Πέμπτη, 11 Απριλίου 2019

Cancer Oncology


Glutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) promotes epithelial‐mesenchymal transition in breast cancer cells by regulating SPDEF/CDH1 signaling
AbstractGlutamate Ionotropic Receptor Kainate Type Subunit 3 (GRIK3) is an important excitatory neurotransmitter receptor that plays a significant role in various neurodegenerative diseases. However, the biological functions of GRIK3 in malignancies are largely unknown because of limited related studies. Here, we primarily reported that the expression of GRIK3 was higher in breast cancer tissues than in adjacent noncancerous tissues. GRIK3 expression was also positively correlated with the...
Molecular Carcinogenesis
Thu Apr 11, 2019 18:39
Saliva Tests Can Identify HPV16 - PrecisionVaccinations
Saliva Tests Can Identify HPV16  PrecisionVaccinationsIn a cancer detection editorial published in JAMA, Ricardo J. Ramirez, MD and Jose P. Zevallos, MD, MPH, concluded that oral rinse samples are reliable when ...
Cancer of Tongue - Google News
Thu Apr 11, 2019 22:44
Hyperammonemia after capecitabine associated with occult impairment of the urea cycle
This paper describes a patient with hyperammonemia and delirium induced by capecitabine chemotherapy. Capecitabine and 5‐fluorouracil potentially induce hyperammonemia by inhibiting pyrimidine biosynthesis and thus decreasing ammonia utilization. The patient had risk factors for 5‐fluorouracil‐induced hyperammonemia, including genetic susceptibility and occult liver dysfunction, which are not rare.AbstractBackgroundCancer patients receiving chemotherapy often complain of "chemobrain" or...
Cancer Medicine
Thu Apr 11, 2019 19:10
Can acetylcysteine ameliorate cisplatin‐induced toxicities and oxidative stress without decreasing antitumor efficacy? A randomized, double‐blind, placebo‐controlled trial involving patients with head and neck cancer
The use of antioxidants, such as acetylcysteine, in patients receiving chemotherapy is currently a hot topic in the literature. There are no studies in humans to verify the effect of acetylcysteine on toxicity, oxidative stress, and clinical response to cisplatin. This is the first randomized, double‐blind, placebo‐controlled trial to investigate this issue.AbstractThe protective antioxidant activity of acetylcysteine (NAC) against toxicity due to cisplatin has been reported in experimental...
Cancer Medicine
Thu Apr 11, 2019 19:10
Application of Artificial Intelligence for Preoperative Diagnostic and Prognostic Prediction in Epithelial Ovarian Cancer Based on Blood Biomarkers
Purpose: We aimed to develop an ovarian cancer–specific predictive framework for clinical stage, histotype, residual tumor burden, and prognosis using machine learning methods based on multiple biomarkers.Experimental Design: Overall, 334 patients with epithelial ovarian cancer (EOC) and 101 patients with benign ovarian tumors were randomly assigned to "training" and "test" cohorts. Seven supervised machine learning classifiers, including Gradient Boosting Machine (GBM), Support Vector Machine, Random...
Clinical Cancer Research Online First Articles
07:00
Characterization of pediatric hepatocellular carcinoma reveals genomic heterogeneity and diverse signaling pathway activation
AbstractBackgroundPediatric hepatocellular carcinoma (HCC) is a rare liver tumor in children with a poor prognosis. Comprehensive molecular profiling to understand the underlying genomic drivers of this tumor has not been completed, and it is unclear whether nonfibrolamellar pediatric HCC is more genomically similar to hepatoblastoma or adult HCC.ProcedureTo characterize the molecular landscape of these tumors, we analyzed a cohort of 15 pediatric non‐FL‐HCCs by sequencing a panel of cancer‐associated...
Pediatric Blood & Cancer
Thu Apr 11, 2019 19:14
Pediatric ovarian angiosarcoma treated with systemic chemotherapy and cytoreductive surgery with heated intraperitoneal chemotherapy: Case report and review of therapy
AbstractOvarian angiosarcoma is a rare and aggressive vascular tumor, which has a 5‐year overall survival of less than 30% for patients with nonmetastatic disease and almost certain death within 1 year for those with metastasis. Here, we briefly review historical approaches to therapy and present a long‐term survivor in the case of an 11‐year‐old female with metastatic ovarian angiosarcoma. This is the second reported case to utilize heated intraperitoneal chemotherapy in the treatment of...
Pediatric Blood & Cancer
Thu Apr 11, 2019 19:13
Closing the financial toxicity gap for adolescents and young adults with cancer
Pediatric Blood & Cancer
Thu Apr 11, 2019 19:13
PD‐L1 expression in pediatric Epstein‐Barr virus positive classic Hodgkin lymphoma is not associated with 9p24.1 amplification
Pediatric Blood & Cancer
Thu Apr 11, 2019 19:13
Evaluation of pediatric glioma outcomes using intraoperative MRI: a multicenter cohort study
Abstract Background The use of intraoperative MRI (iMRI) during treatment of gliomas may increase extent of resection (EOR), decrease need for early reoperation, and increase progression-free and overall survival, but has not been fully validated, particularly in the pediatric population. Objective To assess the accuracy of iMRI to identify residual tumor...
Latest Results for Journal of Neuro-Oncology
03:00
Role of Oncology Nurses in Primary Palliative Care Growing
Oncology advanced practice registered nurses can play a critical role in providing primary palliative care to patients with cancer. (Source: CancerNetwork)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Palliative Care News
Thu Apr 11, 2019 06:00
Theranostic Outcomes in Clinical Practice of Oncology: What, So What, Now What? What's More
Cancer Biotherapy and Radiopharmaceuticals, Volume 34, Issue 3, Page 135-140, April 2019.
Cancer Biotherapy & Radiopharmaceuticals - Table of Contents
Wed Apr 10, 2019 10:00
Outcomes of non-high grade serous carcinoma after neoadjuvant chemotherapy for advanced-stage ovarian cancer: a Korean gynecologic oncology group study (OV 1708)
Outcomes of patients with ovarian high-grade serous carcinoma (HGSC) treated with neoadjuvant chemotherapy (NAC) have been widely studied, but there is limited information on the outcomes of patients with non-... (Source: BMC Cancer)
MedWorm Cancer & Oncology Research
Thu Apr 11, 2019 02:00
Salivary gland carcinoma in Shanghai (2003 –2012): an epidemiological study of incidence, site and pathology
Salivary gland carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias i... (Source: BMC Cancer)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
Thu Apr 11, 2019 02:00
Quality assurance of non-coplanar, volumetric-modulated arc therapy employing a C-arm linear accelerator, featuring continuous patient couch rotation
To perform quality assurance of non-coplanar, volumetric-modulated arc therapy featuring continuous couch rotation (CCR-VMAT) using a C-arm linear accelerator. (Source: Radiation Oncology)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology Research
Thu Apr 11, 2019 02:00
European Society of Paediatric Radiology Computed Tomography and Dose Task Force: European guidelines on diagnostic reference levels for paediatric imaging
Abstract The recent European Council Directive 2013/59/EURATOM requires the establishment of diagnostic reference levels (DRLs) to optimise radiation dose in diagnostic and interventional radiology procedures. At the time this directive was enacted, just a few European countries had already set paediatric DRLs and many of these were outdated. For this reason, the European Commission launched a project addressing European Guidelines on Diagnostic Reference Levels for Paediatric...
Pediatric Radiology
06:28
Joint European Society of Paediatric Radiology (ESPR) and International Society for Forensic Radiology and Imaging (ISFRI) guidelines: paediatric postmortem computed tomography imaging protocol
Abstract Postmortem CT for investigating childhood deaths is increasingly utilised as a noninvasive adjunct or alternative to standard autopsy; however there are no standardised published imaging protocols. This article describes a standardised imaging protocol that has been developed based on current practices of international postmortem imaging practitioners and experts. This recommendation is expected to be useful for postmortem imaging centres wishing to update their existing...
Pediatric Radiology
06:28
Hermes
Pediatric Radiology
06:28
Intrarenal reflux, an overlooked entity — retrospective analysis of 1,166 voiding cysturethrographies in children
Abstract Background The significance of intrarenal reflux as a risk factor for renal scarring and hypertension has been discussed. Fluoroscopic detection of intrarenal reflux depends on the equipment, the training of the radiologists and the timing of spot film acquisition. Objective To evaluate the prevalence of intrarenal reflux and its association...
Pediatric Radiology
06:28
Technique, pitfalls, quality, radiation dose and findings of dynamic 4-dimensional computed tomography for airway imaging in infants and children
Abstract This retrospective review of 33 children's dynamic 4-dimensional (4-D) computed tomography (CT) images of the airways, performed using volume scanning on a 320-detector array without anaesthesia (free-breathing) and 1.4-s continuous scanning, was undertaken to report technique, pitfalls, quality, radiation doses and findings. Tracheobronchomalacia (airway diameter collapse >28%) was recorded. Age-matched routine chest CT scans and bronchograms acted as benchmarks...
Pediatric Radiology
06:28
Human immunodeficiency virus-related cerebral white matter disease in children
Abstract The human immunodeficiency virus (HIV) epidemic seems largely controlled by anti-retroviral treatment with resultant large numbers of children growing up with the disease on long-term treatment, placing them at higher risk to develop HIV-related brain injury, ongoing cognitive impairment and treatment-related neurological complications. Cerebral white matter involvement is a common radiologic finding in HIV infection and the causes of this have overlapping appearances,...
Pediatric Radiology
06:28
Nurse-Led Prostate Cancer Clinic Examines Patient Anxiety
The clinic educates, evaluates, and guides patients with prostate cancer on available treatments and helps to control associated anxiety. (Source: CancerNetwork)
CancerNetwork
Thu Apr 11, 2019 06:00
Using the THRIVE Program to Teach Self-Care to Oncology Nurses
The THRIVE Program includes an 8-hour retreat designed to teach staff skills for combating compassion fatigue and for promoting resilience. (Source: CancerNetwork)
CancerNetwork
Thu Apr 11, 2019 06:00
Mapping EORTC-QLQ-C30 and QLQ-CR29 onto EQ-5D-5L in Colorectal Cancer Patients
ConclusionsThe mapping algorithm successfully mapped the EORTC QLQ-C30 and QLQ-CR29 scales onto the EQ-5D-5L values; therefore, it enables policymakers to convert cancer-specific questionnaires scores to the preference-based scores. (Source: Journal of Gastrointestinal Cancer)
MedWorm Cancer & Oncology Research
00:00
Enzalutamide versus flutamide for castration-resistant prostate cancer after combined androgen blockade therapy with bicalutamide: study protocol for a multicenter randomized phase II trial (the OCUU-CRPC study)
Enzalutamide is an oral androgen receptor targeted agent that has been shown to improve survival in PREVAIL trials and has been approved for patients with chemo-na ïve metastatic castration-resistant prostate c... (Source: BMC Cancer)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology Research
Thu Apr 11, 2019 02:00
An unusual complication of sacral nerve root injury following bone marrow harvesting: a case report
Hematopoietic stem cell transplantation (HSCT) remains an important therapeutic option for many hematologic malignancies. Bone marrow harvesting from an appropriate donor must be conducted for hematopoietic st... (Source: BMC Cancer)
MedWorm Cancer & Oncology Research
Thu Apr 11, 2019 02:00
Clinical development of targeted and immune based anti-cancer therapies
Cancer is currently the second leading cause of death globally and is expected to be responsible for approximately 9.6 million deaths in 2018. With an unprecedented understanding of the molecular pathways that...
Journal of Experimental & Clinical Cancer Research - Latest Articles
Thu Apr 11, 2019 03:00
Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer
Prostate cancer (PCa) remains a challenge worldwide. Due to the development of castration-resistance, traditional first-line androgen deprivation therapy (ADT) became powerlessness. Epidermal growth factor rec...
Journal of Experimental & Clinical Cancer Research - Latest Articles
Thu Apr 11, 2019 03:00
More Biomarkers Needed in Cancer Immunotherapy More Biomarkers Needed in Cancer Immunotherapy
PD-L1 has proven to be a helpful but limited biomarker in helping clinicians choose cancer patients for immune checkpoint inhibition.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
MedWorm Cancer & Oncology News
00:51
In Melanoma, IO plus HDAC Inhibitor Yields'Impressive Results'In Melanoma, IO plus HDAC Inhibitor Yields'Impressive Results '
Jeffrey Weber comments on a promising approach for heavily pretreated melanoma patients that was recently presented at the 2019 AACR annual meeting.Medscape Oncology (Source: Medscape Allergy Headlines)
MedWorm Cancer & Oncology News
Thu Apr 11, 2019 23:52
New Coriell CEO shares his vision for the Camden institute
His objectives including getting the Camden institute more active in cancer research. (Source: bizjournals.com Health Care:Physician Practices headlines)
MedWorm Cancer & Oncology News
Thu Apr 11, 2019 23:09
Reducing Dex in Antiemetic Regimens'Makes No Sense'Reducing Dex in Antiemetic Regimens'Makes No Sense '
Mark Kris discusses the importance of dexamethasone in antiemetic regimens.Medscape Oncology (Source: Medscape Hematology-Oncology Headlines)
MedWorm Cancer & Oncology News
Thu Apr 11, 2019 20:29
Chemo Drug Shortages Have Little Effect on Cancer Care: Study
(Source: The Doctors Lounge - Oncology)
MedWorm Cancer & Oncology News
Thu Apr 11, 2019 19:00
Presence of Leukemia Cutis Tied to Worse Survival in AML
Hazard ratios for leukemia - specific death, all - cause death higher for patients with AML and LC (Source: The Doctors Lounge - Oncology)MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
MedWorm Cancer & Oncology News
Thu Apr 11, 2019 19:00
Many Cancer Patients Take Alternative Meds But Don ' t Tell Their Doctors
(Source: The Doctors Lounge - Oncology)
MedWorm Cancer & Oncology News
Thu Apr 11, 2019 19:00
Sunscreen ' s Secret Bonus: It Could Help Keep You Cool
(Source: The Doctors Lounge - Oncology)
MedWorm Cancer & Oncology News
Thu Apr 11, 2019 16:00

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