Πέμπτη, 27 Οκτωβρίου 2016

A Comparative Evaluation Of Intravenous Ranitidine And Rabeprazole On Gastric Volume And Ph In Patients Undergoing Surgery Under General Anaesthesia

2016-10-27T06-44-06Z
Source: The Southeast Asian Journal of Case Report and Review
Sumit Kumar Singh, Mukesh Kumar, Usha Suwalka.
Introduction: The morbidity and mortality associated with the complication of Acid aspiration syndrome increases with the volume and acidity of gastric aspirates. Objective: Routine practice often includes use of pharmacological agents to reduce gastric volume and increase gastric pH. The aim of the study was to compare the effectiveness of intravenous Rabeprazole and intravenous Ranitidine on gastric fluid volume and pH in patients undergoing elective surgery under general anesthesia. Material and Methods: This prospective randomised double blind study was conducted on 90 healthy adult patients of either sex undergoing elective surgery under general anesthesia of age group 18-60 years and three groups were assigned with, Group 1 received intravenous Ranitidine 50 mg, Group 2 received intravenous Rabeprazole 20 mg, Group 3 received 5ml of normal saline(control group) before one hr, on the day of surgery and gastric volume and pH estimated just before induction of anaesthesia. Results: Volume of the gastric aspirates in preintubation was 15.8±2.73 ml in Group 1 (Ranitidine), 14.2±2.93 ml in Group 2 (Rabeprazole) and 20.8±2.81 ml in Group 3 (Control). There was significant (p=0.03) decrease in gastric volume with Rabeprazole compared to Ranitidine. The pH values determined in preintubation was 3.21±0.68 in Group 1 (Ranitidine), 3.66±0.79 in Group 2 (Rabeprazole) and 2.62±0.79 in Group 3 (Control). There was significant (p=0.018) increase in pH with Rabeprazole compared to Ranitidine. Conclusion: From present study it may be concluded that Ranitidine and Rabeprazole both are effective in reducing gastric volume and pH. As compared to Rabeprazole, Ranitidine is less effective in reducing gastric volume and pH but still more commonly used due to its cost effectiveness.


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