Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization

The biological effect of charged-particle beams depends on both dose and particle spectrum. As one of the physical quantities describing the particle spectrum of charged-particle beams, we considered the linear energy transfer (LET) throughout this study. We investigated a new therapeutic technique using two or more ion species in one treatment session, which we call an intensity modulated composite particle therapy (IMPACT), for optimizing the physical dose and dose-averaged LET distributions in a patient as its proof of principle. Protons and helium, carbon, and oxygen ions were considered as ion species for IMPACT. For three cubic targets of 4  ×  4  ×  4, 8  ×  8  ×  8, and 12  ×  12  ×  12 cm 3 , defined at the center of the water phantom of 20  ×  20  ×  20 cm 3 , we made IMPACT plans of two composite fields with opposing and orthogonal geometries. The prescribed dose to the target was fixed at 1 Gy, while the prescribed LET to the target was varied from ...

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