Applications of Immunogenomics to Cancer

Publication date: 9 February 2017
Source:Cell, Volume 168, Issue 4
Author(s): X. Shirley Liu, Elaine R. Mardis
Cancer immunogenomics originally was framed by research supporting the hypothesis that cancer mutations generated novel peptides seen as “non-self” by the immune system. The search for these “neoantigens” has been facilitated by the combination of new sequencing technologies, specialized computational analyses, and HLA binding predictions that evaluate somatic alterations in a cancer genome and interpret their ability to produce an immune-stimulatory peptide. The resulting information can characterize a tumor’s neoantigen load, its cadre of infiltrating immune cell types, the T or B cell receptor repertoire, and direct the design of a personalized therapeutic.

Teaser

The development of new high-throughput technologies facilitates the application of immunogenomics to cancer.


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