Τρίτη, 9 Απριλίου 2019

MedWorm Cancer & Oncology Research


A Rat Model of Radiation Vasculitis for the Study of Mesenchymal Stem Cell-Based Therapy.
Authors: Zhang J, Tao X, Sun M, Ying R, Su W, Wei W, Meng X Abstract Radiation vasculitis is one of the most common detrimental effects of radiotherapy for malignant tumors. This is developed at the vasculature of adjacent organs. Animal experiments have showed that transplantation of mesenchymal stem cells (MSCs) restores vascular function after irradiation. But the population of MSCs being engrafted into irradiated vessels is too low in the conventional models to make assessment of therapeutic...
MedWorm Cancer & Oncology Research
05:34
The mechanism of miR-16-5p protection on LPS-induced A549 cell injury by targeting CXCR3.
CONCLUSION: miR-16-5p can protect LPS-induced A549 cell injury, and its mechanism may be related to the targeted regulation of CXCR3, which could provide a new target for targeted therapy of lung cancer. PMID: 30957556 [PubMed - in process] (Source: Artificial Cells, Nanomedicine and Biotechnology)
MedWorm Cancer & Oncology Research
02:47
Update in the Management of Pleural Effusions.
Authors: Aboudara M, Maldonado F Abstract Pleural effusions are a common clinical problem for the primary care physician. Over the past 10 years, there has been a paradigm shift in the field due to emergence of new evidence, which includes the ubiquitous use of thoracic ultrasound, the reemergence of pleuroscopy as a diagnostic and therapeutic modality, the widespread use of indwelling pleural catheters for malignant pleural effusions, and the evidence-based approach to management of complex...
MedWorm Cancer & Oncology Research
02:41
Impact of Taurine on the proliferation and apoptosis of human cervical carcinoma cells and its mechanism.
CONCLUSIONS: Tau inhibited the proliferation and induced the apoptosis of cervical cancer SiHa cells. The MST1 protein plays an important role in the Tau-induced apoptosis of cervical cancer cells. PMID: 30958437 [PubMed - in process] (Source: Chinese Medical Journal)
MedWorm Cancer & Oncology Research
02:38
Application of robot-assisted laparoscopic pelvic exenteration in treating gynecologic malignancies.
Authors: Yang QY, Tang JY PMID: 30958440 [PubMed - in process] (Source: Chinese Medical Journal)
MedWorm Cancer & Oncology Research
02:38
Radiofrequency deep hyperthermia combined with chemotherapy in the treatment of advanced non-small cell lung cancer.
CONCLUSIONS: Hyperthermia combined with chemotherapy might lead to the development of better therapeutic strategy for advanced NSCLC with malignant pleural effusion patients. Also, it could greatly reduce the chemotherapy toxic effects in the incidence of weakness and gastrointestinal adverse reactions in advanced NSCLC patients. PMID: 30958433 [PubMed - in process] (Source: Chinese Medical Journal)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com...
MedWorm Cancer & Oncology Research
02:38
Causes of hospitalization in sickle cell diseased children in western region of Saudi Arabia. A single center study.
CONCLUSION: This study revealed high rate of hospitalization of SCD children because of acute painful crisis, ACS, infection, and anemia. These admissions causes could potentially be continuously assessed to minimize the rate of hospitalization. PMID: 30957136 [PubMed - in process] (Source: Saudi Medical Journal)
MedWorm Cancer & Oncology Research
02:27
Proteomics insights into the pathology and prognosis of chronic lymphocytic leukemia.
Authors: Alsagaby SA, Alhumaydhi FA Abstract Chronic lymphocytic leukemia (CLL) is an incurable malignant disease of B-lymphocytes characterized by drastically heterogeneous clinical courses. Proteomics is an advanced approach that allows a global profiling of protein expression, providing a valuable chance for the discovery of disease-related proteins. In the last 2 decades, several proteomics studies were conducted on CLL to identify aberrant protein expression underpinning the malignant...
MedWorm Cancer & Oncology Research
02:27
Transcriptomics-based validation of the relatedness of heterogeneous nuclear ribonucleoproteins to chronic lymphocytic leukemia as potential biomarkers of the disease aggressiveness.
Conclusion: The cognate transcripts of 14 of our CLL-related proteins significantly predicted CLL prognosis. PMID: 30957125 [PubMed - in process] (Source: Saudi Medical Journal)
MedWorm Cancer & Oncology Research
02:27
Community Engagement to Address Cancer Health Disparities: A Process EVALUATION using the Partnership Self-Assessment Tool.
CONCLUSIONS: Community-academic partnerships are promising approaches to help address cancer health disparities in African American communities. Factors that influence decision making and participation within partnerships require further research. PMID: 30956251 [PubMed - in process] (Source: Progress in Community Health Partnerships)
MedWorm Cancer & Oncology Research
00:53
Facile Fabrication of pH-responsive Nanoparticles from Cellulose Derivatives via Schiff base formation for Controlled Release
This study demonstrates the formation of a group of novel pH-sensitive and drug-loadable NPs, which provide a simple and efficient drug delivery system for the potential application for cancer treatment.Graphical abstractNovel pH-responsive nanoparticles as promising delivery system were designed and constructed using 2,3-dialdehyde cellulose derivatives. The resulting nanoparticles showed adjustable loading capacity that was tuned by changing the ratio of oleylamine and amino-containing compounds....
MedWorm Cancer & Oncology Research
00:39
Preparation of platinum(II) complexes with naphthalene imide derivatives and exploration of their in vitro cytotoxic activities
MedWorm Cancer & Oncology Research
00:14
Impact of food insecurity and malnutrition on the burden of Non-communicable diseases and death in Ethiopia: A situational analysis.
CONCLUSION: The SDGs are a target to call for comprehensive and it should have participatory approaches worldwide. Therefore, Ethiopian government and all policy-makers should be given great attention in order to improve the overall problems in the country. Especially, it requires the knowledge, commitment and responsibilities of politicians, researchers, health professionals and all stakeholders in the country. PMID: 30958340 [PubMed - as supplied by publisher] (Source: Human Antibodies)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 23:16
Metastases-free survival rate in non-metastatic castration-resistant prostate cancer: Now living on its own!
Publication date: Available online 8 April 2019Source: Actas Urológicas Españolas (English Edition)Author(s): A. Juárez-Soto (Source: Actas Urologicas Espanolas)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 22:43
APOBEC-mediated Mutagenesis as a Likely Cause of FGFR3 S249C Mutation Over-representation in Bladder Cancer
Publication date: Available online 8 April 2019Source: European UrologyAuthor(s): Ming-Jun Shi, Xiang-Yu Meng, Philippe Lamy, A. Rouf Banday, Jie Yang, Aura Moreno-Vega, Chun-Long Chen, Lars Dyrskjøt, Isabelle Bernard-Pierrot, Ludmila Prokunina-Olsson, François RadvanyiAbstractFGFR3 is one of the most frequently mutated genes in bladder cancer and a driver of an oncogenic dependency. Here we report that only the most common recurrent FGFR3 mutation, S249C (TCC → TGC), represents an APOBEC-type motif...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 22:41
Solid Science for the Upside but Lack of Solid Science for the Downside—Towards Cutting-edge Prostate-cancer Screening
Publication date: Available online 8 April 2019Source: European UrologyAuthor(s): Gunnar Steineck, Olof Akre, Anna Bill-Axelson (Source: European Urology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 22:41
Incidence of and Risk Factors for Delayed Acute Kidney Injury in Patients undergoing Colorectal Surgery
ConclusionAKI commonly occurs beyond the perioperative period. Careful risk stratification and modification of risk factors may prevent delayed AKI in patients undergoing colorectal cancer surgery. (Source: The American Journal of Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 22:13
Epidemiology and antifungal susceptibility patterns of candidemia from a tertiary centre in Western Australia.
Authors: Boan P, Gardam D Abstract Candidemia is a common invasive fungal infection with a high mortality rate. We performed a retrospective audit of candidemia at a tertiary centre in Western Australia, 2005-2014. There were 167 episodes of candidemia due to 173 isolates of Candida. Candida albicans (40.5%), Candida glabrata complex (30.6%), Candida parapsilosis complex (14.4%) were the most common species causing candidemia across the study. Of the tested isolates, 17.7% (11/62) were...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:47
Inter-laboratory comparison of Ki-67 proliferating index detected by visual assessment and automated digital image analysis.
CONCLUSION: Proliferation remains one of the most important parameters for tumor characterization helpful in making clinical decisions, but it should be used with great caution. Standardization of the Ki-67 assessment is essential and proliferating index should be expressed as exact numeric value. For patients with proliferative index near the cut-off value, other factors must be considered in making clinical decisions. PMID: 30958325 [PubMed - as supplied by publisher] (Source: Breast Disease)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:44
Performance of survivin mRNA as a biomarker for breast cancer among Vietnamese women.
CONCLUSION: Results provide the initial evidence of the expression of survivin mRNA in breast cancer patients in Vietnam, suggesting the role of survivin mRNA in breast cancer molecular pathology. PMID: 30958326 [PubMed - as supplied by publisher] (Source: Breast Disease)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:44
Oncology nurses' knowledge about Lymphedema Assessment, Prevention, and  Management among Women with Breast Cancer.
CONCLUSIONS: The results indicated that there is a need for a structured educational program to improve oncology nurses knowledge regarding BCRL. PMID: 30958327 [PubMed - as supplied by publisher] (Source: Breast Disease)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:44
Comparison of Study Activity Times for "Full" versus "Fast MRI" for Breast Cancer Screening
ConclusionsThe realized gains in patient flow rate were lower than expected based on scan times (65%) because of increased technologist activity time for the AB-MR protocol. (Source: Journal of the American College of Radiology)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:37
Longitudinal Visualization of Viable Cancer Cell Intratumoral Distribution in Mouse Models Using Oatp1a1-Enhanced Magnetic Resonance Imaging
Objectives Multimodality reporter gene imaging provides valuable, noninvasive information on the fate of engineered cell populations. To complement magnetic resonance imaging (MRI) measures of tumor volume and 2-dimensional reporter-based optical measures of cell viability, reporter-based MRI may offer 3-dimensional information on the distribution of viable cancer cells in deep tissues. Materials and Methods Here, we engineered human and murine triple-negative breast cancer cells with lentivirus...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:35
Quantitative Multiparametric Breast Ultrasound: Application of Contrast-Enhanced Ultrasound and Elastography Leads to an Improved Differentiation of Benign and Malignant Lesions
Objectives The aim of this study was to evaluate breast multiparametric ultrasound (mpUS) and its potential to reduce unnecessary breast biopsies with 1, 2, or 3 additional quantitative parameters (Doppler, elastography, and contrast-enhanced ultrasound [CEUS]) to B-mode and investigate possible variations with different reader experience. Materials and Methods This prospective study included 124 women (age range, 18–82 years; mean, 52 years), each with 1 new breast lesion, scheduled for ultrasound-guided...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:35
Matching and Homogenizing Convolution Kernels for Quantitative Studies in Computed Tomography
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:35
Low-Dose Perfusion Computed Tomography for Breast Cancer to Quantify Tumor Vascularity: Correlation With Prognostic Biomarkers
Objectives The aim of this study was to investigate the feasibility of using low-dose perfusion computed tomography (CT) in breast cancers for quantification of tumor vascularity and to correlate perfusion indexes with prognostic biomarkers. Materials and Methods This preliminary study was approved by our institutional review board. Signed informed consent was obtained from all 70 enrolled patients with invasive breast cancers. Low-dose perfusion CT was performed with the patient in the prone...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:35
Bone metastases with multiple fluid-fluid levels from gastric cancer: a case report and review of literature
We report the case of a 54-year-old man with 6  months of progressive sacral pain. Computed tomography showed a large osteolytic mass in the sacrum with multiple osteolytic foci in the ilium and lumbar spine. Magnetic resonance imaging revealed multiple fluid-fluid levels in the sacral lesion as well as in the lumbar foci. The multiple bone les ions were initially diagnosed as a primary sacral malignancy with multiple bone metastases. A biopsy of the sacral lesion under the guidance of computed tomography...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:35
Value of low-dose whole-body CT in the management of patients with multiple myeloma and precursor states
ConclusionWhole-body CT provides important information for disease monitoring and detection of incidental findings, thereby improving the management of patients with MM. (Source: Skeletal Radiology)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:35
Valspodar-modulated chemotherapy in human ovarian cancer cells SK-OV-3 and MDAH-2774.
In this study, we evaluated the effect of valspodar and cisplatin co-treatment on cell viability, cell death and oxidative status in ovarian cancer cells. The two cisplatin-resistant human ovarian cancer cell lines SK-OV-3 and MDAH-2774 were treated with cisplatin, valspodar, or cisplatin+valspodar for 24 and 48 hours. Untreated cells were used as control group. Cell viability was evaluated by MTT assay. Cell death was assessed by TUNEL and comet assay. Lipid peroxidation (malondialdehyde) and protein...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:19
Clear cell urothelial carcinoma of the urinary bladder - a rare pathological entity. A case report and a systematic review of the literature.
In this study, we report a case of an 81-year-old male, presenting with gross hematuria and acute urinary retention, which was subsequently diagnosed with CCUC at our pathology department. Furthermore, we provide a short systematic review of the literature (PubMed, Scopus, Science Citation Index) for this rare histopathological entity and a brief discussion about its morphological and immunohistochemical (IHC) characteristics. PMID: 30957722 [PubMed - as supplied by publisher] (Source: Bosnian...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:19
Internodal HER2 heterogeneity of axillary lymph node metastases in breast cancer patients.
Authors: Baroš IV, Tanasković N, Pellas U, Eri Ž, Tadić Latinović L, Tot T Abstract Determination of human epidermal growth factor receptor 2 (HER2) status is important for adequate treatment of breast cancer (BC) patients. The novel HER2 gene protein assay (GPA) is particularly convenient, as it allows the simultaneous assessment of HER2 protein expression and gene amplification at individual cell level. Here we investigated the frequency of internodal HER2 heterogeneity in axillary lymph...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 21:19
Ann Oncol; +35 new citations
35 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Ann Oncol These pubmed results were generated on 2019/04/09PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Ann Oncol)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 20:41
Occupational Lung Disease.
This article reviews the broad range of types of occupational lung diseases, including airways disease, pneumoconioses, and cancer. Common causes of occupational lung disease are reviewed with specific examples and clinical features. Emphasis on the importance of a detailed history to make an accurate diagnosis of an occupational lung disease is discussed. PMID: 30955520 [PubMed - in process] (Source: Clinical Lung Cancer)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 19:13
Interventional Pulmonology: A Focused Review for Primary Care Physicians.
This article provides a broad overview of the field to serve as a resource for primary care physicians. PMID: 30955509 [PubMed - in process] (Source: Clinical Lung Cancer)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 19:13
Lung Cancer.
Authors: Nasim F, Sabath BF, Eapen GA Abstract Lung cancer is the world's leading cause of cancer death. Screening for lung cancer by low-dose computed tomography improves mortality. Various modalities exist for diagnosis and staging. Treatment is determined by subtype and stage of cancer; there are several personalized therapies that did not exist just a few years ago. Caring for the patient with lung cancer is a complex task. This review provides a broad outline of this disease, helping...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 19:13
Effect of Vitamin D Supplementation on Relapse-Free Survival in Patients With Digestive Tract Cancers
This randomized clinical trial compares the effects of vitamin D supplementation vs placebo on 5-year relapse-free survival after surgical resection of stage I-III esophageal, gastric, small bowel, and colorectal cancers. (Source: JAMA)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 02:00
Having the Conversation I Encourage Others to Have About End-of-Life Care
In this narrative medicine essay, a palliative care physician with breast cancer talks about the end-of-life conversations she and her husband have, recalling how her priorities have changed through life stages and how she uses her experiences to inform her interactions with her own cancer patients. (Source: JAMA)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 02:00
Insights From 2 New Trials on Vitamin D as Cancer Therapy
Over the past 30 years, extensive research has explored the use of nutritional supplements for prevention of cancer. Despite what appears to be strong observational evidence, randomized clinical trials of beta carotene, ascorbic acid, alpha tocopherol, selenium, and folic acid all failed to show evidence of efficacy for cancer chemoprevention. The colorectum has been particularly well studied: trials of these interventions examining adenoma recurrence have been uniformly negative as well. (Source:...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 02:00
Association of Patient Characteristics and Tumor Genomics With Non –Small Cell Lung Cancer Outcomes
This cancer epidemiology study links electronic health record (EHR) data with comprehensive genomic profiling to identify patient characteristics and gene alterations associated with overall survival, response to targeted and immune therapies, and other clinical outcomes in patients non –small cell lung cancer (NSCLC). (Source: JAMA)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 02:00
Effect of High- vs Standard-Dose Vitamin D 3 on Progression-Free Survival of Colorectal Cancer
This phase 2 randomized clinical trial compares the effects of high-dose vs standard-dose vitamin D3 added to standard chemotherapy on progression-free survival among patients with metastatic colorectal cancer. (Source: JAMA)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 02:00
MPT0G413, A Novel HDAC6-Selective Inhibitor, and Bortezomib Synergistically Exert Anti-tumor Activity in Multiple Myeloma Cells
In conclusion, MPT0G413 and BTZ synergistically inhibit MM viability, providing a framework for the clinical evaluation of combined therapies for MM. Introduction Multiple myeloma (MM) is a B cell malignancy characterized by the proliferation of bone marrow (BM) plasma cells and the production of large amounts of abnormal immunoglobulins (1) In the United States, it was estimated that 30,770 new MM cases would be diagnosed in 2018, accounting for 1.8% of newly diagnosed cancer cases (2)....
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Prospective assessment of taste impairment and nausea during radiotherapy for head and neck cancer
AbstractDysgeusia and nausea are common side effects observed in head and neck cancer patients treated with either exclusive radiotherapy or combined modality treatment. The aim of the present study was to prospectively evaluate dysgeusia, during treatment and follow-up, using the chemotherapy-induced taste alteration scale (CiTAS), a metrics based on 18-items exploring three dimensions (quantitative and qualitative changes in taste perception, anddiet-related issues) identified through a four-factor...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Re: re: Squamous cell carcinoma of the tongue in a patient with dyskeratosis congenita: a rare entity
Publication date: Available online 8 April 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Khuzema Saifuddin Fatehi, Shivakumar Thiagarajan (Source: British Journal of Oral and Maxillofacial Surgery)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 18:36
Metastasis of submandibular gland carcinoma to the toe bone: a case report
We report a 62-year-old woman who presented with pain caused by bony metastases as the first symptom eight years after being diagnosed with submandibular ACC. Although such cases are rare, they indicate that when patients who have had cancer visit the hospital with other symptoms, clinicians should make sure to rule out metastasis. (Source: British Journal of Oral and Maxillofacial Surgery)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 18:36
Unexpected Synergy Reveals New Therapeutic Strategy in SCLC
Publication date: Available online 8 April 2019Source: Trends in Pharmacological SciencesAuthor(s): Benjamin J. Drapkin, Anna F. FaragoDNA damage repair (DDR) inhibition and immune checkpoint blockade (ICB) have each individually shown modest clinical activity in small cell lung cancer (SCLC). Recently, Sen and colleagues (Cancer Discov. 2019;https://doi.org/10.1158/2159-8290.CD-18-1020) demonstrated that DDR inhibition can activate the stimulator of interferon genes (STING) innate immune pathway,...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 18:07
Triptolide and Its Derivatives as Cancer Therapies
Publication date: Available online 8 April 2019Source: Trends in Pharmacological SciencesAuthor(s): Pawan Noel, Daniel D. Von Hoff, Ashok K. Saluja, Mohana Velagapudi, Erkut Borazanci, Haiyong HanTriptolide, a compound isolated from a Chinese medicinal herb, possesses potent antitumor, immunosuppressive, and anti-inflammatory properties, but is clinically limited due to its poor solubility, bioavailability, and toxicity. Recently, Minnelide, a water-soluble prodrug of triptolide, was shown to have...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 18:07
Subcellular compartmentalization of NAD+ and its role in cancer: A sereNADe of metabolic melodies
Publication date: Available online 8 April 2019Source: Pharmacology & TherapeuticsAuthor(s): Yi Zhu, Jiaqi Liu, Joun Park, Priyamvada Rai, R. Grace ZhaiAbstractNicotinamide adenine dinucleotide (NAD+) is an essential biomolecule involved in many critical processes. Its role as both a driver of energy production and a signaling molecule underscores its importance in health and disease. NAD+ signaling impacts multiple processes that are dysregulated in cancer, including DNA repair, cell proliferation,...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 18:07
Cordycepin Inhibits Drug-resistance Non-small Cell Lung Cancer Progression by Activating AMPK Signaling Pathway
Publication date: Available online 8 April 2019Source: Pharmacological ResearchAuthor(s): Chunli Wei, Xiaojun Yao, Zebo Jiang, Yuwei Wang, Dianzheng Zhang, Xi Chen, Xingxing Fan, Chun Xie, Jingliang Cheng, Junjiang Fu, Elaine Lai-Han LeungAbstractLung cancer is the most commonly diagnosed cancer worldwide and it is also the most leading cause of cancer-related deaths. Although multiple generations of targeted therapeutic drugs such as gefitinib and afatinib specifically targeting the epidermal growth...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 18:07
Chemical fingerprints, antioxidant, enzyme inhibitory, and cell assays of three extracts obtained from Sideritis ozturkii Aytaç & Aksoy: An endemic plant from Turkey
This study was geared towards assessing the possible antioxidant, enzyme inhibitory, and cytotoxic activities of ethyl acetate, methanol, and water extracts of Sideritis ozturkii Aytaç & Aksoy. The phytochemical profiles of the studied extracts were characterised by HPLC-MS/MS. The methanol extract, rich in phenolics (78.04 mg gallic acid equivalent/g), exhibited the strongest antioxidant activities. However, the ethyl acetate extract was the most active extract in the enzyme inhibitory assays....
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 18:07
Pharmacological and transcriptome profiling analyses of Fufang E'jiao Jiang during chemotherapy-induced myelosuppression in mice
ConclusionFEJ has the hematopoietic effect in chemotherapy-induced myelosuppression mice. It might be achieved by improving the proliferative capacity of HSCs and the differentiation ability of HPCs. The molecular mode of action of FEJ might be the improvement of the bone marrow microenvironment via ECM-receptor interaction, the promoted proliferation of HSC through regulation of PI3K-AKT signaling pathway, and the involvement of osteoblasts and osteoclasts. MMP2 and COL1A1 appear to be the key relevant...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 18:07
Protoberberine compounds extracted from Chelidonium majus L. as novel natural photosensitizers for cancer therapy
ConclusionOur results strongly suggest that the components of the natural plant protoberberine fraction (BBR-F) extracted from C. majus may represent promising novel photosensitive agents and can be applied in cancer photodynamic therapy as natural photosensitizers.Graphical abstract (Source: Phytomedicine)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 18:06
NOD-like receptor signaling in inflammation-associated cancers: from functions to targeted therapies
ConclusionIn this review, we discuss how NLR signaling is involved in inflammation-associated cancers, and highlight the NLR-targeted botanicals and synthetic small molecules in cancer intervention.Graphical Abstract (Source: Phytomedicine)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 18:06
The risk of adverse obstetric outcomes and the abnormal growth of offspring in women with a history of thyroid cancer.
CONCLUSION: Women with a history of thyroid cancer have similar pregnancy outcomes and offspring growth to those with no such history. PMID: 30957663 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 17:50
Identification of rare variants predisposing to thyroid cancer.
CONCLUSIONS: Our data identify rare germline variants that may play important roles in NMTC predisposition. We propose that in future research including functional characterization, these variants and genes be considered primary candidates for thyroid cancer predisposition. PMID: 30957677 [PubMed - as supplied by publisher] (Source: Thyroid : official journal of the American Thyroid Association)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 17:50
Proper management of suspicious actinic cheilitis
Actinic cheilitis (AC) is a variant of actinic keratosis which is known to be a premalignant condition that could develop into squamous cell carcinoma (SCC). Epimyoepithelial carcinoma (EC) is a very rare sali... (Source: Maxillofacial Plastic and Reconstructive Surgery)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 02:00
MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages
MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages, Published online: 09 April 2019; doi:10.1038/s41388-019-0811-9MST1R kinase accelerates pancreatic cancer progression via effects on both epithelial cells and macrophages (Source: Oncogene)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Obesity and the Risk of Gastrointestinal Cancers
AbstractObesity is a risk factor for all major gastrointestinal cancers. With the rapid increase in the prevalence of obesity worldwide, this link could lead to an elevated burden of cancers of the digestive system. Currently, three main mechanisms explaining the link between excess adiposity and gastrointestinal cancer risk are being considered, including altered insulin signaling, obesity-associated chronic low-grade inflammation, and altered sex hormone metabolism, although new potential mechanisms...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Impact of tumor-infiltrating LAMP-3 dendritic cells on the prognosis of esophageal squamous cell carcinoma
ConclusionAt the local tumor site, mature LAMP-3 DCs might be associated with increasing tumor infiltrating CD8 T cells. (Source: Esophagus)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Re: "Effects of Short-Term Hypothyroidism on the Lipid Transfer to High-Density Lipoprotein and Other Parameters Related to Lipoprotein Metabolism in Patients Submitted to Thyroidectomy for Thyroid Cancer" by Sigal et al. (Thyroid 2019;29:53–58)
Thyroid, Ahead of Print. (Source: Thyroid)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Corrigendum: Tetrac and NDAT Induce Anti-proliferation via Integrin αvβ3 in Colorectal Cancers With Different K-RAS Status
Corrigendum: Tetrac and NDAT Induce Anti-proliferation via Integrin αvβ3 in Colorectal Cancers With Different K-RAS Status Yu-Tang Chin1,2†, Zong-Rong He3,4†, Chi-Long Chen5†, Hsiao-Ching Chu6, Yih Ho1,7, Po-Yu Su8, Yu-Chen S. H. Yang9, Kuan Wang1,8, Ya-Jung Shih1,8, Yi-Ru Chen1,8, Jens Z. Pedersen10, Sandra Incerpi11, André Wendindondé Nana12, Heng-Yuan Tang13, Hung-Yun Lin1,12,13,14,15*, Shaker A. Mousa13, Paul J. Davis13,16 and Jacqueline Whang-Peng1,2,12* 1Taipei Cancer Center, Taipei Medical...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Both 3,3 ′,5-triiodothyronine and 3,5-diodo-L-thyronine Are Able to Repair Mitochondrial DNA Damage but by Different Mechanisms
In conclusion, both T3 and T2 are capable of inducing protective effects against mtDNA oxidative stress, but they affect different pathways. In the present study, we did not investigate the possible involvement of other homeostatic mechanisms possibly counteracting the oxidative stress, such as autophagy. However, this aspect has been recently investigated by Iannucci et al. (29), demonstrating that in the liver of HFD-treated rats, the administration of either T3 or T2 affected the autophagy mechanisms,...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
circSMARCA5 Functions as a Diagnostic and Prognostic Biomarker for Gastric Cancer.
Discussion: Our results demonstrated that circSMARCA5 was decreased and exerted tumor-suppressive effects in GC. circSMARCA5 can function as a potential biomarker for GC prognosis and diagnosis. PMID: 30956729 [PubMed - in process] (Source: Disease Markers)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 17:16
High Expression of LTBP2 Contributes to Poor Prognosis in Colorectal Cancer Patients and Correlates with the Mesenchymal Colorectal Cancer Subtype.
In this study, we aimed to analyze the mRNA and protein expression levels of LTBP2 in CRC tissues and then estimate their values as a potential prognostic biomarker. We detected the mRNA expression of LTBP2 in 28 cases of fresh CRC tissues and 4 CRC cell lines and the protein expression of LTBP2 in 483 samples of CRC tissues, matched tumor-adjacent tissues, and benign colorectal diseases. LTBP2 protein expression was then correlated to patients' clinical features and overall survival. Both LTBP2...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 17:16
Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF
Publication date: Available online 8 April 2019Source: Cancer CellAuthor(s): María Teresa Blasco, Carolina Navas, Guillermo Martín-Serrano, Osvaldo Graña-Castro, Carmen G. Lechuga, Laura Martín-Díaz, Magdolna Djurec, Jing Li, Lucia Morales-Cacho, Laura Esteban-Burgos, Javier Perales-Patón, Emilie Bousquet-Mur, Eva Castellano, Harrys K.C. Jacob, Lavinia Cabras, Monica Musteanu, Matthias Drosten, Sagrario Ortega, Francisca Mulero, Bruno SainzSummaryFive-year survival for pancreatic ductal adenocarcinoma...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 17:02
Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness
Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness, Published online: 09 April 2019; doi:10.1038/s41388-019-0809-3Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness (Source: Oncogene)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Addiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation
Addiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation, Published online: 09 April 2019; doi:10.1038/s41388-019-0813-7Addiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation (Source: Oncogene)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation
Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation, Published online: 09 April 2019; doi:10.1038/s41388-019-0798-2Axitinib exposure triggers endothelial cells senescence through ROS accumulation and ATM activation (Source: Oncogene)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer
NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer, Published online: 09 April 2019; doi:10.1038/s41388-019-0806-6NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer (Source: Oncogene)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition
The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition, Published online: 09 April 2019; doi:10.1038/s41388-019-0802-xThe anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition (Source: Oncogene)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Cancers, Vol. 11, Pages 503: NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells —A Potential Target for Adjuvant Radiotherapy
In this study we revealed functional expression of Ca2+-permeable NMDARs in three glioblastoma cell lines. Therefore, we investigated the impact of this receptor on cell survival, migration and DNA double-strand break (DSB) repair in the presence of both, glutamate and NMDAR antagonists, and after clinically relevant doses of ionizing radiation. Our results indicate that treatment with NMDAR antagonists slowed the growth and migration of glutamate-releasing LN229 cells, suggesting that activation...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Carbon-ion radiotherapy for lymph node oligo-recurrence: a multi-institutional study by the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS)
ConclusionsC-ion RT for LN oligo-recurrence appeared to be effective and safe. C-ion RT may provide a survival benefit to patients with LN oligo-recurrence, particularly to those with few LN metastases, smaller LN diameters, and longer disease-free intervals. (Source: International Journal of Clinical Oncology)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Correction to: Monitoring of intracerebellarly-administered natural killer cells with fluorine-19 MRI
There was a typo in author Andrew Wahba 's name in the initial online publication. The original article has been corrected. (Source: Journal of Neuro-Oncology)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Impact of Chemotherapy Regimens on Normal Tissue Complication Probability Models of Acute Hematologic Toxicity in Rectal Cancer Patients Receiving Intensity Modulated Radiation Therapy With Concurrent Chemotherapy From a Prospective Phase III Clinical Trial
Conclusion: Patients receiving FOLFOX have lower BM tolerance to CRT than those receiving 5FU. Low-dose radiation to the PBM is predictive for HT2+ in patients who received 5FU. NTCP modeling in FOLFOX group predicts much higher risk of HT3+ than 5FU group. Introduction Rectal cancer is a common malignancy in the world (1). Several randomized trials have demonstrated that preoperative radiotherapy (RT) combined fluorouracil (FU)-based chemotherapy improves locoregional control (LRC) in patients...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
N6-Methyladenosine (m6A): A Promising New Molecular Target in Acute Myeloid Leukemia
In conclusion, the high structural diversity of these compounds pinpoints the significant range of inhibition strategies that can be conceived to target the class I methyltransferases. Although the structural details of the various members of this family are unique, the success stories of drug design for several enzymes belonging to this family portends the likely achievement of discovering potent and selective inhibitors of METTL3/METTL14. Author Contributions AF and AP wrote the manuscript. ZI...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Clinical Evaluation of Commercial Atlas-Based Auto-Segmentation in the Head and Neck Region
Conclusions: The performance of AS AC generally increased as the population of the atlas library increased. However, the performance does not drastically vary in the larger atlas libraries in contrast to the logic that bigger atlas library should lead to better results. In fact, the results do not vary significantly toward the larger atlas library. It is necessary for the institutions to independently research the optimal number of subjects. Introduction Manual contouring of target and critical...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
A Computed Tomography-Based Radiomic Prognostic Marker of Advanced High-Grade Serous Ovarian Cancer Recurrence: A Multicenter Study
Conclusions: Radiomic signature and radiomic nomogram may be low-cost, non-invasive means for successfully predicting risk for postoperative advanced HGSOC recurrence before or during the perioperative period. Radiomic signature is a potential prognostic marker that may allow for individualized evaluation of patients with advanced HGSOC. Introduction Ovarian cancer is the leading cause of gynecological cancer-related deaths (1). Seventy percent of these deaths are due to high-grade serous ovarian...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness
Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness, Published online: 09 April 2019; doi:10.1038/s41388-019-0804-8Impaired microRNA processing by DICER1 downregulation endows thyroid cancer with increased aggressiveness (Source: Oncogene)
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 00:00
Metabolomic profiling for the identification of novel diagnostic markers in prostate cancer: an update.
Authors: Lucarelli G, Loizzo D, Ferro M, Rutigliano M, Vartolomei MD, Cantiello F, Buonerba C, Di Lorenzo G, Terracciano D, De Cobelli O, Bettocchi C, Ditonno P, Battaglia M Abstract INTRODUCTION: An altered metabolic regulation is involved in the development and progression of different cancer types. As well as this, many genes associated with tumors are shown to have an important role in control of the metabolism. The incidence of prostate cancer (PCa) is increased in men with metabolic...
MedWorm Cancer & Oncology Research
Tue Apr 09, 2019 16:37

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