Treatment options for metastatic renal cell carcinoma (RCC) are limited. In this study, we investigated impact of prostaglandin E2 (PGE2) receptor 4 (EP4) on RCC metastasis. We found that knockdown of EP4 in two RCC cell lines, ACHN and SN12C, does not affect xenograft tumor take or growth rate in mice, but reduces metastasis by decreasing tumor intravasation. Using chick chorioallantoic membrane (CAM) assay, we confirmed that blockade of EP4 signaling inhibits tumor intravasation. In vitro studies associated EP4 expression and activity with RCC cell transendothelial migration (TEM).
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Ich konzipiere den in London wirkende Schweizer Maler Heinrich Füssli (Henry Fuseli, 1741-1825) als Klassizist, die eine neue Sichtweise der...
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Publication date: August 2017 Source: International Journal of Biological Macromolecules, Volume 101 Author(s): Toiba Majeed, Idrees Ahme...
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I'm asked by all of my doctoral students at some point during their writing to give them good dissertation examples. I'm not complai...
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Purpose: Using gene-disrupted allogeneic T cells as universal effector cells provides an alternative and potentially improves current chime...
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