CD155, an onco-immunologic molecule in human tumors

Abstract

CD155 is the fifth member in nectin-like molecule family, and functions as the receptor of poliovirus, therefore CD155 is also called necl-5 or PVR. As an immunoglobulin-like adhesion molecule, CD155 is involved in cell motility, and NK and T cell -mediated immunity. CD155 is barely or weakly expressed in various normal human tissues, but frequently overexpressed in human malignant tumors. CD155 overexpression promotes tumor cell invasion and migration, and is associated with tumor progression and poor prognosis. As the ligand for both costimulatory receptor CD226 and coinhibitory receptor TIGIT and CD96 on NK and T cells, CD155 seems to play a dual role in oncoimmunity. However, some recent studies indicate that CD155 overexpression may induce tumor immune escape. Taken together, CD155 may be considered as a target for the treatment of tumors with CD155 overexpression.

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