Cryo-EM Captures the Dynamics of Ion Channel Opening

Publication date: 26 January 2017
Source:Cell, Volume 168, Issue 3
Author(s): John L. Rubinstein
In this issue of Cell, Hite and MacKinnon (2017) report the open conformation structure of Slo2.2, a neuronal Na⁺-activated K⁺ channel. More importantly, 3D classification of electron cryomicroscopy (cryo-EM) images allows visualization of the structural transition that occurs as the open probability of individual channels increases with added sodium.

Teaser

In this issue of Cell, Hite and MacKinnon (2017) report the open conformation structure of Slo2.2, a neuronal Na⁺-activated K⁺ channel. More importantly, 3D classification of electron cryomicroscopy (cryo-EM) images allows visualization of the structural transition that occurs as the open probability of individual channels increases with added sodium.


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