Publication date: June 2017
Source:International Journal of Biological Macromolecules, Volume 99
Author(s): Pitchaya Treenate, Pathavuth Monvisade
The aim of this study is to investigate in vitro drug release profiles of pH-sensitive hydrogels composed of hydroxyethylacryl chitosan (HC) and sodium alginate (SA). The hydrogels were crosslinked by dipping method using different ionic crosslinkers (e.g., Ca2+, Zn2+ and Cu2+). The crosslinking reaction was confirmed by FT-IR. Swelling behavior and stability of the hydrogels in simulated digestive media were investigated. The result indicated that the combination between HC and SA could delay the degradation time of the hydrogels. Calcium crosslinking system showed higher stability than that of zinc or copper crosslinking system. In vitro drug release profiles were studied using paracetamol as a soluble model drug. The amount of paracetamol release in simulated gastric fluid (SGF) was relatively low (<20%). In simulated intestinal fluid (SIF), the burst release of paracetamol was depressed with increasing HC content and/or applying crosslinker. The HC75SA25 formulation demonstrated the linearity of drug release profile. Additionally, the amount of drug release from the 0.5M calcium HC50SA50 hydrogel in SIF was lower than 20%. The comprehensive results of this study suggested their potential in the application of site-specific oral drug delivery in intestine and colon.
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2muL3FY
via IFTTT
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Publication date: Available online 4 January 2018 Source: European Journal of Radiology Author(s): Peiyao Zhang, Jing Wang, Qin Xu, Zhen...
-
Publication date: March 2017 Source: Free Radical Biology and Medicine, Volume 104 from #AlexandrosSfakianakis via Alexandros G.Sfak...
-
Dtsch med Wochenschr DOI: 10.1055/s-0043-100054 Hintergrund und Fragestellung Ein etablierter Weg, die optimale Behandlung von Tumorpatien...
-
Background Hyperthyroidism is associated with increased thrombotic risk. As contact system activation through formation of neutrophil extrac...
-
Deepak Thapa, Vanita Ahuja, Deepanshu Dhiman Indian Journal of Anaesthesia 2017 61(12):1012-1014 from #AlexandrosSfakianakis via Alexa...
-
Abstract Limited memory size is considered as a major bottleneck in data centers for intelligent urban computing. It is shown that there e...
-
ecancer is supporting #BowelCancerAwarenessMonth https://t.co/opXxCAAxzE from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inore...
-
Linked Article: Maintz et al. Br J Dermatol 2017; 176:481–487 . from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader h...
-
Angelina Jolie’s openness about her diagnosis has undoubtedly raised public awareness of the importance of inherited cancers. Although Desai...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου