A Red Carpet for Iron Metabolism

Publication date: 26 January 2017
Source:Cell, Volume 168, Issue 3
Author(s): Martina U. Muckenthaler, Stefano Rivella, Matthias W. Hentze, Bruno Galy
200 billion red blood cells (RBCs) are produced every day, requiring more than 2 × 10¹⁵ iron atoms every second to maintain adequate erythropoiesis. These numbers translate into 20 mL of blood being produced each day, containing 6 g of hemoglobin and 20 mg of iron. These impressive numbers illustrate why the making and breaking of RBCs is at the heart of iron physiology, providing an ideal context to discuss recent progress in understanding the systemic and cellular mechanisms that underlie the regulation of iron homeostasis and its disorders.

Teaser

The regulation of iron homeostasis and its related disorders arise from interwoven systemic and cellular mechanisms.


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