Consolidation chemotherapy after definite concurrent chemoradiation in patients with non-operable esophageal cancer: Is it useful?

Definitive chemoradiation (CRT) [definitive CRT (dCRT)] is considered as standard of care for esophageal cancer patients not suitable for surgery due to the local extent of disease or as a result of comorbidities [1]. Since the report of the RTOG 85-01 trial [2], four courses of cisplatin (CDDP)/5-fluorouracil (FU) combined with radiation therapy are regarded as standard for dCRT [1]. Oxaliplatin/FU/folinic acid (FOLFOX) can also be delivered as a safe and convenient alternative of CDDP/FU, following the results of the PRODIGE-5 trial [3,4].

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