Atherosclerosis

Audit of pcsk9 inhibitor prescribing in the north east of england Publication date: September 2018 Source: Atherosclerosis Supplements, Volume 34 Author(s): P. Banerjee, R.D.G. Neely, S. Pattman, S. Artham, P. Carey, S. Kamaruddin, S. Mada, J. Weaver, S. Chiu

Epidemiology of cardiovascular risk factors in two population-based studies Publication date: September 2018 Source: Atherosclerosis Supplements, Volume 35 Author(s): Elena Olmastroni, Evgeny V. Shlyakhto, Aleksandra O. Konradi, Oxana P. Rotar, Asiiat S. Alieva, Maria A. Boyarinova, Andrea Baragetti, Liliana Grigore, Fabio Pellegatta, Elena Tragni, Alberico L. Catapano, Manuela Casula Abstract We aimed to compare cardiovascular risk factors prevalence in Italy and Russia through cross-sectional database analysis. The study has been based on data from ESSE-RF and from baseline of PLIC study, two population-based epidemiological studies aimed to investigate prevalence of risk factors and evaluating contribution of traditional and new risk factors into morbidity and cardiovascular mortality. A total of 2203 patients with left and right intima-media thickness (IMT) measurements constituted the source population (1205 from PLIC study and 998 from ESSE-RF study). Sample of ESSE-RF study had slightly more diabetic and hypertensive individuals, while the percentage of subjects with high cholesterol value was lower than in the other sample (67.1% vs 79.9%). The median LDL-C value was higher among individuals not treated with statins in the PLIC sample (p < 0.001), while was comparable among subjects receiving statin therapy. On the other hand, the percentage of individuals with positive cardiovascular history was higher in ESSE-RF sample. This could also explain the higher mean IMT value (0.71 ± 0.17 vs 0.63 ± 0.13) in the whole sample, and among patients without past cardiovascular events (regardless of statin treatment), despite some differences in major risk factors. Despite Russian and Italian populations are culturally and geographically different, they are not so different based on characteristics analyzed.

Large artery stiffness according to different assessment methods in adult population of St.Petersburg Publication date: September 2018 Source: Atherosclerosis Supplements, Volume 35 Author(s): A.S. Alieva, O.P. Rotar, A.V. Orlov, M.A. Boyarinova, E.V. Moguchaya, A.N. Rogoza, A.O. Konradi, E.V. Shlyakhto Abstract Objective The aim of the present study was to assess the prevalence of increased arterial stiffness by different diagnostic methods and its association with cardiovascular risk in Russian population-based cohort. Design and methods In terms of Russian epidemiological study ESSE-RF a random selection of 452 apparently healthy Saint-Petersburg inhabitants aged 25–65 years was performed. Fasting lipids, glucose and blood pressure measurements were performed. We used 3 diagnostic methods of arterial stiffness assessment: pulse wave velocity by applanation tonometry (SphygmoCor - PWV-S) and pulse wave velocity by volumetric sphygmography (VaSera - PWV-V), and cardio-ankle vascular index (CAVI) by VaSera. Results 341 (75,4%) had normal parameters of arterial stiffness assessed by all methods. Spearmen's coefficient of correlation and "kappa" coefficient for PWV-S and CAVI were 0,74 and 0,04, for PWV-S and PWV-V - 0,10 and 0,06, for CAVI and PWV-V - 0,28 and 0,03, respectively. There was a significant correlation between cardiovascular risk (defined by SCORE) and PWV-S (r = 0,38, p < 0,001) and a non-significant trend of increasing CAVI along with cardiovascular risk (r = 0,35, p = 0,14). Conclusions Different methods of arterial stiffness assessment showed a weak correlation with each other. Carotid-femoral pulse wave velocity detected by applanation tonometry is associated with high cardiovascular risk score and might be considered as better additional risk marker for cardiovascular risk stratification.

Effect of combination therapy with pcsk9 inhibitors and lipoprotein apheresis Publication date: September 2018 Source: Atherosclerosis Supplements, Volume 34 Author(s): A. Pottle, C. Browne, E. Neves, M. Barbir

An experience of dedicated fh service implementation in hull and east yorkshire hospitals nhs trust Publication date: September 2018 Source: Atherosclerosis Supplements, Volume 34 Author(s): P. Sutton, R. Dunn, R. Desborough, M. Malik, A. Bandyopadhyay, K. Haramblos, D. Narayanan

Setting up a regional fh service; a summary of the achievements and challenges Publication date: September 2018 Source: Atherosclerosis Supplements, Volume 34 Author(s): K. Mitchell, J. Webster, C. Tuson, C. Burton, P. Sutton, R. Dunn, D. Chandrajay, D. Narayanan, M. Mansfield, J. Barth, A. Bandyopadhyay, K. Haralambos, B. Power, J. Jessop

? Dual pathology for pancreatitis in pregnancy Publication date: September 2018 Source: Atherosclerosis Supplements, Volume 34 Author(s): O. Kirresh, U. Srirangalingam, C. Lunken

Unusual presentation of rhabdomyolysis after co-administration of statin and clarithromycin Publication date: September 2018 Source: Atherosclerosis Supplements, Volume 34 Author(s): O. Kirresh, C. Lunken

The impact of socio-economic status on case finding for familial hypercholesterolaemia. Publication date: September 2018 Source: Atherosclerosis Supplements, Volume 34 Author(s): L. Gritzmacher, K. Haralambos, P. Downie, G. Bayly

Patient experience at a dedicated multidisciplinary non-alcoholic fatty liver disease (nafld) clinic encompassing cardiovascular risk assessment and management. a new model of care? Publication date: September 2018 Source: Atherosclerosis Supplements, Volume 34 Author(s): A. Goyale, M.G. Misas, D. Roccarina, D.R. Nair, E. Tsochatzis