Prognostic value of combining a quantitative image feature from positron emission tomography with clinical factors in oligometastatic non-small cell lung cancer

Publication date: Available online 28 November 2017
Source:Radiotherapy and Oncology
Author(s): Garrett L. Jensen, Christine M. Yost, Dennis S. Mackin, David V. Fried, Shouhao Zhou, Laurence E. Court, Daniel R. Gomez
Background and purposeOligometastatic non-small cell lung cancer (NSCLC) is a heterogeneous condition with few known risk stratification factors. A quantitative imaging feature (QIF) on positron emission tomography (PET), gray-level co-occurrence matrix energy, has been linked with outcome of nonmetastatic NSCLC. We hypothesized that GLCM energy would enhance the ability of models comprising standard clinical prognostic factors (CPFs) to stratify oligometastatic patients based on overall survival (OS).Materials and methodsWe assessed 79 patients with oligometastatic NSCLC (≤3 metastases) diagnosed in 2007–2015. The primary and largest metastases at diagnosis were delineated on pretreatment scans with GLCM energy extracted using imaging biomarker explorer (IBEX) software. Iterative stepwise elimination feature selection based on the Akaike information criterion identified the optimal model comprising CPFs for predicting OS in a multivariate Cox proportional hazards model. GLCM energy was tested for improving prediction accuracy.ResultsEnergy was a significant predictor of OS (P = 0.028) in addition to the selected CPFs. The c-indexes for the CPF-only and CPF + Energy models were 0.720 and 0.739.ConclusionsIncorporating Energy strengthened a CPF model for predicting OS. These findings support further exploration of QIFs, including markers of the primary tumor vs. those of the metastatic sites.



from Imaging via alkiviadis.1961 on Inoreader http://ift.tt/2AG5nzf