Publication date: Available online 19 December 2017
Source:Journal of Neuroradiology
Author(s): Qian Jia, Linlin Gao, Jiarong Zhang, Tao Wu, Piu Chan
Background and purposePatients with Parkinson's disease (PD) have difficulty performing self-initiated movements. The neural mechanism of this deficiency remains unclear. In the present study, we used functional magnetic resonance imaging (fMRI) to investigate the functional connectivity of the subthalamic nucleus (STN) during self-initiated movement in patients with PD.Materials and MethodsfMRI were acquired from patients with PD and age- and sex-matched healthy control subjects during a self-initiated right hand tapping task. We selected the bilateral sensorimotor subregions of the STN as regions of interest for our connectivity analysis.Results and ConclusionsWe found that the STN contralateral to voluntary hand movement exhibited enhanced connectivity with the midbrain, thalamus, putamen, and so on in patients with PD compared to control subjects. In contrast, the STN ipsilateral to the hand movement exhibited enhanced connectivity with the midbrain and insula in PD patients compared to control subjects. Connectivity between the STN contralateral to the hand movement and the primary motor cortex and supplementary motor area was positively correlated with the severity of bradykinesia. Our findings suggest that STN-related connectivity in the hyperdirect and indirect basal ganglia pathways is strengthened during self-initiated movement in patients with PD. These disrupted network connections may contribute to bradykinesia.
from Imaging via alkiviadis.1961 on Inoreader http://ift.tt/2Dfqc2B
Τετάρτη 20 Δεκεμβρίου 2017
Altered functional connectivity of the subthalamic nucleus during self-initiated movement in Parkinson's disease
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