Skin Commensal Antigens: Taking the Road Less Traveled

Publication date: Available online 22 February 2018
Source:Trends in Immunology
Author(s): Miqdad O. Dhariwala, Tiffany C. Scharschmidt
Although our knowledge of host–commensal interactions has increased exponentially, the mechanisms linking a specific commensal, its detection by the immune system, and its impact on tissue function are still often poorly understood. In a recent study in Cell, Linehan et al. dissect one of these interactions in the context of the skin, and demonstrate that Staphylococcus epidermidis antigens, presented through a non-classical pathway, drive the accumulation of CD8⁺ T cells that promote wound healing.



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