Prevalence of Healthcare-Associated Infections and Antimicrobial Use Among Adult Inpatients in Singapore Acute-Care Hospitals: Results From the First National Point Prevalence Survey

<span class="paragraphSection"><div class="boxTitle">Abstract</div><div class="boxTitle">Background.</div>We conducted a national point prevalence survey (PPS) to determine the prevalence of healthcare-associated infections (HAIs) and antimicrobial use (AMU) in Singapore acute-care hospitals.<div class="boxTitle">Methods.</div>Trained personnel collected HAI, AMU, and baseline hospital- and patient-level data of adult inpatients from 13 private and public acute-care hospitals between July 2015 and February 2016, using the PPS methodology developed by the European Centre for Disease Prevention and Control. Factors independently associated with HAIs were determined using multivariable regression.<div class="boxTitle">Results.</div>Of the 5415 patients surveyed, there were 646 patients (11.9%; 95% confidence interval [CI], 11.1%–12.8%) with 727 distinct HAIs, of which 331 (45.5%) were culture positive. The most common HAIs were unspecified clinical sepsis (25.5%) and pneumonia (24.8%). <span style="font-style:italic;">Staphylococcus aureus</span> (12.9%) and <span style="font-style:italic;">Pseudomonas aeruginosa</span> (11.5%) were the most common pathogens implicated in HAIs. Carbapenem nonsusceptibility rates were highest in <span style="font-style:italic;">Acinetobacter</span> species (71.9%) and <span style="font-style:italic;">P. aeruginosa</span> (23.6%). Male sex, increasing age, surgery during current hospitalization, and presence of central venous or urinary catheters were independently associated with HAIs. A total of 2762 (51.0%; 95% CI, 49.7%–52.3%) patients were on 3611 systemic antimicrobial agents; 462 (12.8%) were prescribed for surgical prophylaxis and 2997 (83.0%) were prescribed for treatment. Amoxicillin/clavulanate was the most frequently prescribed (24.6%) antimicrobial agent.<div class="boxTitle">Conclusions.</div>This survey suggested a high prevalence of HAIs and AMU in Singapore’s acute-care hospitals. While further research is necessary to understand the causes and costs of HAIs and AMU in Singapore, repeated PPSs over the next decade will be useful to gauge progress at controlling HAIs and AMU.</span>

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