Physicians have been arguing over alcohol, and the meaning of moderation and excess, for more than two millennia. In the classical tradition wine was held in high regard, embodying the heat and moisture characteristic of living things. Like any medicine, though, it was only beneficial in the correct proportions. In excess it could dry the body by provoking urination, and its vapours could rise to the head and fog the faculty of reason. Medical attitudes began to shift most radically after the 18th-century Gin Craze, as mainstream opinion turned against intoxication in its most potent forms.
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