Tracking reorganization of large-scale effective connectivity in aphasia following right hemisphere stroke.

Tracking reorganization of large-scale effective connectivity in aphasia following right hemisphere stroke.

Brain Lang. 2017 Mar 29;170:12-17

Authors: Gow DW, Ahlfors SP

Abstract
In this paper we demonstrate the application of new effective connectivity analyses to characterize changing patterns of task-related directed interaction in large (25-55 node) cortical networks following the onset of aphasia. The subject was a left-handed woman who became aphasic following a right-hemisphere stroke. She was tested on an auditory word-picture verification task administered one and seven months after the onset of aphasia. MEG/EEG and anatomical MRI data were used to create high spatiotemporal resolution estimates of task-related cortical activity. Effective connectivity analyses of those data showed a reduction of bilateral network influences on preserved right-hemisphere structures, and an increase in intra-hemispheric left-hemisphere influences. She developed a connectivity pattern that was more left lateralized than that of right-handed control subjects. Her emergent left hemisphere network showed a combination of increased functional subdivision of perisylvian language areas and recruitment of medial structures.

PMID: 28364641 [PubMed - as supplied by publisher]

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