Τρίτη, 19 Μαρτίου 2019

Otology Neurotology

International Collaborative Assessment of the Validity of the EAONO-JOS Cholesteatoma Staging System
Objective: Assessment of validity of the Japanese Otological Society and the European Academy of Otology and Neurotology (EAONO–JOS) cholesteatoma staging system (EJS) through international collaboration to investigate: (a) feasibility of retrospectively staging previously acquired data, (b) strengths and weaknesses of the staging system. Method: Nine centers with prospective cholesteatoma databases were recruited. Cases were allocated to EJS Stage at each center using details from time of...
Otology & Neurotology - Published Ahead-of-Print
Wed Mar 13, 2019 02:00
Further Evidence of the Relationship Between Cochlear Implant Electrode Positioning and Hearing Outcomes
Background: Postoperative imaging studies by numerous groups have revealed that final cochlear implant (CI) electrode position impacts audiological outcomes with scalar location consistently shown to be a significant factor. Modiolar proximity has been less extensively studied, and findings regarding the effect of insertion depth have been inconsistent. Methods: Using previously developed automated algorithms, we determined CI electrode position in an Institutional Review Board-approved database...
Otology & Neurotology - Published Ahead-of-Print
Wed Mar 13, 2019 02:00
Management of Ménière's Disease: How Does the Coexistence of Vestibular Migraine Affect Outcomes?
Objective: To report the incidence of vestibular migraine (VM) in patients with Ménière's disease (MD) and investigate whether management outcomes of MD differ by the association of VM. Study Design: Retrospective cohort study. Setting: Tertiary care academic center. Patients: MD patients (n = 251) with/without VM who were managed for 5 years in a dizziness clinic. Main Outcome Measures: Influence of VM on management outcomes and hearing at the latest follow-up in stepwise...
Otology & Neurotology - Published Ahead-of-Print
Wed Mar 13, 2019 02:00
The Effect of Cochlear Coverage on Auditory and Speech Performance in Cochlear Implant Patients
Objective: To determine the effect of cochlear coverage on audiological and speech parameters in patients with cochlear implants. Previous work has investigated the effect of tailoring electrode size to a cochlear implant recipient's individual cochlear duct length (CDL). However, no clear relationship has been found between speech development and the extent of electrode insertion, and the benefits of apical stimulation are not yet clear. Methodology: In this retrospective study, we assessed...
Otology & Neurotology - Published Ahead-of-Print
Thu Mar 07, 2019 02:00
Efficacy and Safety of AM-111 in the Treatment of Acute Unilateral Sudden Deafness—A Double-blind, Randomized, Placebo-controlled Phase 3 Study
Objective: To confirm the efficacy and safety of AM-111 (brimapitide), a cell-penetrating c-Jun N-terminal Kinase (JNK) inhibitor, in patients suffering from severe to profound acute unilateral idiopathic sudden sensorineural hearing loss (ISSNHL). Study design: Prospective, double-blind, randomized, placebo-controlled phase 3 study with follow-up visits on Days 3, 7, 28, and 91. Setting: Fifty-one European and Asian sites (tertiary referral centers, private ENT practices). Patients:...
Otology & Neurotology - Published Ahead-of-Print
Tue Mar 05, 2019 02:00

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