Regeneration of complex oral organs using 3D cell organization technology.

Regeneration of complex oral organs using 3D cell organization technology.

Curr Opin Cell Biol. 2017 Dec 28;49:84-90

Authors: Oshima M, Ogawa M, Tsuji T

Abstract
The development of organoid techniques for regenerative therapy has progressed remarkably with the use of tissue-derived stem cells and pluripotent stem cells based on stem cell biology and tissue engineering technology. To realize whole-organ replacement therapy as next-generation regenerative medicine, it is expected that fully functional bioengineered organs can be reconstructed using an in vitro three-dimensional (3D) bioengineered organ germ and organoids by stem cell manipulation and self-organization. In this mini-review, we focused on substantial advances of 3D bioengineering technologies for the regeneration of complex oral organs with the reconstruction of 3D bioengineered organ germ using organ-inductive potential embryo-derived epithelial and mesenchymal cells. These bioengineering technologies have the potential for realization of future organ replacement therapy.

PMID: 29289879 [PubMed - as supplied by publisher]

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