Emerging Biological Principles of Metastasis

Publication date: 9 February 2017
Source:Cell, Volume 168, Issue 4
Author(s): Arthur W. Lambert, Diwakar R. Pattabiraman, Robert A. Weinberg
Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge.

Teaser

Metastatic growth is responsible for a majority of cancer-related deaths and understanding the cellular and molecular mechanisms driving it will yield new insights toward approaching cancer therapies.


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