Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA) which has been evaluated in the treatment of major depression. Mirtazapine has a unique mode of biochemical action: it affects both the serotonin and norepinephrine systems in the central nervous system, but it lacks the anticholinergic and cardiovascular effects of other antidepressants, such as tricyclic antidepressants. Mirtazapine, due to its characteristic pharmacological action (enhancement of central noradrenergic and serotonergic activity), is able to neutralize or reverse some side effects that are likely to occur when other classes of antidepressants are administered.
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