Treatment options for metastatic renal cell carcinoma (RCC) are limited. In this study, we investigated impact of prostaglandin E2 (PGE2) receptor 4 (EP4) on RCC metastasis. We found that knockdown of EP4 in two RCC cell lines, ACHN and SN12C, does not affect xenograft tumor take or growth rate in mice, but reduces metastasis by decreasing tumor intravasation. Using chick chorioallantoic membrane (CAM) assay, we confirmed that blockade of EP4 signaling inhibits tumor intravasation. In vitro studies associated EP4 expression and activity with RCC cell transendothelial migration (TEM).
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from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2oLOayI via IFTTT
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Publication date: 18 April 2017 Source: Cell Reports, Volume 19, Issue 3 Author(s): David Estoppey, Chia Min Lee, Marco Janoschke, Boon He...
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Abstract Functionalised electrospun polyamide-6 (PA-6) nanofibres incorporating gadolinium oxide nanoparticles conjugated to zinc tetracar...
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Cytokine-dependent renewal of stem cells is a fundamental requisite for tissue homeostasis and regeneration. Spermatogonial progenitor cells...
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Yahoo Health Ken Brookes Lost 102 Pounds: 'I Never Want to Go Back to Being Unhealthy' Yahoo Health My wife died of ovarian ...
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Own a website? Manage your page to keep your users updated View some of our premium pages: . . . . Upgrade to a Premium Page from #Alexand...
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Abstract Background Cells in the intervertebral disc have unique phenotypes and marker genes that separate the nucleus pulposus (NP), an...
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Radiation Research, Volume 187, Issue 6 , Page 647-658, June 2017. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader ...
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Publication date: Available online 23 February 2017 Source: Journal of Biomechanics Author(s): Lipika Parida, Udita Uday Ghosh, Venkat Pad...
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