Antinociceptive Activity of Methanol Extract of Tabebuia hypoleuca (C. Wright ex Sauvalle) Urb. Stems

Objective: The aim of this study was to evaluate the antinociceptive activity of the methanol extract of Tabebuia hypoleuca stems (THME). Material and methods: The animals were divided into five groups of eight mice in each test (negative control, positive control and three groups treated with THME at doses of 150, 300 and 500 mg/kg, p.o.). The antinociceptive effect of THME was evaluated using the writhing, formalin, tail flick and hot plate models in mice. Results: In the writhing test, THME (150, 300 and 500 mg/kg) produced significantly (p

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