Prognostic indicators of improved survival and quality of life in surgically treated oral cancer.

Publication date: Available online 31 January 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): G. Tirelli, A. Gatto, P. Bonini, M. Tofanelli, A. Piccinato, Z.M. Arnež
OBJECTIVENo published study has analysed the prognostic factors of surgically treated oral squamous cell carcinoma (OSCC) in relation to both survival and quality of life (QoL). The aim of this study was to analyse postoperative QoL in relation to survival in order to identify which parameters can predict the long-term outcome allowing the best QoL.STUDY DESIGNThis retrospective cohort study considered 167 patients affected by OSCC treated surgically at the Otolaryngology Department of Cattinara Hospital (Trieste, Italy) by a single surgeon. We collected data about the main prognostic factors and the postoperative QoL 12 month after surgery.RESULTSThe 5-year overall survival rate was equal to 68.1% while the 5-year disease-specific-survival (DSS) was 77.8%. In this sample, 32% of patients also underwent adjuvant radio-chemotherapy. On stepwise Cox regression, the best predictors of DSS were the N stage (p<0.001) and tumor depth of invasion (DOI)(p<0.001). QoL was affected by N stage, DOI, invasive surgical approach, radiotherapy and neck dissection (p<0.05).CONCLUSIONThe prognostic factors that affect both survival rates and residual QoL are the surgical approach, the neck stage and the DOI, all of which can be minimized by early diagnosis.



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