Agitation thrombolysis and catheter-directed thrombolysis for normotensive patients with acute pulmonary thromboembolism

Abstract

Objective

To assess the feasibility, efficacy, and safety of agitation thrombolysis and catheter-directed thrombolysis (AT–CDT) in the treatment of normotensive patients with acute pulmonary thromboembolism (PTE).

Methods

A total of 37 consecutive patients of normotensive PTE were treated by AT–CDT between October 2011 and January 2016. Clinical outcomes and mortality were evaluated after the treatment, and follow-up was carried out after hospital discharge.

Results

AT–CDT was technically successful in 93.7% (36/37) patients, with one case died from respiratory failure during procedure. The clinical success rate was 91.9% (34/37), one patient died from intracranial hemorrhage 9 days after agitation, and one case showed no improvement. A total of 83.8% (31/37) cases were clinical cured and 8.1% (3/37) cases were relieved during hospitalization. Three cases died of respiratory failure caused by PTE, and two cases died of diseases unrelated to PTE (lung carcinoma/hemoptysis) during a 20–1524 days of follow-up.

Conclusion

AT–CDT may be a feasible, effective, and safe treatment for normotensive patients with acute PTE.

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