Studies on the relationship between P13K/AKT signal pathway-mediated MMP-9 gene and lung cancer

OBJECTIVE: The present study has been planned to explore the relationship between P13K/AKT signal pathway-mediated matrix metalloproteinase-9 (MMP-9) gene and lung cancer.

PATIENTS AND METHODS: The adjacent lesion tissues were removed from 68 cases of patients with lung cancer admitted to our hospital from February 2013 to February 2015. They were selected as observation group, and the pulmonary adjacent normal section specimens from 18 cases were taken as control group. The differences in expression quantities of P13K, AKT and MMP-9 genes in adjacent lesion tissues and adjacent normal tissues were detected by fluorescence quantitative PCR technology, enzyme-linked immunosorbent assay (ELISA), Western-blotting technology and immunohistochemical technique and SP staining technology.

RESULTS: The mRNA expression quantities of P13K, AKT and MMP-9 genes in adjacent lesion tissues increased significantly in comparison to adjacent normal tissues, and the differences were statistically significant (p<0.05). The results of Spearman correlation detection showed that the expression quantity of MMP-9 in adjacent lesion tissues had significantly positive correlation with that of P13K and AKT (r=0.232, p<0.05).

CONCLUSIONS: MMP-9 gene could promote the generation of lung cancer through P13K/AKT signal pathway, which provides certain theoretical and experimental basis for subsequent diagnosis and treatment of lung cancer.

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