Dendritic Cell Trafficking and Function in Rare Lung Diseases.

Dendritic Cell Trafficking and Function in Rare Lung Diseases.

Am J Respir Cell Mol Biol. 2017 Jun 06;:

Authors: Liu H, Jakubzick C, Osterburg AR, Nelson RL, Gupta N, McCormack FX, Borchers MT

Abstract
Dendritic cells (DCs) are highly specialized immune cells that capture antigens and then migrate to lymphoid tissue and present antigen to T cells. This critical function of DCs is well defined and recent studies further demonstrate that DCs are also key regulators of several innate immune responses. Studies focused on the roles of DCs in the pathogenesis of common lung diseases such as asthma, infection and cancer have traditionally driven our mechanistic understanding of pulmonary DC biology. The emerging development of novel DC reagents, techniques and genetically modified animal models has provided abundant data revealing distinct populations of DCs in the lung and allow us to examine mechanisms of DC development, migration and function in pulmonary disease with unprecedented detail. This enhanced understanding of DCs permits the examination of the potential role of DCs in diseases with known or suspected immunological underpinnings. Recent advances in the study of rare lung diseases including, pulmonary Langerhans cell histiocytosis, sarcoidosis, hypersensitivity pneumonitis, and pulmonary fibrosis, reveal expanding potential pathogenic roles for DCs. Here, we provide a review of DC development, trafficking and effector functions in the lung and discuss how alterations in these DC pathways contribute to the pathogenesis of rare lung diseases.

PMID: 28586276 [PubMed - as supplied by publisher]

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