The emerging role of non-traditional ubiquitination in oncogenic pathways [Molecular Bases of Disease]

The addition of ubiquitin (Ub) to a target protein has long been implicated in the process of degradation and is the primary mediator of protein turnover in the cell. Recently however, many non-proteolytic functions of ubiquitination have emerged as key regulators of cellular homeostasis. In this review, we will describe the various non-traditional functions of ubiquitination, with particular focus on and how they can be used as signalling entities in cancer formation and progression. Elaboration of this topic can lead to a better understanding of oncogenic mechanisms, as well as the discovery of novel druggable proteins within the Ub pathway.

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