms used for tissue maintenance and repair. Ge et al. now show that skin tumors exhibit merged chromatin profiles from distinct stem cell lineages. This “lineage infidelity” recreates a state akin to transient wound repair that persists to maintain uncontrolled growth.

Teaser

Tumors have long been suspected of hijacking stem cell mechanisms used for tissue maintenance and repair. Ge et al. now show that skin tumors exhibit merged chromatin profiles from distinct stem cell lineages. This “lineage infidelity” recreates a state akin to transient wound repair that persists to maintain uncontrolled growth.


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