Transcriptional Addiction in Cancer

Publication date: 9 February 2017
Source:Cell, Volume 168, Issue 4
Author(s): James E. Bradner, Denes Hnisz, Richard A. Young
Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs. These dysregulated programs can cause cancer cells to become highly dependent on certain regulators of gene expression. Here, we discuss how transcriptional control is disrupted by genetic alterations in cancer cells, why transcriptional dependencies can develop as a consequence of dysregulated programs, and how these dependencies provide opportunities for novel therapeutic interventions in cancer.

Teaser

Gene dysregulation in cancer cells leads to tumor-specific transcriptional dependencies that can be targeted by a new generation of anti-cancer drugs.


from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2kc84fh
via IFTTT