Postmortem concentrations of -hydroxybutyrate (GHB) in peripheral blood and brain tissue — differentiating between postmortem formation and antemortem intake

Gamma-hydroxybutyrate (GHB) is a naturally-occurring neurotransmitter as well as a psychoactive compound. GHB has been used medically for various purposes including as a general anesthetic, treatment of narcolepsy and alcohol withdrawal [1]. It has also been used illegally as an intoxicant, as a means for drug-facilitated sexual assault and as a muscle growth-promoting agent [1]. On the illicit market GHB is often referred to as “liquid ecstasy” or “fantasy”. Chemically, GHB is closely related to the neurotransmitter gamma-aminobutyric acid (GABA) for which it is both a metabolite and a precursor [2].

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