Juvenile systemic lupus erythematosus (jSLE): Auditory pathway affection in relation to disease activity.

Juvenile systemic lupus erythematosus (jSLE): Auditory pathway affection in relation to disease activity.

Int J Pediatr Otorhinolaryngol. 2017 Feb;93:150-156

Authors: Kotait MA, Abd Elnabi HH, Gabr TA

Abstract
BACKGROUND: Juvenile Systemic lupus erythematosus (jSLE) is an autoimmune disease with the potential to affect a variety of organs in children or adolescents. jSLE is characterized by its severity and more widespread organ involvement specially central nervous system.
OBJECTIVES: To evaluate auditory processing and cognitive functions in children and adolescents with SLE taking into consideration the disease severity.
METHODS: This work included 40 normal hearing pediatric patients diagnosed as SLE (23 with active disease and 17 with inactive disease) and a control group included 30 matched healthy children. The methodology included basic audiologic evaluation, mismatch negativity (MMN) in response to speech and tone stimuli and memory tests.
RESULTS: Children with jSLE showed impaired hearing thresholds. They also showed impaired MMN recording in response to speech or tone stimuli with impaired memory subtests.
CONCLUSIONS: Peripheral and central auditory systems are affected in jSLE. This affection is worse with active disease.

PMID: 28109488 [PubMed - in process]

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