Transcranial magnetic stimulation as a biomarker for epilepsy

<span class="paragraphSection">Sir, We read with interest the report by <a href="#aww345-B3" class="reflinks">Badawy <span style="font-style:italic;">et al.</span> (2013<span style="font-style:italic;">a</span>)</a> highlighting changes in cortical excitability in subjects with epilepsy and their siblings. It adds to the body of work of this group consistently showing that cortical excitability, measured by transcranial magnetic stimulation (TMS) may have potential as an epilepsy biomarker (<a href="#aww345-B1" class="reflinks">Badawy and Jackson, 2012</a>; <a href="#aww345-B4" class="reflinks">Badawy <span style="font-style:italic;">et al.</span>, 2013<span style="font-style:italic;">b</span></a>, <a href="#aww345-B6" class="reflinks">2014</a>, <a href="#aww345-B7" class="reflinks">2015</a>). Responses to TMS were shown to have a relatively large interindividual variability (see for example <a href="#aww345-B9" class="reflinks">Valls-Solé <span style="font-style:italic;">et al.</span>, 1992</a>; <a href="#aww345-B8" class="reflinks">Du <span style="font-style:italic;">et al.</span>, 2014</a>). Badawy <span style="font-style:italic;">et al.</span>rsquo;s. reports do not provide clear information on interindividual variability. To estimate the variability across these reports, we extracted the data from some of their figures and compared these.</span>

from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2mBQVx6
via IFTTT