Neuroendocrine tumors encompass a variety of neoplasms with distinct anatomical localizations and clinical behaviors. The WHO-classification from 2010 and the European Neuroendocrine Tumor Society classify NETs according to their proliferative activity into grade 1 and 2 (G1 and G2) well differentiated neuroendocrine tumors (WDNETs) (≤20 mitoses/10 high power fields (HPF); Ki-67 index ≤20%) or grade 3 (G3) tumors (>20 mitoses/10 HPF; Ki-67 index >20%) that can be either well or poorly differentiated neuroendocrine carcinomas (NECs) [1,2].
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