Σάββατο, 23 Μαρτίου 2019

Chemotherapy

Ivabradine in Cancer Treatment-Related Left Ventricular Dysfunction
Conclusions: The ability to improve symptoms and LVEF in unfit cancer patients makes ivabradine a reasonable pharmacological tool for treating CTrLVD.Chemotherapy 2018;63:315 –320 (Source: Chemotherapy)
Chemotherapy
Thu Mar 07, 2019 17:06
False Positive Cardiotoxicity Events in Cancer-Related Clinical Trials: Risks Related to Imperfect Noninvasive Parameters
Conclusion: A 3.60% false positive rate in trials where the expected level of toxicity is low suggests that false positives are troubling and may exceed true positive results. Strategies to reduce the number of false positive results include making confirmatory studies mandatory. Evaluating increases along with decreases obtains some estimation of variance.Chemotherapy 2018;63:324 –329 (Source: Chemotherapy)
Chemotherapy
Thu Mar 07, 2019 17:06
Overexpression of TEL-MN1 Fusion Enhances Resistance of HL-60 Cells to Idarubicin
Conclusion: Taken together, our results indicated that TEL-MN1 fusion is an oncogene involved in the leukemogenesis process and TEL-MN1 overexpression enhanced resistance of HL-60 cells to idarubicin, which may provide a useful tool for studying the mechanism of leukemogenesis and drug resistance.Chemotherapy 2018;63:308 –314 (Source: Chemotherapy)
Chemotherapy
Thu Mar 07, 2019 17:06
Relative Factors Analysis of Imatinib Trough Concentration in Chinese Patients with Gastrointestinal Stromal Tumor
Conclusion: IM Cmin at steady state was significantly associated with body weight and body surface area. Monitoring of IM Cmin might be particularly important for the optimal treatment with IM of male patients and those who have undergone gastrectomy.Chemotherapy 2018;63:301 –307 (Source: Chemotherapy)
Chemotherapy
Thu Mar 07, 2019 17:06
Use of Rifabutin as an Alternative Agent for Human Brucellosis: A Case Report
We present a case that developed intolerance to many anti-brucella drugs, who was then successfully treated with a combination of rifabutin, ofloxacin, and ceftriaxone.Chemotherapy 2018;63:321 –323 (Source: Chemotherapy)
Chemotherapy
Thu Mar 07, 2019 17:06
A case of otitis externa caused by <em>Schizophyllum commune</em>: An approach to antimicrobial stewardship using Gram staining of otorrhea in a medical clinic
Publication date: Available online 21 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Masako Maeda, Toshihiko Maeda, Akihiro Nakamura, Masaru KomatsuAbstractRecently, basidiomycete Schizophyllum commune has been reported as a cause of allergic bronchopulmonary mycosis. However, it is rare as a cause of otitis externa. We experienced a very rare case of otitis externa caused by S. commune in a 68-year-old man with a history of chronic otitis media. We performed Gram staining at the...
Journal of Infection and Chemotherapy
Fri Mar 22, 2019 16:20
Positivity rate of interferon-γ release assays for estimating the prevalence of latent tuberculosis infection in renal transplant recipients in Japan
Publication date: Available online 21 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Hidetoshi Igari, Naotake Akutsu, Satoru Ishikawa, Hiromichi Aoyama, Kazunori Otsuki, Masayuki Hasegawa, Michihiro Maruyama, Mizue Tsuyuzaki, Kiminori Suzuki, Kenichi SaigoAbstractRenal transplant recipients are at increased risk of reactivating latent tuberculosis infection (LTBI) and developing active tuberculosis. QuantiFERON®-TB Gold Plus (QFT-Plus) has two TB-specific antigens tubes (TB1 and...
Journal of Infection and Chemotherapy
Fri Mar 22, 2019 16:20
Second nationwide surveillance of bacterial pathogens in patients with acute uncomplicated cystitis conducted by Japanese Surveillance Committee from 2015 to 2016: antimicrobial susceptibility of <em>Escherichia coli</em>, <em>Klebsiella pneumoniae</em>, and <em>Staphylococcus saprophyticus</em>
Publication date: Available online 21 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Hiroshi Hayami, Satoshi Takahashi, Kiyohito Ishikawa, Mitsuru Yasuda, Shingo Yamamoto, Koichiro Wada, Kanao Kobayashi, Ryoichi Hamasuna, Shinichi Minamitani, Tetsuya Matsumoto, Hiroshi Kiyota, Kazuhiro Tateda, Junko Sato, Hideaki Hanaki, Naoya Masumori, Hiroyuki Nishiyama, Jun Miyazaki, Kiyohide Fujimoto, Kazushi Tanaka, Shinya UeharaAbstractThe Japanese Surveillance Committee conducted a second...
Journal of Infection and Chemotherapy
Fri Mar 22, 2019 16:20
Analytical and clinical evaluation of a point-of-care molecular diagnostic system and its influenza A/B assay for rapid molecular detection of the influenza virus
Publication date: Available online 21 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Yusaku Akashi, Hiromichi Suzuki, Atsuo Ueda, Yumi Hirose, Daisuke Hayashi, Hironori Imai, Hiroichi IshikawaAbstractRecently, rapid molecular detection systems have been used for point-of-care testing for the diagnosis of influenza worldwide. Here, we evaluated the performance of the cobas Liat system and the cobas Influenza A/B assay (Liat) using fresh nasopharyngeal samples collected from a Japanese...
Journal of Infection and Chemotherapy
Fri Mar 22, 2019 16:20
Reduced rates of antimicrobial resistance in <em>Staphylococcus intermedius</em> group and <em>Escherichia coli</em> isolated from diseased companion animals in an animal hospital after restriction of antimicrobial use
Publication date: Available online 21 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Goro Kurita, Yuzo Tsuyuki, Yoshiteru Murata, Takashi Takahashi, Veterinary Infection Control Association (VICA) AMR Working GroupAbstractThe 2016 National Action Plan aims for reduction in antimicrobial resistance (AMR) to tetracyclines, third-generation cephalosporins, and fluoroquinolones in Escherichia coli isolates from livestock: to lower the tetracycline resistance of E. coli to 33% or less;...
Journal of Infection and Chemotherapy
Fri Mar 22, 2019 16:20
Clinical impact of extended blood culture examination: Too much of a good thing
Publication date: Available online 21 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Hideharu Hagiya, Nanoka Yoneda, Keigo Kimura, Tomomi Mitsui, Akiko Ueda, Atsuko Sunada, Isao Nishi, Futoshi Nakagami, Hiromi Rakugi, Kazunori TomonoAbstractBlood culture is the most critical examination for diagnosing bacterial infections. The longer the blood culture incubation period, the higher the chances of identifying bacterial strains. However, unnecessary extension of the incubation period...
Journal of Infection and Chemotherapy
Thu Mar 21, 2019 15:53
Non-adherence to antimicrobial stewardship prospective audit and feedback advice: Risk factors and clinical consequences
Publication date: Available online 20 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Christopher D. Horton, Matthew D.M. Rawlins, Laurens Manning, Paul R. IngramAbstractAmongst 325 patients receiving restricted antimicrobials whose management was subject to antimicrobial stewardship prospective audit and feedback, adherence to advice was 78%. Non-adherence was associated with diabetic patients, giving more than 1 piece of advice and receipt of piperacillin/tazobactam therapy, and...
Journal of Infection and Chemotherapy
Thu Mar 21, 2019 15:53
Psoitis and multiple venous thromboses caused by Panton Valentine Leukocidin-positive methicillin-sensitive <em>Staphylococcus aureus</em> in a 12-year-old girl: A case report
Publication date: Available online 20 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Hitoshi Ogata, Koo Nagasawa, Noriko Takeuchi, Sho Hagiwara, Daisuke Sawada, Tomotaka Umimura, Yuki Konno, Fumiya Yamaide, Rieko Takatani, Tomozumi Takatani, Taiji Nakano, Haruka Hishiki, Naruhiko Ishiwada, Naoki ShimojoAbstractPanton Valentine Leukocidin (PVL) is one of the many toxins produced by Staphylococcus aureus. In Japan, PVL-positive S. aureus strains are mainly methicillin-resistant S. aureus...
Journal of Infection and Chemotherapy
Thu Mar 21, 2019 15:53
Analysis of respiratory syncytial virus fusion protein from clinical isolates of Korean children in palivizumab era, 2009–2015
Publication date: Available online 15 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Soo-Han Choi, Ki Sup Park, Yae-Jean KimAbstractIntroductionRespiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections among infants and young children. The fusion (F) protein of RSV is a major target for monoclonal antibodies and vaccine candidates. We analyzed sequence polymorphisms of the RSV F protein and investigated palivizumab-resistance mutation in clinical...
Journal of Infection and Chemotherapy
Sat Mar 16, 2019 13:15
Evaluation of pharmacokinetic/pharmacodynamic and clinical outcomes with 6-hourly empiric piperacillin-tazobactam dosing in hematological malignancy patients with febrile neutropenia
Publication date: Available online 15 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Nicholas Weber, Kathryn Jackson, Brett McWhinney, Jacobus Ungerer, Glen Kennedy, Jeffrey Lipman, Jason A. RobertsAbstractBackgroundPiperacillin-tazobactam is commonly used in neutropenic sepsis at standard doses that do not account for inter-individual differences in age, bodyweight and renal function. This study was designed to assess the rate of attainment of pharmacokinetic/pharmacodynamic (PK/PD)...
Journal of Infection and Chemotherapy
Fri Mar 15, 2019 12:58
Effectiveness on high-grade cervical abnormalities and long-term safety of the quadrivalent human papillomavirus vaccine in Japanese women
Publication date: Available online 15 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Masaru Sakamoto, Etsuko Miyagi, Yukari Sumi, Kohzo Aisaka, Naohiko Kuno, Hiroshi Nagano, Saiko Asahara, Shi Rong Han, Akira Wakana, Shinya Murata, Miyuki Sawata, Yoshiyuki TanakaAbstractThis study for the first time assessed quadrivalent human papillomavirus (qHPV) vaccine effectiveness against HPV6/11/16/18-related high-grade cervical disease in Japanese women (16–26 years old), as previously...
Journal of Infection and Chemotherapy
Fri Mar 15, 2019 12:58
Visceral disseminated varicella zoster virus infection with brachial plexus neuritis detected by fluorodeoxyglucose positron emission tomography and computed tomography
Publication date: Available online 14 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Shin Lee, Hikaru Tsukasaki, Takahiro YamauchiAbstractVaricella zoster virus (VZV) infection sometimes result in visceral disseminated VZV infection (VD-VZV), which is a fulminant disease featured by abdominal pain and the absence of skin lesions, particularly occurs in the immunosuppressive patients. Brachial plexus neuritis (BPN) is another rare type of VZV infection usually appears without blisters....
Journal of Infection and Chemotherapy
Fri Mar 15, 2019 12:58
Cefotaxime-non-susceptibility of <em>Haemophilus influenzae</em> induced by additional amino acid substitutions of G555E and Y557H in altered penicillin-binding protein 3
Publication date: Available online 14 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Ayako Mizoguchi, Shigemi HitomiAbstractCefotaxime-non-susceptible Haemophilus influenzae has rarely been isolated from clinical specimens. Although several reports have shown that amino acid (AA) alteration in penicillin-binding protein 3 (PBP3), encoded by the ftsI gene, reduces activity of cefotaxime, precise mechanisms conferring the non-susceptibility have been unclear. We analyzed the ftsI...
Journal of Infection and Chemotherapy
Fri Mar 15, 2019 12:58
Disseminated nocardiosis with <em>Nocardia brasiliensis</em> bacteremia in a patient with rheumatoid arthritis using tocilizumab
Publication date: Available online 7 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Ryosuke Yamate, Takashi Matono, Takashi Yaguchi, Yusuke Fujii, Yuki Goto, Kazunori Tobino, Hiroshi Imura, Shuji NaganoAbstractHere, we present a case of disseminated nocardiosis, involving pneumonia, percutaneous abscess, and bacteremia, in a 67-year-old Japanese woman. She had also been treated for rheumatoid arthritis with prednisolone, methotrexate, and tocilizumab (interleukin-6 receptor inhibitor)....
Journal of Infection and Chemotherapy
Thu Mar 07, 2019 12:43
Does urinary tract infection caused by extended-spectrum β-lactamase-producing <em>Escherichia coli</em> show same antibiotic resistance when it recurs?
Publication date: Available online 7 March 2019Source: Journal of Infection and ChemotherapyAuthor(s): Sun Tae Ahn, Sang Woo Kim, Jong Wook Kim, Hong Seok Park, Du Geon Moon, Mi Mi OhAbstractThis study was performed to evaluate what percentage of urinary tract infections (UTIs) caused by extended spectrum β-lactamase (ESBL)-producing strains recurs with ESBL-producing strains during follow up and to assess the risk factors for recurrence with ESBL-producing Escherichia coli strains on subsequent...
Journal of Infection and Chemotherapy
Thu Mar 07, 2019 12:43



Alexandros Sfakianakis
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